HFIP-triggered C3-hydroalkylation of imidazo[1,2-a]pyridines with maleimides

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-07-18 DOI:10.1016/j.tet.2025.134844

Juanjuan Gao , Xinlei Fu , Xue Zhu , Shuqin Yu , LongHui Wu , Xinyuan Liao , Kai Yang , Yifan Cao

引用次数: 0

Abstract

Herein, a facile HFIP-triggered C(sp²)-H hydroalkylation of imidazo[1,2-a]pyridines with maleimides via Michael addition process has been described. A series of C3-succinylated imidazo[1,2-a]pyridines were prepared in moderate to good yields in the absence of transition metals. The protocol was characterized by simple operation, a broad substrate scope, and scale-up synthesis. Furthermore, the synthesized target compounds also have the potential for further derivatization to obtain more biologically active compounds.

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hfip触发咪唑[1,2-a]吡啶与马来酰亚胺的c3 -氢烷基化反应

本文描述了咪唑[1,2-a]吡啶与马来酰亚胺通过Michael加成反应的C(sp2)-H氢烷基化反应。在不含过渡金属的情况下，以中高收率制备了一系列c3 -琥珀化咪唑[1,2- A]吡啶。该方法具有操作简单、底物适用范围广、可按比例放大合成等特点。此外，所合成的目标化合物还具有进一步衍生化以获得更具有生物活性的化合物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.