{"title":"Microvascular flow imaging in musculoskeletal ultrasound: from technical innovation to clinical integration.","authors":"Giulia Pacella, Michela Bruno, Ludovica Liguori, Annamaria Pascale, Raffaele Natella, Marcello Zappia","doi":"10.15557/jou.2026.0006","DOIUrl":"https://doi.org/10.15557/jou.2026.0006","url":null,"abstract":"<p><p>Recent advances in Doppler ultrasound have led to the development of microvascular flow imaging, a technique designed to overcome the limitations of color and Power Doppler in detecting slow, small-vessel flow. This narrative review summarizes the technical foundations, clinical applications, and emerging perspectives of microvascular technologies in musculoskeletal ultrasound, emphasizing their role as a bridge between morphological and functional imaging. Microvascular flow imaging employs spatiotemporal clutter-suppression algorithms and high-frame-rate acquisition to visualize low-velocity blood flow within capillaries smaller than 100 µm, without the need for contrast agents. The method enhances detection of microvascularity in tendons, synovium, and peripheral nerves, providing early indicators of inflammatory or degenerative activity. Proprietary vendor implementations share the same physical principles but differ in algorithmic filtering and signal rendering. Clinically, microvascular flow imaging has demonstrated superior sensitivity compared with Power Doppler for detecting subclinical synovitis, assessing tendinopathies, and evaluating entrapment neuropathies, offering both quantitative and prognostic insights. Although microvascular flow imaging improves diagnostic sensitivity and supports dynamic, contrast-free assessment of tissue perfusion, its routine implementation remains limited by the absence of standardized acquisition protocols, validated quantitative metrics, and inter-vendor harmonization. Ongoing research into AI-based vascular quantification and portable point-of-care systems may enhance reproducibility, accessibility, and integration into everyday musculoskeletal imaging. Overall, microvascular flow imaging represents a pivotal step toward functional musculoskeletal ultrasound, with expanding diagnostic, prognostic, and theranostic potential.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260006"},"PeriodicalIF":1.5,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bülent Alyanak, Burak Tayyip Dede, Fatih Bağcıer, Mustafa Turgut Yıldızgören
{"title":"Ultrasound of the common peroneal nerve at the knee: a structured scanning protocol.","authors":"Bülent Alyanak, Burak Tayyip Dede, Fatih Bağcıer, Mustafa Turgut Yıldızgören","doi":"10.15557/jou.2026.0008","DOIUrl":"https://doi.org/10.15557/jou.2026.0008","url":null,"abstract":"<p><p>The common peroneal nerve is one of the most frequent sites of neuropathy around the knee. Owing to its superficial course, it is highly vulnerable to both trauma and mechanical compression. High-frequency ultrasonography enables real-time, dynamic evaluation of the common peroneal nerve along its entire trajectory from the popliteal fossa to the exit from the peroneal tunnel. This article presents a stepwise, structured ultrasound protocol for the assessment of the common peroneal nerve in the peri-knee region. Supported by illustrative images and videos, the protocol is expected to facilitate practical applicability in daily practice and improve diagnostic accuracy. Furthermore, the guiding role of ultrasonography in interventional planning is highlighted.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260008"},"PeriodicalIF":1.5,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin Dallaudiere, Nicolas Bouguennec, Nicolas Graveleau, Philippe Meyer, Lionel Pesquer
{"title":"Static and dynamic ultrasound assessment of peripheral meniscal lesions: diagnostic value and clinical applications.","authors":"Benjamin Dallaudiere, Nicolas Bouguennec, Nicolas Graveleau, Philippe Meyer, Lionel Pesquer","doi":"10.15557/jou.2026.0007","DOIUrl":"https://doi.org/10.15557/jou.2026.0007","url":null,"abstract":"<p><p>Meniscal injuries are frequent findings in clinical practice and may arise from acute trauma, progressive degeneration, or joint instability. While MRI remains the gold-standard modality for identifying these lesions, ultrasound has emerged as a valuable complementary technique thanks to its accessibility, low cost, real-time capability, and ability to perform dynamic assessments at the point of care. Increasingly, clinicians and radiologists are relying on ultrasound to detect and characterize subtle meniscal abnormalities that might otherwise be missed or underestimated. This review summarizes the principal static and dynamic sonographic features associated with meniscal tears, complex disruptions, and unstable flap fragments. Particular attention is given to the identification of ramp lesions, which involve the meniscocapsular junction and can be challenging to diagnose using conventional imaging alone. The article also discusses the evaluation of meniscal extrusion, a key indicator of structural compromise and a predictor of osteoarthritic progression. By highlighting characteristic ultrasound patterns and demonstrating how dynamic maneuvers can enhance diagnostic confidence, this work underscores the expanding role of ultrasound as an efficient, patient-centered imaging tool that complements MRI and supports a more comprehensive assessment of meniscal mechanical pathology. These insights ultimately contribute to more accurate treatment planning and improved patient outcomes.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260008"},"PeriodicalIF":1.5,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vito Chianca, Edoardo Cesaro, Marco Curti, Nicola Landi, Antonio Fontanarosa, Marcello Zappia, Filippo Del Grande
{"title":"Meralgia paresthetica: from qualitative ultrasound assessment to quantitative multimodality imaging.","authors":"Vito Chianca, Edoardo Cesaro, Marco Curti, Nicola Landi, Antonio Fontanarosa, Marcello Zappia, Filippo Del Grande","doi":"10.15557/jou.2026.0010","DOIUrl":"https://doi.org/10.15557/jou.2026.0010","url":null,"abstract":"<p><p>Meralgia paresthetica is a sensory mononeuropathy of the lateral femoral cutaneous nerve that remains frequently underdiagnosed despite its characteristic clinical presentation. Burning pain, paresthesia, and numbness over the anterolateral thigh may mimic hip, lumbar, or pelvic disorders, contributing to diagnostic delay. Imaging has gained increasing relevance in the evaluation of meralgia paresthetica, both for confirming neuropathy and for identifying contributory anatomical factors. High-resolution ultrasound enables direct visualization of the lateral femoral cutaneous nerve, characterization of its anatomical variants, and detection of focal changes at typical entrapment sites. Quantitative ultrasound parameters, particularly cross-sectional area, provide additional objective information and may help distinguish symptomatic nerves from normal variants, while elastography offers preliminary insight into chronic stiffness alterations. Magnetic resonance imaging complements ultrasound by allowing assessment of deeper nerve segments and by differentiating intrinsic signal abnormalities from extrinsic compression. Advanced techniques such as diffusion tensor imaging, although still investigational for this small sensory nerve, may eventually provide microstructural information beyond the capabilities of conventional sequences. This review summarizes current knowledge on the anatomy of the lateral femoral cutaneous nerve, outlines qualitative and quantitative ultrasound approaches, and discusses how multimodal imaging can support a more comprehensive and confident evaluation of patients with meralgia paresthetica.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260010"},"PeriodicalIF":1.5,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound of the distal tibiofibular syndesmosis.","authors":"Abdullah Alkorbi, Ramy Mansour","doi":"10.15557/jou.2026.0004","DOIUrl":"https://doi.org/10.15557/jou.2026.0004","url":null,"abstract":"<p><strong>Purpose: </strong>To review the anatomy, biomechanics, ultrasound technique, and imaging features of the distal tibiofibular syndesmosis, and to highlight the role of ultrasound relative to MRI in evaluating syndesmotic injuries.</p><p><strong>Methods: </strong>A literature-based narrative review was performed, focusing on normal and pathologic ultrasound findings of the syndesmotic ligaments and their MRI correlation.</p><p><strong>Results: </strong>The anterior inferior tibiofibular ligament is the most commonly visualized and injured structure. It is best seen in an oblique axial plane, extending from the tibial to the fibular tubercle. It appears as a thin, well-defined, fibrillar, echogenic band crossing the syndesmotic interval. The posterior inferior tibiofibular ligament is best seen posteriorly, slightly deeper and thicker, extending between the posterior tibia and fibula. Ultrasound examination of acute ligament injury shows ligament thickening, loss of normal fibrillar pattern, fiber discontinuity, or the presence of small, avulsed bone fragments. Ultrasound of chronic ligament injury shows thinning, irregularity, or heterogeneous scarring. Hypoechoic fibrotic changes or calcification at insertion sites can also be seen. Ultrasound provides high-resolution, real-time imaging capable of detecting ligament tears and assessing tibiofibular instability under stress. Dynamic ultrasound demonstrates good correlation with MRI for identifying acute syndesmotic disruptions, particularly in athletic or acute trauma settings.</p><p><strong>Conclusion: </strong>Ultrasound is a valuable and accessible modality for evaluating distal tibiofibular syndesmotic injuries. It complements MRI by providing immediate, functional assessment, aiding in timely diagnosis and management of high ankle sprains. Ultrasound should be considered in the imaging algorithm for suspected syndesmotic injuries, especially in sports and trauma settings.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260004"},"PeriodicalIF":1.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound imaging of small peripheral nerves - a primer for radiologists.","authors":"Aakanksha Agarwal, Abhishek Chandra, Palak Dhakar, Mahesh Prakash","doi":"10.15557/jou.2026.0005","DOIUrl":"https://doi.org/10.15557/jou.2026.0005","url":null,"abstract":"<p><p>High-resolution imaging has transformed the evaluation of small superficial peripheral nerves, enabling earlier detection of neuropathies, traumatic injuries, and entrapments. Among available modalities, ultrasound is particularly well suited for this purpose owing to its high spatial resolution, dynamic assessment capabilities, and ability to guide interventions. Normal nerves can be recognized on ultrasound by their fascicular architecture and characteristic honeycomb appearance, which helps distinguish them from adjacent tendons, vessels, and connective tissue. High-frequency transducers allow improved delineation of fascicular detail, while small-footprint probes enable imaging of nerves in anatomically constrained regions, establishing ultrasound as a reliable and cost-effective tool for evaluating peripheral nerve injuries. Because of spatial resolution limitations, magnetic resonance imaging has restricted ability to evaluate submillimeter-sized nerves; high-resolution ultrasound is therefore particularly effective in localizing pathological nerves - both in terms of the exact site of involvement and the length of the affected segment. This review article highlights in detail the sonographic techniques, pitfalls, and key anatomic landmarks for visualizing small peripheral nerves in the upper and lower extremities, with particular emphasis on nerves that are frequently under-evaluated in routine clinical practice yet often contribute to allodynia. Normal anatomical appearance on ultrasound is provided for better understanding along with examples of pathologies affecting these nerves.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260005"},"PeriodicalIF":1.5,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aponeurotic expansion of the supraspinatus tendon: sonographic spectrum and proposed classifications.","authors":"Saulius Rutkauskas","doi":"10.15557/jou.2026.0003","DOIUrl":"https://doi.org/10.15557/jou.2026.0003","url":null,"abstract":"<p><strong>Aim: </strong>The aponeurotic expansion of the supraspinatus tendon is a recognized but underappreciated anatomical structure of the shoulder. Its sonographic appearance may mimic or coexist with pathology of adjacent tendons, particularly the long head of the biceps tendon, creating diagnostic challenges. Although described in prior literature, many atypical variants remain insufficiently documented. This study aimed to characterize atypical sonographic manifestations of the aponeurotic expansion of the supraspinatus tendon and to propose new classifications based on its relationship with the supraspinatus tendon, its position within the rotator interval, and its association with the long head of the biceps tendon.</p><p><strong>Material and methods: </strong>Between October 2018 and September 2025, a total of 3,600 shoulder ultrasound examinations were performed. Nineteen patients (15 women, four men; mean age 60.7 years, range 24-82 years) with pathologically altered aponeurotic expansions were retrospectively identified. Each case was evaluated for structural and positional changes in relation to the supraspinatus, long head of the biceps, and subscapularis tendons.</p><p><strong>Results: </strong>The most frequent supraspinatus-aponeurotic expansion relationship was minor intrasubstance tearing (31.6%), followed by complete supraspinatus tears with retraction (21.1%). At the rotator interval, subluxation was observed in 36.8% of cases. Regarding interactions with the long head of the biceps tendon, aponeurotic expansion dislocation with preserved intragroove biceps alignment was most common (31.6%). Several theoretical subtypes were not observed.</p><p><strong>Conclusions: </strong>Ultrasound enables detailed assessment of the aponeurotic expansion of the supraspinatus tendon. The proposed classifications provide a structured framework for clinical practice and may guide future research into the diagnostic and functional significance of this complex region.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260003"},"PeriodicalIF":1.5,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound evaluation of the ulnar nerve in cubital tunnel syndrome: anatomy, normal and abnormal findings, and postoperative aspects.","authors":"Aurelio Cosentino, Yacine Carlier, Winston J Rennie, Lionel Pesquer","doi":"10.15557/jou.2026.0002","DOIUrl":"https://doi.org/10.15557/jou.2026.0002","url":null,"abstract":"<p><p>Cubital tunnel syndrome is the second most common compressive neuropathy of the upper limb after carpal tunnel syndrome and results from entrapment of the ulnar nerve around the elbow. High-resolution ultrasound has become a central diagnostic modality because of its excellent spatial resolution, capacity for dynamic assessment, and broad availability in clinical practice. This review offers an integrated and updated overview of the ultrasonographic evaluation of the ulnar nerve in cubital tunnel syndrome, detailing relevant anatomy, characteristic normal and pathological appearances, and key considerations in postoperative follow-up. The ulnar nerve may be compressed at several anatomical sites, including the arcade of Struthers, the retrocondylar groove, Osborne's ligament within the cubital tunnel, and the aponeurosis between the two heads of the flexor carpi ulnaris. Typical sonographic abnormalities include focal or segmental nerve enlargement, disruption or loss of the normal fascicular architecture, and changes in echogenicity. Dynamic maneuvers during ultrasound examination can further identify nerve subluxation, dislocation, or snapping over the medial epicondyle, all of which may contribute to clinical symptoms. Postoperative ultrasound evaluation is increasingly important for detecting complications or persistent compression following in-situ decompression, medial epicondylectomy, or anterior transposition. A standardized and reproducible ultrasound protocol is therefore essential for accurate diagnosis, appropriate management, and follow-up. Radiologists play a pivotal role in this multidisciplinary approach by providing detailed imaging assessments that guide surgical decision-making and help optimize patient outcomes.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260002"},"PeriodicalIF":1.5,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13036381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena Gallardo, Elena Julian, Carmen Gonzalez, Jose Luis Izquierdo, Rosa Landeras
{"title":"Ultrasound in inflammatory conditions of subcutaneous and articular adipose tissue in the extremities.","authors":"Elena Gallardo, Elena Julian, Carmen Gonzalez, Jose Luis Izquierdo, Rosa Landeras","doi":"10.15557/jou.2026.0001","DOIUrl":"10.15557/jou.2026.0001","url":null,"abstract":"<p><p>Adipose tissue of the extremities has been largely neglected in musculoskeletal ultrasound (US), beyond the assessment of superficial nodules or the exclusion of deep complications in superficial infections. Three developments have brought it to the fore: a more refined understanding of its anatomy and function - recognizing adipose tissue not merely as a passive fat store but as a metabolic and endocrine organ and a regulator of inflammation; advances in US technique; and the wider adoption of US across medical specialties, particularly dermatology and plastic surgery. Panniculitis refers to inflammation of the subcutaneous tissue and encompasses numerous disorders with considerable clinical overlap. Patients typically present with painful nodules in the extremities and often require histopathological confirmation. Histologically, panniculitides are classified according to the predominant site of involvement - septal, lobular, or mixed. US correlates strongly with these patterns. This review describes the principal sonographic appearances of the most frequent panniculitides and highlights key clinical and pathological features that help narrow the differential diagnosis. Entities that may mimic panniculitis on US are also discussed. Beyond diagnosis, ultrasonography supports disease assessment and monitoring, and it reliably guides targeted biopsy. Finally, the US features of inflammation in articular and periarticular adipose tissue are summarized, with emphasis on findings that should be considered during routine joint US examinations, as such involvement often accompanies internal derangement and may also represent the primary source of patient-reported symptoms.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"26 104","pages":"20260001"},"PeriodicalIF":1.5,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura S Oerters, Sophie H K Maasewerd, Mark Born, Maximilian Hohenadel, Andreas C Heydweiller, Christina Oetzmann von Sochaczewski
{"title":"Agreement between sonographic and pathoanatomic classifications of pediatric urachal remnants.","authors":"Laura S Oerters, Sophie H K Maasewerd, Mark Born, Maximilian Hohenadel, Andreas C Heydweiller, Christina Oetzmann von Sochaczewski","doi":"10.15557/jou.2025.0032","DOIUrl":"10.15557/jou.2025.0032","url":null,"abstract":"<p><strong>Aim: </strong>Ultrasound is the favorite method for follow-up of urachal remnants when conservative management is chosen instead of surgical resection. However, the success of conservative management depends on the type of urachal anomaly, and the agreement between sonographic and pathoanatomic diagnoses has not yet been assessed.</p><p><strong>Material and methods: </strong>We retrospectively included all minors treated for a urachal anomaly at two German pediatric surgical centers between January 2008 and December 2020. Ultrasound examinations were conducted by specialized pediatric radiologists and compared with pathoanatomic reports following resection of the urachal anomaly, with respect to its type.</p><p><strong>Results: </strong>We included 15 patients with a median age of 0.2 years. The crude agreement between ultrasound and pathoanatomic diagnosis was 70%, and Cohen's κ was 0.66 (95% confidence interval: 0.3 - 1, z = 3.83, <i>p</i> <0.001).</p><p><strong>Conclusions: </strong>Ultrasound identified the type of urachal anomaly with sufficient accuracy in this cohort; however, these findings should be corroborated by a substantially larger study.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 103","pages":"20250032"},"PeriodicalIF":1.5,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}