Molecular Imaging and Radionuclide Therapy最新文献

{"title":"Immune Checkpoint Inhibitor-associated Periaortitis Detected on ¹⁸F-FDG PET/CT: A Rare Case of Nivolumab Toxicity.","authors":"Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Asiya Al Busaidi, Najeeb Ahmed, Shah P Numani","doi":"10.4274/mirt.galenos.2026.67984","DOIUrl":"10.4274/mirt.galenos.2026.67984","url":null,"abstract":"<p><p>We report a case of a 64-year-old male with metastatic non-small-cell lung carcinoma who was undergoing neoadjuvant chemoimmunotherapy with cisplatin, pemetrexed, and nivolumab. Restaging ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) demonstrated segmental, linear ¹⁸F-FDG uptake along the abdominal aortic wall with corresponding crescentic soft-tissue thickening. Differential diagnoses included intramural hematoma, focal aortitis, atherosclerotic plaque, and tumor thrombus. CT angiography revealed a mildly enhancing periaortic soft-tissue rim involving a 5 cm infrarenal aortic segment, consistent with isolated periaortitis, likely induced by immunotherapy. Steroid therapy was initiated. Follow-up ¹⁸F-FDG PET/CT showed complete metabolic resolution, supporting an immune-related etiology. ¹⁸F-FDG PET/CT played a crucial role in early recognition of this immune-related adverse event by sensitively detecting vascular inflammation and guiding further evaluation with CT angiography. Early PET-based detection enabled timely initiation of steroid therapy, preventing potential vascular complications.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"263-266"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of ⁶⁸Ga-FAPi PET/CT in Staging and Restaging of Breast Cancer Subtypes with Limited ¹⁸F-FDG Uptake.","authors":"Gamze Beydağı, Nalan Alan Selçuk, Kaan Akçay, Ayşegül Görmez, Neşet Köksal, Serkan Çelik, Bala Başak Öven, Levent Kabasakal","doi":"10.4274/mirt.galenos.2026.21957","DOIUrl":"10.4274/mirt.galenos.2026.21957","url":null,"abstract":"<p><strong>Objectives: </strong>Breast cancer is highly heterogeneous, and certain histopathologic subtypes-particularly invasive lobular carcinoma-exhibit low glucose metabolism that limits ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) performance. Fibroblast activation protein inhibitor (FAPi) imaging with Gallium-68 (⁶⁸Ga)-FAPi PET/CT has emerged as a promising alternative for such tumors. The aim of this study was to evaluate the efficacy of ⁶⁸Ga-FAPi PET/CT in staging, restaging, and recurrence detection of breast cancer, with emphasis on subtypes for which ¹⁸F-FDG PET/CT has low sensitivity.</p><p><strong>Methods: </strong>Twenty-nine women with pathologically confirmed breast cancer (mean age 57.7±11.6 years) were prospectively enrolled. Histopathology (available in 24 patients) showed lobular carcinoma in 16, ductal carcinoma in 6, signet ring cell carcinoma in 1, and mucinous carcinoma in 1. All underwent both ⁶⁸Ga-FAPi and ¹⁸F-FDG PET/CT within one week for staging or restaging. Maximum standardized uptake values (SUV_max) of primary tumors and metastases were recorded for both tracers and compared using paired t-tests.</p><p><strong>Results: </strong>In 7/29 patients (24.1%), neither ¹⁸F-FDG PET/CT nor ⁶⁸Ga-FAPi PET/CT detected pathological findings. Disease stage increased in 13/29 (44.8%) after ⁶⁸Ga-FAPi PET/CT, including 10 patients with no pathologic findings on ¹⁸F-FDG PET/CT; nine were upstaged to stage 4 and one to stage 3. Additionally, one patient progressed from stage 1 to 2, one from 2 to 3, and another from 3 to 4. Among patients with lobular carcinoma, 8/16 (50%) were upstaged with ⁶⁸Ga-FAPi PET/CT. Detection of nodal and distant metastases in lobular carcinoma was higher with ⁶⁸Ga-FAPi than ¹⁸F-FDG. ⁶⁸Ga-FAPi PET/CT also demonstrated higher SUV_max in primary lesions and metastases (p<0.05).</p><p><strong>Conclusion: </strong>⁶⁸Ga-FAPi PET/CT provides a significant advantage for staging and restaging breast cancer-especially lobular carcinoma and other low ¹⁸F-FDG-avid subtypes-supporting its potential role in clinical decision-making and treatment planning.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"175-182"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Papillary Thyroid Microcarcinomas Detected by Nuclear Medicine Imaging: Distinct Clinicopathological Features Compared with Conventional Modalities.","authors":"Seda Hanife Oğuz, İpek Çınar, Banu Ertürk, Gürsan Kaya, Cenk Sökmensüer, Jale Karakaya, Murat Fani Bozkurt, Alper Gürlek","doi":"10.4274/mirt.galenos.2026.92653","DOIUrl":"10.4274/mirt.galenos.2026.92653","url":null,"abstract":"<p><strong>Objectives: </strong>Papillary thyroid carcinomas detected by nuclear medicine imaging techniques may have a worse prognosis than those identified by conventional methods. However, it remains unclear whether this applies to papillary thyroid microcarcinomas (PTMCs).</p><p><strong>Methods: </strong>Patients diagnosed with PTMC at Hacettepe University Faculty of Medicine between 2008 and 2020 were categorized into three groups: (1) incidental PTMCs (Inc-PTMC; n=249), (2) non-incidental PTMCs (NonInc-PTMC; n=134), and (3) PTMCs detected by nuclear medicine imaging methods (NM-PTMC; n=24). Tumor pathological characteristics, including multifocality, extrathyroidal extension, vascular invasion, and lymph node involvement, were analyzed. Logistic regression analysis was performed to assess the association between detection method and tumor aggressiveness while adjusting for potential confounders.</p><p><strong>Results: </strong>Patients in NM-PTMC group were significantly older at diagnosis (54.7±11.2 years) than those in Inc-PTMC (51.1±11.3 years) and NonInc-PTMC (46.9±11.7 years, p=0.001) groups. Tumor size was larger in NM-PTMCs (4.8±2.5 mm) and NonInc-PTMCs (5.3±2.2 mm) compared to Inc-PTMCs (3.4±2.4 mm, p<0.0001). Multiple logistic regression analysis revealed that NM-PTMCs had a markedly higher risk of cervical lymph node metastasis compared with both Inc-PTMCs [odds ratio (OR): 36.04; 95% confidence interval (CI): 6.02-215.59, p=0.001) and NonInc-PTMCs (OR: 8.68; 95% CI: 1.15-65.22, p=0.036). NM-PTMC also had an increased risk of positive surgical margins compared with Inc-PTMC (OR: 5.08; 95% CI: 1.57-16.39, p=0.006), whereas only NonInc-PTMC had a higher risk of extrathyroidal extension (OR: 3.19; 95% CI: 1.48-8.84, p=0.003). The detection method was not associated with multifocality.</p><p><strong>Conclusion: </strong>Nuclear medicine-detected PTMCs may differ in their clinicopathological profile from other PTMC subgroups and may represent an intermediate phenotype between Inc-PTMC and NonInc-PTMC.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"35 3","pages":"194-203"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent ¹⁸F-FDG Uptake in a Post-treatment Hodgkin's Lymphoma: Not Always Residual Disease.","authors":"Dounia Nakro, Ayat Mouaden, Siham Mesmoudi, Imad Ghfir, Hasnae Guerrouj","doi":"10.4274/mirt.galenos.2026.50465","DOIUrl":"10.4274/mirt.galenos.2026.50465","url":null,"abstract":"<p><p>We report the case of a 31-year-old woman with osseous Hodgkin's lymphoma who underwent post-therapeutic ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography. The scan revealed a hypermetabolic lesion in the pubic symphysis and iliac crests, initially suggestive of residual disease. Multimodal evaluation, including ^99mTc-methoxy-isobutyl-isonitrile scintigraphy, laboratory tests revealed primary hyperparathyroidism, and biopsy confirmed a brown tumor. This case highlights the importance of integrating multimodal imaging and pathology to avoid misinterpretation of ¹⁸F-FDG-avid lesions.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"244-247"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Functional Imaging in Tumor-induced Osteomalacia: ⁶⁸Ga-DOTATATE, ¹⁸F-FDG, and ⁶⁸Ga-FAPI PET/CT Findings.","authors":"Zehranur Tosunoğlu, Utku Erdem Soyaltın, İpek Öztürk, Meryem Kaya, Burcu Esen Akkaş, Esra Arslan","doi":"10.4274/mirt.galenos.2026.26214","DOIUrl":"10.4274/mirt.galenos.2026.26214","url":null,"abstract":"<p><p>Tumor-induced osteomalacia, resulting from tumoral overproduction of fibroblast growth factor 23, is a rare paraneoplastic syndrome clinically characterized by muscle weakness, bone pain, and pathological fractures. Fewer than 1,000 cases have been reported in the literature. Laboratory findings typically include hypophosphatemia, normal or decreased levels of 1.25-dihydroxy vitamin D, and normal or elevated levels of FGF23. Functional imaging methods, particularly somatostatin receptor imaging, play an important role in the localization of the tumor. In this case of tumor-induced osteomalacia, we presented the findings from gallium-68 (⁶⁸Ga)-DOTATATE, ⁶⁸Ga-fibroblast, and ¹⁸F-fluorodeoxyglucose positron emission tomography imaging modalities used for tumor localization.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"238-240"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extremely Rare Primary Gastric Alveolar Rhabdomyosarcoma in an Adult: ¹⁸F-FDG PET/CT Findings.","authors":"Bengisu Yılmaz Bildik, İmren Baydemir, Cem Leblebici, İbrahim Taşkın Rakıcı, Elife Akgün, Göksel Alçın, Esra Arslan","doi":"10.4274/mirt.galenos.2026.51482","DOIUrl":"10.4274/mirt.galenos.2026.51482","url":null,"abstract":"<p><p>Approximately 85-90% of all rhabdomyosarcoma (RMS) cases occur in children and adolescents. In adults, RMS accounts for only 2-5% of all soft tissue sarcomas. The annual incidence in adults is 0.3-0.5 per 1,000,000 and is classified as a \"very rare tumor.\" More than 95% of RMSs are extragastric. Primary gastric RMS is reported extremely rarely in adults, and the estimated incidence is <0.01/1,000,000/year. This rate is <0.01% of all gastric malignancies and <1% of all adult RMSs. We report the ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography findings in an adult with primary gastric alveolar RMS, highlighting the metabolic characteristics of this extraordinarily rare malignancy.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"270-273"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Skull Base Metastasis from Pediatric Extremity Chondroblastic Osteosarcoma Detected by Surveillance ¹⁸F-FDG PET/CT: A Case Report with Focused Literature Review.","authors":"Seçkin Bilgiç, Hüseyin Galip Şahin, İrem Köroğlu, Ulviye Yalçınkaya, Eray Alper","doi":"10.4274/mirt.galenos.2026.50374","DOIUrl":"10.4274/mirt.galenos.2026.50374","url":null,"abstract":"<p><p>A 15-year-old girl who had previously undergone surgery and chemotherapy for non-metastatic chondroblastic osteosarcoma of the left fibula was evaluated with ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) during routine follow-up while in clinical remission. Imaging demonstrated a 36 × 17 mm hypermetabolic lesion in the right occipital condyle maximum standard uptake value [(SUV_max): 16.5], with adjacent bone and soft-tissue extension, together with a concurrent ¹⁸F-FDG-avid pulmonary nodule (SUV_max: 3.4). Shortly after imaging, the patient developed mild neck discomfort and right-sided tongue deviation, suggesting hypoglossal nerve involvement. Biopsy of the skull base lesion and histopathological evaluation of the pulmonary nodule confirmed metastatic chondroblastic osteosarcoma with concordant morphology and immunophenotype. The patient underwent biopsy of the occipital lesion, surgical excision, radiotherapy, and wedge resection of the pulmonary metastasis. Skull base involvement from osteosarcoma arising in the extremities is exceptional and is particularly rare in pediatric patients. This case highlights the complementary role of whole-body ¹⁸F-FDG PET/CT in detecting atypical metastatic sites that may not be routinely assessed by conventional surveillance strategies. In addition, the focused literature review underscores the exceptional rarity of skull base involvement in pediatric chondroblastic osteosarcoma and supports the need for heightened awareness of uncommon metastatic patterns.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"35 3","pages":"280-285"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Primary Tumor and Immune Organ Metabolic Parameters Derived from Pretreatment ¹⁸F-FDG PET/CT in Gastric Adenocarcinoma: A Retrospective Survival Analysis.","authors":"Halim Özçevik, Müge Öner Tamam, Merve Nur Acar Tayyar","doi":"10.4274/mirt.galenos.2026.96630","DOIUrl":"10.4274/mirt.galenos.2026.96630","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association of primary tumor volume-based parameters and immune organ (liver, spleen, bone marrow) metabolic parameters and their derived ratios [spleen-to-liver ratio (SLR), bone marrow-to-liver ratio (BLR), spleen-to-bone marrow ratio (SBR)], measured on pretreatment ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT), with overall survival in gastric adenocarcinoma.</p><p><strong>Methods: </strong>127 patients with histopathologically confirmed gastric adenocarcinoma who underwent pretreatment ¹⁸F-FDG PET/CT were retrospectively evaluated. Maximum standardized uptake value, mean standardized uptake value, metabolic tumor volume, total lesion glycolysis (TLG) and immune-organ SUVs were measured and the ratios calculated. Survival analyses used the Kaplan-Meier method, log-rank test, and Cox regression.</p><p><strong>Results: </strong>There were 91 death events (71.7%); the Kaplan-Meier median overall survival was 16.56 months, with 1-, 3-, and 5-year survival rates of 58.3%, 33.1%, and 28.1%, respectively. No significant independent association with overall survival was demonstrated for any of the primary-tumor or immune-organ PET/CT parameters; the SBR was lower in deceased patients (p=0.041) and showed a non-significant protective trend at the univariate level [hazard ratio (HR)=0.802 per 1 standard deviation (SD); 95% confidence interval (CI) 0.621-1.038; p=0.093)], which was not supported by cut-off-based or multivariable analyses. In the primary multivariable model, distant metastasis independently increased the hazard of death (HR=1.798; 95% CI 1.187-2.723; p=0.006), whereas TLG SLR, and BLR showed no independent significance. In the stage-adjusted model, advanced stage remained independently associated with OS (HR=4.403; p=0.001).</p><p><strong>Conclusion: </strong>In this gastric adenocarcinoma cohort with a high proportion of advanced-stage disease, no independent association with overall survival was demonstrated for any of the evaluated tumor- or immune-organ PET/CT parameters; established clinicopathological factors showed stronger prognostic associations than the PET-derived parameters. The prognostic role of immune organ metabolism in gastric cancer should be evaluated in large prospective studies.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"35 3","pages":"223-237"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"⁶⁸Ga-DOTATATE Uptake in Rare Metastatic/Inoperable Mediastinal Paraganglioma with Anomalous Coronary Supply.","authors":"Berna Okudan, Refia Yükseltürk, Mustafa Özdemir","doi":"10.4274/mirt.galenos.2026.39260","DOIUrl":"10.4274/mirt.galenos.2026.39260","url":null,"abstract":"<p><p>Mediastinal paragangliomas (PGLs) are extremely rare neuroendocrine tumors. Clinical presentation varies and tumor resection can be challenging due to bleeding and risk of catecholamine surges in functional tumors. We report on a case 68 with a DOTATATE avid mediastinal mass which was histopathologically confirmed as a PGL that was fed by the coronary artery in whole-body positron emission tomography/computed tomography imaging using gallium-68-DOTATATE.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"241-243"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separation of ⁹⁰Y Microspheres and Imaging with PET/CT: Phantom Study.","authors":"Özge Demir, Emre Karayel, Nami Yeyin","doi":"10.4274/mirt.galenos.2026.60973","DOIUrl":"10.4274/mirt.galenos.2026.60973","url":null,"abstract":"<p><strong>Objectives: </strong>Yttrium 90 (⁹⁰Y) microspheres are utilized in the treatment of liver tumors. This study aimed to prepare ⁹⁰Y suitable for experimental studies by separating it from within the microspheres and imaging it cartographically in positron emission tomography/computed tomography (PET/CT).</p><p><strong>Methods: </strong>⁹⁰Y microspheres were incubated for 2 hours in a solution containing 5.5 molar sodium chloride (NaCl) and 6 molar hydrochloric acid at pH 5. After this period, separation was achieved by passing through a 0.22 μm pore size polytetrafluoroethylene filter. A liver phantom, mimicking human liver equivalent dimensions and containing two simulated tumors, was filled with ⁹⁰Y and imaged scintigraphically in PET/CT.</p><p><strong>Results: </strong>The true ⁹⁰Y ratios between the large simulated tumor and the small simulated tumor compared to normal liver tissue were approximately 10:1 and 2:1, respectively. PET/CT images yielded these ratios as 11.3 and 2.13 for the large and small tumors, respectively. Homogeneous distribution of ⁹⁰Y within the simulated liver tissue was observed.</p><p><strong>Conclusion: </strong>The separation technique enabled preparation of a homogeneous ionic ⁹⁰Y solution suitable for quantitative PET/CT phantom imaging and may facilitate future phantom-based dosimetric studies.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"35 3","pages":"204-210"},"PeriodicalIF":0.9,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}