Clinical Neurophysiology Practice最新文献

{"title":"Feasibility and tolerability of multimodal peripheral electrophysiological techniques in a cohort of patients with spinal muscular atrophy","authors":"Leandra A.A. Ros,&nbsp;Boudewijn T.H.M. Sleutjes,&nbsp;Diederik J.L. Stikvoort García,&nbsp;H. Stephan Goedee,&nbsp;Fay-Lynn Asselman,&nbsp;Leonard H. van den Berg,&nbsp;W. Ludo van der Pol ,&nbsp;Renske I. Wadman","doi":"10.1016/j.cnp.2023.06.001","DOIUrl":"10.1016/j.cnp.2023.06.001","url":null,"abstract":"<div><h3>Objective</h3><p>Electrophysiological techniques are emerging as an aid in identifying prognostic or therapeutic biomarkers in patients with spinal muscular atrophy (SMA), but electrophysiological assessments may be burdensome for patients. We, therefore, assessed feasibility and tolerability of multimodal peripheral non-invasive electrophysiological techniques in a cohort of patients with SMA.</p></div><div><h3>Methods</h3><p>We conducted a single center, longitudinal cohort study investigating the feasibility and tolerability of applying multimodal electrophysiological techniques to the median nerve unilaterally. Techniques consisted of the compound muscle action potential scan, motor nerve excitability tests, repetitive nerve stimulation and sensory nerve action potential. We assessed tolerability using the numeric rating scale (NRS), ranging from 0 (no pain) to 10 (worst possible pain), and defined the protocol to be tolerable if the NRS score ≤ 3. The protocol was considered feasible if it could be performed according to test and quality standards.</p></div><div><h3>Results</h3><p>We included 71 patients with SMA types 1–4 (median 39 years; range 13–67) and 63 patients at follow-up. The protocol was feasible in 98% of patients and was well-tolerated in up to 90% of patients. Median NRS score was 2 (range 0–6 at baseline and range 0–4 at follow-up (p &lt; 0.01)). None of the patients declined follow-up assessment.</p></div><div><h3>Conclusions</h3><p>Multimodal, peripheral, non-invasive, electrophysiological techniques applied to the median nerve are feasible and well-tolerated in adolescents and adults with SMA types 1–4.</p></div><div><h3>Significance</h3><p>Our study supports the use of non-invasive multimodal electrophysiological assessments in adolescents and adults with SMA types 1–4.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 123-131"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f4/cc/main.PMC10404501.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9963099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tibial nerve SEPs in diagnosing lumbar spinal stenosis: The utility of segmental evaluation using P15 and N21","authors":"Kiyoshi Matsukura ,&nbsp;Keiichi Hokkoku ,&nbsp;Taiji Mukai ,&nbsp;Chizuko Oishi ,&nbsp;Takamichi Kanbayashi ,&nbsp;Toshiyuki Takahashi ,&nbsp;Masahiro Sonoo","doi":"10.1016/j.cnp.2023.03.001","DOIUrl":"10.1016/j.cnp.2023.03.001","url":null,"abstract":"<div><h3>Objective</h3><p>To establish the utility of the additional evaluation of the P15 potential generated at the greater sciatic foramen in the tibial nerve somatosensory evoked potentials (SEPs) in diagnosing lumbar spinal stenosis (LSS).</p></div><div><h3>Methods</h3><p>We retrospectively reviewed tibial nerve SEP findings in patients having MRI-confirmed LSS at the cauda equina or conus/epiconus region. P15 and N21 potentials were recorded and the following findings were defined as localizing abnormalities: 1) normal P15 latency either with prolonged P15-N21 interval or with absent N21; 2) decreased ratio of the N21 amplitude to P15 amplitude. As non-localizing abnormalities, N21 and P38 latencies were also evaluated. Tibial nerve F-wave findings were also investigated.</p></div><div><h3>Results</h3><p>According to the entry criteria, 18 patients were included, 15 with cauda equina lesions and 3 with conus/epiconus lesions. Localizing abnormalities in SEPs were found in 67% of patients, achieving significantly higher sensitivity than delayed P38 latency (28%), and higher sensitivity than N21 abnormalities (39%), though this was not significant. Localizing abnormalities were observed even in 6 out of 11 patients lacking both sensory symptoms and signs. Tibial nerve F-wave was abnormal in 36% of 14 patients with F-wave examinations, whereas the localizing abnormalities in SEPs were found in 64% of the same patient population. P15 amplitude was depressed in 4 patients (22%), which may indicate the involvement of the dorsal root ganglion in LSS, although its latency was normal even for these patients.</p></div><div><h3>Conclusions</h3><p>Tibial nerve SEPs with the recording of P15 and N21 potentials achieved sufficiently high sensitivity in diagnosing LSS. They have the advantage over F-wave in that they can localize the lesion at the cauda equina or conus/epiconus level.</p></div><div><h3>Significance</h3><p>Tibial nerve SEPs are promising in evaluating LSS, especially in documenting sensory tract involvement in cases lacking sensory symptoms/signs.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 49-57"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10064344/pdf/main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9242444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quadripulse transcranial magnetic stimulation inducing long-term depression in healthy subjects may increase seizure risk in some patients with intractable epilepsy","authors":"Setsu Nakatani-Enomoto ,&nbsp;Ritstuko Hanajima ,&nbsp;Masashi Hamada ,&nbsp;Hideyuki Matsumoto ,&nbsp;Yasuo Terao ,&nbsp;Stefan Jun Groiss ,&nbsp;Takenobu Murakami ,&nbsp;Mitsunari Abe ,&nbsp;Hiroyuki Enomoto ,&nbsp;Kensuke Kawai ,&nbsp;Rumiko Kan ,&nbsp;Shin-ichi Niwa ,&nbsp;Hirooki Yabe ,&nbsp;Yoshikazu Ugawa","doi":"10.1016/j.cnp.2023.07.001","DOIUrl":"10.1016/j.cnp.2023.07.001","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to assess the efficacy and safety of quadripulse transcranial magnetic stimulation-50 (QPS-50) in patients with intractable epilepsy.</p></div><div><h3>Methods</h3><p>Four patients were included in the study. QPS-50, which induces long-term depression in healthy subjects, was administered for 30 min on a weekly basis for 12 weeks. Patients’ clinical symptoms and physiological parameters were evaluated before, during, and after the repeated QPS-50 period. We performed two control experiments: the effect in MEP (Motor evoked potential) size after a single QPS-50 session with a round coil in nine healthy volunteers, and a follow-up study of physiological parameters by repeated QPS-50 sessions in four other healthy participants.</p></div><div><h3>Results</h3><p>Motor threshold (MT) decreased during the repeated QPS-50 sessions in all patients. Epileptic symptoms worsened in two patients, whereas no clinical worsening was observed in the other two patients. In contrast, MT remained unaffected for 12 weeks in all healthy volunteers.</p></div><div><h3>Conclusions</h3><p>QPS-50 may not be effective as a treatment for intractable epilepsy.</p></div><div><h3>Significance</h3><p>In intractable epilepsy patients, administering repeated QPS-50 may paradoxically render the motor cortex more excitable, probably because of abnormal inhibitory control within the epileptic cortex. The possibility of clinical aggravation should be seriously considered when treating intractable epilepsy patients with non-invasive stimulation methods.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 137-142"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/71/main.PMC10387517.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9922874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiology of cerebellar ataxias and gait disorders","authors":"Mario Manto ,&nbsp;Mariano Serrao ,&nbsp;Stefano Filippo Castiglia ,&nbsp;Dagmar Timmann ,&nbsp;Elinor Tzvi-Minker ,&nbsp;Ming-Kai Pan ,&nbsp;Sheng-Han Kuo ,&nbsp;Yoshikazu Ugawa","doi":"10.1016/j.cnp.2023.07.002","DOIUrl":"10.1016/j.cnp.2023.07.002","url":null,"abstract":"<div><p>There are numerous forms of cerebellar disorders from sporadic to genetic diseases. The aim of this chapter is to provide an overview of the advances and emerging techniques during these last 2 decades in the neurophysiological tests useful in cerebellar patients for clinical and research purposes. Clinically, patients exhibit various combinations of a vestibulocerebellar syndrome, a cerebellar cognitive affective syndrome and a cerebellar motor syndrome which will be discussed throughout this chapter. Cerebellar patients show abnormal Bereitschaftpotentials (BPs) and mismatch negativity. Cerebellar EEG is now being applied in cerebellar disorders to unravel impaired electrophysiological patterns associated within disorders of the cerebellar cortex. Eyeblink conditioning is significantly impaired in cerebellar disorders: the ability to acquire conditioned eyeblink responses is reduced in hereditary ataxias, in cerebellar stroke and after tumor surgery of the cerebellum. Furthermore, impaired eyeblink conditioning is an early marker of cerebellar degenerative disease. General rules of motor control suggest that optimal strategies are needed to execute voluntary movements in the complex environment of daily life. A high degree of adaptability is required for learning procedures underlying motor control as sensorimotor adaptation is essential to perform accurate goal-directed movements. Cerebellar patients show impairments during online visuomotor adaptation tasks. Cerebellum-motor cortex inhibition (CBI) is a neurophysiological biomarker showing an inverse association between cerebellothalamocortical tract integrity and ataxia severity. Ataxic gait is characterized by increased step width, reduced ankle joint range of motion, increased gait variability, lack of intra-limb inter-joint and inter-segmental coordination, impaired foot ground placement and loss of trunk control. Taken together, these techniques provide a neurophysiological framework for a better appraisal of cerebellar disorders.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 143-160"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/60/main.PMC10429746.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10104532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical neurophysiology of COVID-19-direct infection, long-term sequelae and para-immunization responses: A literature review","authors":"M. Ayman Haykal,&nbsp;Daniel L. Menkes","doi":"10.1016/j.cnp.2022.09.005","DOIUrl":"10.1016/j.cnp.2022.09.005","url":null,"abstract":"<div><p>The COVID-19 pandemic resulting from the SARS-CoV-2 virus is in its third year. There is continuously evolving information regarding its pathophysiology and its effects on the nervous system. Clinical neurophysiology techniques are commonly employed to assess for neuroanatomical localization and/or defining the spectrum of neurological illness. There is an evolving body of literature delineating the effects of the SARS-CoV-2 virus on the nervous system as well as para-immunization responses to vaccination against this virus. This review focuses on the use of neurophysiological diagnostic modalities in the evaluation of potential acute and long-term neurological complications in patients that experience direct infection with SARS-CoV-2 and analyzes those reports of para-immunization responses to vaccination against the SARS-CoV-2 virus. The neurophysiological modalities to be discussed include electroencephalography (EEG), evoked potentials (EPs), nerve conduction studies and electromyography (EMG/NCV), autonomic function tests, transcranial magnetic stimulation (TMS) and Transcranial Doppler ultrasound (TCD).</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 3-11"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/cb/main.PMC9574576.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10385907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is epileptiform activity related to developmental language disorder? Findings from the HelSLI study","authors":"Hanna-Reetta Lajunen ,&nbsp;Marja Laasonen ,&nbsp;Pekka Lahti-Nuuttila ,&nbsp;Miika Leminen ,&nbsp;Sini Smolander ,&nbsp;Sari Kunnari ,&nbsp;Eva Arkkila ,&nbsp;Leena Lauronen","doi":"10.1016/j.cnp.2023.03.004","DOIUrl":"10.1016/j.cnp.2023.03.004","url":null,"abstract":"<div><h3>Objective</h3><p>To study if interictal epileptiform discharges (IEDs) are associated with language performance or pre-/perinatal factors in children with developmental language disorder (DLD).</p></div><div><h3>Methods</h3><p>We recorded routine EEG in wake and sleep in 205 children aged 2.9–7.1 years with DLD, without neurologic diseases or intellectual disability. We examined the language performance of the children and collected data on pre-/perinatal factors.</p></div><div><h3>Results</h3><p>Interictal epileptiform discharges were not associated with lower language performance. Children with so-called “rolandic”, <em>i.e</em>. centrotemporoparietal, IEDs had better language skills, but age explained this association. Most pre-/perinatal factors evaluated did not increase the risk of rolandic IEDs, except for maternal smoking (OR 4.4, 95% CI 1.4–14). We did not find electrical status epilepticus during slow-wave sleep (ESES)/spike-and-wave activation in sleep (SWAS) in any children.</p></div><div><h3>Conclusions</h3><p>Interictal epileptiform discharges are not associated with lower language performance, and ESES/SWAS is not common in children with DLD.</p></div><div><h3>Significance</h3><p>Routine EEGs do not bring additional information about language performance in children with DLD who do not have any neurologic diseases, seizures, intellectual disability, or regression of language development.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 65-70"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10176248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9469166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ambulatory EEG in the management of patients with epilepsy in resource-limited Latin American populations","authors":"Alioth Guerrero-Aranda ,&nbsp;Francisco J. Taveras-Almonte ,&nbsp;Fridha V. Villalpando-Vargas ,&nbsp;Karla López-Jiménez ,&nbsp;Gloria M. Sandoval-Sánchez ,&nbsp;Julio Montes-Brown","doi":"10.1016/j.cnp.2023.10.001","DOIUrl":"https://doi.org/10.1016/j.cnp.2023.10.001","url":null,"abstract":"<div><h3>Objective</h3><p>Ambulatory electroencephalography (AEEG) monitoring allows for prolonged recordings in normal environments, such as patients’ homes, and is recognized as a cost-effective alternative to inpatient long-term video-EEG primarily in resource-limited countries. We aim to describe the impact of AEEG on the assessment of patients with suspected or confirmed epilepsy in two independent Latin-American populations with limited resources.</p></div><div><h3>Methods</h3><p>We included 63 patients who had undergone an AEEG due to confirmed/suspected epilepsy. Clinical (demographic, current antiseizure medication and indication) and electroencephalographic (duration of the study, result, and impact on clinical decision-making) were reviewed and compared.</p></div><div><h3>Results</h3><p>The main indication for an AEEG was the differentiation of seizures from non-epileptic events with 57% of patients. It was categorized as positive in 36 patients and did have an impact on the clinical decision-making process in 57% of patients. AEEG captured clinical events in 35 patients (20 epileptic and 15 non-epileptic).</p></div><div><h3>Conclusions</h3><p>AEEG proves to be a valuable tool in resource-limited settings for assessing suspected or confirmed epilepsy cases, with a significant impact on clinical decisions.</p></div><div><h3>Significance</h3><p>Our study provides valuable insights into the use of AEEG in under-resourced regions, shedding light on the challenges and potential benefits of this tool in clinical practice.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 197-202"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2467981X23000264/pdfft?md5=f71c3bbc06eab1ace763ecb46720c569&pid=1-s2.0-S2467981X23000264-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134656000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future is data-driven: A call to clinical neurophysiology laboratories to standardize your NCS data","authors":"Øystein Dunker,&nbsp;Marie U. Lie,&nbsp;Aristomo Andries,&nbsp;Kristian Bernhard Nilsen,&nbsp;Petter Omland,&nbsp;Andrew Reiner,&nbsp;Martijn R. Tannemaat,&nbsp;Robert H. Reijntjes,&nbsp;Joe F. Jabre","doi":"10.1016/j.cnp.2023.05.002","DOIUrl":"10.1016/j.cnp.2023.05.002","url":null,"abstract":"","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 111-112"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43647549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lance-Adams Syndrome: Case series and literature review","authors":"Judy Zheng ,&nbsp;Zachary Storad ,&nbsp;Mustafa Al-Chalabi ,&nbsp;Khaled Gharaibeh ,&nbsp;Sidra Saleem ,&nbsp;Ajaz Sheikh ,&nbsp;Naeem Mahfooz","doi":"10.1016/j.cnp.2023.08.002","DOIUrl":"10.1016/j.cnp.2023.08.002","url":null,"abstract":"<div><h3>Background</h3><p>Lance-Adams Syndrome (LAS) is a rare complication of successful cardiopulmonary resuscitation (CPR). It is a form of posthypoxic myoclonus characterized by action or intention myoclonus developing days to months after an hypoxic insult to the brain. LAS, especially early in a patient’s clinical course, can be challenging to diagnose. Electroencephalogram (EEG) pattern of midline spike-wave discharge associated with favorable prognosis. There is no consensus in treatment of LAS but use of various anti-epileptic medications has been documented in literature.</p></div><div><h3>Case Presentation</h3><p>In this case series, all of the patients presented after achieving return of spontaneous circulation (ROSC) and subsequently developed myoclonus. EEG findings beyond the initial hospitalization continued to show later showed changes consistent with LAS in three of the four patients. Different combinations of AEDs were used in the management of LAS with variable success and adverse effects.</p></div><div><h3>Conclusion</h3><p>Our cases highlight that the characteristic EEG pattern can be useful in the diagnosis of LAS and allow for better prognostication and management in patients with posthypoxic myoclonus. We reviewed the available literature to better understand the prevalence, mechanism, clinical presentation, diagnosis, and management of LAS.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 187-193"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/cc/main.PMC10562981.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41215613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nerve ultrasonographic findings in diabetes mellitus are determined by anatomical location and type of diabetes","authors":"Marianna Tóth ,&nbsp;Annamária Szőke ,&nbsp;Zsuzsanna Arányi","doi":"10.1016/j.cnp.2023.04.004","DOIUrl":"10.1016/j.cnp.2023.04.004","url":null,"abstract":"<div><h3>Objective</h3><p>A prospective ultrasound study to analyze nerve size and its modifying factors in type 1 and type 2 diabetes mellitus.</p></div><div><h3>Methods</h3><p>The cross-sectional areas (CSAs) of motor and sensory nerves in both upper and lower limbs were measured at 14 measurement points, using high resolution ultrasound in 26 patients with type 1 and 76 patients with type 2 diabetes, and in 50 control subjects. All diabetic patients underwent electrophysiological assessment to check for the presence of polyneuropathy.</p></div><div><h3>Results</h3><p>Significant mild/moderate diffuse nerve enlargement was demonstrated in type 2 diabetes, more pronounced at compression sites versus non-compression sites, and on the upper limbs versus lower limbs (p value for pooled DM2 v. control group: &lt;0.001). In type 1 diabetes, nerve enlargement was found only at one compression site (median nerve wrist; p = 0.002). No significant difference was found between patients with or without polyneuropathy.</p></div><div><h3>Conclusions</h3><p>The primary predictors of nerve size in diabetes are anatomical location (i.e. compression sites versus non-compression sites, upper versus lower limbs) and type of diabetes. Changes occur before the electrophysiological signs of polyneuropathy are detected.</p></div><div><h3>Significance</h3><p>Nerve ultrasound may contribute to early recognition of the neuropathic complications of diabetes.</p></div>","PeriodicalId":45697,"journal":{"name":"Clinical Neurophysiology Practice","volume":"8 ","pages":"Pages 115-122"},"PeriodicalIF":1.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42529013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}