发布求助
文献互助 智能选刊 最新文献

Tetrahedron最新文献

筛选
英文 中文
Amberlyst-15 mediated unprecedented oxidation: tunability of the oxidation of diarylmethanols or ether formation Amberlyst-15介导的前所未有的氧化：二芳基甲醇氧化或醚形成的可调性
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2026-01-23 DOI: 10.1016/j.tet.2026.135149
Sekar Yuvasree, Rajagopal Nagarajan
{"title":"Amberlyst-15 mediated unprecedented oxidation: tunability of the oxidation of diarylmethanols or ether formation","authors":"Sekar Yuvasree,&nbsp;Rajagopal Nagarajan","doi":"10.1016/j.tet.2026.135149","DOIUrl":"10.1016/j.tet.2026.135149","url":null,"abstract":"<div><div>Oxidation of alcohols to the carbonyl compounds is an important and routine transformation useful in the variety of organic syntheses. Several methods have been reported for this transformation and are well documented in literature. We have discovered an unprecedented environmentally benign method for the selective oxidation of diarylmethanols to ketones and ether formation mediated by Amberlyst-15. Amberlyst-15 has been found to be selective, efficient, and recyclable, with yields obtained in the range of 20–90 %.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135149"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of 4,4-difluoro-3-Hydroxy-3,4-dihydroisoquinolinones via Rh-catalyzed C–H activation of benzamides with 2,2-difluorovinyl tosylate in water 2,2-二氟乙烯酰基tosylate在水中催化C-H活化苯酰胺合成4,4-二氟-3-羟基-3,4-二氢异喹啉酮
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2026-01-06 DOI: 10.1016/j.tet.2026.135134
Shai Fang , Zhenli Luo , Huixuan Zhu , Cheng Jiang , Jing Qu , Jia-Qiang Wu
{"title":"Synthesis of 4,4-difluoro-3-Hydroxy-3,4-dihydroisoquinolinones via Rh-catalyzed C–H activation of benzamides with 2,2-difluorovinyl tosylate in water","authors":"Shai Fang ,&nbsp;Zhenli Luo ,&nbsp;Huixuan Zhu ,&nbsp;Cheng Jiang ,&nbsp;Jing Qu ,&nbsp;Jia-Qiang Wu","doi":"10.1016/j.tet.2026.135134","DOIUrl":"10.1016/j.tet.2026.135134","url":null,"abstract":"<div><div>An efficient and environmentally benign protocol for the synthesis of 4,4-difluoro-3-hydroxy-3,4-dihydroisoquinolin-1(2H)-ones via Rh(III)-catalyzed C–H activation of N-methoxybenzamides with 2,2-difluorovinyl tosylate in water has been developed. This strategy utilizes water as a green reaction medium, demonstrating good functional group tolerance and providing the target products in moderate to good yields. The reaction proceeds under mild conditions, highlighting the potential of aqueous-phase C–H activation for constructing valuable fluorinated heterocycles. The practicality of this method was further validated by gram-scale synthesis and diverse derivatizations of the products.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135134"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145922625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent developments in C–H functionalization of azauracils 杜鹃花C-H功能化研究进展
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2025-12-30 DOI: 10.1016/j.tet.2025.135128
Juanjuan Wu , Leilei Wang , Kelu Yan
{"title":"Recent developments in C–H functionalization of azauracils","authors":"Juanjuan Wu ,&nbsp;Leilei Wang ,&nbsp;Kelu Yan","doi":"10.1016/j.tet.2025.135128","DOIUrl":"10.1016/j.tet.2025.135128","url":null,"abstract":"<div><div>Azauracils, as an important class of nitrogen-containing aromatics, exhibits a wide range of pharmaceutical and biological activities. The structural modification and functionalization of these compounds have emerged as a prominent research focus in contemporary organic synthesis. This review systematically summarizes the latest developments in direct C–H alkylation, arylation, acylation, phosphonation, borylation, silylation, and fluoroalkylation of azauracil derivatives. The characteristics of these transformations, substrate universality, synthetic applications, and reaction mechanisms are emphasized. In addition, potential research directions in this field are discussed, aiming to provide theoretical insights for the development and application of therapeutic agents.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135128"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145872718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of bufalin and digitoxigenin derivatives 蟾毒灵和洋地黄苷衍生物的合成
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2025-12-11 DOI: 10.1016/j.tet.2025.135092
Veronica B. Hubble , Camila A. Suarez , Primali V. Navaratne , Isabel M. de la Torre Roehl , Alfred N. Fonteh , Michael G. Harrington , Michael D. Bartberger , Scott C. Virgil , Brian M. Stoltz
{"title":"Synthesis of bufalin and digitoxigenin derivatives","authors":"Veronica B. Hubble ,&nbsp;Camila A. Suarez ,&nbsp;Primali V. Navaratne ,&nbsp;Isabel M. de la Torre Roehl ,&nbsp;Alfred N. Fonteh ,&nbsp;Michael G. Harrington ,&nbsp;Michael D. Bartberger ,&nbsp;Scott C. Virgil ,&nbsp;Brian M. Stoltz","doi":"10.1016/j.tet.2025.135092","DOIUrl":"10.1016/j.tet.2025.135092","url":null,"abstract":"<div><div>We report the syntheses of seven novel bufalin derivatives and four digitoxigenin derivatives, inspired by the high affinity of bufalin and digitoxigenin to a ubiquitous enzyme called the Na<sup>+</sup>, K<sup>+</sup>–ATPase and their biological potential as brain Na<sup>+</sup>, K<sup>+</sup>–ATPase modulators. We sought to design and synthesize derivatives that more closely obey CNS-penetrant guidelines set forth by the medicinal chemistry community compared to their natural product class counterparts, by reducing the number of hydrogen bond donors or acceptors and increasing lipophilicity. In addition, we highlight the necessity of a C14 bulky protecting group in the steroid core to set a desired C17-β stereocenter for the synthesis of C17-β-pyridines or pyridones.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135092"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perfluoroalkylation reactions via halogen-bonded electron donor-acceptor (EDA) complexes of amines and perfluoroalkyl halides under visible light 可见光下胺和全氟烷基卤化物的卤素键电子给受体（EDA）配合物的全氟烷基化反应
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2026-01-23 DOI: 10.1016/j.tet.2026.135156
Koto Tagami, Tomoko Yajima
{"title":"Perfluoroalkylation reactions via halogen-bonded electron donor-acceptor (EDA) complexes of amines and perfluoroalkyl halides under visible light","authors":"Koto Tagami,&nbsp;Tomoko Yajima","doi":"10.1016/j.tet.2026.135156","DOIUrl":"10.1016/j.tet.2026.135156","url":null,"abstract":"<div><div>Amines are known to form halogen bonds with perfluoroalkyl halides, enabling the formation of electron donor–acceptor (EDA) complexes. In recent years, visible light-induced radical perfluoroalkylation reactions based on halogen-bonded EDA complexes have attracted increasing attention. This review provides a comprehensive overview of perfluoroalkylation reactions mediated by amines, categorized into two major sections: reactions employing amines as external catalysts and those in which the amines themselves serve as substrates and non-catalyze reactions. In the first part, we systematically summarize the types of amines used under optimal conditions and evaluated during conditional screening. By analyzing these reports, we highlighted the trends in amine selection for effective halogen bonding with perfluoroalkyl halides and identified the amines that have proven to be successful. The second part focuses on catalyst-free systems in which amines undergo perfluoroalkylation by acting as both halogen bond acceptor and reactive substrates. These examples were further classified based on the structural type of the anime. Finally, we discuss perspectives and future directions by considering unexplored and less-studied amines and their potential to form productive halogen-bonded EDA complexes with perfluoroalkyl halides. This structure-focused review aims to serve as a guide for designing new amine–perfluoroalkyl systems and for understanding the structure–reactivity relationships that govern visible-light-induced radical processes.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135156"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TFA-mediated oxidative dehydrogenative coupling of quinoxalinones with edaravone and its analogs tfa介导的喹诺啉酮与依达拉奉及其类似物的氧化脱氢偶联
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2026-01-19 DOI: 10.1016/j.tet.2026.135154
Peipei Ma, Yuan Wang, Haifeng Gan, Jianliang Zhu
{"title":"TFA-mediated oxidative dehydrogenative coupling of quinoxalinones with edaravone and its analogs","authors":"Peipei Ma,&nbsp;Yuan Wang,&nbsp;Haifeng Gan,&nbsp;Jianliang Zhu","doi":"10.1016/j.tet.2026.135154","DOIUrl":"10.1016/j.tet.2026.135154","url":null,"abstract":"<div><div>A novel protocol of TFA-mediated oxidative coupling of quinoxalinones with 5-pyrazolones to prepare 4-quinoxalinon-pyrazolones has been realized under air. The protocol was carried out under metal-free conditions and the reactions proceeded in moderate to excellent yields. This protocol can be applied to the efficient synthesis of quinoxalinone drug analogs. Mechanistic investigation suggested that ionic pathway exists and TFA plays an important role in the formation of the products.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135154"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diastereoselective synthesis of N-acyl dopamine dimers in Aspongopus 尾条鼠n -酰基多巴胺二聚体的非对映选择性合成
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2026-01-13 DOI: 10.1016/j.tet.2026.135138
Linming Zuo , Xianheng Wang , Guoyi Lou , Changkuo Zhao
{"title":"Diastereoselective synthesis of N-acyl dopamine dimers in Aspongopus","authors":"Linming Zuo ,&nbsp;Xianheng Wang ,&nbsp;Guoyi Lou ,&nbsp;Changkuo Zhao","doi":"10.1016/j.tet.2026.135138","DOIUrl":"10.1016/j.tet.2026.135138","url":null,"abstract":"<div><div>A diastereoselective synthesis of the core skeleton of a natural dopamine dimer from catechol was accomplished in several</div><div>steps. The structure was charactered by <sup>1</sup>H NMR, <sup>13</sup>C NMR, HRMS and X-ray spectrum. The total synthesis of the <strong>core skeleton</strong> provides a tool for the SAR and pharmacology research of N-acyl dopamine dimers <strong>13a-j</strong>.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135138"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel pyridine based 1,3,4-oxadiazole hybrids: Synthesis, biological potential, molecular docking studies and ADMET properties 新型吡啶基1,3,4-恶二唑杂化物：合成、生物学潜力、分子对接研究和ADMET性质
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2026-01-05 DOI: 10.1016/j.tet.2025.135110
Darshan H. Divetia , Devayat R. Bhadarka , Vijay H. Dodiya , Jainish U. Joshi , Paresh K. Patel , Tushar J. Karkar
{"title":"Novel pyridine based 1,3,4-oxadiazole hybrids: Synthesis, biological potential, molecular docking studies and ADMET properties","authors":"Darshan H. Divetia ,&nbsp;Devayat R. Bhadarka ,&nbsp;Vijay H. Dodiya ,&nbsp;Jainish U. Joshi ,&nbsp;Paresh K. Patel ,&nbsp;Tushar J. Karkar","doi":"10.1016/j.tet.2025.135110","DOIUrl":"10.1016/j.tet.2025.135110","url":null,"abstract":"<div><div>A novel series of pyridine–1,3,4-oxadiazole hybrid derivatives was synthesized using both conventional and microwave-assisted techniques. The synthetic route involved condensation of isoniazid with various substituted aromatic aldehydes to form hydrazones, followed by cyclization and acetylation in the presence of acetic anhydride. Microwave-assisted synthesis offered significantly higher yields and shorter reaction times compared to conventional methods, supporting a greener approach. The synthesized compounds were characterized using IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectrometry. Biological screening revealed that compounds bearing electron-donating groups exhibited notable antibacterial activity, while fluoro-substituted analogues demonstrated superior antifungal potency. Cytotoxicity studies confirmed their safety with negligible activity against HeLa cells. Molecular docking studies supported the antimicrobial results, indicating strong binding affinities toward topoisomerase IV and CYP51. Overall, the results highlight pyridine–1,3,4-oxadiazole hybrids as promising scaffolds for future antimicrobial drug development.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135110"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly regio- and diastereoselective synthesis of spiropyrrolidine-fused pyrrolo[2,1-a]isoquinolines through dearomative (3 + 2) cycloaddition reactions 通过脱芳（3 + 2）环加成反应高区域选择性和非对映选择性合成螺吡咯烷-融合吡咯[2,1-a]异喹啉类化合物
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2026-01-19 DOI: 10.1016/j.tet.2026.135155
Kai-Kai Wang, Liang-Man Wu, Bo-Wen Zhang, Yi-Fan Zhang, Yu Tang, Si-Qi Wei, Yan-Rui Ma, Guo-Yi Yan, Rongxiang Chen
{"title":"Highly regio- and diastereoselective synthesis of spiropyrrolidine-fused pyrrolo[2,1-a]isoquinolines through dearomative (3 + 2) cycloaddition reactions","authors":"Kai-Kai Wang,&nbsp;Liang-Man Wu,&nbsp;Bo-Wen Zhang,&nbsp;Yi-Fan Zhang,&nbsp;Yu Tang,&nbsp;Si-Qi Wei,&nbsp;Yan-Rui Ma,&nbsp;Guo-Yi Yan,&nbsp;Rongxiang Chen","doi":"10.1016/j.tet.2026.135155","DOIUrl":"10.1016/j.tet.2026.135155","url":null,"abstract":"<div><div>In the study, we report a dearomative (3 + 2) cycloaddition reaction between pyrrolidinone-based Morita-Baylis-Hillman (MBH) carbonates and isoquinolines. The reaction represents an effective strategy for the rapid formation of the biologically significant and structurally complex spiropyrrolidine-fused pyrrolo[2,1-<em>a</em>]isoquinoline core in high yields (up to 99 % yields) with excellent regio- and diastereoselectivities (in all cases, &gt;25:1 dr) in a single step without the requirement for any catalysts. Moreover, the synthetic utility of this approach is further demonstrated through scale-up reactions and synthetic transformations of the resulting products. Additionally, molecular docking studies have unveiled that the novel spiroheterocyclic privileged structures, which integrate pyrrolidine and pyrrolo[2,1-<em>a</em>]isoquinoline moieties, hold potential antiparasitic activity.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135155"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cobalt-catalyzed anti-Markovnikov-selective hydrosilylation of perfluoroalkylethylenes to access perfluoroalkylethylated silane derivatives 钴催化的反马可夫尼科夫选择性全氟烷基乙烯硅氢化反应以获得全氟烷基乙基化硅烷衍生物
IF 2.2 3区 化学
Tetrahedron Pub Date : 2026-05-01 Epub Date: 2026-01-18 DOI: 10.1016/j.tet.2026.135151
Huiqin Wei , Renning Dong , Yangjie Huang , Zhiqiang Weng , Fang Ke
{"title":"Cobalt-catalyzed anti-Markovnikov-selective hydrosilylation of perfluoroalkylethylenes to access perfluoroalkylethylated silane derivatives","authors":"Huiqin Wei ,&nbsp;Renning Dong ,&nbsp;Yangjie Huang ,&nbsp;Zhiqiang Weng ,&nbsp;Fang Ke","doi":"10.1016/j.tet.2026.135151","DOIUrl":"10.1016/j.tet.2026.135151","url":null,"abstract":"<div><div>A mild and cost-effective cobalt-catalyzed <em>anti</em>-Markovnikov-selective hydrosilylation of perfluoroalkylethylenes has been developed. This procedure facilitates the synthesis of linear perfluoroalkylethylated silane derivatives with high site selectivity, chemoselectivity, and catalytic efficiency. The practicality of this approach is further demonstrated by its successful application in large-scale reactions and the conversion of the synthesized perfluoroalkylethylated silane derivatives into 2-perfluoroalkyl ethanol.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"193 ","pages":"Article 135151"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书