The Complementary Roles of ¹⁸F-Fluorocholine and ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in an Evaluation of A Patient With Parathyroid Carcinoma: A Case Report.

IF 1.1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Radionuclide Therapy Pub Date : 2025-09-05 DOI:10.4274/mirt.galenos.2025.58966

Nikola Pantic, Lenka Grujicic, Branislava Radovic, Dragana Sobic Saranovic, Vera Artiko, Strahinja Odalovic

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引用次数: 0

Abstract

¹⁸Fluorine-fluorocholine (¹⁸F-FCH) is a radiopharmaceutical used in primary hyperparathyroidism. The data about its utility in malignancies other than prostate and hepatocellular carcinoma is limited. We present the case of a patient who was referred for ¹⁸F-FCH positron emission tomography/computed tomography (PET/CT) due to the persistently elevated parathormone and calcium levels following total thyroidectomy with left lower parathyroidectomy for parathyroid carcinoma (PTC). Previously, the patient underwent ¹⁸Fluorine-fluorodeoxyglucose (¹⁸F-FDG) PET/CT. The latter method detected multiple mediastinal and hilar lymph nodes, as well as nodular lesions in lungs and osteolytic bone lesions with an increased tracer uptake, whereas ¹⁸F-FCH PET/CT detected an increased tracer uptake not only in lesions at all of the abovementioned areas, but also in the nodular lesion in the neck corresponding to a local relapse as well, with bone lesions showing higher avidity for ¹⁸F-FDG than for ¹⁸F-FCH. The case we present shows that ¹⁸F-FCH PET/CT has an additive value to ¹⁸F-FDG PET/CT in an evaluation of patients with PTC.

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18f -氟胆碱和18f -氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在甲状旁腺癌患者评价中的互补作用：1例报告。

氟-氟胆碱（18F-FCH）是一种用于原发性甲状旁腺功能亢进的放射性药物。关于它在前列腺癌和肝细胞癌以外的恶性肿瘤中的应用的数据是有限的。我们报告了一例因甲状旁腺癌（PTC）而行甲状腺全切除术和左下甲状旁腺切除术后甲状旁腺激素和钙水平持续升高的患者，他被转诊进行了18F-FCH正电子发射断层扫描/计算机断层扫描（PET/CT）。此前，患者接受了18F-FDG PET/CT检查。后一种方法检测到多个纵隔和肺门淋巴结，以及肺部结节性病变和溶骨性病变，示踪剂摄取增加，而18F-FCH PET/CT检测到示踪剂摄取增加，不仅在所有上述区域的病变中，而且在颈部结节性病变中也对应局部复发，骨病变对18F-FDG的可见性高于18F-FCH。我们提出的病例表明，18F-FCH PET/CT在评估PTC患者方面具有18F-FDG PET/CT的附加价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.