化学计量学控制的1,2-萘醌在无金属和无溶剂条件下的化学选择性机械化学吲哚

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-09-06 DOI:10.1016/j.tet.2025.134917

Edson de Oliveira Lima Filho , Raquel Nery Simão , Marcela Cristina Pereira de Barros , Guilherme Pereira Guedes , Vitor Francisco Ferreira , Fernando de Carvalho da Silva

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引用次数: 0

摘要

在这项研究中，我们报道了一种新的方法，通过机械化学吲哚-萘醌的吲哚-萘醌（1,2）的吲哚-萘醌衍生物的化学计量控制的化学选择性合成。采用机械化学技术在无溶剂条件下进行反应。值得注意的是，该方法能够对对称和非对称三取代产物的形成进行选择性控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Stoichiometry-controlled chemoselective mechanochemical indolation of 1,2-naphthoquinones under metal- and solvent-free conditions

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Stoichiometry-controlled chemoselective mechanochemical indolation of 1,2-naphthoquinones under metal- and solvent-free conditions

In this study, we report the development of a novel methodology for the synthesis of stoichiometry-controlled chemoselective of fifteen (mono or tris)-indole-naphthalen(di)one derivatives by mechanochemical indolation of 1,2-naphthoquinone. The reactions were conducted under solvent-free conditions using the mechanochemical technique. Notably, the method enables selective control over the formation of both symmetric and non-symmetric trisubstituted products.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.