Tetrahedron最新文献_第4页

Ball-milling promoted ring-opening selenocyanation of cyclic sulfonium salts with KSeCN 球磨促进环磺酸盐与KSeCN的开环硒氰化反应

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-10 DOI: 10.1016/j.tet.2025.134816

Sha Peng, Li Tang, Ni-Dan Meng, Han-Yue Peng, Wen-Shi Yao, Shan-Shan Tang, Li-Hua Yang, Long-Yong Xie

引用次数: 0

Bispidine moiety-driven simplified eleutherobin analogues: Synthesis and biological evaluation 比斯匹啶驱动的简化刺柳皂苷类似物：合成和生物学评价

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-08 DOI: 10.1016/j.tet.2025.134824

Mariia A. Salykina , Alexander S. Bunev , Natalia A. Lozinskaya , Sergey E. Sosonyuk

引用次数: 0

Hexafluoroisopropanol (HFIP)-mediated catalyst-free microwave-assisted novel multicomponent method to access 3-acyl 1,4-diaryl/alkyl pyrroles 六氟异丙醇（HFIP）介导的无催化剂微波辅助新型多组分法获得3-酰基1,4-二芳基/烷基吡咯

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-08 DOI: 10.1016/j.tet.2025.134815

Manubolu Guravaiah , Gunna Sampurnamma , Thondooru Sruthi , Vinod D. Jadhav , Bandi Ramakrishna , Raju Doddipalla , Satya Rama Krishna Seemakurti , Vidavalur Siddaiah , Katta Venkateswarlu

{"title":"Hexafluoroisopropanol (HFIP)-mediated catalyst-free microwave-assisted novel multicomponent method to access 3-acyl 1,4-diaryl/alkyl pyrroles","authors":"Manubolu Guravaiah , Gunna Sampurnamma , Thondooru Sruthi , Vinod D. Jadhav , Bandi Ramakrishna , Raju Doddipalla , Satya Rama Krishna Seemakurti , Vidavalur Siddaiah , Katta Venkateswarlu","doi":"10.1016/j.tet.2025.134815","DOIUrl":"10.1016/j.tet.2025.134815","url":null,"abstract":"<div><div>It is becoming increasingly common for synthetic chemists to engage in a variety of synthetic transformations using 1,1,1,3,3,3-hexafluoroisopropanol (HFIP), a strong hydrogen bonding-donating, redox-stable polar solvent. Herein, we describe an HFIP-mediated green protocol for the synthesis of novel pyrroles under catalyst-free microwave-assisted conditions. The substituted pyrroles are formed in good to excellent yields (52–99 %) in 1 h from a novel multicomponent reaction of 1-aryl/heteroaryl/alkyl/cycloalkyl substituted 3-(dimethylamino)propenones, aryl/heteroaryl/alkyl/cycloalkyl amines and α-bromo ketones. Furthermore, the structures of products were confirmed by their physical properties, <sup>1</sup>H & <sup>13</sup>C NMR and mass spectral data, and validated by single crystal X-ray diffraction analysis of <strong>4aq</strong> and <strong>4aw</strong>. For the current method, HFIP is recycled and reused. This protocol features catalyst-free conditions, easy recyclability and efficient reusability of HFIP, application of microwaves, ease of handling, short reaction times, high yields of products with vast substrate scope, and preparation of novel pyrroles. This protocol has also been applied for the construction of anticancer agent, 3-aroyl-1,4-diarylpyrrole (ARDAP) (<strong>5</strong>) [with about 8-fold increase of yield and 6.5-fold decrease of time], and a steroid-based complex pyrrole <strong>4bp</strong>.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134815"},"PeriodicalIF":2.1,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new route to functionalized nitriles, isoxazolines, isoxazoles and hydroximic acids via nitrile oxide generation from secondary nitro compounds 由仲硝基化合物生成氧化腈制备功能化腈、异恶唑、异恶唑和羟肟酸的新途径

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-08 DOI: 10.1016/j.tet.2025.134825

Alexander Baranovsky, Yuri Charnou, Peter Kurman, Siarhei Shepialevich

引用次数: 0

Synthesis of unsymmetrical urea derivatives via domino ring-opening/Pd-catalyzed decarboxylative cross-coupling reaction of isatin-3-oxime and isocyanide 异氰酸酯与异氰酸酯开环/ pd催化脱羧交叉偶联反应合成不对称尿素衍生物

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-07 DOI: 10.1016/j.tet.2025.134809

Pooja Soam, Kirti Singh, Parmjeet Kaur, Vikas Tyagi

引用次数: 0

[3+2]-cycloaddition reactions of α-trifluoromethyl imino esters with nitrile Imines: Construction of penta-substituted 5-CF3-1,2,4-triazolines [3+2]- α-三氟甲基亚胺酯与腈亚胺的环加成反应：五取代5-CF3-1,2,4-三唑啉的构建

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-07 DOI: 10.1016/j.tet.2025.134812

Ying Fan , Ruikang Wang , Gaowang Yang , Peng Jin , Zuyu Bai , Ke-Hu Wang , Danfeng Huang , Yulai Hu

引用次数: 0

Transition metal infused magnetic nanocatalysts for the synthesis of biaryls through Suzuki-Miyaura coupling reaction 过渡金属注入磁性纳米催化剂用于Suzuki-Miyaura偶联反应合成双芳烯

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-07 DOI: 10.1016/j.tet.2025.134813

Sumanth Hegde , Aakash Venkatesan , Aatika Nizam , Vasantha Veerappa Lakshmaiah , Suresh Babu Naidu Krishna

{"title":"Transition metal infused magnetic nanocatalysts for the synthesis of biaryls through Suzuki-Miyaura coupling reaction","authors":"Sumanth Hegde , Aakash Venkatesan , Aatika Nizam , Vasantha Veerappa Lakshmaiah , Suresh Babu Naidu Krishna","doi":"10.1016/j.tet.2025.134813","DOIUrl":"10.1016/j.tet.2025.134813","url":null,"abstract":"<div><div>Over the last three decades, there has been a growing interest in the Suzuki-Miyaura cross coupling reaction (SMCR) and its applications. This widely used powerful reaction provides a practical synthetic route for the direct formations of C(sp<sup>2</sup>)-C(sp<sup>2</sup>) bonds. The widespread popularity of Suzuki-Miyaura products highlights the importance of developing regenerable nanocatalysts within comprehensive green synthetic strategies. These nanocatalysts, often utilizing transition metals, provide a valuable route to these products. Increased research focus on regenerable nanocatalysts has led to the design of diverse magnetic nanoparticles, frequently functionalized with transition metals, aiming to optimize reaction efficiency and catalyst recovery. This review covers literature from 2017 onwards, focusing on magnetically separable nanocatalysts, particularly those based on palladium, nickel, cobalt, and copper nanoparticles, for their application in SMCR. A key emphasis is placed on nanocatalysts demonstrating high recyclability without compromising reaction yield.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134813"},"PeriodicalIF":2.1,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical strategies for selective carbohydrate scaffold modification 选择性碳水化合物支架修饰的电化学策略

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-07 DOI: 10.1016/j.tet.2025.134814

Pedro J. Tortajada, Helena Lundberg

引用次数: 0

The photocatalytic journey of heteroatoms: Illuminating aza-Henry reactions in organic synthesis 杂原子的光催化之旅：对有机合成中aza-Henry反应的启发

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-05 DOI: 10.1016/j.tet.2025.134803

Vishwa K. Patel, Divyani P. Patel, Satish Kumar Singh

{"title":"The photocatalytic journey of heteroatoms: Illuminating aza-Henry reactions in organic synthesis","authors":"Vishwa K. Patel, Divyani P. Patel, Satish Kumar Singh","doi":"10.1016/j.tet.2025.134803","DOIUrl":"10.1016/j.tet.2025.134803","url":null,"abstract":"<div><div>Heteroatoms play a critical role in synthetic chemistry and the development of organic materials, significantly influencing molecular structure and reactivity. This review highlights the pivotal role of heteroatoms in synthetic chemistry and organic materials, with a specific focus on advancements in photocatalyzed aza-Henry reaction in the formation of <em>β</em>-nitroamine compounds. This study emphasizes the aza-Henry reaction, a highly adaptable approach for the synthesis of <em>β</em>-nitroamine compounds, which serve as crucial intermediates in both medicinal and synthetic chemistry. Their unique electronic and steric properties allow for the construction of innovative reagents, catalysts, and materials with applications spanning pharmaceuticals, polymers, and photochemistry. Special attention is given to the role of visible light and heteroatom catalysts in the synthesis of complex nitrogen-containing compounds. This strategy avoids harsh reaction conditions and expands the substrate scope and selectivity by utilizing heteroatom catalysts in conjunction with visible-light activation, offering a sustainable and efficient strategy for the synthesis of structurally diverse <em>β</em>-nitroamine compounds. This approach not only broadens substrate scope but also enhances reaction selectivity, reinforcing its significance in complex molecule synthesis under environmentally benign conditions.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134803"},"PeriodicalIF":2.1,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-pot three-component construction of benzo[4,5]imidazo[1,2-a]benzo[4,5]thieno[3,2-d]pyrimidines through [5+1+3] cascade cyclization 通过[5+1+3]级联环化一锅三组分构建苯并[4,5]咪唑[1,2-a]苯并[4,5]噻唑[3,2-d]嘧啶

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-07-05 DOI: 10.1016/j.tet.2025.134811

Jiao Wang, Botao Wang, Ting Shao, Zheng Li

引用次数: 0