Stoichiometry-controlled chemoselective mechanochemical indolation of 1,2-naphthoquinones under metal- and solvent-free conditions

Abstract

In this study, we report the development of a novel methodology for the synthesis of stoichiometry-controlled chemoselective of fifteen (mono or tris)-indole-naphthalen(di)one derivatives by mechanochemical indolation of 1,2-naphthoquinone. The reactions were conducted under solvent-free conditions using the mechanochemical technique. Notably, the method enables selective control over the formation of both symmetric and non-symmetric trisubstituted products.