Tetrahedron最新文献_第4页

Stoichiometry-controlled chemoselective mechanochemical indolation of 1,2-naphthoquinones under metal- and solvent-free conditions 化学计量学控制的1,2-萘醌在无金属和无溶剂条件下的化学选择性机械化学吲哚

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-06 DOI: 10.1016/j.tet.2025.134917

Edson de Oliveira Lima Filho , Raquel Nery Simão , Marcela Cristina Pereira de Barros , Guilherme Pereira Guedes , Vitor Francisco Ferreira , Fernando de Carvalho da Silva

引用次数: 0

Synthesis and characterization of electroluminescent materials: Dinuclear platinum complexes featuring 2-naphthylisoquinoline cyclometalating ligands 电致发光材料的合成与表征：2-萘基异喹啉环金属化配体双核铂配合物

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-06 DOI: 10.1016/j.tet.2025.134933

Jialu Liu , Fanyuan Meng , Danfeng He , Keyue Xu , Wenjing Xiong , Weiguo Zhu

{"title":"Synthesis and characterization of electroluminescent materials: Dinuclear platinum complexes featuring 2-naphthylisoquinoline cyclometalating ligands","authors":"Jialu Liu , Fanyuan Meng , Danfeng He , Keyue Xu , Wenjing Xiong , Weiguo Zhu","doi":"10.1016/j.tet.2025.134933","DOIUrl":"10.1016/j.tet.2025.134933","url":null,"abstract":"<div><div>(2niq)2Pt2(μ-PhOXT)2, (2niq)2Pt2(μ-tBuOXT)2 (2niq)2Pt2(μ-C6OXT)2 and (2niq)2Pt2(μ-C12OXT)2, were designed and synthesized, featuring 2-naphthylisoquinoline as the chelating ligand and arylthioxadiazole as the auxiliary ligand. The results showed that the photoluminescence quantum yield (PLQY) of these four dinuclear platinum complexes in dichloromethane solution were 8.2 %, 13.7 %, 18.3 % and 12.6 %, respectively. In pure thin films, their luminescence lifetimes were 1435, 554, 448, and 1266 ns, respectively. Meanwhile, the (2niq)2Pt2(μ-PhOXT)2-, (2niq)2Pt2(μ-tBuOXT)2-, (2niq)2Pt2(μ-C6OXT)2- and (2niq)2Pt2(μ-C12OXT)2-doped polymer light-emitting devices (PLEDs) exhibited deep-red to near-infrared electroluminescence characteristics with emission peaks in the range of 686–706 nm. The maximum external quantum efficiencies (EQEs) were 3.00 %, 3.89 %, 5.03 %, and 5.16 %, respectively. The results revealed that device performance improved with increasing alkyl chain length of the auxiliary ligand, which might be attributed to enhanced charge transport properties. This work provided new insights into the design of efficient deep-red to near-infrared luminescent platinum complexes by introducing alkyl chains into the auxiliary ligands. It offered a novel strategy for modulating the EQEs of the devices based on these platinum complexes from the perspective of auxiliary ligands, thereby advancing PLED applications.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"187 ","pages":"Article 134933"},"PeriodicalIF":2.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on structural modifications of parthenin extracted from Parthenium hysterophorus L 帕提宁提取物的结构修饰研究进展

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-05 DOI: 10.1016/j.tet.2025.134919

Navneet Kaur , Loveleen Kaur , Manvinder Kaur , Harvinder Singh Sohal , Ajay Sharma , Gopal Singh Attar , Haesook Han , Pradip K. Bhowmik

{"title":"A review on structural modifications of parthenin extracted from Parthenium hysterophorus L","authors":"Navneet Kaur , Loveleen Kaur , Manvinder Kaur , Harvinder Singh Sohal , Ajay Sharma , Gopal Singh Attar , Haesook Han , Pradip K. Bhowmik","doi":"10.1016/j.tet.2025.134919","DOIUrl":"10.1016/j.tet.2025.134919","url":null,"abstract":"<div><div>Parthenin is a sesquiterpene lactone extracted from Parthenium hysterophorus that possesses a broad spectrum of biological activities, including anti-inflammatory, antimicrobial, anticancer, and allelopathic properties. However, its clinical applications are hindered by cytotoxicity, poor solubility, low bioavailability, and instability in physiological conditions. To address these challenges, numerous structural modifications have been explored to improve its pharmacokinetic properties while enhancing its therapeutic potential. This review provides a comprehensive overview of the chemical modifications of parthenin, including hydroxylation, halogenation, Michael addition, and lactone ring alterations. Modifications, particularly in the lactone and cyclopentenone rings, can significantly enhance its anticancer, antimicrobial, and anti-inflammatory activities while reducing toxicity. The review also highlights recent pharmacological advancements and outlines promising directions for future drug development based on the parthenin derivatives. Overall, the study underscores the value of parthenin and its derivatives as innovative therapeutic agents and contributes to the progress of natural product-based drug design.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"187 ","pages":"Article 134919"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionalization of indazoles and azaindazoles via palladium-catalyzed cross-coupling and transition metal-free C–H activation: current advances and applications – an eight-year update 通过钯催化的交叉偶联和无过渡金属C-H活化的茚唑和氮杂唑的功能化：目前的进展和应用-八年的更新

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-04 DOI: 10.1016/j.tet.2025.134918

Khalid Boujdi , Yassine El Baraka , Ghanem Hamdoun , Nabil El Brahmi , Saïd El Kazzouli

引用次数: 0

A new type of chiral ligands: Design and the evaluation of their performance in catalytic asymmetric reactions 一种新型手性配体：设计及其催化不对称反应性能评价

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-04 DOI: 10.1016/j.tet.2025.134929

Chao Yao , Xueyan Chen , Chuang Qu , Yan Zhao , Yue-Ming Li

引用次数: 0

FeCl3/I2-catalyzed tandem aerobic oxidative annulation of α-aminoketone hydrochlorides with aldehydes: synthesis of substituted oxazoles FeCl3/ i2催化α-氨基酮与醛的串联好氧环化反应：取代恶唑的合成

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-03 DOI: 10.1016/j.tet.2025.134913

Jian Wang , Xiaoyue Chen , Xiaole Ni , Zhen Zhang , Jinhong He , Liming Shao

引用次数: 0

Unsupported nanoporous platinum catalyst for the chemoselective hydrogenation of imines and reductive amination of benzaldehydes and anilines 用于亚胺化学选择性加氢和苯甲醛和苯胺还原胺化的无负载纳米多孔铂催化剂

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-03 DOI: 10.1016/j.tet.2025.134912

Wenfei Tong , Ruyi Jiang , Wanguo Wei , Tienan Jin , Xiaojun Zheng , Yuhui Zhao , Zhiqiang Zhang

引用次数: 0

Direct synthesis of 2-(benzylamino)benzoic acids by using benzaldehydes and 2-aminobenzoic acids with catalysis of p-toluenesulfonic acid 苯甲醛和2-氨基苯甲酸在对甲苯磺酸催化下直接合成2-（苄基氨基）苯甲酸

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-03 DOI: 10.1016/j.tet.2025.134915

Chao-Tun Cao, Xueqian Peng, Zhao Zeng, Chenzhong Cao

{"title":"Direct synthesis of 2-(benzylamino)benzoic acids by using benzaldehydes and 2-aminobenzoic acids with catalysis of p-toluenesulfonic acid","authors":"Chao-Tun Cao, Xueqian Peng, Zhao Zeng, Chenzhong Cao","doi":"10.1016/j.tet.2025.134915","DOIUrl":"10.1016/j.tet.2025.134915","url":null,"abstract":"<div><div>Direct reductive amination of carbonyl compounds is a promising method for the synthesis of amine derivatives. Usually, stoichiometric reducing agents generate significant waste products, some of which are hazardous and difficult to handle. Therefore, it is highly desirable to synthesize amines using reducing agents that cause low environmental pollution and minimize hazardous by-products. In this work, It was discovered that substituted benzaldehydes and substituted 2-aminobenzoic acids can be directly converted into substituted 2-(benzylamino)benzoic acids using p-toluenesulfonic acid (TsOH) as a catalyst in a one-pot method, where the only by-product is substituted benzoic acid. The reaction mechanism was investigated, and the results showed that the Schiff base's carbon-nitrogen double bond is reduced by benzaldehyde under TsOH catalysis, resulting in 2-(benzylamino)benzoic acid. This phenomenon was not observed previously. The advantage of this method lies in its mild reaction conditions, as it requires neither metal catalysis nor additional reducing agents.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"187 ","pages":"Article 134915"},"PeriodicalIF":2.2,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile synthesis of diverse 2-aminopyrimidines by phosphorus oxychloride-promoted C2-selective amination of pyrimidines 氯氧磷促进2-氨基嘧啶的c2选择性胺化反应制备多种2-氨基嘧啶

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-02 DOI: 10.1016/j.tet.2025.134906

Lei Zhao , Yi-Lei Huang , Peng Xie , Huang-Di Feng , Guan Wang , Jun-Hai Huang

引用次数: 0

Synthesis of tetrahydroquinoline via hydrosilylation-transfer hydrogenation of quinoline with silane and water catalyzed by a switchable Lewis and Brønsted acid system 硅氢化反应合成四氢喹啉-硅烷和水在Lewis和Brønsted酸体系催化下的转移加氢反应

IF 2.2 3区化学

Tetrahedron Pub Date : 2025-09-02 DOI: 10.1016/j.tet.2025.134910

Tianwei Liu , Haiying Wang

{"title":"Synthesis of tetrahydroquinoline via hydrosilylation-transfer hydrogenation of quinoline with silane and water catalyzed by a switchable Lewis and Brønsted acid system","authors":"Tianwei Liu , Haiying Wang","doi":"10.1016/j.tet.2025.134910","DOIUrl":"10.1016/j.tet.2025.134910","url":null,"abstract":"<div><div>Employing a single catalyst in various forms within a reaction system to synergistically catalyzed reactions represent an efficient and convenient synthetic strategy. Using B(C6F5)3 as a catalyst, the direct synthesis of tetrahydroquinoline was achieved through the catalyzed hydrosilylation and transfer hydrogenation of quinoline with silane in the presence of water. Through control experiments, it has been demonstrated that this reaction was catalyzed synergistically by both the Lewis acid and Brønsted acid. The Lewis acid B(C6F5)3 catalyzes the hydrosilylation of quinoline, yielding a N-silylated-dihydroquinoline. Meanwhile, the Brønsted acid B(C6F5)3·H2O mediates the transfer hydrogenation of N-silylated-dihydroquinoline in the presence of quinoline and silane, forming the N-silylated-tetrahydroquinoline, ultimately yielding the desired product upon subsequent hydrolysis. Compared to traditional methods of reducing quinoline to tetrahydroquinoline using H2, this reaction features mild conditions and high efficiency. Compared with other reaction systems for quinoline reduction using B(C6F5)3 as the catalyst, silanes and/or boranes as hydride sources, and amines and/or indoles as proton sources, this method employs water as the proton source, exhibiting the advantages of being green and cost-effective. Moreover, this system demonstrates that in the presence of water, B(C6F5)3 can switch between Lewis acid and Brønsted acid forms and exhibit a new mode of catalytic reaction.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"187 ","pages":"Article 134910"},"PeriodicalIF":2.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0