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Research progress in synthesis of Lepadiformine 左二福明的合成研究进展
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-07-03 DOI: 10.1016/j.tet.2025.134804
Xuesong Gu , Meng Zhao , Lanlan Sun , Ying Xiong
{"title":"Research progress in synthesis of Lepadiformine","authors":"Xuesong Gu ,&nbsp;Meng Zhao ,&nbsp;Lanlan Sun ,&nbsp;Ying Xiong","doi":"10.1016/j.tet.2025.134804","DOIUrl":"10.1016/j.tet.2025.134804","url":null,"abstract":"<div><div>Lepadiformine, a structurally unique azaspiro-fused tricyclic marine alkaloid, exhibits cytotoxicity against diverse cell lines and demonstrates significant activity against cardiovascular diseases. It has attracted considerable attention in the field of synthetic chemistry. The key challenges include the stereoselective construction of the azacrown carbon stereocenter and the assembly of its intricate tricyclic system. Following its initial isolation, numerous research groups have explored diverse synthetic strategies targeting this molecular architecture. These efforts have yielded multiple synthetic pathways characterized by varying degrees of efficiency and stereochemical control. This review systematically examines the evolution of synthetic approaches to Lepadiformine, with particular emphasis on innovative methodologies for spirocycle formation and asymmetric induction at the pivotal quaternary carbon center.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134804"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of very large cavitand-based bimolecular capsules 超大空腔基双分子胶囊的合成
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-07-03 DOI: 10.1016/j.tet.2025.134807
Zsolt Csók , Leonidas-Dimitrios Syntrivanis , Naidel A.M.S. Caturello , Rodrigo Q. Albuquerque , László Kollár
{"title":"Synthesis of very large cavitand-based bimolecular capsules","authors":"Zsolt Csók ,&nbsp;Leonidas-Dimitrios Syntrivanis ,&nbsp;Naidel A.M.S. Caturello ,&nbsp;Rodrigo Q. Albuquerque ,&nbsp;László Kollár","doi":"10.1016/j.tet.2025.134807","DOIUrl":"10.1016/j.tet.2025.134807","url":null,"abstract":"<div><div>Very large, ‘three-storey’ tetra(amido)cavitands and their dimeric capsules were designed and synthesized by the combination of a highly efficient, five-step covalent synthetic procedure with noncovalent, spontaneous self-assembly. Semi-empirical calculations suggest that the two halves of these capsular assemblies are held together by four intermolecular hydrogen bonds between the neighboring N–H⋯O<img>C groups installed on the upper rim of each cavitand ‘hemisphere’. Using the modified Stokes-Einstein equation, the hydrodynamic radius of capsule <strong>6<sub>2</sub></strong> was found to be 14.8 Å<sup>3</sup>, which is in relatively good agreement with the theoretical approximation (13.0 Å<sup>3</sup>). The semi-empirical calculations also revealed that these bimolecular capsules have an intercavity volume of about 1940 Å<sup>3</sup>. However, the presence of enlarged lateral portals may pose some limitations on their use as host molecules.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134807"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total synthesis of an elusive indole alkaloid isolated from Halichondria melanodocia 从黑藻中分离的一种难以捉摸的吲哚生物碱的全合成
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-07-03 DOI: 10.1016/j.tet.2025.134800
Javier Rivera-Mendoza , Ángel A. Nolasco-Hernández , Leticia Quintero , Vladimir Carranza-Téllez , Fernando Sartillo-Piscil
{"title":"Total synthesis of an elusive indole alkaloid isolated from Halichondria melanodocia","authors":"Javier Rivera-Mendoza ,&nbsp;Ángel A. Nolasco-Hernández ,&nbsp;Leticia Quintero ,&nbsp;Vladimir Carranza-Téllez ,&nbsp;Fernando Sartillo-Piscil","doi":"10.1016/j.tet.2025.134800","DOIUrl":"10.1016/j.tet.2025.134800","url":null,"abstract":"<div><div>The total synthesis of an elusive indole alkaloid isolated from the marine sponge <em>Halichondria melanodocia</em>, is reported. Since previous synthetic efforts to prepare <strong>1a</strong> failed (<strong>1b</strong> obtained, instead), probably because there are few methods for selective installation of <em>exo</em>/<em>endo</em> double bonds at C3 position of piperidines, the recent development of a <em>β-</em>C−H alkenylation of <em>N</em>-heterocycles followed by double-bond isomerization enabled the stereoselective and transition-metal-free total synthesis of the indole title alkaloid (<strong>1a)</strong>.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134800"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and synthesis of air-stable, storable chiral phosphoramidite ligands for transition-metal-catalyzed enantioselective reactions 过渡金属催化对映选择反应中空气稳定、可储存的手性磷酰胺配体的设计与合成
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-07-03 DOI: 10.1016/j.tet.2025.134797
Nasiri Behzad , Ashouri Akram , Waser Mario
{"title":"Design and synthesis of air-stable, storable chiral phosphoramidite ligands for transition-metal-catalyzed enantioselective reactions","authors":"Nasiri Behzad ,&nbsp;Ashouri Akram ,&nbsp;Waser Mario","doi":"10.1016/j.tet.2025.134797","DOIUrl":"10.1016/j.tet.2025.134797","url":null,"abstract":"<div><div>The synthesis of a new family of phosphoramidite ligands is described through a straightforward two-step process. Selective reduction of cyclohexane dinitriles afforded novel amines, which were subsequently reacted with BINOL-chlorophosphites to yield the corresponding phosphoramidites. Remarkably, these ligands exhibited exceptional stability against air, moisture, and in solution, as confirmed by <sup>31</sup>P NMR spectroscopy. The performance of these ligands was assessed in two benchmark asymmetric reactions—the rhodium-catalyzed arylation of aldehydes and the copper-catalyzed conjugate addition of diethyl zinc to chalcones—demonstrating notable influence of the ligand structure.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134797"},"PeriodicalIF":2.1,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoredox-HAT catalysed α-C–H alkylation of primary amines with vinyl phosphine oxides: New building blocks for spiropyrrolidine synthesis 光氧化还原- hat催化伯胺与乙烯基膦氧化物的α-C-H烷基化：合成螺吡咯烷的新组成部分
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-07-01 DOI: 10.1016/j.tet.2025.134806
Anna G. Kinsella , Joseph J. Bell-Tyrer , Darren Stead , Alexander J. Cresswell
{"title":"Photoredox-HAT catalysed α-C–H alkylation of primary amines with vinyl phosphine oxides: New building blocks for spiropyrrolidine synthesis","authors":"Anna G. Kinsella ,&nbsp;Joseph J. Bell-Tyrer ,&nbsp;Darren Stead ,&nbsp;Alexander J. Cresswell","doi":"10.1016/j.tet.2025.134806","DOIUrl":"10.1016/j.tet.2025.134806","url":null,"abstract":"<div><div>We report a dual photoredox and hydrogen atom transfer (HAT) catalysed α-C–H alkylation of unprotected, aliphatic primary amines with diphenyl(vinyl)phosphine oxide. This simple protocol, which can be run on gram-scale in continuous flow, enables the direct synthesis of γ-amino phosphine oxide building blocks. By condensation with aromatic aldehydes and base-induced 5-<em>endo</em>-trig cyclisation, the latter compounds can be converted into α-arylated, spirocyclic pyrrolidines. Finally, we show that attempted deprotonation of γ-amino phosphine oxides with strong base leads to an unexpected cyclisation to afford cyclic phosphinamide products.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134806"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cp∗Ir(III) Catalyzed greener synthesis of nitrogenous heterocycles using acceptor less dehydrogenative coupling (ADC) strategy Cp * Ir（III）用少受体脱氢偶联（ADC）策略催化更环保的含氮杂环化合物合成
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-06-30 DOI: 10.1016/j.tet.2025.134799
Md Bakibillah , Rahul Kumar Singh , Dilip Sarkar , Deboshmita Mukherjee , Saranita Roy Chowdhury , Sumana Roy , Mahboob Alam , Mohammad Shahidul Islam , Rajesh Kumar Das
{"title":"Cp∗Ir(III) Catalyzed greener synthesis of nitrogenous heterocycles using acceptor less dehydrogenative coupling (ADC) strategy","authors":"Md Bakibillah ,&nbsp;Rahul Kumar Singh ,&nbsp;Dilip Sarkar ,&nbsp;Deboshmita Mukherjee ,&nbsp;Saranita Roy Chowdhury ,&nbsp;Sumana Roy ,&nbsp;Mahboob Alam ,&nbsp;Mohammad Shahidul Islam ,&nbsp;Rajesh Kumar Das","doi":"10.1016/j.tet.2025.134799","DOIUrl":"10.1016/j.tet.2025.134799","url":null,"abstract":"<div><div>In our preliminary research, we demonstrated excellent catalytic activity of Ir(III) complexes coordinated via a picolinamidato moiety. Utilizing these catalysts, we efficiently synthesized α-alkylated ketones through the hydrogen-borrowing methodology, employing ketones and secondary alcohols in the presence of primary alcohols. Furthermore, we successfully applied an acceptor less dehydrogenative coupling (ADC) strategy using the same series of in-house synthesized Ir(III) catalysts to generate a variety of nitrogen-containing heterocycles, including quinoline, pyrrole, and pyridine derivatives under neat (solvent-free) conditions at 90 °C. Encouraged by these results, we extended the catalytic system to the synthesis of additional nitrogen-rich heterocyclic frameworks such as pyrido[2,3-<em>b</em>]pyrazine, 1,8-naphthyridine, and quinazolin-4(3<em>H</em>)-one derivatives, achieving good to excellent yields. This methodology is particularly attractive due to its environmentally benign nature requiring only a small amount of catalyst (0.3 mol%), base (0.2 mol%) and producing only non-toxic by-products H<sub>2</sub> and H<sub>2</sub>O. Overall, this work contributes to the development of sustainable and green synthetic approaches for the construction of valuable nitrogen-containing heterocycles.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134799"},"PeriodicalIF":2.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterization of coumarin derivatives for chemosensor application via experimental and theoretical approaches 香豆素衍生物在化学传感器中的合成与表征
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-06-26 DOI: 10.1016/j.tet.2025.134796
Mahesh Madar , Venkatesan Srinivasan , Manjunath P. Eelager , Nagarjuna Prakash Dalbanjan , Kavyashree Nagappa Kummur , Venugopala Nayak , Mahantesh M. Basanagouda , Ashok Sidarai
{"title":"Synthesis and characterization of coumarin derivatives for chemosensor application via experimental and theoretical approaches","authors":"Mahesh Madar ,&nbsp;Venkatesan Srinivasan ,&nbsp;Manjunath P. Eelager ,&nbsp;Nagarjuna Prakash Dalbanjan ,&nbsp;Kavyashree Nagappa Kummur ,&nbsp;Venugopala Nayak ,&nbsp;Mahantesh M. Basanagouda ,&nbsp;Ashok Sidarai","doi":"10.1016/j.tet.2025.134796","DOIUrl":"10.1016/j.tet.2025.134796","url":null,"abstract":"<div><div>Coumarin-based fluorescence probes are potential candidates for selective sensing of explosive materials and toxins. In this present study, we designed and developed novel coumarin derivatives with minor modifications from coumarin and sesamol by a simple condensation method. Moreover, the prepared coumarin derivatives, such as <strong>6BMC</strong> and <strong>7BMC</strong> were characterized by different spectroscopic analyses. The photophysical properties were analyzed through steady-state absorption and fluorescence spectral studies. The substitution of a methyl group strongly affects the non-radiative deactivation as a result, the hyperconjugation increases for <strong>7BMC</strong> than <strong>6BMC</strong>. The fluorescence probe was used to detect numerous nitroaromatic compounds and demonstrated a rapid, highly selective, and sensitive fluorescence 'Turn Off' response to picric acid (PA) in a THF/H<sub>2</sub>O solution, among other nitroaromatics. The fluorescence \"Turn Off\" response in the presence of PA is due to the photoinduced electron transfer, as proven by lifetime measurements and DFT analysis. The calculated limit of detection is 0.36 and 0.57 μM for <strong>6BMC</strong> and <strong>7BMC</strong>, respectively. The findings indicate that the coumarin derivatives are efficient probes for selective sensing of picric acid at a micromolar level.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134796"},"PeriodicalIF":2.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional group exchange alters the 1,5-hydrogen atom transfer propensity in radical cascade reactions 官能团交换改变自由基级联反应中1,5-氢原子的转移倾向
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-06-26 DOI: 10.1016/j.tet.2025.134802
Hibiki Asai, Koichi Hagiwara, Masayuki Inoue
{"title":"Functional group exchange alters the 1,5-hydrogen atom transfer propensity in radical cascade reactions","authors":"Hibiki Asai,&nbsp;Koichi Hagiwara,&nbsp;Masayuki Inoue","doi":"10.1016/j.tet.2025.134802","DOIUrl":"10.1016/j.tet.2025.134802","url":null,"abstract":"<div><div>In 2023, we reported a total synthesis of puberuline C (<strong>1</strong>), a C<sub>19</sub>-diterpenoid alkaloid with an intricately fused hexacyclic ABCDEF-ring system. The B- and F-rings were constructed in a single step by a radical cascade reaction. After 7-<em>endo</em> cyclization of the B-ring, a facile 1,5-hydrogen atom transfer on the tertiary amine generated an electron-rich α-amino radical, thereby enabling 6-<em>exo</em> cyclization of the F-ring. To explore the generality of this unique cascade process, we exchanged the tertiary amine with an ether, prepared a radical precursor, and examined the radical reaction. We found that only the first cyclization occurred from the radical precursor, while the 1,5-hydrogen atom transfer leading to formation of the α-alkoxy radical was inhibited. The disparate outcomes between the tertiary amine and ether were rationalized by the density functional theory calculation, providing new valuable information for designing substrates for radical cascade reactions.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"184 ","pages":"Article 134802"},"PeriodicalIF":2.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating the catalytic properties of dinuclear Schiff base copper (II) complex in the reduction of nitro aromatics and dyes 研究了双核希夫碱铜（II）配合物在还原硝基芳烃和染料中的催化性能
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-06-26 DOI: 10.1016/j.tet.2025.134798
Abu Taha, Nowsheenah Farooq, Nitu Singh, Mohammad Shaheer, Saleem Javed, Maqsood Ahmad Malik, Athar Adil Hashmi
{"title":"Investigating the catalytic properties of dinuclear Schiff base copper (II) complex in the reduction of nitro aromatics and dyes","authors":"Abu Taha,&nbsp;Nowsheenah Farooq,&nbsp;Nitu Singh,&nbsp;Mohammad Shaheer,&nbsp;Saleem Javed,&nbsp;Maqsood Ahmad Malik,&nbsp;Athar Adil Hashmi","doi":"10.1016/j.tet.2025.134798","DOIUrl":"10.1016/j.tet.2025.134798","url":null,"abstract":"<div><div>The release of harmful pollutants such as aromatic nitro compounds (ANCs) and synthetic organic dyes into the water bodies has posed a serious concern to the environment as well as humans. ANCs are considered to be very harmful for human health hence categorized as priority pollutants by Environmental Protection Agency (EPA). The need of the present time is to check these harmful organic pollutants from water bodies and other media using advanced techniques. There are several methods for the removal of these pollutants from water bodies, such as adsorption, reduction, oxidation, etc. Herein, we have synthesized a Schiff base dinuclear copper (II) complex (SBDC) for rapid reduction of ANCs and organic dyes. The synthesized Schiff base ligand (SBL) and SBDC were characterized by FT-IR, 1H NMR, ESI-MS, UV–visible spectroscopy, elemental analysis, EDX, elemental mapping, and FE-SEM. Theoretical studies like structure optimization, molecular electrostatic potential (MEP) and frontier molecular orbital (FMO) also done for SBL and SBDC. The SBDC was found to be very efficient for the reduction of aromatic nitro compounds and synthetic organic dyes. Reaction kinetics, rate constant, and other calculations were performed using pseudo-first-order kinetics for 4-nitrophenol, 4-nitroaniline, nitrobenzene, methyl orange, and Rhodamine B.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"184 ","pages":"Article 134798"},"PeriodicalIF":2.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One-pot synthesis of substituted quinolines and 3,3′-(arylmethylene)bis(1H-indoles) via a metal-free polyphosphoric acid-mediated acetylene hydrolysis strategy 无金属多磷酸介导乙炔水解一锅法合成取代喹啉和3,3 ' -（芳基亚甲基）双（1h -吲哚）
IF 2.1 3区 化学
Tetrahedron Pub Date : 2025-06-25 DOI: 10.1016/j.tet.2025.134801
Nikolai A. Arutiunov, Dinara C. Makieva, Anna M. Zatsepilina, Inna V. Aksenova, Kirill V. Tolstov, Daria A. Shtal, Anastasia A. Korneeva, Elena V. Alexandrova, Alexander V. Aksenov
{"title":"One-pot synthesis of substituted quinolines and 3,3′-(arylmethylene)bis(1H-indoles) via a metal-free polyphosphoric acid-mediated acetylene hydrolysis strategy","authors":"Nikolai A. Arutiunov,&nbsp;Dinara C. Makieva,&nbsp;Anna M. Zatsepilina,&nbsp;Inna V. Aksenova,&nbsp;Kirill V. Tolstov,&nbsp;Daria A. Shtal,&nbsp;Anastasia A. Korneeva,&nbsp;Elena V. Alexandrova,&nbsp;Alexander V. Aksenov","doi":"10.1016/j.tet.2025.134801","DOIUrl":"10.1016/j.tet.2025.134801","url":null,"abstract":"<div><div>Simple one-pot methods for the synthesis of polysubstituted quinolines and 3,3 ′-(arylmethylene) bis (1<em>H</em>-indoles) have been developed using a polyphosphoric acid-mediated alkynes hydrolysis strategy. Sequential addition of substituted alkynes to an <em>o</em>-nitro(<em>o</em>-aminophenyl)carbonyl compound under solvent-free conditions followed by cyclization in polyphosphoric acid afforded 15 diverse quinolines in good to excellent yields. Furthermore, a three-component reaction between aldehydes, acetylenes, and arylhydrazines provided a simple and rapid method for the synthesis of 3,3′-(arylmethylene)bis(1<em>H</em>-indoles) from readily available reagents.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"184 ","pages":"Article 134801"},"PeriodicalIF":2.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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