Molecular Imaging and Radionuclide Therapy最新文献

{"title":"The PSMA-PET Conundrum: A Survey of UK Prostate Cancer Surgeons and Their Use of PSMA-PET Prior to Radical Prostatectomy.","authors":"Rustam Nariman Karanjia, Pallab Kumar Sarkar, Humayun Bashir, Sashi S Kommu","doi":"10.4274/mirt.galenos.2025.78700","DOIUrl":"10.4274/mirt.galenos.2025.78700","url":null,"abstract":"<p><strong>Objectives: </strong>Prostate-specific membrane antigen-positron emission tomography (PSMA-PET) has significantly improved sensitivity and specificity for detecting metastatic disease in prostate cancer compared to traditional computed tomography and bone scans. It is now recommended by the European Association of Urology for staging intermediate and high-risk disease, however, there are no recommendations on its incorporation into practice due to lack of long-term survival data. We aimed to identify the current use of PSMA-PET in high-volume prostate cancer centres to see whether there is standardisation in its use and interpretation prior to robotic-assisted laparoscopic prostatectomy (RALP).</p><p><strong>Methods: </strong>An anonymised SurveyMonkey^® was sent to multiple high-volume surgeons across the United States (UK), with all questions optional. Participants were asked about their personal practices for PSMA-PET staging, for both intermediate and high-risk disease, and how it would change their management if considering RALP.</p><p><strong>Results: </strong>Thirty-one participants responded across 17 different UK centres. 11/31 (35%) used PSMA-PET a lone as primary staging for high-risk prostate cancer, with 6/30 (20%) using it for intermediate staging as well. Of the 23 surgeons that routinely perform lymph node dissection (LND) in high-risk cases, 13/23 (57%) would obviate performing it if the PSMA was negative. If a patient was found to have positive nodes on PSMA-PET, 12/31 (39%) surgeons will still offer RALP. Individual answers also varied within same centres.</p><p><strong>Conclusion: </strong>The current interpretation of PSMA-PET for staging and treatment before RALP varies widely amongst surgeons, particularly regarding LND. A national consensus statement is needed to help standardise treatment practice for patients until robust long-term survival data exists.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 3","pages":"188-193"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dr. A. Cahid Civelek Exemplifies the Act of Integrating Patient Care, Staff Education, Research, and Global Knowledge Sharing.","authors":"Hong Zhang","doi":"10.4274/mirt.galenos.2025.57614","DOIUrl":"10.4274/mirt.galenos.2025.57614","url":null,"abstract":"","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 3","pages":"168-172"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Bone Scintigraphy in Detection of Disseminated Coccidioides Fungemia.","authors":"Turgut Bora Cengiz, Caroline Diane Wilson","doi":"10.4274/mirt.galenos.2025.65471","DOIUrl":"10.4274/mirt.galenos.2025.65471","url":null,"abstract":"<p><p>Although extrapulmonary Coccidioides infection is rare, it has been shown to disseminate to the skin and musculoskeletal system, with a strong affinity for bone. We present a case of disseminated Coccidioides infection with bone scintigraphy indicating diffuse fungemia despite equivocal serum assay, leading to appropriate antifungal therapy and a full recovery.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"228-230"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive Malignant Thrombus Revealed by ¹⁸F-FDG PET/CT in Patient with Papillary Thyroid Cancer.","authors":"Merve Nida Calderon Tobar, Lütfü Perktaş, Hasan Önner, Gonca Kara Gedik","doi":"10.4274/mirt.galenos.2025.15986","DOIUrl":"10.4274/mirt.galenos.2025.15986","url":null,"abstract":"<p><p>A 59-year-old man admitted to the hospital complained of left arm and neck pain. Magnetic resonance imaging was performed for possible cervical discopathy. It revealed that in the C7 vertebral body, lesions with surrounding bone marrow edema were observed, which were compatible with metastasis that caused cervical stenosis. Cervical stenosis surgery was performed, and the lesion was pathologically diagnosed as a metastasis of thyroid carcinoma. ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) scan was ordered for further evaluation. The PET/CT images showed an increased ¹⁸F-FDG uptake from the left internal jugular vein to the right atrium. It was considered a malignant thrombus.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"231-233"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Acute Polyarticular Gout Disease Detected with ¹⁸F-FDG PET/CT.","authors":"Zehranur Tosunoğlu, Ayşe Nur Toksöz Yıldırım, Esra Arslan, Göksel Alçın, Elife Akgün","doi":"10.4274/mirt.galenos.2025.03764","DOIUrl":"10.4274/mirt.galenos.2025.03764","url":null,"abstract":"<p><p>Gout is an inflammatory arthropathy that develops due to the accumulation of monosodium urate crystals in the joints in adults. In approximately half of the cases, it presents as monoarthritis with an acute attack involving the first metatarsophalangeal joint. The first attack is rarely polyarticular. Herein, we present a male patient who presented with swelling and acute pain in the 5^th toe but ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography showed symmetric polyarticular involvement which was mimicking arthritis.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"249-251"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Interesting Case of Fornix Rupture Discovered Accidentally on Bone Scintigraphy.","authors":"Salah Nabih Oueriagli, Ayoub Dribla, Omar Ait Sahel, Yassir Benameur, Abderrahim Doudouh","doi":"10.4274/mirt.galenos.2025.43402","DOIUrl":"10.4274/mirt.galenos.2025.43402","url":null,"abstract":"<p><p>A 62-year-old male patient, with bladder carcinoma, was referred to our institution for Technetium-99m methylene diphosphonate bone scintigraphy to assess for bone metastasis. While the bone scan showed no abnormal uptake, extraosseous uptake was detected in the left perirenal and pelvic regions on the whole body scan. Computed tomography showed fornix rupture and demonstrated tracer pooling in the perirenal collection. Our diagnosis was very consistent, and oriented the therapeutic attitude towards a percutaneous drainage for the perinephric urinary leak.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"246-248"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of ⁶⁸Ga-PSMA PET/CT in Metastatic Prostate Cancers at the Time of Diagnosis and Correlation with Obesity.","authors":"Özge Ulaş, Zekiye Hasbek","doi":"10.4274/mirt.galenos.2025.46762","DOIUrl":"10.4274/mirt.galenos.2025.46762","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the relationship between Galium-68 prostate-specific membrane antigen positron emission tomography combined with computed tomography (⁶⁸Ga-PSMA PET/CT) quantitative parameters and patient obesity, prostate-specific antigen (PSA) levels, and metastasis type in prostate cancer.</p><p><strong>Methods: </strong>In the present study, we included 112 patients diagnosed with prostate cancer between 2020 and 2024. These patients underwent ⁶⁸8Ga-PSMA PET/CT imaging for staging purposes, with locoregional or distant metastasis detected in the imaging results.</p><p><strong>Results: </strong>No significant correlation was observed between body mass index (BMI) classification and prostate gland maximum standard uptake values (SUV_max), metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized uptake value lean (SUL), or SUV_mean values. A weak inverse correlation was found between BMI and PSA levels (p=0.08, r=-0.248), with PSA values decreasing as patient weight increased. The presence of locoregional disease or distant metastasis was not significantly associated with prostate gland SUV_max, MTV, TLG, SUV_mean, or SUL values (p=0.25; 0.667; 0.667; 0.244; 0.126, respectively). However, a significant association was detected between PSA levels and distant metastases or locoregional disease (p=0.02), with higher PSA values observed in patients with distant metastases compared to those with locoregional disease. Additionally, significant correlations were found between the D'Amico risk classification and the prostate gland SUV_max, TLG, SUL, and SUV_mean values (p=0.035, 0.037, 0.012, 0.028, respectively).</p><p><strong>Conclusion: </strong>PSA levels may assist in estimating whether metastases are local or distant. However, due to the weak inverse correlation between BMI and PSA, it is important that low PSA levels may not necessarily indicate localized disease during clinical evaluation.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"173-179"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Tumors Uncovered: Insights from ⁶⁸Ga PSMA PET-CT.","authors":"Sana Munir Gill, Aamna Hassan, Waqas Ahmad, Islah Ud Din","doi":"10.4274/mirt.galenos.2025.15870","DOIUrl":"10.4274/mirt.galenos.2025.15870","url":null,"abstract":"<p><p>Galium-68 prostate-specific membrane antigen positron emission tomography combined with computed tomography (⁶⁸Ga PSMA PET-CT) is receptor specific imaging, which has increasingly been used in the staging and restaging of prostate carcinoma (PCa). PSMA is type II transmembrane glycoprotein expressed in cytosol of normal prostatic tissue with 100-1000-fold over expression in PCa. It is also expressed in the endothelium of tumor-associated neo vasculature of non-prostatic solid tumor such as transitional cell and renal cell carcinoma, hepatocellular, thyroid, and brain cancers. We hereby present a case where PSMA PET scan showed three tumors proved on follow up imaging.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"224-227"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET/CT Detection of Extensive Pleural Metastasis in Rare Malignancy Thymoma.","authors":"Mehmet Oğuz Kartal, Berna Okudan","doi":"10.4274/mirt.galenos.2025.80947","DOIUrl":"10.4274/mirt.galenos.2025.80947","url":null,"abstract":"<p><p>The majority of metastatic pleural lesions are caused by malignancies such as bronchogenic carcinoma (40%), breast cancer (20%), lymphoma (10%), and ovarian or gastric carcinomas (5%). However, pleural metastases from thymoma are extremely rare. In this report, we present the ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) imaging findings of a patient with thymoma and extensive pleural metastases. Although biopsy remains the gold standard for diagnosis, it is important to consider high grade thymoma in the differential diagnosis, as extensive pleural involvement observed on ¹⁸F-FDG PET/CT imaging can mimic both primary and metastatic pleural malignancies. Recognizing this possibility can assist in more accurate interpretation of imaging findings.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 3","pages":"252-254"},"PeriodicalIF":1.1,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Complementary Roles of ¹⁸F-Fluorocholine and ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in an Evaluation of A Patient With Parathyroid Carcinoma: A Case Report.","authors":"Nikola Pantic, Lenka Grujicic, Branislava Radovic, Dragana Sobic Saranovic, Vera Artiko, Strahinja Odalovic","doi":"10.4274/mirt.galenos.2025.58966","DOIUrl":"https://doi.org/10.4274/mirt.galenos.2025.58966","url":null,"abstract":"<p><p>¹⁸Fluorine-fluorocholine (¹⁸F-FCH) is a radiopharmaceutical used in primary hyperparathyroidism. The data about its utility in malignancies other than prostate and hepatocellular carcinoma is limited. We present the case of a patient who was referred for ¹⁸F-FCH positron emission tomography/computed tomography (PET/CT) due to the persistently elevated parathormone and calcium levels following total thyroidectomy with left lower parathyroidectomy for parathyroid carcinoma (PTC). Previously, the patient underwent ¹⁸Fluorine-fluorodeoxyglucose (¹⁸F-FDG) PET/CT. The latter method detected multiple mediastinal and hilar lymph nodes, as well as nodular lesions in lungs and osteolytic bone lesions with an increased tracer uptake, whereas ¹⁸F-FCH PET/CT detected an increased tracer uptake not only in lesions at all of the abovementioned areas, but also in the nodular lesion in the neck corresponding to a local relapse as well, with bone lesions showing higher avidity for ¹⁸F-FDG than for ¹⁸F-FCH. The case we present shows that ¹⁸F-FCH PET/CT has an additive value to ¹⁸F-FDG PET/CT in an evaluation of patients with PTC.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}