Molecular Imaging and Radionuclide Therapy最新文献

{"title":"Complete Treatment Response of Isolated Lacrimal IgG4-Related Disease on ¹⁸F-FDG PET/CT Imaging.","authors":"Ali Kibar, Sertaç Asa, Onur Erdem Şahin, Lebriz Uslu-Beşli, Sait Sağer, Kerim Sönmezoğlu, Haluk Burçak Sayman","doi":"10.4274/mirt.galenos.2025.51196","DOIUrl":"10.4274/mirt.galenos.2025.51196","url":null,"abstract":"<p><p>We describe a case of a 57-year-old woman with isolated immunoglobulin G4-related disorder affecting her lacrimal glands. Pre-treatment ¹⁸F-fluorodeoxyglucose-positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) showed diffuse enlargement and increased FDG uptake in both lacrimal glands. After immunosuppressive treatment, ¹⁸F-FDG PET/CT showed no significant FDG uptake, and the sizes of both glands returned to normal.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"117-119"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Primary Squamous Cell Urachal Carcinoma Staged with ¹⁸F-FDG PET/CT.","authors":"Yavor Gramatikov, Alexander Stoychev, Georgi Gaydarov, Stamen Andreev, Nikolay Halachev, Valeria Hadzhiyska","doi":"10.4274/mirt.galenos.2025.21347","DOIUrl":"10.4274/mirt.galenos.2025.21347","url":null,"abstract":"<p><p>Primary squamous cell urachal carcinoma is an exceedingly rare epithelial neoplasm and an aggressive malignancy, originating from the urachal remnants. In contrast to mucinous adenocarcinoma, the most common histological type, squamous cell urachal carcinoma demonstrates high 2-deoxy-2-¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake, making ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT) a valuable tool for evaluating regional lymph node involvement and detecting distant metastases. Optimal surgical management, the need for systemic therapy, and the overall prognosis are largely determined by accurate clinical staging, which is mainly based on the widely recognized Sheldon and Mayo classifications. We present a rare case of primary squamous cell urachal carcinoma on ¹⁸F-FDG PET/CT in a young woman, with correlation to surgical and histopathological findings.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"131-133"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147515578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG-PET/MRI Demonstration of Extensive Spinal Cord Metastases in a Patient with Ovarian Carcinoma.","authors":"Cansu Güneren, Sertaç Asa, Haluk Burçak Sayman","doi":"10.4274/mirt.galenos.2026.83097","DOIUrl":"10.4274/mirt.galenos.2026.83097","url":null,"abstract":"<p><p>Spinal cord involvement is a rare manifestation of metastatic ovarian carcinoma. We report a case of high-grade serous ovarian cancer initially diagnosed in 2020. After cytoreductive surgery and multiple chemotherapy regimens, the patient developed brain metastases followed by small hypermetabolic foci along the spinal canal detected on ¹⁸F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (¹⁸F-FDG PET/MRI). These lesions, primarily located in the cervical region, were confirmed by contrast-enhanced spinal MRI but were more clearly visualized on ¹⁸F-FDG PET/MRI. Intramedullary spinal cord metastases are extremely rare and often underdiagnosed. While MRI remains the standard for anatomical assessment, ¹⁸F-FDG PET/MRI demonstrated superior lesion detection and definition in this case. This highlights the potential of hybrid imaging for improved diagnostic sensitivity in patients with suspected central nervous system involvement.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"142-144"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"⁶⁸Ga-PSMA PET/CT Detects a Rare Case of Breast Metastasis from Prostate Cancer.","authors":"Georgi Gaydarov, Petya Nikolova, Mihaela Ilcheva, Nikolay Halachev, Valeria Hadzhiyska","doi":"10.4274/mirt.galenos.2025.98475","DOIUrl":"10.4274/mirt.galenos.2025.98475","url":null,"abstract":"<p><p>Positron emission tomography/computed tomography (PET/CT) with Galium-68 prostate-specific membrane antigen (⁶⁸Ga-PSMA) PET/CT) is a valuable tool for initial staging, recurrence detection, and assessment of treatment response in men with prostate cancer. Metastatic spread to regional and distant lymph nodes, bone, lung and liver is well known and expected in patients with castration-resistant disease. However, the application of a highly sensitive whole-body imaging modality such as ⁶⁸Ga-PSMA PET/CT can reveal metastatic foci in rare or unusual locations. We present the case of an 82-year-old patient with prostate adenocarcinoma who underwent long-term androgen deprivation therapy. A ⁶⁸Ga-PSMA PET/CT scan was performed in June 2021 due to significant prostate-specific antigen elevation and revealed disease progression with widespread regional and distant metastases, including a soft-tissue mass in the right breast that demonstrated intense radiotracer uptake; this mass was subsequently resected and histologically confirmed. This case underscores the excellent diagnostic performance of ⁶⁸Ga-PSMA PET/CT for atypical metastatic sites.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"120-122"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145935369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Renal Metastases from Lung Adenocarcinoma Revealed on ¹⁸F-FDG PET/CT.","authors":"Intissar El Moatassim, Ayat Mouaden, Kenza Bouzidi, Imad Ghfir, Hasnae Guerrouj","doi":"10.4274/mirt.galenos.2025.35253","DOIUrl":"10.4274/mirt.galenos.2025.35253","url":null,"abstract":"<p><p>Lung cancer is the leading cause of cancer-related deaths worldwide. While metastasis to distant organs is commonly described, renal metastasis remains rare and uncommon. In this paper, we present the case of a 53-year-old man with a history of left apical lung adenocarcinoma who underwent fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (CT) for suspected recurrence. The scan revealed a recurrent pulmonary mass with metastatic spread, notably showing intense bilateral focal FDG uptake in the kidneys. A metastatic origin was suspected and subsequently confirmed by CT-guided renal biopsy. Although rare and typically observed in advanced stages of the disease, this case underscores the importance of carefully evaluating focal FDG uptake in the renal cortex to ensure accurate staging and optimal management of oncologic patients.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"114-116"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolically Silent Diffuse Hepatic Involvement in Multiple Myeloma: An ¹⁸F-FDG-PET/CT Pitfall.","authors":"Seçkin Bilgiç, Merve Okuyan, Efrah İbrahim","doi":"10.4274/mirt.galenos.2026.09475","DOIUrl":"10.4274/mirt.galenos.2026.09475","url":null,"abstract":"<p><p>Diffuse hepatic involvement in multiple myeloma is rare and may present a diagnostic challenge ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT). We present the case of a 59-year-old man with a 3-year history of multiple myeloma who developed progressive hepatomegaly and perihepatic ascites. ¹⁸F-FDG PET/CT demonstrated marked diffuse liver enlargement without any focal or diffuse hepatic 18F-FDG uptake, while mild diffuse skeletal uptake suggested a globally ¹⁸F-FDG-low myeloma phenotype. Given the discordance between severe morphological findings and the absence of hepatic metabolic activity, a liver biopsy was performed, which revealed diffuse sinusoidal infiltration by CD138-positive, lambda-restricted plasma cells and excluded hepatic amyloidosis. Following systemic therapy, hepatomegaly and ascites regressed, while hepatic ¹⁸F-FDG uptake remained absent. Written informed consent for publication was obtained from the patient. This case highlights an important limitation of ¹⁸F-FDG PET/CT in detecting diffuse hepatic myeloma and emphasizes the need for multimodal diagnostic integration.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"137-141"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydatic Cyst Infection of the Tibia Mimicking Chondrosarcoma on ¹⁸F-FDG PET/CT Scan.","authors":"Furkan Avcı, Batuhan Kocabeyoğlu, İpek Tamsel, Hüseyin Kaya, Başak Doğanavşargil, Zehra Özcan","doi":"10.4274/mirt.galenos.2025.13540","DOIUrl":"10.4274/mirt.galenos.2025.13540","url":null,"abstract":"<p><p>A hydatid cyst is a zoonotic infection caused by <i>Echinococcus granulosus</i>. The liver and lungs are the most affected organs. Although rare, osseous involvement by hydatid cyst disease can occur because the rigid bone trabeculae prevent formation of the characteristic adventitia. While fluorodeoxyglucose (FDG) positron emission tomography (PET) findings in hepatic and pulmonary hydatid cysts are well described, this case, to the best of our knowledge, represents the first report of bone hydatid disease located in an extremity evaluated by ¹⁸F-FDG PET/computed tomography.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"127-130"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Lean Body Mass ¹⁸F-FDG PET/CT Parameters to Predict Pathologic Findings in Overweight Endometrial Cancer Cases.","authors":"Furkan Avcı, Alpay Tunç, Burçin Karaşah Erkek, Ahmet Aydın Özsaran, Gürdeniz Serin, Osman Zekioğlu, Zeynep Burak","doi":"10.4274/mirt.galenos.2026.48108","DOIUrl":"10.4274/mirt.galenos.2026.48108","url":null,"abstract":"<p><strong>Objectives: </strong>Endometrial cancer is the second most common gynaecologic cancer in women worldwide. Due to the biology of endometrial cancer, most patients are overweight. Standard uptake value (SUV) measurements are known to vary depending on the patient's body weight. We aimed to evaluate whether lean body mass-adjusted ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) parameters [lean body mass-corrected standardized uptake value (SUL)-based metrics] are superior to conventional SUV-based parameters for predicting adverse histopathologic features in overweight patients with endometrial cancer, and to explore their association with progression-free survival (PFS).</p><p><strong>Methods: </strong>In this retrospective single-center study, 73 overweight patients with endometrial cancer who underwent preoperative ¹⁸F-FDG PET/CT followed by primary surgery were included. SUV- and SUL-based metabolic parameters were compared with histopathologic risk factors. ROC analyses were performed to determine discriminatory performance and optimal cut-off values. PFS was assessed using Kaplan-Meier analysis.</p><p><strong>Results: </strong>SUV_mean (SUL_mean) demonstrated significant associations with deep myometrial invasion, lymphovascular space invasion, lymph node involvement, and higher tumor grade. In ROC analysis, SUL_mean showed moderate discriminatory ability for lymph node involvement (area under the curve: 0.78). However, PFS did not differ significantly between groups stratified by the ROC-derived SUL_mean cut-off (log-rank p=0.46).</p><p><strong>Conclusion: </strong>Lean body mass-adjusted PET parameters, particularly SUL_mean, were more strongly associated with adverse histopathologic features than conventional SUV metrics in overweight patients with endometrial cancer. Although SUL-based parameters may contribute to preoperative risk assessment, their prognostic value for survival remains uncertain.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"35 2","pages":"105-113"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT in Progressive Oncocytic Carcinoma of the Parotid Gland-Case Study.","authors":"Dushica Todorova Stefanovski, Aleksandar Iliev, Goran Spirov, Sinisha Stojanoski, Nevena Manevska","doi":"10.4274/mirt.galenos.2026.02779","DOIUrl":"10.4274/mirt.galenos.2026.02779","url":null,"abstract":"<p><p>Oncocytic carcinoma of the salivary glands is a very rare entity, that mainly presents in the parotid gland, either arises de-novo or is being associated with a benign oncocytoma in up to 50%. Our patient was a 60 years old male with histopathological finding of oncocytic (oxyphilic) carcinoma originating from the parotid gland with metastasis in cervical lymph nodes (postoperative stage IVA, pTNM = pT2 pN2b pMx G2 R0). On the initial preoperative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) increased metabolic activity was seen in level IB and IIA cervical lymph nodes, suspicious for metastasis. Surgical biopsy of the parotid gland revealed oncocytic carcinoma, and then radical surgery was performed. Afterwards, patients started with immunotherapy, but because of disease progression (metastasis in the cervical, axillary, mediastinal lymph nodes and thyroid) detected on the control PET/CT scans, he was switched to chemotherapy. The patient died four years after being diagnosed with the primary cancer.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"145-149"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extrapulmonary Tuberculosis Mimicking Malignancy.","authors":"Cansu Güneren, Rabia Lebriz Uslu Beşli, Haluk Burçak Sayman","doi":"10.4274/mirt.galenos.2025.43925","DOIUrl":"10.4274/mirt.galenos.2025.43925","url":null,"abstract":"<p><p>Tuberculosis (TB) remains a significant public health problem in developing countries, but its diagnosis can be challenging as it may mimic malignancy or other granulomatous diseases. Although pulmonary TB is the most common form, TB can spread hematogenously, lymphatically, or by direct extension to any tissue or organ. We report a 62-year-old female who underwent ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) for malignancy evaluation, was diagnosed with extrapulmonary TB, and had her treatment response assessed with ¹⁸F-FDG PET/CT.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"123-126"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}