IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-12 DOI: 10.1016/j.talanta.2026.129402

Jiajia Wang , Lingling Ji , Yuyao Zhang , Yang Wang , Bingwei Ai , Jian Dong

{"title":"A SERS-active microneedle for detecting oxidative capacity and redox potential of rats with high glucose-induced stress","authors":"Jiajia Wang , Lingling Ji , Yuyao Zhang , Yang Wang , Bingwei Ai , Jian Dong","doi":"10.1016/j.talanta.2026.129402","DOIUrl":"10.1016/j.talanta.2026.129402","url":null,"abstract":"<div><div>To detect oxidative capacity and redox potential of organism simultaneously, a surface-enhanced Raman scattering-active microneedle was fabricated by integrating oxidative capacity and redox potential surface-enhanced Raman scattering probes in two grooves on an acupuncture needle, respectively. Different redox pairs solutions were used to assess the detection feasibility of the surface-enhanced Raman scattering-active microneedles. Oxidative capacity surface-enhanced Raman scattering probes, based on <em>p</em>-phenylenediamine, can discriminate minor changes in oxidative capacity, and redox potential surface-enhanced Raman scattering probes, based on an anthraquinone derivative, distinguish changes in redox potential of different redox pairs. Rats with or without high glucose-induced stress were utilized to evaluate the detection feasibility of the surface-enhanced Raman scattering-active microneedles in vivo. In different tissues, the two parameters show slight discrepancies. In the muscles of rats with high glucose-induced stress, no correlation was observed among oxidative capacity, redox potential, and blood glucose levels. The surface-enhanced Raman scattering-active microneedles would be a versatile tool for researches of oxidative capacity and redox potential in physiological and pathological processes.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"302 ","pages":"Article 129402"},"PeriodicalIF":6.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemiluminescent sensor based on copper nanosheets for the detection of sulfamethoxazole 基于铜纳米片的电化学发光传感器检测磺胺甲恶唑

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-13 DOI: 10.1016/j.talanta.2026.129403

Yuxia Luo , Jinfang Wang , Lan Luo , Le Li , Jixiang Liu , Xiangyuan Ouyang , Fangfang Chen

{"title":"Electrochemiluminescent sensor based on copper nanosheets for the detection of sulfamethoxazole","authors":"Yuxia Luo , Jinfang Wang , Lan Luo , Le Li , Jixiang Liu , Xiangyuan Ouyang , Fangfang Chen","doi":"10.1016/j.talanta.2026.129403","DOIUrl":"10.1016/j.talanta.2026.129403","url":null,"abstract":"<div><div>Sulfadimethoxine (SDM) is commonly used to inhibit bacterial growth, but its residual presence in food poses a potential risk to public health. Therefore, sensitive and accurate detection of SDM residues is of significant importance. In this study, a highly sensitive \"turn-on\" electrochemiluminescence (ECL) aptamer sensor was developed for sulfadimidine (SDM) detection using DNA nanosheet-templated copper nanoclusters (DNS-CuNCs) as the luminophores, while carboxylated multi-walled carbon nanotubes modified with 3-glycidoxypropyltrimethoxysilane (MWCNTs-COOH/GPTMS) acted as the electrode functionalization substrate. Additionally, aptamer-modified polydopamine nanospheres (PDAs-APT) were introduced into the system as ECL quenchers to realize target-induced \"turn-on\" ECL signal activation. A silanization modification strategy was employed to introduce abundant functional groups on the electrode surface, thereby enabling stable immobilization of DNS-CuNCs and enhancing electron transfer efficiency. Hybridization between PDAs-APT and the complementary DNA of DNS-CuNCs quenched the ECL signal, and the specific binding of SDM to PDAs-APT triggered the release of PDAs-APT from the hybrid system, thereby enabling the restoration of the ECL signal. The sensor exhibited a wide linear range from 10 fg mL<sup>−1</sup> to 500 ng mL<sup>−1</sup>, with a low detection limit of 4.23 fg mL<sup>−1</sup>. The ECL aptamer sensor demonstrated excellent selectivity against interfering antibiotics and showed good reproducibility with a relative standard deviation of 1.09 %. Moreover, the method was successfully applied to SDM detection in milk samples. These results indicate that the proposed ECL aptamer sensor offers advantages of simplicity, high sensitivity, and low cost, making it a promising tool for SDM residue detection in complex food matrices.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"302 ","pages":"Article 129403"},"PeriodicalIF":6.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver-needle-based solid phase microextraction coupled with constant flow desorption ionization for obtaining quasi-molecular ions of 1,2-Bis(2,4,6-tribromophenoxy) ethane: Enabling accurate mass spectrometry identification 基于银针的固相微萃取与恒流解吸电离相结合，用于获得1,2-二（2,4,6-三溴苯氧基）乙烷的准分子离子：实现准确的质谱鉴定。

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-09 DOI: 10.1016/j.talanta.2026.129384

Shuo Gao , Xiaoxuan Han , Xiaoxu Huo , XiaoFeng Dong , Chunguang Liu , Yong Tian

{"title":"Silver-needle-based solid phase microextraction coupled with constant flow desorption ionization for obtaining quasi-molecular ions of 1,2-Bis(2,4,6-tribromophenoxy) ethane: Enabling accurate mass spectrometry identification","authors":"Shuo Gao , Xiaoxuan Han , Xiaoxu Huo , XiaoFeng Dong , Chunguang Liu , Yong Tian","doi":"10.1016/j.talanta.2026.129384","DOIUrl":"10.1016/j.talanta.2026.129384","url":null,"abstract":"<div><div>Accurate mass spectrometric analysis of the emerging pollutant 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE) remains significantly challenging due to the difficulty in generating its molecular or quasi-molecular ions. This study developed a novel technique termed silver-needle-based solid-phase microextraction constant flow desorption ionization mass spectrometry (silver-needle-based SPME-CFDI-MS) for the highly efficient ionization and detection of BTBPE. By utilizing the silver needle as both a solid-phase microextraction fiber and a corona discharge electrode, this method enables preconcentration of BTBPE from water samples, followed by its desorption, ionization, and detection via CFDI-MS. During the CFDI process, corona discharge on the silver needle produces Ag<sup>+</sup>, while the flowing solvent desorbs BTBPE from its surface, resulting in the formation of BTBPE quasi-molecular ions ([BTBPE + Ag]<sup>+</sup>). The characteristic mass and tandem mass spectra of BTBPE were subsequently acquired. Under optimized parameters, the limit of detection for BTBPE reached 21 ng L<sup>−1</sup>, with a linear range from 0.10 to 3.5 μg L<sup>−1</sup> (R<sup>2</sup> > 0.9969). The intra-day (<em>n</em> = 8, c = 0.5 μg L<sup>−1</sup>) and inter-day (<em>n</em> = 3 per day for 5 days, c = 1.0 μg L<sup>−1</sup>) precision values were 9.2 % and 16.4 %, respectively. The method was successfully applied to detect trace BTBPE in real river water and soil samples, with spike recoveries of 80–120 % demonstrating its accuracy and practicality for environmental analysis.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"302 ","pages":"Article 129384"},"PeriodicalIF":6.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145964885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: The 23rd International Conference on flow injection analysis and related techniques (ICFIA2024). 第23届流动注射分析及相关技术国际会议（ICFIA2024）。

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-20 DOI: 10.1016/j.talanta.2026.129437

Chalermpong Saenjum, Kate Grudpan

引用次数: 0

Millifluidic ion-selective optodes with integrated optical detection for colorimetric quantification of urinary calcium 集成光学检测的微流离子选择光电器件用于尿钙的比色定量

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-04 DOI: 10.1016/j.talanta.2026.129358

Yonghao Li, Rebecca Goodhart, Aishwarya Patel, Xuewei Wang

{"title":"Millifluidic ion-selective optodes with integrated optical detection for colorimetric quantification of urinary calcium","authors":"Yonghao Li, Rebecca Goodhart, Aishwarya Patel, Xuewei Wang","doi":"10.1016/j.talanta.2026.129358","DOIUrl":"10.1016/j.talanta.2026.129358","url":null,"abstract":"<div><div>Measurement of urinary calcium concentration is essential for the diagnosis and management of various disorders related to calcium metabolism, including kidney stones, hypoparathyroidism, and hyperparathyroidism. Current testing protocols require patients to visit clinical laboratories or hospitals, and no at-home devices are currently approved for quantitative self-testing of urinary calcium. In this work, we report a low-cost and user-friendly colorimetric sensor for urinary calcium measurement. The sensor consists of a segment of sensing oil contained within a millifluidic channel, such as a pipette tip. The oil incorporates hydrophobic sensing chemicals typically used in ion-selective optodes, including a chromoionophore, an ion exchanger, and an ionophore. It is specially formulated to fully extract calcium ions from urine under exhaustive conditions, providing a highly sensitive response. The sensor exhibits a linear response for 0–10 mM calcium ions, enabling accurate diagnosis of both hypercalciuria and hypocalciuria. A custom-built absorbance detector, consisting of a paired light-emitting diode and photodetector, is attached to the pipette tip to measure the absorbance of the sensing oil and quantify calcium ions in urine. The colorimetric sensor is applied to five urine samples before and after calcium spiking. The calcium concentrations of the unspiked samples determined by the current method overall match those obtained by the reference methods although there are biases. The recovery rate ranges from 94 % to 103 % for the spiked samples, suggesting high reliability of the biphasic colorimetric sensor for high concentrations of urinary calcium. Given the cost of <20¢ for the chemicals and pipette tip for each test and the cost of < $50 for the custom-built optical detector, this sensing method holds promise for urinary calcium testing in resource-limited settings such as at patients’ homes and in clinics.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"302 ","pages":"Article 129358"},"PeriodicalIF":6.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unmasking hazardous compounds in cannabidiol-containing oils using planar bioassays and high-resolution mass spectrometry 使用平面生物测定和高分辨率质谱法揭示含大麻二酚油中的有害化合物

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2025-12-18 DOI: 10.1016/j.talanta.2025.129273

Annika Haase , Gertrud Morlock

{"title":"Unmasking hazardous compounds in cannabidiol-containing oils using planar bioassays and high-resolution mass spectrometry","authors":"Annika Haase , Gertrud Morlock","doi":"10.1016/j.talanta.2025.129273","DOIUrl":"10.1016/j.talanta.2025.129273","url":null,"abstract":"<div><div>Oils containing cannabidiol (CBD) produced from <em>Cannabis sativa</em> L. became popular due to their health benefits. They contain not only known but also unknown active compounds. Hence, for the first time, an effect-directed non-target screening of 13 CBD oils for hazardous compounds was performed using high-performance thin-layer chromatography coupled with highly efficient duplex and multiplex planar bioassays, providing 13 different biological or toxicological endpoints. Antimicrobial (against Gram-positive/-negative bacteria), anti-/estrogenic, anti-/androgenic, cytotoxic (against <em>Saccharomyces</em> and three different <em>Salmonella</em> strains), neurotoxic/-modulating, genotoxic, and mutagenic compounds were found in the CBD oils. Selected hazardous substance zones were automatically eluted from the chromatogram and analyzed by high-resolution mass spectrometry. The tentatively assigned hazardous substances were bought as reference standards, co-analyzed, and confirmed to be various cannabinoids, assumedly oxidized acylglycerides, the estrogenic contaminants dibutyl phthalate and diisobutyl phthalate, and the estrogenic and mutagenic mycotoxin zearalenone, including metabolites. For more sustainability, the CBD oil analysis was successfully performed with the miniaturized open-source 2LabsToGo-Eco, which makes effect-directed non-target screening affordable for everyone.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"302 ","pages":"Article 129273"},"PeriodicalIF":6.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic investigation of analyte protectants to overcome matrix effects for gas chromatographic analysis of tobacco alkaloids and primary aromatic amines across diverse matrices 在不同基质的烟草生物碱和伯胺气相色谱分析中克服基质效应的分析物保护剂的系统研究

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-03 DOI: 10.1016/j.talanta.2025.129343

Yaqiong Qin , Xiaoyu Wang , Lining Pan , Rana Tayyarah , Zhiguo Wang , Yu Liu , Ran Wan , Haijian Su , Xuejie Li , Li Chen , Huapeng Cui

{"title":"Systematic investigation of analyte protectants to overcome matrix effects for gas chromatographic analysis of tobacco alkaloids and primary aromatic amines across diverse matrices","authors":"Yaqiong Qin , Xiaoyu Wang , Lining Pan , Rana Tayyarah , Zhiguo Wang , Yu Liu , Ran Wan , Haijian Su , Xuejie Li , Li Chen , Huapeng Cui","doi":"10.1016/j.talanta.2025.129343","DOIUrl":"10.1016/j.talanta.2025.129343","url":null,"abstract":"<div><div>The application of analyte protectants (APs) is recognized as an effective and practical strategy to enhance analyte signals in matrix-free solutions and compensate for matrix effects (MEs) in gas chromatography (GC) analysis. However, systematic investigations into promising APs for basic analytes and elucidation of the underlying molecular mechanisms remain limited. In this study, two classes of basic analytes with diverse polarity and basicity, including tobacco alkaloids (TAs) and primary aromatic amines (PAAs), were selected as target analytes. A total of 29 candidates covering a broad range of polarity, basicity, and volatility were systematically evaluated to identify the promising APs for TAs and PAAs. According to individual and average analyte peak enhancement factors, several polyamines, including diethylenetriamine, tris(2-aminoethyl)amine, spermine, pentaethylenehexamine, and the diamine 1,11-diaminoundecane, were identified as the potential APs. Corresponding combinations of these APs for TAs and PAAs at optimized concentrations were validated to significantly reduce the limits of quantification from 1.58 to 307.85 to 1.26–43.43 ng/mL in solvent and improve recovery rates from 92.3 to 352.1 to 80.3–111.5 % in complex matrices. Consistent signal responses across diverse matrices further highlight the developed APs effectively overcome the MEs, ensuring the accurate and robust determinations in practical applications. Furthermore, density functional theory (DFT) calculations revealed that the superior enhancement effects of these APs are primarily attributed to lower interaction energies and stronger hydrogen-bonding interactions with silanol groups in the GC system.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"302 ","pages":"Article 129343"},"PeriodicalIF":6.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary analysis of pristine, UV-aged and extracted microplastics using single particle ICP-MS and OF2i-Raman spectroscopy 利用单颗粒ICP-MS和of2i -拉曼光谱对原始、紫外老化和提取的微塑料进行互补分析

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-07 DOI: 10.1016/j.talanta.2025.129339

Manuel Candussi , Christian Neuper , Raquel Gonzalez de Vega , Matthias Elinkmann , Harald Fitzek , Christian Hill , Patrizia Marie Schmidt , Svenja Seiffert , David Clases

{"title":"Complementary analysis of pristine, UV-aged and extracted microplastics using single particle ICP-MS and OF2i-Raman spectroscopy","authors":"Manuel Candussi , Christian Neuper , Raquel Gonzalez de Vega , Matthias Elinkmann , Harald Fitzek , Christian Hill , Patrizia Marie Schmidt , Svenja Seiffert , David Clases","doi":"10.1016/j.talanta.2025.129339","DOIUrl":"10.1016/j.talanta.2025.129339","url":null,"abstract":"<div><div>Microplastics are of growing concern due to their ubiquity and potential risks to ecosystems and human health. Their small size, chemical diversity, and coexistence with natural colloids make comprehensive analysis difficult. Here, we evaluate two emerging single particle techniques, single particle inductively coupled plasma-mass spectrometry (SP ICP-MS) and optofluidic force induction coupled with Raman spectroscopy (OF2i-Raman), for their ability to provide complementary information at single microplastic resolution. SP ICP-MS determined carbon mass per particle and enabled detection of degradation-induced trends in size and abundance, while OF2i-Raman identified polymer type and molecular changes via optical trapping and inelastic light scattering.</div><div>OF2i-Raman is a novel method in the field of microplastic research and was therefore first benchmarked by analysing mixed suspensions of polymethylmethacrylate (PMMA), polystyrene (PS), and polyamide-6 (PA-6), as well as PA-6 in a soil extract to assess selectivity under complex matrix conditions. Subsequently, both techniques were applied in parallel to study the UV-induced degradation of PA-6 and low-density polyethylene (LDPE) as relevant industrial polymers. SP ICP-MS detected longitudinal carbon loss and relative changes in particle sizes and numbers, while OF2i-Raman revealed polymer-specific structural alterations and detected spectral fingerprints even after extended irradiation.</div><div>Together, SP ICP-MS and OF2i-Raman link elemental mass with molecular identity, providing complementary insights into microplastic degradation. While SP ICP-MS remains confined to controlled laboratory experiments due to its limited selectivity and size range, OF2i-Raman extends the analytical window to complex matrices and mixed polymer systems.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"302 ","pages":"Article 129339"},"PeriodicalIF":6.1,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated sample preparation systems for food analysis: A mini-review 用于食品分析的自动样品制备系统：小型综述

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-12 DOI: 10.1016/j.talanta.2026.129395

Qiong Xue , Chang Liu , Xiao-Hua Zhou , Dezhao Kong , Jinghui Zhang , Wei Shen , Sheng Tang

引用次数: 0

Development and validation of an indirect competitive ELISA for cyenopyrafen detection using a novel monoclonal antibody 基于新型单克隆抗体的cyenopyrafen间接竞争性ELISA检测方法的建立与验证。

IF 6.1 1区化学

Talanta Pub Date : 2026-05-15 Epub Date: 2026-01-14 DOI: 10.1016/j.talanta.2026.129416

Tianyu Lan , Jiexin Zheng , Bo Xu , Kerui Dan , Chunlei Cao , Feng Sun , Qiyang Zhao , Yue He , Jing Li , Yongliang Cui , Yaohai Zhang

引用次数: 0

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