{"title":"Comparison of <sup>68</sup>Ga-FAPI-04 and <sup>68</sup>Ga-PSMA in a Case of Interstitial Lung Disease.","authors":"Hasan Önner, Abidin Kılınçer","doi":"10.4274/mirt.galenos.2024.93270","DOIUrl":null,"url":null,"abstract":"<p><p>We present the <sup>68</sup>Ga-prostate-specific membrane antigen (PSMA) and <sup>68</sup>Ga-fibroblast activation protein inhibitor (FAPI)-04 positron emission tomography/computed tomography (PET/CT) findings comparatively of a 76-year-old man with a history of progressive dyspnea and evidence of interstitial lung disease (ILD) abnormalities on high-resolution CT. Moderate PSMA uptake was observed in areas with ILD abnormalities on <sup>68</sup>Ga-PSMA PET/CT. <sup>68</sup>Ga-FAPI-04 PET/CT showed relatively higher FAPI-04 uptake in these regions. These findings offer the potential to assess disease activity at the cellular and molecular levels. This approach may provide valuable insight into the pathophysiology of ILD beyond the structural changes captured by traditional imaging methods.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"34 2","pages":"129-131"},"PeriodicalIF":1.1000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134950/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Imaging and Radionuclide Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/mirt.galenos.2024.93270","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
We present the 68Ga-prostate-specific membrane antigen (PSMA) and 68Ga-fibroblast activation protein inhibitor (FAPI)-04 positron emission tomography/computed tomography (PET/CT) findings comparatively of a 76-year-old man with a history of progressive dyspnea and evidence of interstitial lung disease (ILD) abnormalities on high-resolution CT. Moderate PSMA uptake was observed in areas with ILD abnormalities on 68Ga-PSMA PET/CT. 68Ga-FAPI-04 PET/CT showed relatively higher FAPI-04 uptake in these regions. These findings offer the potential to assess disease activity at the cellular and molecular levels. This approach may provide valuable insight into the pathophysiology of ILD beyond the structural changes captured by traditional imaging methods.
期刊介绍：
Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.
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