68Ga-FAPI-04与68Ga-PSMA在间质性肺疾病中的比较

IF 1.1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI:10.4274/mirt.galenos.2024.93270

Hasan Önner, Abidin Kılınçer

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引用次数: 0

摘要

我们报告了一位76岁男性患者的68ga -前列腺特异性膜抗原（PSMA）和68ga -成纤维细胞活化蛋白抑制剂(FAPI)-04正电子发射断层扫描/计算机断层扫描（PET/CT）的结果，该患者有进行性呼吸困难史，并有间质性肺疾病（ILD）异常的证据。68Ga-PSMA PET/CT在ILD异常区域观察到中度PSMA摄取。68Ga-FAPI-04 PET/CT显示这些区域的FAPI-04摄取相对较高。这些发现提供了在细胞和分子水平上评估疾病活动的潜力。这种方法可以为ILD的病理生理学提供有价值的见解，超越传统成像方法所捕获的结构变化。

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Comparison of ⁶⁸Ga-FAPI-04 and ⁶⁸Ga-PSMA in a Case of Interstitial Lung Disease.

We present the ⁶⁸Ga-prostate-specific membrane antigen (PSMA) and ⁶⁸Ga-fibroblast activation protein inhibitor (FAPI)-04 positron emission tomography/computed tomography (PET/CT) findings comparatively of a 76-year-old man with a history of progressive dyspnea and evidence of interstitial lung disease (ILD) abnormalities on high-resolution CT. Moderate PSMA uptake was observed in areas with ILD abnormalities on ⁶⁸Ga-PSMA PET/CT. ⁶⁸Ga-FAPI-04 PET/CT showed relatively higher FAPI-04 uptake in these regions. These findings offer the potential to assess disease activity at the cellular and molecular levels. This approach may provide valuable insight into the pathophysiology of ILD beyond the structural changes captured by traditional imaging methods.

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来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.