The Effect of GLUT-1-XbaI G>T and HaeIII T>C Polymorphisms on ¹⁸F-FDG Uptake Rates.

IF 1.1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI:10.4274/mirt.galenos.2025.93797

Melih Kısaarslan, Yasemin Adalı, Veli Kaan Aydın, Yasemin Berberoğlu, Doğangün Yüksel, Aylin Köseler

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引用次数: 0

Abstract

Objectives: To investigate the effects of glut polymorphisms on ¹⁸Fluorine-fluorodeoxyglucose (¹⁸F-FDG) uptake rates.

Methods: The ¹⁸F-FDG positron emission tomography/computed tomography images and mass lesion metabolism standard uptake value maximum (SUV_max) results of the patients were evaluated. Glucose transporter protein-1 (GLUT-1)-XbaI G>T (rs2754218) and HaeIII T>C (rs1385129) polymorphisms and their effects on ¹⁸F-FDG uptake rates were investigated using DNA obtained from peripheral blood.

Results: When the Xbal G>T genotype distribution of the patients was examined, the Xbal G/G genotype was found to be 87%, the Xbal G/T genotype 12%. The XbaI T/T phenotype was detected in only one patient (1%). In the HaeIII T>C genotype distribution, the HaeIII C/C genotype was found as 54%, the HaeIII T/C genotype as 31%, and the HaeIII T/T genotype as 15%. When the Xbal and HaeIII genotypes were examined together, the number of polymorphic genotypes was significantly higher in the lung and bronchial tumor groups compared to other cancer types.

Conclusion: The presence of polymorphism in at least one of the two gene regions, in the lung-bronchial tumor group and the high SUV_max value in this patient group, may indicate a change in the involvement rates.

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GLUT-1-XbaI G bbbbc和haeii T bbbbc多态性对18F-FDG摄取速率的影响

目的：探讨过剩多态性对18氟-氟脱氧葡萄糖（18F-FDG）摄取速率的影响。方法：对患者的18F-FDG正电子发射断层扫描/计算机断层扫描图像及肿块病变代谢标准摄取值最大值（SUVmax）结果进行评价。利用外周血DNA研究葡萄糖转运蛋白1 (GLUT-1)-XbaI G>T （rs2754218）和HaeIII T>C （rs1385129）多态性及其对18F-FDG摄取速率的影响。结果：对患者的Xbal G/G基因型分布进行分析，发现Xbal G/G基因型占87%，Xbal G/T基因型占12%。XbaI T/T表型仅在1例（1%）患者中检测到。在HaeIII T/C基因型分布中，HaeIII C/C基因型占54%，HaeIII T/C基因型占31%，HaeIII T/T基因型占15%。当Xbal和HaeIII基因型一起检测时，与其他癌症类型相比，肺部和支气管肿瘤组的多态性基因型数量显著高于其他癌症类型。结论：在肺支气管肿瘤组中，两个基因区域中至少有一个存在多态性，且该患者组的SUVmax值较高，可能表明累及率发生了变化。

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来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.