Molecular Imaging and Radionuclide Therapy最新文献

{"title":"Validation of Simplified Renal Dosimetry Protocols for ¹⁷⁷Lu-DOTATATE Therapy Using the IDAC-dose Software.","authors":"Anji Yokouchi, Takayuki Shibutani, Takahiro Konishi, Hiroto Yoneyama, Hajime Ichikawa, Hiroshi Wakabayashi","doi":"10.4274/mirt.galenos.2026.39775","DOIUrl":"10.4274/mirt.galenos.2026.39775","url":null,"abstract":"<p><strong>Objectives: </strong>The multi-time-point imaging method for renal dosimetry in lutetium-177 (¹⁷⁷Lu)-DOTATATE therapy imposes a significant burden. This study aimed to validate simplified two-time-point (2TP) and three-time-point (3TP) protocols using the International Commission on Radiological Protection-compliant IDAC-Dose 2.1 software.</p><p><strong>Methods: </strong>This retrospective study analyzed 28 kidneys obtained from 17 patients with neuroendocrine neoplasms. Renal absorbed doses from a reference four-time-point (4TP) schedule (4, 24, 72, and 120 hours) were compared with ten simplified protocols using statistical analyses of error and agreement.</p><p><strong>Results: </strong>Protocols that included the 120-hour time point demonstrated significantly higher accuracy. The 2TP (4, 24) protocol showed a profound underestimation [mean percentage error (MPE): -14.3%] and a high error. In contrast, the 2TP (24, 120) protocol showed excellent agreement [MPE: 0.57%, mean absolute percent error (MAPE): 5.5%]. Among 3TP methods, the 3TP (24, 72, 120) protocol yielded the highest accuracy (MAPE: 1.97%).</p><p><strong>Conclusion: </strong>Accurate renal dosimetry in ¹⁷⁷Lu-DOTATATE therapy can be achieved with simplified protocols. Incorporating a late-phase time point (around 120 hours) is essential for reliable estimation. The 2TP (24, 120) and 3TP (24, 72, 120) combinations are suggested as feasible alternatives to the standard 4TP method.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"35 2","pages":"92-104"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of ⁶⁸Ga-FAPI PET/CT Versus ¹⁸F-FDG PET/CT in Laryngeal Cancer Staging.","authors":"Ebuzer Kalender, Edanur Ekinci Yıldırım, Buket Eren, Umut Elboğa, Ertan Şahin","doi":"10.4274/mirt.galenos.2026.93764","DOIUrl":"10.4274/mirt.galenos.2026.93764","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether gallium-68 fibroblast activation protein inhibitor positron emission tomography/computed tomography ⁶⁸Ga-FAPI PET/CT is superior to ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG) PET/CT in the staging of patients with laryngeal cancer (LC).</p><p><strong>Methods: </strong>A total of 14 patients diagnosed with LC were retrospectively included in the study, of whom 13 were male and 1 female, with a mean age of 65 years. All participants were initially referred to our department for staging with ¹⁸F-FDG PET/CT. Subsequently, each patient underwent a ⁶⁸Ga-FAPI PET/CT scan three days following the ¹⁸F-FDG PET/CT. Both sets of imaging studies were independently evaluated by two experienced nuclear medicine physicians, and the findings were systematicaly compared to assess potential differences in diagnostic performance.</p><p><strong>Results: </strong>The median maximum standard uptake values (SUV_max) of primary tumors was significantly higher in ⁶⁸Ga-FAPI PET/CT 10.95; range: 3.5-19.2) compared to ¹⁸F-FDG PET/CT (4.85; range: 2.2-10.9). Lymph node involvement was observed on FDG scans in 3 patients, in ipsilateral levels 2 and/or 3, with a median SUV_max of 3.7 (range: 2.4-4.1). FAPI PET/CT also detected lymph node involvement at the same levels in 3 patients, with a notably higher SUV_max of 7.9 (range: 6.8-10.4).</p><p><strong>Conclusion: </strong>In this study, our results suggest that ⁶⁸Ga-FAPI PET/CT demonstrates superior radiotracer uptake in both primary tumors and lymph nodes, which may enhance detection sensitivity for LC staging compared with ¹⁸F-FDG PET/CT. Nevertheless, further prospective studies with larger patient populations are warranted to validate these preliminary observations and determine the clinical value of this emerging imaging modality.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"85-91"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of ¹⁸F-FDG-PET/CT in Managing a Case of Fungal Prosthetic Valve Endocarditis.","authors":"Komal Bishnoi, P Sai Sradha Patro, Girish Kumar Parida, Kanhaiyalal Agrawal, Debananda Sahoo","doi":"10.4274/mirt.galenos.2026.43179","DOIUrl":"10.4274/mirt.galenos.2026.43179","url":null,"abstract":"<p><p>Approximately 0.1% of all prosthetic cardiac valves are affected by fungal endocarditis (bacterial endocarditis being the most common cause), which has a high case fatality rate. Post-treatment clinical improvement and a negative blood culture do not definitively rule out the presence of residual active disease. Among imaging techniques, trans-oesophageal echocardiography has higher sensitivity than transthoracic echocardiography, but has its own limitations. Functional imaging with ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) has shown to have high overall sensitivity, specificity, and accuracy for the diagnosis and follow-up evaluation of prosthetic valve infective endocarditis, thereby significantly influencing clinical management. Here, we report a rare case of a patient with Marfan syndrome and fungal prosthetic valve endocarditis, in which ¹⁸F-FDG-PET/CT played a significant role in management decision.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"134-136"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147366371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Insights into ¹⁸F-FDG and ⁶⁸Ga-FAPI PET Imaging in Glioma: Diagnostic Value, Tumor Grading, and Clinical Implications.","authors":"Raydel BrianKwee Amalo, Hendra Budiawan, Budi Darmawan","doi":"10.4274/mirt.galenos.2026.84704","DOIUrl":"10.4274/mirt.galenos.2026.84704","url":null,"abstract":"<p><p>Gliomas are the most common primary malignant brain tumors and are characterized by heterogeneous growth and complex biology, which complicate accurate diagnosis and management. While magnetic resonance imaging (MRI) remains the clinical standard, its limitations in delineating tumor margins and distinguishing recurrence from treatment-induced changes highlight the need for complementary molecular imaging. ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET) has been extensively studied, providing valuable prognostic information by reflecting tumor glycolytic activity. However, its diagnostic utility is hampered by high cortical background uptake and by poor sensitivity in detecting low-grade gliomas. Conversely, glioma-68 fibroblast activation protein inhibitor (FAPI) PET targets cancer-associated fibroblasts, offering superior tumor-to-background contrast and improved visualization of infiltrative margins. Comparative studies suggest that FAPI PET better discriminates between low- and high-grade gliomas, correlates with tumor stromal activity, and aids in therapy planning by differentiating true progression from post-treatment changes. Despite these advantages, the evidence base for FAPI remains limited, largely derived from small cohorts and pilot studies. Standardized imaging protocols and larger prospective trials are necessary to validate its role. Overall, ¹⁸F-FDG and FAPI PET provide complementary insights into glioma biology, and their integration with MRI and amino acid tracers may refine diagnostic accuracy, therapeutic planning, and prognostic assessment in clinical neuro-oncology.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"150-156"},"PeriodicalIF":0.9,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Truncation Artifact Presenting as Cropped Projections and Wedge Defect in Sinogram During Single-Photon Emission Computed Tomography.","authors":"Mohsen Qutbi, Reyhane Ahmadi, Amirmohammad Alinejad","doi":"10.4274/mirt.galenos.2025.58265","DOIUrl":"10.4274/mirt.galenos.2025.58265","url":null,"abstract":"<p><p>Truncation artifact during single-photon emission computed tomography occurs when some part of body, such as left ventricle in myocardial perfusion imaging, lies outside the field-of-view during image acquisition. Improper adjustment of axis of rotation of detectors regarding the patient on the scanning table is the main cause. Large or slim patient body habitus is reported as source of this artifact. However, there may be other sources including that in our case, in which the artifact was present in prone position but not in supine imaging. The appearance was one-sided incremental cropping of projections of one of detectors and a wedge-shaped or triangular defect in the corresponding sinogram. This finding may suggest a possible mechanical instability of the gantry during motion over the patient's left side in prone imaging.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"51-54"},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"⁹⁹mTc-MDP Bone Scintigraphy in a Case of X-Linked Spondyloepiphyseal Dysplasia Tarda.","authors":"Ikram Zahfir, Salah Oueriagli Nabih, Meryem Aboussabr, Yassir Benameur, Omar Ait Sahel, Abderrahim Doudouh","doi":"10.4274/mirt.galenos.2025.83713","DOIUrl":"10.4274/mirt.galenos.2025.83713","url":null,"abstract":"<p><p>Spondyloepiphyseal dysplasia tarda (SEDT) is a rare X-linked skeletal disorder affecting the spine and long bones, leading to short stature, spinal deformities, and joint stiffness. It is caused by genetic mutations, and primarily affects males. Diagnosis is confirmed by imaging and genetic testing. We report the case of a 33 years old patient with a history of X-linked SEDT, who presented with pain in the lower limbs and pelvis, accompanied by limited mobility. Bone scan with ⁹⁹mTc-methylene diphosphonate (MDP) revealed a polyostotic SEDT involvement, periarticular ossifications, and bony bridges in the active phase. The authors highlight the role of bone scan with ⁹⁹mTc-MDP in diagnosing this rare disease.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"58-60"},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145649650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Primary Tumor: Malignancy Risk and Evaluation Strategies for ¹⁸F-FDG PET/CT-Detected Incidentalomas.","authors":"Yasemin Keskin, Damla Bağcı, Ali Haluk Ulucanlar, Gülin Uçmak","doi":"10.4274/mirt.galenos.2025.75768","DOIUrl":"10.4274/mirt.galenos.2025.75768","url":null,"abstract":"<p><strong>Objectives: </strong>The increasing use of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) imaging has led to the frequent detection of incidentalomas. This study aimed to investigate the prevalence, locations, malignancy rates, and clinical evaluations of incidentalomas detected during preoperative staging with ¹⁸F-FDG PET/CT in patients with surgically relevant primary tumors.</p><p><strong>Methods: </strong>A total of 251 patients who underwent preoperative ¹⁸F-FDG PET/CT imaging between January 2019 and December 2023 were retrospectively analyzed. Incidental uptake sites were classified into six anatomical regions: thyroid, colon, rectum, prostate, cervix/uterus, and breast. Data regarding maximum standardized uptake value (SUV_max) values, biopsy status, imaging follow-up, and histopathological outcomes were recorded and compared with population-based incidence data from the literature.</p><p><strong>Results: </strong>The most frequent incidentalomas were detected in the thyroid (11.6%), followed by cervix/uterus (9.6%), colon (7.6%), prostate (4.4%), breast (2.4%), and rectum (2.0%). Malignancy was confirmed in incidentalomas of the thyroid (85.7%), prostate (83.3%), colon (71.4%), rectum (50.0%), and breast (33.3%). Malignancy rates for the thyroid, breast, colorectal, and prostate groups were significantly higher than population-based estimates (p<0.05). No statistically significant correlation was found between SUV_max and malignancy status across localization groups.</p><p><strong>Conclusion: </strong>Incidental findings on ¹⁸F-FDG PET/CT imaging are common and carry a considerable risk of malignancy, particularly in thyroid, prostate, and colorectal sites. Given the observed diagnostic yield, further clinical evaluation, including tissue diagnosis, should be considered in cases with focal uptake, especially when located in high-risk anatomical regions. Awareness of these findings is essential for timely management and appropriate therapeutic decision-making.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"28-34"},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145783272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Soft Tissue and Muscle Metastases in Papillary Thyroid Carcinoma: Insights from ¹³¹I Scintigraphy and ¹⁸F-FDG PET/CT.","authors":"Mohd Fazrin Mohd Rohani, Siti Zarina Amir Hassan","doi":"10.4274/mirt.galenos.2025.77698","DOIUrl":"10.4274/mirt.galenos.2025.77698","url":null,"abstract":"<p><p>Distant metastases from well-differentiated thyroid carcinoma typically involve the lungs and bones. We report a rare case of metastatic papillary thyroid carcinoma presenting as soft tissue lesion, detected by Iodine-131 whole-body scintigraphy in a 44-year-old asymptomatic male. The patient had previously undergone a total thyroidectomy and bilateral modified radical neck dissection, receiving radioiodine for pT3bN1bMx multifocal classical papillary thyroid carcinoma. Further evaluation with ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography revealed additional sites of soft tissue and muscle metastasis, along with extensive nodal, lung, and skeletal involvement. These findings indicated advanced disease with a poor prognosis, necessitating a change in the treatment plan.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"47-50"},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145490496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intense FAPI Uptake of Pancreatic Tissue Can Mask the Tumor Activity of Pancreatic Cancer: The Importance of Dual-Tracer PET Imaging.","authors":"Elife Akgün, Ahmet Ertuğrul Öztürk, Göksel Alçın, Mert Mahsuni Sevinç, Esra Arslan","doi":"10.4274/mirt.galenos.2025.91069","DOIUrl":"10.4274/mirt.galenos.2025.91069","url":null,"abstract":"<p><p>Fibroblast activation protein (FAPI), a type II transmembrane glycoprotein is a promising target to image epithelial originated cancers. Pancreatic cancer is characterized with [⁶⁸Ga]Ga-FAPI-04 and ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) uptake in varying degree. However physiologic uptake and uptake associated with acute/chronic pancreatitis makes interpretation challenging. We would like to present a case of pancreatic cancer whose tumor could not delineated from rest pancreatic tissue in [⁶⁸Ga]Ga-FAPI-04 positron emission tomography/computed tomography (PET/CT) images due to intense FAPI uptake in whole pancreas but more remarkable in ¹⁸F-FDG PET/CT images.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":" ","pages":"70-72"},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145970979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative characterization of ¹⁸F-PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 PET-CT Imaging in Suspected Prostate Cancer: A Single-centre Experience.","authors":"Bal Sanghera, Gerry Lowe, Sophie Sanghera, Wai Lup Wong","doi":"10.4274/mirt.galenos.2025.92259","DOIUrl":"10.4274/mirt.galenos.2025.92259","url":null,"abstract":"<p><strong>Objectives: </strong>We record quantitative differences between ¹⁸F-prostate specific membrane antigen (¹⁸F-PSMA)-1007 and [⁶⁸Ga]Ga-PSMA-11 positron emission tomography (PET) prostate scans at our centre to investigate if significant differences exist between suspected lesion and lesion/ background parameters studied. We also assess the potential impact of such differences on tracer interchangeability when supply is constrained.</p><p><strong>Methods: </strong>Sixty-one [⁶⁸Ga]Ga-PSMA-11 and seventy-two ¹⁸F-PSMA-1007 patients were analysed in two cohorts, each comprising 200 lesions. Clinical reports were used to determine maximum standard uptake values (SUV_max) was recorded for suspected lesions (T). Similarly, normalisations of mean standardized uptake (SUV_mean) and standardized uptake value-peak (SUV_peak) using lean body mass (SUV_Ibm) and body surface area (SUV_bsa) were estimated. SUV_mean of liver backgrounds (B) was recorded to estimate T/B ratios. Metabolic tumour volume and total lesion PSMA (TL-PSMA) were investigated as functional volume surrogates. The Mann-Whitney U test was used to identify significant differences between the [⁶⁸Ga]Ga-PSMA-11 and ¹⁸F-PSMA-1007 distributions.</p><p><strong>Results: </strong>Significant differences were observed for lesion SUV_max (p=0.0004), SUV_peak (p=0.0017), SUV_mean (p=0.0007), SUV_Ibm (p=0.0002), and SUV_bsa (p=0.0005) in lesions with higher [⁶⁸Ga]Ga-PSMA-11 SUV. Similarly, significant differences were observed in liver SUV_max (p<0.0001), SUV_peak (p<0.0001), and SUV_mean (p<0.0001), with higher values for ¹⁸F-PSMA-1007. T/B (p<0.0001) and TL-PSMA (p=0.0063) also exhibited significantly higher [⁶⁸Ga]Ga-PSMA-11 values.</p><p><strong>Conclusion: </strong>Consistent, predictable, and significant differences were observed in ¹⁸F-PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 PET scans of lesion, liver, volume surrogates, supporting tracer interchangeability for patients with suspected prostate cancer. Our results also support the recent commissioning of PSMA-based PET tracers in England.</p>","PeriodicalId":44681,"journal":{"name":"Molecular Imaging and Radionuclide Therapy","volume":"35 1","pages":"35-43"},"PeriodicalIF":1.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12869094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}