HFIP-triggered C3-hydroalkylation of imidazo[1,2-a]pyridines with maleimides

Herein, a facile HFIP-triggered C(sp²)-H hydroalkylation of imidazo[1,2-a]pyridines with maleimides via Michael addition process has been described. A series of C3-succinylated imidazo[1,2-a]pyridines were prepared in moderate to good yields in the absence of transition metals. The protocol was characterized by simple operation, a broad substrate scope, and scale-up synthesis. Furthermore, the synthesized target compounds also have the potential for further derivatization to obtain more biologically active compounds.