Performance of 68Ga-PSMA PET/CT in Metastatic Prostate Cancers at the Time of Diagnosis and Correlation with Obesity.

IF 1.1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Özge Ulaş, Zekiye Hasbek
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引用次数: 0

Abstract

Objective: The aim of this study was to evaluate the relationship between Galium-68 prostate-specific membrane antigen positron emission tomography combined with computed tomography (68Ga-PSMA PET/CT) quantitative parameters and patient obesity, prostate-specific antigen (PSA) levels, and metastasis type in prostate cancer.

Methods: In the present study, we included 112 patients diagnosed with prostate cancer between 2020 and 2024. These patients underwent 688Ga-PSMA PET/CT imaging for staging purposes, with locoregional or distant metastasis detected in the imaging results.

Results: No significant correlation was observed between body mass index (BMI) classification and prostate gland maximum standard uptake values (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized uptake value lean (SUL), or SUVmean values. A weak inverse correlation was found between BMI and PSA levels (p=0.08, r=-0.248), with PSA values decreasing as patient weight increased. The presence of locoregional disease or distant metastasis was not significantly associated with prostate gland SUVmax, MTV, TLG, SUVmean, or SUL values (p=0.25; 0.667; 0.667; 0.244; 0.126, respectively). However, a significant association was detected between PSA levels and distant metastases or locoregional disease (p=0.02), with higher PSA values observed in patients with distant metastases compared to those with locoregional disease. Additionally, significant correlations were found between the D'Amico risk classification and the prostate gland SUVmax, TLG, SUL, and SUVmean values (p=0.035, 0.037, 0.012, 0.028, respectively).

Conclusion: PSA levels may assist in estimating whether metastases are local or distant. However, due to the weak inverse correlation between BMI and PSA, it is important that low PSA levels may not necessarily indicate localized disease during clinical evaluation.

68Ga-PSMA PET/CT在转移性前列腺癌诊断时的表现及其与肥胖的相关性
目的:探讨镓-68前列腺特异性膜抗原正电子发射断层扫描联合计算机断层扫描(68Ga-PSMA PET/CT)定量参数与前列腺癌患者肥胖、前列腺特异性抗原(PSA)水平及转移类型的关系。方法:在本研究中,我们纳入了2020年至2024年间诊断为前列腺癌的112例患者。这些患者接受了688Ga-PSMA PET/CT成像进行分期,在成像结果中检测到局部或远处转移。结果:体重指数(BMI)分类与前列腺最大标准摄取值(SUVmax)、代谢肿瘤体积(MTV)、病变总糖酵解(TLG)、标准化摄取值lean (SUL)、SUVmean值均无显著相关性。BMI与PSA水平呈弱负相关(p=0.08, r=-0.248), PSA值随体重增加而降低。局部疾病或远处转移的存在与前列腺SUVmax、MTV、TLG、SUVmean或SUL值无显著相关性(p=0.25;0.667;0.667;0.244;分别为0.126)。然而,PSA水平与远处转移或局部疾病之间存在显著相关性(p=0.02),与局部疾病相比,远处转移患者的PSA值更高。此外,D'Amico风险分级与前列腺SUVmax、TLG、SUL和SUVmean值之间存在显著相关性(p分别为0.035、0.037、0.012、0.028)。结论:PSA水平可以帮助判断转移是局部还是远处。然而,由于BMI与PSA之间呈弱负相关,在临床评估中,PSA水平低可能不一定表明局部疾病,这一点很重要。
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来源期刊
Molecular Imaging and Radionuclide Therapy
Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.30
自引率
0.00%
发文量
50
期刊介绍: Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.
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