Molecular Imaging and Radionuclide Therapy最新文献

A Comprehensive Diagnostic Assessment of Thyroid Nodules Utilizing Scintigraphy and Telomere Lengths (T/S ratios). 利用闪烁成像和端粒长度（T/S比）对甲状腺结节的综合诊断评估。

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2025.85429

Fulya Koç Öztürk, Semra Usta Özdemir, Ersen Karakılıç, Fatma Sılan

{"title":"A Comprehensive Diagnostic Assessment of Thyroid Nodules Utilizing Scintigraphy and Telomere Lengths (T/S ratios).","authors":"Fulya Koç Öztürk, Semra Usta Özdemir, Ersen Karakılıç, Fatma Sılan","doi":"10.4274/mirt.galenos.2025.85429","DOIUrl":"10.4274/mirt.galenos.2025.85429","url":null,"abstract":"Objectives: This study aims to evaluate the effectiveness and role of telomere length measurements in leukocytes, plasma free cell DNA (cfDNA), and biopsy cells, along with technetium-99m (Tc-99m) methoxyisobutylisonitrile (MIBI) scintigraphy, as non-invasive methods for diagnosing malignant thyroid lesions.Methods: Data from 128 patients, who underwent ultrasound, Tc-99m MIBI scintigraphy, and fine-needle biopsy with a preliminary diagnosis of malignant thyroid nodules, were analyzed. In 98 patients, telomere lengths in leukocytes (from blood), cfDNA (from plasma), and biopsy cells were measured using the quantitative polymerase chain reaction method, and the relative telomere/single copy gene (T/S) ratio was calculated. Based on cytological examination results, patients were categorized into three groups: malignant, benign, and suspicious. Group differences were analyzed using the Kruskal-Wallis and Chi-square tests, and correlations between variables were examined with Spearman correlation analysis.Results: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of Tc-99m MIBI scintigraphy for diagnosing malignant thyroid nodules were 64.70%, 79.16%, 29.72%, 83.51%, and 67.96%, respectively. While these results align with the literature, the positive predictive value was notably lower. No significant differences were observed in telomere lengths (T/S ratios) in leukocytes, plasma, or tissue between the groups.Conclusion: Tc-99m MIBI scintigraphy demonstrates reasonable diagnostic accuracy for identifying malignancy in thyroid nodules. Contrary to limited reports, telomere length measurements may not be a reliable method for predicting thyroid malignancy. Larger studies are needed to further explore these findings.","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 2","pages":"97-106"},"PeriodicalIF":0.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated candidiasis on FDG-PET/CT. FDG-PET/CT显示播散性念珠菌病。

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2025.93276

Yassir Benameur, Adnane Hammani, Kamal Doghmi, Abderrahim Doudouh

{"title":"Disseminated candidiasis on FDG-PET/CT.","authors":"Yassir Benameur, Adnane Hammani, Kamal Doghmi, Abderrahim Doudouh","doi":"10.4274/mirt.galenos.2025.93276","DOIUrl":"10.4274/mirt.galenos.2025.93276","url":null,"abstract":"Disseminated candidiasis presents a significant diagnostic and therapeutic challenge in immunocompromised patients, particularly those with hematological malignancies like leukemia. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) is a crucial imaging modality in oncology and infection, outperforming conventional imaging in diagnosing and managing fungal infections, especially in cases of fever of unknown origin. We present a compelling case of a young leukemia patient with persistent fever, demonstrating FDG-avid lesions in various organs, including the liver, spleen, and left kidney, indicative of disseminated candidiasis.This highlights the critical role of 18F-FDG-PET/CT in situations where invasive procedures like liver biopsy are challenging or contraindicated. Such instances underscore the paramount importance of utilizing advanced imaging techniques for accurate diagnosis and treatment, especially in the complex clinical setting of immunocompromised individuals, with hematological malignancies. This case emphasizes the significant contribution of 18F-FDG-PET/CT as a non-invasive diagnostic tool, enhancing patient care and enabling more effective management strategies amidst challenging medical circumstances.","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 2","pages":"165-167"},"PeriodicalIF":0.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Poor Prognostic Stigma of Hepatic Superscan on ¹⁸F-FDG PET Imaging. 肝超扫18F-FDG PET显像预后不良的柱头。

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2024.56689

Dhuha Al-Adhami, Malik Juweid, Akram Al-Ibraheem

引用次数: 0

The Effect of GLUT-1-XbaI G>T and HaeIII T>C Polymorphisms on ¹⁸F-FDG Uptake Rates. GLUT-1-XbaI G bbbbc和haeii T bbbbc多态性对18F-FDG摄取速率的影响

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2025.93797

Melih Kısaarslan, Yasemin Adalı, Veli Kaan Aydın, Yasemin Berberoğlu, Doğangün Yüksel, Aylin Köseler

{"title":"The Effect of GLUT-1-XbaI G>T and HaeIII T>C Polymorphisms on 18F-FDG Uptake Rates.","authors":"Melih Kısaarslan, Yasemin Adalı, Veli Kaan Aydın, Yasemin Berberoğlu, Doğangün Yüksel, Aylin Köseler","doi":"10.4274/mirt.galenos.2025.93797","DOIUrl":"10.4274/mirt.galenos.2025.93797","url":null,"abstract":"Objectives: To investigate the effects of glut polymorphisms on 18Fluorine-fluorodeoxyglucose (18F-FDG) uptake rates.Methods: The 18F-FDG positron emission tomography/computed tomography images and mass lesion metabolism standard uptake value maximum (SUVmax) results of the patients were evaluated. Glucose transporter protein-1 (GLUT-1)-XbaI G>T (rs2754218) and HaeIII T>C (rs1385129) polymorphisms and their effects on 18F-FDG uptake rates were investigated using DNA obtained from peripheral blood.Results: When the Xbal G>T genotype distribution of the patients was examined, the Xbal G/G genotype was found to be 87%, the Xbal G/T genotype 12%. The XbaI T/T phenotype was detected in only one patient (1%). In the HaeIII T>C genotype distribution, the HaeIII C/C genotype was found as 54%, the HaeIII T/C genotype as 31%, and the HaeIII T/T genotype as 15%. When the Xbal and HaeIII genotypes were examined together, the number of polymorphic genotypes was significantly higher in the lung and bronchial tumor groups compared to other cancer types.Conclusion: The presence of polymorphism in at least one of the two gene regions, in the lung-bronchial tumor group and the high SUVmax value in this patient group, may indicate a change in the involvement rates.","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 2","pages":"90-96"},"PeriodicalIF":0.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined ⁶⁸Ga-PSMA PET/CT and mpMRI Findings Improve Tumor Localization and Biopsy Guidance in the Initial Diagnosis of Prostate Cancer. 结合68Ga-PSMA PET/CT和mpMRI结果，提高肿瘤定位和活检对前列腺癌初步诊断的指导作用。

IF 0.9

Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2024.75547

Yavor Gramatikov, Petia Nikolova, Mihaela Ilcheva, Valentin Yotovski, Nikolay Halachev, Valeria Hadzhiyska

{"title":"Combined 68Ga-PSMA PET/CT and mpMRI Findings Improve Tumor Localization and Biopsy Guidance in the Initial Diagnosis of Prostate Cancer.","authors":"Yavor Gramatikov, Petia Nikolova, Mihaela Ilcheva, Valentin Yotovski, Nikolay Halachev, Valeria Hadzhiyska","doi":"10.4274/mirt.galenos.2024.75547","DOIUrl":"10.4274/mirt.galenos.2024.75547","url":null,"abstract":"Gallium-68 (68Ga)-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is a relatively new imaging modality that has already proved its role in the initial staging of prostate cancer and in biochemical recurrence following definitive primary therapy. Furthermore, emerging data several ongoing studies demonstrate its potential role in the primary diagnosis of this malignancy. We present a 67-year-old male patient with increasing clinical suspicion of prostate cancer despite a previous negative prostate gland biopsy. He was referred to our nuclear medicine department for a 68Ga-PSMA PET/CT with the aim of improving tumor localization and assisting in the guidance of repeat prostate biopsy. One month before presentation of elevated prostate-specific antigen levels, he underwent multiparametric magnetic resonance imaging (mpMRI), which revealed a prostate imaging reporting and data system 4 lesion in the right lobe of the prostate gland. The MRI lesion completely matched a PRIMARY score 5 lesion registered by PET/CT. Furthermore, we detected another suspicious finding in the left lobe (PRIMARY score 4). The patient underwent PSMA PET/CT-guided MRI/ultrasonography fusion transperineal biopsy of both lesions. The latter were histologically confirmed as prostate carcinoma with a Gleason score of 3+4 =7.","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 2","pages":"146-148"},"PeriodicalIF":0.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of ⁶⁸Ga-FAPI-04 and ⁶⁸Ga-PSMA in a Case of Interstitial Lung Disease. 68Ga-FAPI-04与68Ga-PSMA在间质性肺疾病中的比较

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2024.93270

Hasan Önner, Abidin Kılınçer

引用次数: 0

⁶⁸Ga-PSMA-Avid Sinonasal Intestinal-Type Adenocarcinoma. 68Ga-PSMA-Avid鼻窦肠型腺癌。

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2024.48403

Hasan Önner, Halil Özer, Muhammet Fatih Gökmen, Orhan Önder Eren

引用次数: 0

Physiological Distribution of ¹⁸F-FDG in the Spinal Cord of Disease-Free Subjects 无病受试者脊髓18F-FDG的生理分布。

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 Epub Date: 2025-05-15 DOI: 10.4274/mirt.galenos.2025.56514

Selin Kesim, Salih Özgüven

{"title":"Physiological Distribution of 18F-FDG in the Spinal Cord of Disease-Free Subjects","authors":"Selin Kesim, Salih Özgüven","doi":"10.4274/mirt.galenos.2025.56514","DOIUrl":"10.4274/mirt.galenos.2025.56514","url":null,"abstract":"Objectives: 18Fluorine-fluorodeoxyglucose (18F-FDG) uptake in the spinal cord is not unusual and may mimic metastatic disease. The physiological characterization and variability of spinal cord 18F-FDG metabolism provide valuable information, especially in patients with suspected malignancies. We aimed to investigate the physiological 18F-FDG uptake pattern within the spinal cord and its associations in a normal population.Methods: We retrospectively analyzed 18F-FDG positron emission tomography/computed tomography images of 140 adult patients who were confirmed to be disease-free over a one-year follow-up period. The maximal and mean standard uptake values (SUVmax, SUVmean) were measured at each mid-vertebral level from C1 to L5, and normalized to liver and blood pool uptake. Correlations between 18F-FDG uptake and patient demographics, clinical parameters, and environmental temperature were evaluated.Results: 18F-FDG uptake demonstrated a decreasing trend from the cervical to lumbar vertebrae, with a notable increase at the lower thoracic levels (T11-T12). There was a significant negative correlation between 18F-FDG uptake and age (p<0.001), fasting glucose level (p=0.016), and diabetic status (p=0.003). No significant association was found between spinal cord 18F-FDG uptake and gender, weight, height, body mass index, 18F-FDG dose, or environmental temperature.Conclusion: Normal distribution of 18F-FDG in the spinal cord of disease-free individuals decreases from cervical to lumbar levels, although it notably increases at the lower thoracic and mid-lower cervical levels. Uptake significantly decreases with age, with a higher fasting blood glucose level, and in diabetic patients.","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"107-113"},"PeriodicalIF":0.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidentally Detected High-Grade Follicular Derived Non-Anaplastic Thyroid Carcinoma on ⁶⁸Ga-PSMA PET-CT. 偶然在68Ga-PSMA PET-CT上发现高级别滤泡性非间变性甲状腺癌。

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2025.46693

Parneet Singh, Srijani Mandal, Amit Kumar Adhya, Girish Kumar Parida, Kanhaiyalal Agrawal

引用次数: 0

Pancreatic Involvement in Follicular Lymphoma Detected on ¹⁸FDG-PET/CT. 18FDG-PET/CT检测滤泡性淋巴瘤累及胰腺。

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Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI: 10.4274/mirt.galenos.2024.87004

Yassir Benameur, Salah Oueriagli Nabih, Omar Ait Sahel, Abderrahim Doudouh

引用次数: 0