The optimal montage to mark interictal epileptiform discharges and high-frequency oscillations in intraoperative electrocorticography

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.06.007

Ziyi Wang , Jiaojiao Guo , Eline Schaft , Sem Hoogteijling , Cyrille H. Ferrier , Gerhard H. Visser , Dongqing Sun , Friso Hoefnagels , Taku Inada , Sandra van der Salm , Geertjan Huiskamp , Nicole van Klink , Maryse van’t Klooster , Maeike Zijlmans , On behalf of the RESPect database study group

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引用次数: 0

Abstract

Objective

In intraoperative electrocorticography (ioECoG), interictal epileptiform discharges (IEDs) and high-frequency oscillations (HFOs; ripples 80–250 Hz, fast ripples (FRs) 250–500 Hz) can be identified in average or bipolar montage. We studied how montage choice affects event identification.

Methods

Two reviewers independently marked IEDs and HFOs across three montages (average, horizontal- and vertical-bipolar) from 13 patients who were seizure-free after ioECoG-guided surgery. We analyzed the number of channels-with-events, total events count, events morphology (maximum-amplitude, duration, frequency), number of instances with overlapping events across multiple channels (event_instance), concordance of event_instances over montages, and percentage of channels-with-events in the resected-area.

Results

Bipolar montages yielded more channels-with-events, higher counts, and greater maximum-amplitude of IEDs and ripples compared to average montages. Average and horizontal-bipolar montages yielded more IED_instances than vertical-bipolar montages. Average montages detected the highest percentage of event_instances occurring only in this montage. Event duration, frequency, and percentage of channels-with-events in the resected-area did not differ across montages.

Conclusions

All three ioECoG montages are clinically useful to find epileptic events. The bipolar montage detects more events with greater amplitude, while the average montage uncovers a wider variety of unique events. Combining montages provides complementary information.

Significance

This study quantitatively revealed how different montages capture epileptiform events.

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术中皮质电图中标记间歇癫痫样放电和高频振荡的最佳蒙太奇

目的观察术中皮质电图（ioECoG）、癫痫样间期放电（ied）和高频振荡（HFOs）；波纹80-250赫兹，快速波纹（FRs） 250-500赫兹)可以在平均或双极蒙太奇中识别。我们研究了蒙太奇选择如何影响事件识别。方法两名评论者独立标记了13例在ioecog引导下无癫痫发作的患者的三个蒙太奇（平均、水平和垂直双极）的ied和hfo。我们分析了带有事件的通道数量、总事件计数、事件形态（最大振幅、持续时间、频率）、跨多个通道（event_instance）重叠事件的实例数量、事件实例在蒙太奇上的一致性，以及被切除区域中带有事件的通道的百分比。结果与平均蒙太奇相比，双极蒙太奇产生了更多的带事件通道，更高的数量和更大的ied和涟漪的最大振幅。平均和水平双极蒙太奇比垂直双极蒙太奇产生更多的IED_instances。平均蒙太奇检测到仅在该蒙太奇中发生的event_instances的最高百分比。在不同的蒙太奇中，事件持续时间、频率和带有事件的通道的百分比没有差异。结论三种脑电图蒙太奇对癫痫事件的诊断均有临床价值。双极蒙太奇以更大的振幅检测到更多的事件，而平均蒙太奇揭示了更广泛的独特事件。组合蒙太奇提供了互补的信息。意义：本研究定量揭示了不同蒙太奇如何捕捉癫痫样事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.