Sławomir Witkowski, Jerzy Węgrzynowski, Michał Krekora, Iwona Maroszyńska, Anna Mazurek-Kula, Piotr Grzelak, Katarzyna Januszewska, Iwona Strzelecka, Maria Respondek-Liberska
{"title":"Total anomalous pulmonary venous connection - prenatal echocardiography and neonatal follow-up.","authors":"Sławomir Witkowski, Jerzy Węgrzynowski, Michał Krekora, Iwona Maroszyńska, Anna Mazurek-Kula, Piotr Grzelak, Katarzyna Januszewska, Iwona Strzelecka, Maria Respondek-Liberska","doi":"10.15557/jou.2025.0012","DOIUrl":"https://doi.org/10.15557/jou.2025.0012","url":null,"abstract":"<p><p>Total anomalous pulmonary venous connection is a rare congenital heart defect that can be diagnosed prenatally and might be very important for perinatal management. In addition to other cardiac abnormalities (levocardia, situs inversus, small left ventricle, double outlet right ventricle, parallel great vessels, and hypoplastic aortic arch), total anomalous pulmonary venous connection of a subdiaphragmatic type was diagnosed during a prenatal echocardiography examination in the second half of pregnancy. Fetal echocardiography monitoring showed no signs of congestive heart failure. The neonate was born at 38 weeks of gestation at our tertiary center. Postnatal echocardiography revealed significant progression in neonatal hemodynamics, and early cardiac surgery, involving repair of the pulmonary veins, pulmonary artery banding, and aortic arch reconstruction, was performed with a good outcome. This case is an excellent example of the value of prenatal echocardiography.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 101","pages":"20250012"},"PeriodicalIF":1.3,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Point-of-care ultrasound: a viable alternative for assessing ulnar neuropathy in rheumatoid arthritis?","authors":"Adel Azzam, Mohamed Mansy, Abdel Hamid Ghazaly, Hegazy Al-Tamimy","doi":"10.15557/jou.2025.0013","DOIUrl":"https://doi.org/10.15557/jou.2025.0013","url":null,"abstract":"<p><strong>Aim of the study: </strong>This study seeks to evaluate the effectiveness of ultrasound measurements of the ulnar nerve cross-sectional area in comparison to electrodiagnostic tests for identifying ulnar nerve entrapment at the elbow in rheumatoid arthritis.</p><p><strong>Patients and methods: </strong>This study was designed as a cross-sectional observational analysis involving 90 individuals, divided into three groups: Group A consisted of 30 individuals diagnosed with rheumatoid arthritis without clinical signs of ulnar neuropathy at the elbow; Group B included 30 individuals with rheumatoid arthritis exhibiting clinical indicators of ulnar neuropathy at the elbow; and Group C comprised 30 healthy controls. Each participant underwent a thorough medical history assessment, along with both clinical and neurological evaluations. Additionally, ultrasound and electrophysiological assessments of the ulnar nerve were performed.</p><p><strong>Results: </strong>There was no significant demographic difference between the groups, except for age, which was notably lower in Group A compared to Group B. Additionally, abnormalities in nerve conduction studies and cross-sectional area were found to be significantly greater in Group B (<i>p</i> <0.0001). The cross-sectional area demonstrated diagnostic accuracy rates of 52.22%, 62.22%, and 78.89% for identifying ulnar neuropathy at Guyon's canal, the medial epicondyle, and based on the elbow-to-wrist ratio, respectively.</p><p><strong>Conclusion: </strong>Ultrasonography exhibits high diagnostic accuracy, especially with the cross-sectional area at the medial epicondyle and the elbow-to-wrist cross-sectional area ratio serving as important indicators for ulnar nerve entrapment in patients with rheumatoid arthritis.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 101","pages":"20250013"},"PeriodicalIF":1.3,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nils Daum, Jannis Schwanemann, Michael Blaivas, Michael Ignacio Prats, Roman Hari, Beatrice Hoffmann, Christian Jenssen, Alexander Krutz, Claudia Lucius, Ricarda Neubauer, Florian Recker, Roxana Sirli, Susan Cambell Westerway, Constantinos Zervides, Dieter Nürnberg, Gregor Barth, Nasenien Nourkami-Tutdibi, Christoph Frank Dietrich
{"title":"Teaching methods, facilities, and institutions in student ultrasound education (SUSE): e-learning, simulation, and ultrasound skills labs.","authors":"Nils Daum, Jannis Schwanemann, Michael Blaivas, Michael Ignacio Prats, Roman Hari, Beatrice Hoffmann, Christian Jenssen, Alexander Krutz, Claudia Lucius, Ricarda Neubauer, Florian Recker, Roxana Sirli, Susan Cambell Westerway, Constantinos Zervides, Dieter Nürnberg, Gregor Barth, Nasenien Nourkami-Tutdibi, Christoph Frank Dietrich","doi":"10.15557/jou.2025.0014","DOIUrl":"https://doi.org/10.15557/jou.2025.0014","url":null,"abstract":"<p><p>To acquire ultrasound skills, students need access to educational resources for both theoretical and practical knowledge. Effective training depends on the availability of educational content, training opportunities, and facilities - all of which are often scarce. E-learning platforms, simulation, and ultrasound skills labs are potential solutions to complement supervised real-life bedside training on patients and improve ultrasound education. This review discusses the advantages and disadvantages of e-learning, simulation, and ultrasound skills labs in the specific context of student education. E-learning platforms and teaching videos support students by offering flexible, accessible learning, allowing them to engage with material at their own pace. These digital resources complement practical lessons by providing essential theoretical knowledge that can be applied during hands-on sessions. Simulation creates a controlled environment for skill development and enhances patient safety, especially during interventional procedures. However, simulation equipment's high cost and technical complexity strain budgets and require specialized staff and training. Simulators often fail to replicate real-life variability, limiting skill transfer to patient care. The establishment of ultrasound skills labs offers a solid, long-term opportunity for skill retention but requires sufficient and sustainable funding. In conclusion, e-learning, simulation, and ultrasound skills labs can be valuable components of student ultrasound education if used deliberately. They should be included in a blended medical curriculum incorporating real-world clinical experiences to ensure effective transfer of learning to clinical practice.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 101","pages":"20250014"},"PeriodicalIF":1.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Grzegorz Postek, Paweł Zalewski, Iwona Sadowska-Krawczenko
{"title":"Two-dimensional shear wave elastography for assessing liver, spleen, and kidneys in healthy newborns.","authors":"Grzegorz Postek, Paweł Zalewski, Iwona Sadowska-Krawczenko","doi":"10.15557/jou.2025.0010","DOIUrl":"https://doi.org/10.15557/jou.2025.0010","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the study was to obtain two-dimensional shear wave elastography measurements of the liver, spleen and kidneys in healthy full-term newborns, as well as to assess its feasibility in this age group.</p><p><strong>Materials and methods: </strong>We performed two-dimensional shear wave elastography of the liver, spleen and kidneys using a linear transducer at least 60 minutes after food intake in a group of 58 healthy, full-term, spontaneously breathing newborns. A series of 5 measurements using 5-mm-diameter regions of interest were performed, with the results expressed in m/s and kPa. Exam feasibility was assessed using the IQR/Median ratio as ≤30% for kPa, and ≤15% for m/s. Descriptive statistics, Shapiro-Wilk W, Levene's, Mann-Whitney U tests and Spearman correlation analysis were used for statistical assessment.</p><p><strong>Results: </strong>The feasibility of the exam was 68.97% for the right liver lobe, 67.24% for the left lobe, 91.07% for the spleen, 89.29% for the right kidney, 85.71% for the left kidney. Mean results: right liver lobe: 1.43 m/s, SD ±0.11, 6.04 kPa, SD ±0.97, left liver lobe: 1.41 m/s, SD ±0.12, 5.86 kPa, SD ±1.02, spleen: 2.36 m/s, SD ±0.21, 16.99 kPa, SD ±3.21, right kidney: 1.92 m/s, SD ±0.18, 11.34 kPa, SD ±3.21, left kidney: 1.88 m/s, SD ±0.16, 10.81 kPa, SD ±1.80. The splenic-hepatic elastography index for m/s and kPa results was as follows: mean 1.65, SD ±0.20, mean 2.82, SD ±0.73, respectively. No differences were found between the right vs left lobe of the liver, or the right vs left kidney; there was no correlation between the measurements and gender or food intake interval >60 minutes. A positive correlation was found between the results for the right and left lobe of the liver and age, and the results for the left lobe of the liver and body weight.</p><p><strong>Conclusions: </strong>Two-dimensional shear wave elastography of the liver, spleen and kidneys can be successfully performed in healthy neonates. We obtained reliable mean shear wave elastography values for the examined organs.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 100","pages":"20250010"},"PeriodicalIF":1.3,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giorgio Tamborrini, Raphael Micheroli, Vincenzo Ricci, Marco Becciolini, Mario Garcia-Pompermayer, Andres Serrano Belmar Gonzalo, Mireille Toranelli, Felix Margenfeld, Magdalena Müller-Gerbl
{"title":"Enhancing knee imaging via histology and anatomy-driven high-resolution musculoskeletal ultrasound.","authors":"Giorgio Tamborrini, Raphael Micheroli, Vincenzo Ricci, Marco Becciolini, Mario Garcia-Pompermayer, Andres Serrano Belmar Gonzalo, Mireille Toranelli, Felix Margenfeld, Magdalena Müller-Gerbl","doi":"10.15557/jou.2025.0008","DOIUrl":"https://doi.org/10.15557/jou.2025.0008","url":null,"abstract":"<p><strong>Purpose: </strong>To provide an overview of the normal anatomy of the knee using high-resolution ultrasonography.</p><p><strong>Materials and methods: </strong>Normal ultrasound images were obtained from a healthy subject, and corresponding images of human anatomy and histology were acquired from body donors.</p><p><strong>Results: </strong>Several high-resolution ultrasound, anatomical, and histological images were created to illustrate and comprehensively describe the basic standard scans in compliance with international standards. This atlas summarizes a selection of typical normal findings.</p><p><strong>Conclusions: </strong>This overview explains the normal anatomy of the knee as seen by ultrasonography. High-resolution knee musculoskeletal ultrasonography aims to provide an accurate structural evaluation, which requires comprehensive knowledge of sonoanatomy. When used appropriately, contemporary high-resolution musculoskeletal ultrasonography enhances knee imaging by connecting anatomical cross-sections and intricate histology to specific anatomical features.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 100","pages":"20250008"},"PeriodicalIF":1.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasonography-based prediction of carotid artery atherosclerosis using multiple abdominal fat indices.","authors":"Mohit Jain, Subhasish Panda, Shruti Chandak, Ankur Malhotra, Subhashree Dash, Umme Afifa","doi":"10.15557/JoU.2025.0006","DOIUrl":"https://doi.org/10.15557/JoU.2025.0006","url":null,"abstract":"<p><strong>Aim: </strong>Abdominal obesity is recognized as the best predictor of cardiovascular disease risk. While body mass index has traditionally been used to measure obesity, recent evidence suggests that visceral adipose tissue may be a better indicator of cardiovascular disease risk. Various surrogate imaging markers of visceral adipose tissue have recently been described, such as posterior right perinephric fat thickness, preperitoneal fat thickness, and the abdominal wall fat index. This study aimed to examine the link between atherosclerosis through measurement of carotid intima-media thickness and markers of abdominal obesity using ultrasonography.</p><p><strong>Material and methods: </strong>This was a hospital-based prospective observational study. Patients with a body mass index of 25-40 were included as cases and those with a body mass index 18.0-24.9 as controls. Posterior right perinephric fat thickness, preperitoneal fat thickness, and abdominal wall fat index were measured and compared with carotid intima-media thickness in cases.</p><p><strong>Results: </strong>A total of 100 cases and 100 age- and sex-matched controls were included. Body mass index did not show any statistically significant correlations with carotid intima-media thickness in this study. Among the visceral adiposity markers, posterior right perinephric fat thickness was the most sensitive and specific predictor of carotid intima-media thickness, while the abdominal wall fat index was the least sensitive and specific.</p><p><strong>Conclusions: </strong>Ultrasonographic markers of visceral adipose tissue, especially posterior right perinephric fat thickness and preperitoneal fat thickness, demonstrate a stronger association with carotid atherosclerosis than body mass index, making them useful predictors, particularly in individuals with high body mass index. These markers can be measured during routine abdominal ultrasounds to screen for atherosclerosis risk in patients with abdominal obesity.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 100","pages":"20250006"},"PeriodicalIF":1.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11990943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bülent Alyanak, Burak Tayyip Dede, Mustafa Hüseyin Temel, Mustafa Turgut Yildizgören, Fatih Bağcier
{"title":"An overlooked cause of hand pain: myofascial trigger points in the interosseous muscles.","authors":"Bülent Alyanak, Burak Tayyip Dede, Mustafa Hüseyin Temel, Mustafa Turgut Yildizgören, Fatih Bağcier","doi":"10.15557/JoU.2025.0004","DOIUrl":"10.15557/JoU.2025.0004","url":null,"abstract":"","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 100","pages":"20250004"},"PeriodicalIF":1.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Dobek-Brylińska, Edyta Wlaźlak, Wiktor Wlaźlak, Jan Krakowiak, Andrzej Wróbel, Grzegorz Surkont
{"title":"The impact of pelvic floor contraction on urethral mobility and urogenital hiatus size in pelvic floor ultrasound.","authors":"Marta Dobek-Brylińska, Edyta Wlaźlak, Wiktor Wlaźlak, Jan Krakowiak, Andrzej Wróbel, Grzegorz Surkont","doi":"10.15557/JoU.2025.0005","DOIUrl":"10.15557/JoU.2025.0005","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the study was to assess the effect of pelvic floor contraction on urethral mobility and the size of the urogenital hiatus, as well as to compare two ultrasonographic approaches for the assessment of urethral mobility: transperineal with a transabdominal probe and transvestibular with a transvaginal transducer.</p><p><strong>Materials and methods: </strong>Modified Oxford Scale (MOS) was used for clinical evaluation of muscle contraction. The parameters obtained in both ultrasound approaches were assessed for all six Oxford grades. The values of ΔH, ΔD and vector, measured at rest and on pelvic floor muscle contraction, were used to evaluate urethral mobility parameters in both ultrasound methods. Patients with a history of urogynecological surgery, pelvic radiotherapy, significant pelvic prolapse (grade 2 or grater in at least one compartment), as well as those with unilateral or bilateral complete avulsion of the puborectalis muscle were excluded.</p><p><strong>Results: </strong>A total of 272 women were included in the analysis. A statistically significant correlation was found between the contraction force and urethral mobility parameters ΔH and vector-positive and ΔD-negative, obtained in both ultrasound approaches. However, no correlation was demonstrated between the contraction force and changes in the analyzed hiatal parameters. The Bland-Altman analysis showed a high agreement of both measurement methods.</p><p><strong>Conclusions: </strong>The force of pelvic floor muscle contraction, as measured with the Oxford Scale, correlated with urethral mobility in both ultrasound examinations. Assessment of urethral mobility using the three assessed parameters (ΔH, ΔD, vector) allows for the most comprehensive analysis. Only minor differences were found in the analyzed urethral mobility parameters between both ultrasonographic approaches. The impact of pelvic floor muscle contraction on the size of the urogenital hiatus was not confirmed.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 100","pages":"20250005"},"PeriodicalIF":1.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11841739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of hepatic steatosis in obese children and adolescents using immune-inflammatory markers and shear wave elastography.","authors":"Mehmet Akçiçek, Nurullah Dağ","doi":"10.15557/jou.2025.0001","DOIUrl":"https://doi.org/10.15557/jou.2025.0001","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the changes in liver stiffness and immune-inflammatory markers associated with obesity and the degree of hepatic steatosis in obese children and adolescents.</p><p><strong>Methods: </strong>A total of 76 obese children and adolescents aged 6-18 years, with body mass index percentiles >95th, were included in the study. Patients with metabolic syndrome, diabetes mellitus, and chronic liver disease were excluded. A control group of 44 patients of healthy and normal-weight children was included. Laboratory values from the past month were analyzed using patient records. Shear wave elastography and ultrasound examinations were performed on a single device by the same experienced radiologist.</p><p><strong>Results: </strong>The systemic immune-inflammation index and pan-immune inflammation values were significantly higher in obese patients with hepatic steatosis compared to obese patients without hepatic steatosis (<i>p</i> <0.001). Liver stiffness values were significantly higher in steatotic patients compared to nonsteatotic patients (<i>p</i> <0.001). A significant difference was observed between hepatic steatosis grades in terms of immune-inflammation index and pan-immune inflammation value values (<i>p</i> <0.001). There was a strong, positive, statistically significant correlation between liver stiffness and immune-inflammation index and pan-immune inflammation value (<i>p</i> <0.05).</p><p><strong>Conclusions: </strong>Immune-inflammatory biomarkers and shear wave elastography may provide valuable insights into the diagnosis and follow-up of inflammation and fibrosis in the evaluation of hepatic steatosis in obese children and adolescents.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 100","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasonography: an aid in molecular subtyping of breast carcinoma.","authors":"Shruti Thakur, Charu Smita Thakur, Vijay Thakur, Nidhi Rana, Anupam Jhobta, Sumala Kapila","doi":"10.15557/JoU.2025.0003","DOIUrl":"10.15557/JoU.2025.0003","url":null,"abstract":"<p><strong>Introduction: </strong>The recognition of molecular subtypes of breast cancer has initiated a new regimen of targeted therapy. Early diagnosis is a key step in improving survival. Therefore, a cost-effective and widely available imaging tool is needed for the timely detection and prediction of the molecular profile of breast cancer.</p><p><strong>Aim: </strong>To study the predictive value of ultrasonographic features in identifying the estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 neu (HER2/neu) expression status, and molecular subtypes of breast cancer.</p><p><strong>Material and methods: </strong>We conducted a study on 51 histopathologically proven invasive breast carcinoma cases over a period of one and a half years. The patients underwent ultrasonography followed by tissue biopsy. Sonographic parameters were assessed based on BI-RADS imaging features. The molecular subtypes of breast cancer were grouped into four subtypes based on the St. Gallen International Expert Consensus Panel. The predictive value of ultrasonographic features was then studied in relation to the hormone receptor status and molecular subtypes of breast cancer.</p><p><strong>Results: </strong>A significant association between posterior acoustic features and molecular subtypes was seen. Posterior acoustic shadowing was associated with progesterone receptor status with an odds ratio (OR) of 36.58, confidence interval (CI) of 5.527-866.1, and <i>p</i> <0.001. The luminal type A molecular subtype was significantly higher in the posterior acoustic shadowing group (10 cases; 52.63%) with an OR of 3.85, CI of 1.12-13.98, and <i>p</i> of 0.02. The proportion of patients with triple-negative molecular subtype (9 cases, 50%) was significantly higher in the posterior acoustic enhancement group, with an OR of 29.42, CI of 4.117-725.4, and <i>p</i> <0.001. Tumors with circumscribed margins were also highly suggestive of the triple-negative molecular subtype [OR of 5.12, CI of 1.16-24.85, and <i>p</i> of 0.03]. The association between the presence or absence of vascularity and its type with molecular subtypes failed to show statistical significance in our study, although vascularity was more frequently observed in triple-negative molecular subtype and luminal type B Her+ve cases.</p><p><strong>Conclusion: </strong>Certain sonographic features are associated with the estrogen/progesterone receptor hormone receptor status and molecular subtypes of breast cancer. With validation of this association, ultrasound may serve as a basic imaging modality for predicting molecular subtypes of breast cancer even in remote areas, where immunohistochemistry hormone receptor and HER2 testing are not available.</p>","PeriodicalId":45612,"journal":{"name":"Journal of Ultrasonography","volume":"25 100","pages":"20250003"},"PeriodicalIF":1.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}