Tetrahedron最新文献_第10页

Convergent synthesis of the pentasaccharide repeating unit of the cell wall K116 capsular polysaccharide of Acinetobacter baumannii

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-13 DOI: 10.1016/j.tet.2025.134537

Samim Sahaji, Abhijit Rana, Anup Kumar Misra

引用次数: 0

Synthesis of novel 2-alkyl and 2-aryl 4-phosphorylated oxazolines from dimethyl (±)-phosphoserinate

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-11 DOI: 10.1016/j.tet.2025.134471

Víctor Manuel Pérez-Piña , Rubén Oswaldo Argüello-Velasco , Mario Ordoñez , Ivan Romero-Estudillo

引用次数: 0

Unusual transformation of 4-hydroxy-6-methyl-3-nitro-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione into 1-methyl-4-substituted amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-11 DOI: 10.1016/j.tet.2025.134532

Al-Shimaa Badran, Magdy A. Ibrahim, Mai A. Mostafa

引用次数: 0

Chemical diversity of pyrrolobenzazepine derivatives with a nodal nitrogen atom

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-10 DOI: 10.1016/j.tet.2025.134524

Arina Y. Obydennik, Alexander A. Titov, Anna V. Listratova, Alexey V. Varlamov

引用次数: 0

Synthesis of new hybrid compounds of imidazo[1,2-a]pyrimidine/pyridine based on quinoxaline through palladium-catalyzed coupling reactions and heteroannulation

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-08 DOI: 10.1016/j.tet.2025.134521

Marzieh Enjilzadeh, Ali Keivanloo, Mohammad Bakherad

{"title":"Synthesis of new hybrid compounds of imidazo[1,2-a]pyrimidine/pyridine based on quinoxaline through palladium-catalyzed coupling reactions and heteroannulation","authors":"Marzieh Enjilzadeh, Ali Keivanloo, Mohammad Bakherad","doi":"10.1016/j.tet.2025.134521","DOIUrl":"10.1016/j.tet.2025.134521","url":null,"abstract":"<div><div>New hybrid compounds, including imidazo[1,2-a]pyrimidin-2-yl(3-(substituted)quinoxalin-2-yl)methanone and its imidazo[1,2-a]pyridine analogs, have been successfully prepared via palladium-catalyzed reactions. The synthesis involved the reaction of 3-substituted-2-chloroquinoxalines with 2-amino-1-(prop-2-yn-1-yl)pyrimidinium/pyridinium bromide under optimized reaction conditions. These conditions included Pd(PPh3)2Cl2 (5 mol %), CuI (10 mol%) in the presence of Et3N in DMF at 70 °C, resulting in the formation of the desired hybrid compounds. Furthermore, imidazo[1,2-a]pyridine hybrid compounds were synthesized through one-pot multicomponent reactions of 2,3-dicholoroquinoxaline, 2-amino-1-(prop-2-yn-1-yl)pyridinium bromide, primary and secondary amines, under optimized conditions. These processes provided efficient protocols to synthesize novel imidazo[1,2-a]pyrimidine/pyridine based on quinoxaline through palladium-catalyzed reaction with high yields. A one-pot reaction, high reaction yields, energy efficiency, and a straightforward reaction process are significant advantages of this protocol.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"175 ","pages":"Article 134521"},"PeriodicalIF":2.1,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and photophysics of color-pure blue emitters featuring oxaboraphenanthrene as a novel structural motif

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-08 DOI: 10.1016/j.tet.2025.134522

Sunwu Song , Siyang Feng , Liangxuan Wang , Begoña Milián-Medina , Reinhold Wannemacher , Johannes Gierschner , Min Sang Kwon

引用次数: 0

Ligand-induced transformation to cyclic conformation of trimers of porphyrin dendrimer analogs

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-07 DOI: 10.1016/j.tet.2025.134523

Takumi Nakao , Yoshimitsu Tachi , Masatoshi Kozaki

引用次数: 0

One pot synthesis of coumarin fused fluorescein derivative for mercury ion detection: An experimental and theoretical approach

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-05 DOI: 10.1016/j.tet.2025.134518

Praveenakumara A. Valmiki , Lohit Naik , M.S. Thippeswamy , C.V. Maridevarmath , Arun K. Shetter , Amnah Mohammed Alsuhaibani , Moamen S. Refat , G.H. Malimath

{"title":"One pot synthesis of coumarin fused fluorescein derivative for mercury ion detection: An experimental and theoretical approach","authors":"Praveenakumara A. Valmiki , Lohit Naik , M.S. Thippeswamy , C.V. Maridevarmath , Arun K. Shetter , Amnah Mohammed Alsuhaibani , Moamen S. Refat , G.H. Malimath","doi":"10.1016/j.tet.2025.134518","DOIUrl":"10.1016/j.tet.2025.134518","url":null,"abstract":"<div><div>In this study, a highly fluorescent fluorescein-based derivative (2FLC) was synthesized using a one-pot synthesis method. The structure of the molecule was confirmed through physicochemical analysis, including 1H NMR, FT-IR, and mass spectroscopy. The chemosensor property of 2FLC with different metal ions (Cu 2+, Al3+, Ag +, Hg2+, Mg2+, Fe2+, Co2+, K+, Zn2+, Ni2+, Pb2+, Cd2+ and Mn2+) is investigated through absorption and fluorescence studies in a water medium. Interestingly, it is observed that the 2FLC exhibited a remarkable turn-off fluorescence response upon adding Hg2+ ion as compared to different metal ions. Further, competitive metal ion studies indicate that the receptor 2FLC exhibits exceptional selectivity in detecting Hg2+ ion without being affected by other metal ions. The detection limit of 2FLC for targeted Hg2+ ion was 8.87 μM. The binding stoichiometry between the receptor 2FLC and the Hg2+ metal ion was verified using both Job's plot and the Benasi-Hildbrand methods and found to be 1:1. Theoretical studies and FT-IR spectra confirmed the strong binding and formation of 2FLC-Hg2+ complex. Overall, the results suggest that the newly synthesized water-soluble 2FLC molecule may be used as a chemosensor to detect Hg2+ ion.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"175 ","pages":"Article 134518"},"PeriodicalIF":2.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Click synthesis via 1,3-dipolar addition- A versatile route to tetrazine derivatives and In silico corroboration as anti-muscular dystrophy agent

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-04 DOI: 10.1016/j.tet.2025.134520

Satheeshkumar Nagaraj, Karpagam Ezhilarasan, Rajalakshmi Ramarajan

{"title":"Click synthesis via 1,3-dipolar addition- A versatile route to tetrazine derivatives and In silico corroboration as anti-muscular dystrophy agent","authors":"Satheeshkumar Nagaraj, Karpagam Ezhilarasan, Rajalakshmi Ramarajan","doi":"10.1016/j.tet.2025.134520","DOIUrl":"10.1016/j.tet.2025.134520","url":null,"abstract":"<div><div>Click chemistry, celebrated for its efficiency and selectivity, has emerged as a powerful tool for the rapid synthesis of tetrazines. This study introduces a novel approach to accessing tetrazines from symmetrical azines and sodium azide, facilitating the streamlined construction of these versatile compounds. Renowned for their exceptional stability and reactivity, tetrazines are highly coveted in diverse fields including materials science, medicinal chemistry, and imaging. The newly synthesized tetrazine derivatives were rigorously characterized using a suite of spectroscopic techniques, including IR, 1H and 13C NMR, 2D NMR, and mass spectrometry. To assess their reactivity and stability, the energy gap (ΔE) was computed using density functional theory. Furthermore, in silico molecular docking studies were performed against the muscular dystrophy protein 2VD5 to explore its potential biological activity. This innovative synthetic strategy provides a robust platform for the expeditious development of a diverse array of tetrazine-based compounds with promising applications across various scientific domains.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"175 ","pages":"Article 134520"},"PeriodicalIF":2.1,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The application of azoarenes in the synthesis of nitrogen-containing heterocycles

IF 2.1 3区化学

Tetrahedron Pub Date : 2025-02-01 DOI: 10.1016/j.tet.2024.134428

Azim Ziyaei Halimehjani, Nima Sadeghzadeh, Sina Moghaddam

引用次数: 0