N6-α-叠氮乙酰辛酮亚胺：叠氮-炔环加成反应的合成及反应活性

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-09-13 DOI:10.1016/j.tet.2025.134946

Natalia V. Kalganova , Ivan A. Platonov , Alexander F. Smol'yakov , Ivan A. Godovikov , Ilya A. Cherepanov

引用次数: 0

摘要

提出了一种简便的制备方法，用于合成未知的N6-α-叠氮乙酰基辛酮亚胺，并对其在叠氮-炔环加成反应中的反应活性进行了研究。在CuAAC反应的基础上，合成了辛酮亚胺与受保护的葡萄糖、异香豆素和硫辛酸残基的缀合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

N6-α-azidoacetyl sydnone imines: Synthesis and reactivity in azide-alkyne cycloaddition reactions

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N6-α-azidoacetyl sydnone imines: Synthesis and reactivity in azide-alkyne cycloaddition reactions

A convenient preparative method for the synthesis of previously unknown N₆-α-azidoacetyl sydnone imines was developed, and their reactivity in azide – alkyne cycloaddition reactions was investigated. Based on CuAAC reactions, sydnone imine conjugates with protected glucose, isocoumarin, and a lipoic acid residue were synthesized.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.