Clinical Neurophysiology Practice最新文献_第6页

Multimodal tele-epileptology: Challenges on the way to interoperable medical data 多模式远程癫痫学：实现医疗数据互操作的挑战

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.02.004

Sigrid Mues , Arndt Ebert , Marc Kämmerer , Marcus Kremers , Ulrich Sliwka , Rüdiger Hilker-Roggendorf , Dirk Woitalla , Iris Adelt , Thomas Günnewig , Ana Miron , Sulev Haldre , Tipakorn Tumnark , Kanjana Unnwongse , Wenke Grönheit , Tim Wehner , Vanessa Behrens , Jörg Wellmer

{"title":"Multimodal tele-epileptology: Challenges on the way to interoperable medical data","authors":"Sigrid Mues , Arndt Ebert , Marc Kämmerer , Marcus Kremers , Ulrich Sliwka , Rüdiger Hilker-Roggendorf , Dirk Woitalla , Iris Adelt , Thomas Günnewig , Ana Miron , Sulev Haldre , Tipakorn Tumnark , Kanjana Unnwongse , Wenke Grönheit , Tim Wehner , Vanessa Behrens , Jörg Wellmer","doi":"10.1016/j.cnp.2025.02.004","DOIUrl":"10.1016/j.cnp.2025.02.004","url":null,"abstract":"<div><h3>Objective</h3><div>To realize multi-modal data exchange for telemedicine in epilepsy.</div></div><div><h3>Methods</h3><div>TE Ruhr is a multicenter, prospective pilot study. Primary endpoint of the study was the technical implementation of a platform between an epilepsy center and regional neurological departments and international cooperating epilepsy centers, respectively. A multi-professional board was established to develop technical workflows. After completion of the study a survey was conducted among users of the regional arm.</div></div><div><h3>Results</h3><div>Two workflows were developed, 1) a combination of web-application and use of an established teleradiology network, and 2) a web-application only data exchange. Technical workflow 1 comprised local EEG conversion into to a standard format (.besa) and its shipping as DICOM RAW object. Technically, both workflows could be implemented. Yet, workflow 1 was not realisable in peripheral hospitals. Via workflow 2, 149 consults for 144 patients were completed. Users of the regional arm were satisfied (1.6 on a grading scale of 1–6 (1-very good, 6- very bad)).</div></div><div><h3>Conclusion</h3><div>Technical feasibility alone does not determine the actual use of telemedicine. Web applications enables multimodal data exchange, but usability is limited due to lack of interoperability.</div></div><div><h3>Significance</h3><div>Genuine interoperability of medical data remains the desired goal for multi modal data exchange.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 56-62"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controversies: Periodic discharges in critically ill patients –” urgent treatment is essential” 争议：危重病人定期出院——“紧急治疗必不可少”

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.06.010

M. Brandon Westover, Peter W. Kaplan, Aatif M. Husain

引用次数: 0

Rapid recovery after four months of near-tetraplegia: A case report of pan-neurofascin nodopathy and a brief review of emerging questions 近四肢瘫痪4个月后快速恢复：一例泛神经束蛋白病理报告和对新出现问题的简要回顾

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.09.005

Dániel Milanovich, Zsolt Mezei, Anna Katalin Iljicsov, János Bíró, Zsuzsanna Arányi, Magdolna Simó

{"title":"Rapid recovery after four months of near-tetraplegia: A case report of pan-neurofascin nodopathy and a brief review of emerging questions","authors":"Dániel Milanovich, Zsolt Mezei, Anna Katalin Iljicsov, János Bíró, Zsuzsanna Arányi, Magdolna Simó","doi":"10.1016/j.cnp.2025.09.005","DOIUrl":"10.1016/j.cnp.2025.09.005","url":null,"abstract":"<div><h3>Objective</h3><div>Pan-neurofascin nodopathy is a rare form of dysimmune neuropathies, mediated by antibodies against the common epitope of the 140, 155 and 186 neurofascin isoforms. These autoantibodies cause the defect of saltatory action potential spreading, disorganization of the nodal-paranodal ultrastructure, and axonal loss of variable degree.</div></div><div><h3>Methods</h3><div>A 32-year old male presented with the typical symptom of acute onset severe tetraparesis. Electrophysiological findings indicated severe conduction failure, but no appreciable axonal loss. High-resolution ultrasound showed diffuse, but patchy pathology, including mild enlargement and abnormal fascicular structure in proximal arm nerves and the brachial plexus. Symptoms worsened despite plasma exchange, and showed only mild and transient improvement upon repeated intravenous immunoglobulin treatment.</div></div><div><h3>Results</h3><div>After the verification of pan-neurofascin antibodies, rituximab treatment was applied and we observed rapid improvement within weeks, leading to complete remission at 6 weeks.</div></div><div><h3>Conclusions</h3><div>A young male with pan-neurofascin nodopathy presenting as acute-onset symptoms resembling Guillain–Barré syndrome, became asymptomatic following 4 months of near-tetraplegia as a result of rituximab therapy.</div></div><div><h3>Significance</h3><div>In pan-neurofascin nodopathy, rituximab treatment can lead to complete reversal of symptoms, even in cases characterized by prolonged and severe clinical manifestations. We also provide one of the first ultrasound descriptions of a pan-neurofascin case.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 433-439"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurophysiology and muscle histopathology in ICU-acquired muscle weakness: Lessons learned from COVID-19 重症监护下获得性肌肉无力的神经生理学和肌肉组织病理学：从COVID-19中吸取的教训

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.05.001

Eva K. Hejbøl , Atle V. Lomstein , Henrik D. Schrøder , Benjamin Khan , Thomas Harbo , Hatice Tankisi

{"title":"Neurophysiology and muscle histopathology in ICU-acquired muscle weakness: Lessons learned from COVID-19","authors":"Eva K. Hejbøl , Atle V. Lomstein , Henrik D. Schrøder , Benjamin Khan , Thomas Harbo , Hatice Tankisi","doi":"10.1016/j.cnp.2025.05.001","DOIUrl":"10.1016/j.cnp.2025.05.001","url":null,"abstract":"<div><h3>Objective</h3><div>To describe different electrophysiological, histopathological, and ultrastructural patterns of muscle pathology in COVID-19-associated intensive care unit acquired weakness (ICUAW) and raise the question of whether COVID-19-associated critical illness myopathy (CIM) is a distinct entity or is similar to CIM of other causes.</div></div><div><h3>Methods</h3><div>A series of three patients with COVID-19-associated ICUAW were presented.</div><div>Clinical examination, electrophysiological testing, and muscle pathology with light and electron microscopy were reported systematically.</div></div><div><h3>Results</h3><div>All three patients were clinically affected with severe proximal and distal weakness of upper and lower extremities, increased plasma levels of muscle enzymes, and had myopathic electromyography. Furthermore, in two patients, electrophysiological signs of inflammatory myopathy with profuse denervation activity were present. Muscle pathologies were prominent but very diverse. One patient had signs of CIM, another showed severe inflammatory myopathy, and the main finding in the third patient was mitochondrial changes.</div></div><div><h3>Conclusion</h3><div>Although the three cases showed similar clinical and electrophysiological patterns, muscle pathology revealed distinct underlying features. This spectrum of muscle disease among patients with severe COVID-19 includes CIM, autoimmune response to the COVID-19 infection, and mitochondrial dysfunction.</div></div><div><h3>Significance</h3><div>Electrophysiology and histopathology complement each other and are important for determining the etiology, as well as guiding treatment and prognosis.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 172-180"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of clinical neurophysiological assessment on diagnosis and management of tremor disorders 临床神经生理学评估对震颤障碍诊断和治疗的影响

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.05.003

Katherine Longardner , Yasoda Satpathy , Irene Litvan , Dietrich Haubenberger

{"title":"Impact of clinical neurophysiological assessment on diagnosis and management of tremor disorders","authors":"Katherine Longardner , Yasoda Satpathy , Irene Litvan , Dietrich Haubenberger","doi":"10.1016/j.cnp.2025.05.003","DOIUrl":"10.1016/j.cnp.2025.05.003","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the clinical utility of a standardized, non-invasive electrodiagnostic testing protocol in refining the diagnosis and management of patients referred for tremor evaluation.</div></div><div><h3>Methods</h3><div>In this prospective observational study, patients with tremulous limb movements with indeterminate clinical diagnoses involving tremor as a cardinal symptom were referred by movement disorders neurologists. Participants underwent standardized phenotyping and electrodiagnostic studies for tremor analysis including four-channel surface electromyography polygraphy and two-channel accelerometry.</div></div><div><h3>Results</h3><div>Clinical and electrophysiological data from 31 consecutive individuals were analyzed. Electrodiagnostic testing refined the differential diagnosis in 25/31 (80.6 %) participants and changed therapy in 14/29 (48.3 %). Changes included adjusting pharmacotherapy (n = 10), undergoing deep brain stimulation surgery (n = 2), or avoiding invasive procedures (n = 2).</div></div><div><h3>Conclusions</h3><div>We propose that electrodiagnostic testing is a clinically valuable tool that can narrow the differential diagnosis and impact treatment of tremor.</div></div><div><h3>Significance</h3><div>Clinical evaluation alone may be insensitive in diagnosing the tremor type when findings are subtle or when multiple movement disorders coexist. This may lead to inaccurate diagnosis and management, increasing cost and patient burden, and prolonging or preventing a successful journey towards adequate treatment. Clinical neurophysiology is a useful diagnostic procedure that can detect and quantify movements that may be otherwise indistinguishable by visual observation.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 188-201"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144307951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between sleep-deprived, and melatonin-induced sleep electroencephalography in children of different ages: a randomized controlled trial 不同年龄儿童睡眠剥夺和褪黑素诱发睡眠脑电图的比较：一项随机对照试验

IF 2

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI: 10.1016/j.cnp.2025.09.002

Greta Gustafsson , Martin Ulander , Cornelia Lauermann , Johanna Thegerström , Kathe Dahlbom , Anders Broström , Eva Svanborg , Magnus Vrethem

{"title":"Comparison between sleep-deprived, and melatonin-induced sleep electroencephalography in children of different ages: a randomized controlled trial","authors":"Greta Gustafsson , Martin Ulander , Cornelia Lauermann , Johanna Thegerström , Kathe Dahlbom , Anders Broström , Eva Svanborg , Magnus Vrethem","doi":"10.1016/j.cnp.2025.09.002","DOIUrl":"10.1016/j.cnp.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate possible age-specific differences in the diagnostic yield of sleep-deprived, and melatonin-induced pediatric sleep EEGs. The multicenter study was performed prospectively.</div></div><div><h3>Methods</h3><div>Children referred to sleep EEG (n = 169), were stratified into three age groups (2–5; 6–11; 12–17 years) and randomized to sleep induction by melatonin or partial sleep deprivation. Epileptiform activity, sleep, adverse effects, and technical recording quality were compared between study arms and age categories.</div></div><div><h3>Results</h3><div>Epileptiform activity occurred in 36% of the children, without significant differences between melatonin and sleep-deprived EEGs. In 6–11-year-old children, epileptiform abnormalities occurred in 49%, significantly higher than in the other age groups independent of the sleep-inducing method. Sleep, but not the sleep induction method, was significantly associated with the presence of epileptiform activity (OR 9.16). The occurrence of sleep was significantly higher (97%) after melatonin induction compared to sleep deprivation (86%) without age differences. No serious adverse effects were registered.</div></div><div><h3>Conclusions</h3><div>There were no differences concerning the occurrence of epileptiform activity in EEG after melatonin induction or sleep deprivation in children of any age category. Melatonin increased the likelihood of sleep.</div></div><div><h3>Significance</h3><div>Melatonin as a premedication for sleep EEG should be considered safe and efficient in terms of diagnostic yield.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"10 ","pages":"Pages 426-432"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical neurophysiology of REM parasomnias: Diagnostic aspects and insights into pathophysiology 快速动眼期寄生虫的临床神经生理学：诊断方面和病理生理学见解

IF 1.7

Clinical Neurophysiology Practice Pub Date : 2024-01-01 DOI: 10.1016/j.cnp.2023.10.003

Melanie Bergmann , Birgit Högl , Ambra Stefani

{"title":"Clinical neurophysiology of REM parasomnias: Diagnostic aspects and insights into pathophysiology","authors":"Melanie Bergmann , Birgit Högl , Ambra Stefani","doi":"10.1016/j.cnp.2023.10.003","DOIUrl":"10.1016/j.cnp.2023.10.003","url":null,"abstract":"<div><p>Parasomnias are due to a transient unstable state dissociation during entry into sleep, within sleep, or during arousal from sleep, and manifest with abnormal sleep related behaviors, perceptions, emotions, dreams, and autonomic nervous system activity.</p><p>Rapid eye movement (REM) parasomnias include REM sleep behavior disorder (RBD), isolated recurrent sleep paralysis and nightmare disorder. Neurophysiology is key for diagnosing these disorders and provides insights into their pathophysiology.</p><p>RBD is very well characterized from a neurophysiological point of view, also thank to the fact that polysomnography is needed for the diagnosis. Diagnostic criteria are provided by the American Academy of Sleep Medicine and video-polysomnography guidelines for the diagnosis by the International REM Sleep Behavior Disorder Study Group. Differences between the two sets of criteria are presented and discussed. Availability of polysomnography in RBD provides data on sleep electroencephalography (EEG), electrooculography (EOG) and electromyography (EMG). Sleep EEG in RBD shows e.g. changes in delta and theta power, in sleep spindles and K complexes. EMG during REM sleep is essential for RBD diagnosis and is an important neurodegeneration biomarker. RBD patients present alterations also in wake EEG, autonomic function, evoked potentials, and transcranial magnetic stimulation.</p><p>Clinical neurophysiological data on recurrent isolated sleep paralysis and nightmare disorder are scant. The few available data provide insights into the pathophysiology of these disorders, demonstrating a state dissociation in recurrent isolated sleep paralysis and suggesting alterations in sleep macro- and microstructure as well as autonomic changes in nightmare disorder.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 53-62"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000027/pdfft?md5=284f181c314e115bc2779fb68c7c51dd&pid=1-s2.0-S2467981X24000027-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory nerve conduction studies in infants, children and teenagers – An update 婴儿、儿童和青少年的感觉神经传导研究--最新进展

IF 1.7

Clinical Neurophysiology Practice Pub Date : 2024-01-01 DOI: 10.1016/j.cnp.2024.01.001

Tom Frenzel , Anne-Katrin Baum , Hardy Krause , Christoph Arens , Aiden Haghikia , Imke Galazky

{"title":"Sensory nerve conduction studies in infants, children and teenagers – An update","authors":"Tom Frenzel , Anne-Katrin Baum , Hardy Krause , Christoph Arens , Aiden Haghikia , Imke Galazky","doi":"10.1016/j.cnp.2024.01.001","DOIUrl":"10.1016/j.cnp.2024.01.001","url":null,"abstract":"<div><h3>Objective</h3><p>Nerve conduction studies (NCS) in children remain technically challenging and depend on the cooperation of the child. Motor NCS are not compromised by analgosedation but data for sensory NCS are lacking. Here, we ask whether sensory NCS is influenced by analgosedation. We also compare the present data with NCS studies from the 1990s regarding anthropometric acceleration of the contemporary paediatric population.</p></div><div><h3>Methods</h3><p>Sensory NCS of the median nerve and sural nerve were performed in 182 healthy subjects aged 1 to 18 years during general anaesthesia and in 47 of them without analgosedation.</p></div><div><h3>Results</h3><p>Sensory NCS was not influenced by midazolam or propofol. The sensory nerve action potential (SNAP) amplitude and the nerve conduction velocity (NCV) of the sural nerve as well as the SNAP of the median nerve show no significant age dependence in age range 1–18 years. The sensory NCV of the median nerve increased age-dependent.</p></div><div><h3>Conclusions</h3><p>In clinical practice, analgosedation can be used for diagnostic NCS. Sensory NCS data show no relevant secular trend over the last 30 years. Differences due to technical inconsistency predominate.</p></div><div><h3>Significance</h3><p>Analgosedation can improve diagnostic quality of sensory NCS in children. Additionally, we provide sensory NCS values from a large pediatric cohort.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 63-68"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X24000015/pdfft?md5=61bf88b20b03d7d1f52c1913018a1aab&pid=1-s2.0-S2467981X24000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139457901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of sleep deprivation on cortical excitability: A threshold-tracking TMS study and review of the literature 剥夺睡眠对大脑皮层兴奋性的影响：阈值追踪 TMS 研究和文献综述

IF 1.7

Clinical Neurophysiology Practice Pub Date : 2024-01-01 DOI: 10.1016/j.cnp.2023.12.001

Magdalena Mroczek , Amedeo de Grado , Hossain Pia , Zahra Nochi , Hatice Tankisi

{"title":"Effects of sleep deprivation on cortical excitability: A threshold-tracking TMS study and review of the literature","authors":"Magdalena Mroczek , Amedeo de Grado , Hossain Pia , Zahra Nochi , Hatice Tankisi","doi":"10.1016/j.cnp.2023.12.001","DOIUrl":"10.1016/j.cnp.2023.12.001","url":null,"abstract":"<div><h3>Objective</h3><p>Insufficient sleep is linked to several health problems. Previous studies on the effects of sleep deprivation on cortical excitability using conventional transcranial magnetic stimulation (TMS) included a limited number of modalities, and few inter-stimulus intervals (ISIs) and showed conflicting results. This study aimed to investigate the effects of sleep deprivation on cortical excitability through threshold-tracking TMS, using a wide range of protocols at multiple ISIs.</p></div><div><h3>Methods</h3><p>Fifteen healthy subjects (mean age ± SD: 36 ± 3.34 years) were included. The following tests were performed before and after 24 h of sleep deprivation using semi-automated threshold-tacking TMS protocols: short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) at 11 ISIs between 1 and 30 ms, short interval intracortical facilitation (SICF) at 14 ISIs between 1 and 4.9 ms, long interval intracortical inhibition (LICI) at 6 ISIs between 50 and 300 ms, and short-latency afferent inhibition (SAI) at 12 ISIs between 16 and 30 ms.</p></div><div><h3>Results</h3><p>No significant differences were observed between pre- and post-sleep deprivation measurements for SICI, ICF, SICF, or LICI at any ISIs (p < 0.05). As for SAI, we found a difference at 28 ms (p = 0.007) and 30 ms (p = 0.04) but not at other ISIs.</p></div><div><h3>Conclusions</h3><p>Sleep deprivation does not affect cortical excitability except for SAI.</p></div><div><h3>Significance</h3><p>This study confirms some of the previous studies while contradicting others.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 13-20"},"PeriodicalIF":1.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X23000318/pdfft?md5=e67a80b5f9c36abe3de95d1e36740be1&pid=1-s2.0-S2467981X23000318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decreased diaphragm moving distance measured by ultrasound speckle tracking reflects poor prognosis in amyotrophic lateral sclerosis 超声斑点追踪技术测量的膈肌移动距离减少反映了肌萎缩侧索硬化症的不良预后

IF 2

Clinical Neurophysiology Practice Pub Date : 2024-01-01 DOI: 10.1016/j.cnp.2024.10.002

Shunsuke Watanabe , Kenji Sekiguchi , Hirotomo Suehiro , Masaaki Yoshikawa , Yoshikatsu Noda , Naohisa Kamiyama , Riki Matsumoto

{"title":"Decreased diaphragm moving distance measured by ultrasound speckle tracking reflects poor prognosis in amyotrophic lateral sclerosis","authors":"Shunsuke Watanabe , Kenji Sekiguchi , Hirotomo Suehiro , Masaaki Yoshikawa , Yoshikatsu Noda , Naohisa Kamiyama , Riki Matsumoto","doi":"10.1016/j.cnp.2024.10.002","DOIUrl":"10.1016/j.cnp.2024.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>Decreased cephalocaudal diaphragm movement may indicate respiratory dysfunction in amyotrophic lateral sclerosis (ALS). We aimed to evaluate diaphragm function in ALS using ultrasound speckle tracking, an image-analysis technology that follows similar pixel patterns.</div></div><div><h3>Methods</h3><div>We developed an offline application that tracks pixel patterns of recorded ultrasound video images using speckle-tracking methods. Ultrasonography of the diaphragm movement during spontaneous quiet respiration was performed on 19 ALS patients and 21 controls to measure the diaphragm moving distance (DMD) in the cephalocaudal direction during a single respiration. We compared respiratory function measures and analyzed the relationship between the clinical profiles and DMD.</div></div><div><h3>Results</h3><div>DMD was significantly lower in ALS patients than in the control group (0.6 ± 1.4 mm vs 2.2 ± 2.2 mm, <em>p</em> < 0.01) and positively correlated with phrenic nerve compound motor action potential amplitude (R = 0.63, <em>p</em> = 0.01). DMD was negatively correlated with the change in the ALS Functional Rating Scale-Revised scores per month after the exam (R = −0.61, <em>p</em> = 0.02), and those with a larger rate of decline had a significantly lower DMD (<em>p</em> = 0.03).</div></div><div><h3>Conclusions</h3><div>Diaphragm ultrasound speckle tracking enabled the detection of diaphragm dysfunction in ALS.</div></div><div><h3>Significance</h3><div>Diaphragm ultrasound speckle tracking may be useful for predicting prognosis.</div></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"9 ","pages":"Pages 252-260"},"PeriodicalIF":2.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0