Contralateral R1 response in blink reflex in patients with amyotrophic lateral sclerosis

IF 2 Q3 NEUROSCIENCES

Clinical Neurophysiology Practice Pub Date : 2025-01-01 DOI:10.1016/j.cnp.2025.02.005

Julian Theuriet , Adrien Bohic , Maxime Bonjour , Emilien Bernard , Florent Cluse , Juliette Svahn , Laurent Jomir , Anne-Evelyne Vallet , Marion Demia , Lucie Roux , Ioana Cristina Bârsan , Léa Alves , Matthias Dion , Lionel Meens , Martin Moussy , Françoise Bouhour , Yann Péréon , Antoine Pegat

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引用次数: 0

Abstract

Objective

This study aimed to compare the frequency of blink reflex’s contralateral R1 responses (R1′) between patients with amyotrophic lateral sclerosis (ALS), non-ALS motor deficit patients, and healthy volunteers.

Methods

A total of 120 participants were prospectively recruited: 40 with ALS, 40 with a non-ALS motor deficit, and 40 healthy volunteers. Blink reflexes were recorded from orbicularis oculi muscles following supraorbital nerve stimulation.

Results

R1′ was more frequent in the ALS group (42.5 %) compared to healthy volunteers (12.5 %, p = 0.00588), and compared to non-ALS patients (7.5 %, p = 0.000789). Bilateral R1′ was observed only in ALS patients (22.5 %). No clinically significant difference was found in the latencies or amplitudes of the R1, R2, or R1′ responses among groups. R1′ was more frequent in ALS patients with pseudobulbar affect (71.4 %) compared to those without (36.4 %).

Conclusions

The higher frequency of R1′ in ALS highlights its potential role in distinguishing ALS from other motor disorders. Its sensitivity was low, but bilateral R1′ was specific to ALS. The higher frequency of R1′ among ALS patients with pseudobulbar affect potentially reflects corticobulbar neuron degeneration.

Significance

The R1′, especially when bilateral, could serve as an additional diagnostic biomarker for ALS, although its clinical relevance should be considered within the broader diagnostic context.

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肌萎缩性侧索硬化症患者眨眼反射对侧R1反应

目的比较肌萎缩侧索硬化症（ALS）患者、非ALS运动缺陷患者和健康志愿者眨眼反射对侧R1反应频率（R1’）的差异。方法前瞻性招募120名参与者：40名ALS患者，40名非ALS运动缺陷患者和40名健康志愿者。观察眼轮匝肌在眶上神经刺激后的眨眼反射。结果与健康志愿者（12.5%,p = 0.00588）和非ALS患者（7.5%,p = 0.000789）相比，ALS组中r1 '的频率更高（42.5%）。双侧R1 '仅在ALS患者中观察到（22.5%）。各组间R1、R2或R1反应的潜伏期或幅度均无临床显著差异。R1′在有假性球影响的ALS患者中（71.4%）比无假性球影响的ALS患者（36.4%）更常见。结论R1 '在ALS中较高的频率显示了其在区分ALS与其他运动障碍中的潜在作用。其敏感性较低，但双侧R1′对ALS具有特异性。假性球影响的ALS患者R1′频率较高，可能反映了皮质球神经元变性。R1′，特别是双侧时，可以作为ALS的额外诊断生物标志物，尽管其临床相关性应在更广泛的诊断背景下考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology Practice NEUROSCIENCES-

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

71 days

期刊介绍： Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.