cucl2介导的C(sp3)- h和C(sp3)- o氧化/醚双吲哚酰化-双吲哚基甲烷衍生物的合成

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-09-25 DOI:10.1016/j.tet.2025.134949

Chenglei Yang, Xiaotao Qin, Jinkai Hu, Bosen Wang, Jinhui Yang, Dianjun Li

引用次数: 0

摘要

在廉价和容易获得的CuCl2的参与下，在没有配体和氧化剂的情况下，开发了可见光诱导的吲哚和脂肪醚的串联C(sp3)-H氧化，C(sp3)-O裂解和Friedel - Crafts烷基化反应，提供了合成有用的3,3 ' -双吲哚甲烷衍生物，收率中等至较高。这种转化具有广泛的底物范围和良好的官能团相容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-light-enabled CuCl2-mediated tandem C(sp3)-H and C(sp3)-O oxidant/bisindolylation of ethers – Synthesis of bisindolylmethane derivatives

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Visible-light-enabled CuCl2-mediated tandem C(sp3)-H and C(sp3)-O oxidant/bisindolylation of ethers – Synthesis of bisindolylmethane derivatives

Under the participation of cheap and readily available CuCl₂, a visible light-induced tandem C(sp³)-H oxidation, C(sp³)-O cleavage and Friedel−Crafts alkylation of indoles and aliphatic ethers in the absence of ligand and oxidants is developed, affording synthetically useful 3,3′-bisindolylmethane derivatives in moderate to good yields. This transformation exhibits broad substrate scope and good functional group compatibility.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.