功率谱随年龄的变化与综合评分相结合,以评估大脑的脆弱性

IF 2 Q3 NEUROSCIENCES
Julian Ostertag , Aleksandra Migal , David P. Obert , Gerhard Schneider , Pablo Sepúlveda , Matthias Kreuzer
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引用次数: 0

摘要

目的评价全麻诱导时脑电图(EEG)的年龄相关性依赖及其对用于评估衰弱的综合评分的影响。方法利用异丙酚的谱边频率、总功率、α功率和效应位点浓度(Ce)得出sa综合评分。所有这些参数都受年龄、大脑健康、给药剂量和速度的影响。用相关系数和方差膨胀因子确定多重共线性。综合得分“高”与“低”患者的脑电图频谱特征差异采用接收操作者特征曲线下面积(AUC)作为统计检验。结果脑电特征、总功率和α功率呈强相关(ρ = 0.82)。但α功率(ρ = 0.17)和总功率(ρ = 0.2)与异丙酚仅呈弱相关,表明模型较弱。此外,综合评分与年龄呈中度负相关(ρ = -0.44)。我们还观察到显著且强的(AUC <;0.3)在反应性丧失(LOR)前,得分“高”和得分“低”的患者的总功率和除伽马以外的所有EEG波段功率的差异。结论患者年龄对评分中基于脑电图的参数有显著影响。重要的是,在LOR之前,两组之间的频谱EEG特征已经观察到显著差异。这些差异可以允许早期评估患者的大脑状态,并在LOR之前滴定麻醉剂量。该研究还表明,年龄应该被考虑在内,因为它可以驱动“脆弱”的模型。显著性年龄适度影响所有子成分,因此应纳入评分解释。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-dependent changes in the power spectrum conflate composite scores to assess brain frailty

Objective

Evaluating age-related dependencies in the electroencephalogram (EEG) during induction of general anesthesia and their impact on composite scores used to assess frailty.

Methods

A composite score was derived from spectral edge frequency, total power, alpha power, and the effect-site concentration (Ce) of propofol. All these parameters are influenced by age, brain health, and dosage and speed of drug administration. Correlation coefficients and variance inflation factors were used to determine multicollinearity. Differences in the spectral EEG features of patients with “high” and “low” composite scores were assessed by the area under the receiver operator characteristic curve (AUC) as the statistical test.

Results

The EEG features, total power and alpha power, were strongly correlated (ρ = 0.82). But alpha power (ρ = 0.17) and total power (ρ = 0.2) were only weakly correlated with propofol, indicating a weak model. Additionally, the composite score showed a moderate negative correlation with age (ρ = -0.44). We also observed significant and strong (AUC < 0.3) differences in total power and the power of all EEG bands except gamma between patients with a ”high” and a ”low” score before loss of responsiveness (LOR).

Conclusion

Patient age significantly influences EEG-based parameters within the score. Importantly, significant differences in spectral EEG features between the groups were already observable before LOR. These differences could allow for early assessment of a patient’s brain state and to titrate anesthetic dose before LOR. The study also shows that age should be considered as it can drive models for ”frailty”.

Significance

Age moderately influenced all subcomponents and should consequently be factored into score interpretation.
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
47
审稿时长
71 days
期刊介绍: Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.
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