Molecular Imaging and Radionuclide Therapy最新文献

{"title":"The Complementary Roles of ¹⁸F-Fluorocholine and ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in an Evaluation of A Patient With Parathyroid Carcinoma: A Case Report.","authors":"Nikola Pantic, Lenka Grujicic, Branislava Radovic, Dragana Sobic Saranovic, Vera Artiko, Strahinja Odalovic","doi":"10.4274/mirt.galenos.2025.58966","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.58966","url":null,"abstract":"<p><p>¹⁸Fluorine-fluorocholine (¹⁸F-FCH) is a radiopharmaceutical used in primary hyperparathyroidism. The data about its utility in malignancies other than prostate and hepatocellular carcinoma is limited. We present the case of a patient who was referred for ¹⁸F-FCH positron emission tomography/computed tomography (PET/CT) due to the persistently elevated parathormone and calcium levels following total thyroidectomy with left lower parathyroidectomy for parathyroid carcinoma (PTC). Previously, the patient underwent ¹⁸Fluorine-fluorodeoxyglucose (¹⁸F-FDG) PET/CT. The latter method detected multiple mediastinal and hilar lymph nodes, as well as nodular lesions in lungs and osteolytic bone lesions with an increased tracer uptake, whereas ¹⁸F-FCH PET/CT detected an increased tracer uptake not only in lesions at all of the abovementioned areas, but also in the nodular lesion in the neck corresponding to a local relapse as well, with bone lesions showing higher avidity for ¹⁸F-FDG than for ¹⁸F-FCH. The case we present shows that ¹⁸F-FCH PET/CT has an additive value to ¹⁸F-FDG PET/CT in an evaluation of patients with PTC.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Partial Volume Effect in Pre-Dosimetry of Liver Tumors for ⁹⁰Y Radioembolization: A Phantom Study.","authors":"Ayşe Dilaver Akar, Nami Yeyin, Sinem Akyol, Özge Demir, Eylem Gülce Çoker, Mustafa Demir","doi":"10.4274/mirt.galenos.2025.77200","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.77200","url":null,"abstract":"<p><strong>Objectives: </strong>Yttrium-90 (⁹⁰Y) radioembolization has become increasingly important in the treatment of liver tumors. This study aims to experimentally determine the extent to which small liver tumors are affected by the partial volume effect (PVE) in single photon emission computed tomography/computed tomography (SPECT/CT) scintigraphy using technetium-99m-macroaggregated albumin (Tc-99m-MAA), and to investigate the impact of PVE on tumor dosimetry and image quality.</p><p><strong>Methods: </strong>In this experimental study, a custom-designed liver phantom containing four tumor mimics with diameters of 1 cm, 2 cm, 3 cm, and 5 cm was used. The tumor and liver parenchyma volumes were filled with Tc-99m at a ratio of 4.86: 1. The phantom was imaged in a water tank using SPECT/CT according to standard clinical protocols. Volumetric regions of interest were drawn for each lesion and tumor volumes, contrast values (C), contrast to noise ratios (CNR), and absorbed tumor doses were calculated from the counts obtained. Since this study does not involve live subjects and was conducted solely on a phantom model, ethical approval, informed consent, and consent forms are not required for this study.</p><p><strong>Results: </strong>Tumor diameters measured on SPECT/CT images matched those obtained from both CT images and the actual dimensions. The contrast values calculated from the SPECT/CT images for lesions with diameters of 2 cm and 5 cm were 2.03 and 3.89, respectively. Similarly, the corresponding CNR values were 8.64 and 21.07. Tumor-to-normal tissue ratios were 2.03 and 3.89 for the 2 cm and 5 cm lesions, respectively. For the 2 cm lesion, the actual and SPECT/CT-derived absorbed doses were 15.3 Gy and 7.87 Gy, respectively. For the 5 cm lesion, these values were 15.4 Gy and 13.38 Gy, respectively. the absorbed tumor doses significantly decreased as tumor diameter decreased due to the influence of PVE.</p><p><strong>Conclusion: </strong>Tumors smaller than 2 cm in diameter were markedly affected by the PVE. Considering the influence of PVE, or applying appropriate corrections in dosimetric calculations, is of critical importance for improving the accuracy of dosimetry results.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Tumors Uncovered: Insights from ⁶⁸Ga PSMA PET-CT.","authors":"Sana Munir Gill, Aamna Hassan, Waqas Ahmad, Islah Ud Din","doi":"10.4274/mirt.galenos.2025.15870","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.15870","url":null,"abstract":"<p><p>Galium-68 prostate-specific membrane antigen positron emission tomography combined with computed tomography (⁶⁸Ga PSMA PET-CT) is receptor specific imaging, which has increasingly been used in the staging and restaging of prostate carcinoma (PCa). PSMA is type II transmembrane glycoprotein expressed in cytosol of normal prostatic tissue with 100-1000-fold over expression in PCa. It is also expressed in the endothelium of tumor-associated neo vasculature of non-prostatic solid tumor such as transitional cell and renal cell carcinoma, hepatocellular, thyroid, and brain cancers. We hereby present a case where PSMA PET scan showed three tumors proved on follow up imaging.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of ⁶⁸Ga-PSMA PET/CT in Metastatic Prostate Cancers at the Time of Diagnosis and Correlation with Obesity.","authors":"Özge Ulaş, Zekiye Hasbek","doi":"10.4274/mirt.galenos.2025.46762","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.46762","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the relationship between Galium-68 prostate-specific membrane antigen positron emission tomography combined with computed tomography (⁶⁸Ga-PSMA PET/CT) quantitative parameters and patient obesity, prostate-specific antigen (PSA) levels, and metastasis type in prostate cancer.</p><p><strong>Methods: </strong>In the present study, we included 112 patients diagnosed with prostate cancer between 2020 and 2024. These patients underwent ⁶⁸8Ga-PSMA PET/CT imaging for staging purposes, with locoregional or distant metastasis detected in the imaging results.</p><p><strong>Results: </strong>No significant correlation was observed between body mass index (BMI) classification and prostate gland maximum standard uptake values (SUV_max), metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized uptake value lean (SUL), or SUV_mean values. A weak inverse correlation was found between BMI and PSA levels (p=0.08, r=-0.248), with PSA values decreasing as patient weight increased. The presence of locoregional disease or distant metastasis was not significantly associated with prostate gland SUV_max, MTV, TLG, SUV_mean, or SUL values (p=0.25; 0.667; 0.667; 0.244; 0.126, respectively). However, a significant association was detected between PSA levels and distant metastases or locoregional disease (p=0.02), with higher PSA values observed in patients with distant metastases compared to those with locoregional disease. Additionally, significant correlations were found between the D'Amico risk classification and the prostate gland SUV_max, TLG, SUL, and SUV_mean values (p=0.035, 0.037, 0.012, 0.028, respectively).</p><p><strong>Conclusion: </strong>PSA levels may assist in estimating whether metastases are local or distant. However, due to the weak inverse correlation between BMI and PSA, it is important that low PSA levels may not necessarily indicate localized disease during clinical evaluation.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on the Use of the ThyPRO Questionnaire in Turkish Populations: Methodological Consideration.","authors":"Aziz Gültekin","doi":"10.4274/mirt.galenos.2025.29577","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.29577","url":null,"abstract":"","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Disease Progression Predictor by Quantitative Assessment of the Hepatic Accumulation on Postablative Iodine-131 Whole-Body Image in Differentiated Thyroid Cancer.","authors":"Michihiro Nakayama, Kenta Nomura, Sho Kamieda, Ippei Yoshida, Atsushi Fujiya, Takahiro Uno, Atsutaka Okizaki","doi":"10.4274/mirt.galenos.2025.71542","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.71542","url":null,"abstract":"<p><strong>Objectives: </strong>A Iodine-131 (¹³¹I) whole body scan (WBS) is performed to evaluate the treatment response after radioactive iodine (RAI) therapy. Despite the clinical relevance of RAI-refractory differentiated thyroid cancer, a consensus on its precise definition remains lacking. This study investigates the potential utility of hepatic ¹³¹I accumulation as an early predictor for tumor recurrence or progression after RAI administration.</p><p><strong>Methods: </strong>Of 814 patients receiving care at our institution, we enrolled 225 patients who exhibited no accumulation of RAI in the remnant tissues or other lesions on ¹³¹I WBS. We quantified the hepatic uptake ratio [defined as (hepatic uptake/background uptake (H/B)] from WBS. All patients were categorized into group A (H/B ≤1.5) and group B (H/B >1.5), and we assessed between-group differences. The Kaplan-Meier method and Log-rank test were used to analyze the progression-free survival (PFS). Using the Cox proportional hazards model, we identified independent prognostic factors from among the seven known prognostic factors, i.e., H/B, thyroglobulin, sex, age, stage, total ¹³¹I dose, and final therapeutic dose.</p><p><strong>Results: </strong>The 5-year and median PFS were 98.8% and 114.7 months in group A (n: 171) compared with 24.1% and 42.7% months in group B (n: 54), respectively. Group B showed a significant correlation with poor prognosis (p<0.00001). Of the seven prognostic factors, H/B exhibited the highest impact on patient outcomes (hazards ratio for recurrence/disease progression, 42.156; 95% confidence interval: 8.750-203.106).</p><p><strong>Conclusion: </strong>Quantitative evaluation of hepatic uptake on ¹³¹I WBS provides a marker that may help identify patients with differentiated thyroid cancer who are at a high risk of disease progression/recurrence immediately after RAI therapy.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Imaging Findings in a Patient with Squamous Cell Carcinoma of the External Auditory Canal Metastatic to the Dura with Trigeminal Nerve Involvement.","authors":"Güler Silov, İsmet Miraç Çakır, Hande Arslan, Asuman Çelik, Aslı Ayan","doi":"10.4274/mirt.galenos.2025.26937","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.26937","url":null,"abstract":"<p><p>We report the case of a 56-year-old female recently diagnosed with well-differentiated squamous cell carcinoma of the external auditory canal. The patient underwent an 18F-fluorodeoxyglucose positron emission tomography/computed tomography for staging assessment. This examination revealed intense uptake in the right ear canals, tympanic cavity, eustachian canal, parapharyngeal area, and infratemporal fossa. Notably, we identified intracranial dural metastasis, which represents an uncommon site for metastatic spread in general.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile Metastasis from Prostate Cancer: Detection on ¹⁸F-PSMA-1007 PET/CT.","authors":"Hend Komber, Ayah Nawwar, Julie Searle, Iain Lyburn","doi":"10.4274/mirt.galenos.2025.32815","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.32815","url":null,"abstract":"<p><p>A 74-year-old man with a history of prostate cancer and rising prostate-specific antigen underwent ¹⁸F-prostate specific membrane antigen PSMA)-1007 positron emission tomography/computed tomography for investigation of oligometastatic disease. There was evidence of PSMA avid local recurrence findings with pelvic and retroperitoneal nodal metastases and skeletal deposits. Although rare and could easily be mistaken for contamination, a small penile metastasis was found. This is associated with poor prognosis and could impact further management. This case highlights the importance of a detailed review of the penis, to ensure differentiation between urinary activity and pathological uptake.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic Calcifications Mimicking Lymph Nodes on ¹⁸F-PSMA1007 PET.","authors":"Salah Nabih Oueriagli, Omar Ait Sahel, Ikram Zahfir, Meryem Aboussabr, Yassir Benameur, Abderrahim Doudouh","doi":"10.4274/mirt.galenos.2025.78736","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.78736","url":null,"abstract":"<p><p>An 82-year-old patient with high-risk prostate adenocarcinoma, previously treated with radiotherapy and hormone therapy, presented with biochemical recurrence, as evidenced by a prostate-specific antigen level of 10 ng/mL. A positron emission tomography/computed tomography (PET/CT) scan using ¹⁸F-prostate-specific membrane antigen (PSMA ) 1007 revealed significant uptake at the prostate apex and multiple hypermetabolic osseous lesions in the sternum and L3, suggestive of local recurrence and metastasis. However, several hypermetabolic foci in the abdominopelvic region raised suspicion for potential involvement of the lumbar-aortic lymph nodes due to their moderate to intense uptake. After further investigation, these findings were attributed to active aortic calcifications. This case highlights a rare cause of false-positive results in ¹⁸F-PSMA 1007 PET/CT imaging and underscores the need for additional evaluations, such as abdominopelvic magnetic resonance imaging and renal and phosphocalcic assessments, when such results are suspected.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gluteal Muscle Metastasis of Papillary Thyroid Cancer with Increased Somatostatin Receptor Expression in ⁶⁸Ga-DOTATATE PET/MRI.","authors":"Ali Kibar, Sertaç Asa, Lebriz Uslu-Beşli, Mine Önenerk, Sait Sağer, Kerim Sönmezoğlu, Haluk Burçak Sayman","doi":"10.4274/mirt.galenos.2025.89847","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.89847","url":null,"abstract":"<p><p>A 56-year-old male patient underwent total thyroidectomy, and pathology revealed multicentric papillary thyroid cancer. His post-operative stimulated thyroglobulin value was >500 ng/mL. ¹⁸F-fluorodeoxyglucose positron emission tomography (PET) computed tomography revealed hypermetabolic metastatic pulmonary nodules, cervical, and mediastinal lymph nodes. There was also a hypermetabolic lesion in the left gluteal muscle. Due to the patient's history of a pilonidal cyst in the same region, the possibility of an abscess was also considered, and due to the absence of radioactive iodine (RAI) uptake in the lesion, follow-up was deemed appropriate. During follow-up, as the patient progressed to RAI-refractory state, ⁶⁸Ga-DOTATATE PET/magnetic resonance imaging, which was done for radionuclide therapy planning, revealed heterogeneously increased uptake in the gluteal lesion. A subsequent biopsy confirmed the diagnosis of thyroid cancer metastasis.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}