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An AIE fluorescence probe for ratiometric and selective detection of Sn2+ based on proton transfer. 基于质子转移的AIE荧光探针用于Sn2+的比例和选择性检测。
IF 5.6 1区 化学
Talanta Pub Date : 2025-10-01 Epub Date: 2025-04-11 DOI: 10.1016/j.talanta.2025.128078
Duo-Duo Hu, Guangnan Wei, Ping Yang, Dexin Fu, Kuiliang Li
{"title":"An AIE fluorescence probe for ratiometric and selective detection of Sn<sup>2+</sup> based on proton transfer.","authors":"Duo-Duo Hu, Guangnan Wei, Ping Yang, Dexin Fu, Kuiliang Li","doi":"10.1016/j.talanta.2025.128078","DOIUrl":"https://doi.org/10.1016/j.talanta.2025.128078","url":null,"abstract":"<p><p>Detecting Sn<sup>2+</sup> heavy metal ions is crucial for mitigating water pollution and safeguarding human health. This study involved the design and synthesis of a novel fluorescence probe, RTPE-IM, which is a combination of an aggregation-induced emission luminophore (TPE) and rhodamine B. The probe undergoes proton transfer in the presence of Sn<sup>2+</sup> ion, displaying high selectivity and a low detection limit of 0.121 μM. The synthesis and application of this molecule offer a potential strategy for preventing environmental health risks.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"293 ","pages":"128078"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiopep2 (Ang-2) peptide linked DNA walker assay for sensitive and accurate detection of glioma cell. Angiopep2 (Ang-2)肽链DNA walker试验灵敏准确地检测胶质瘤细胞。
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-30 DOI: 10.1016/j.talanta.2025.128903
Shaya Mahati, Xiaoyun Peng, Zhao Yin, Guangchao Li, Wenbin Li
{"title":"Angiopep2 (Ang-2) peptide linked DNA walker assay for sensitive and accurate detection of glioma cell.","authors":"Shaya Mahati, Xiaoyun Peng, Zhao Yin, Guangchao Li, Wenbin Li","doi":"10.1016/j.talanta.2025.128903","DOIUrl":"https://doi.org/10.1016/j.talanta.2025.128903","url":null,"abstract":"<p><p>Liquid biopsy has emerged as a promising alternative for glioma detection; however, the blood-brain barrier restricts the abundance of circulating tumor cells (CTCs) in peripheral blood, posing a significant challenge for sensitive CTCs-based diagnostics of glioma. To address this limitation, we present an Angiopep2 (Ang-2) peptide linked DNA walker assay for colorimetric glioma cell detection with high sensitivity and specificity. This system integrates Ang-2 and a cholesterol labeled tracker (cholesterol-tracker) as dual-targeting ligands, coupled with a DNA walker-mediated signal amplification strategy for enhanced sensitivity and specificity. Compared to conventional immunoassays relying on monoclonal antibodies, our platform demonstrates superior performance due to its preferential binding to intact glioma cells and the signal amplification induced by the λ-exonuclease-driven DNA walking mechanism. The biosensor achieved an exceptionally low detection limit of 0.12 cells/mL and exhibited strong anti-interference capabilities across multiple cell lines. Furthermore, the biosensor maintained ≥96 % of initial signal retained after 21 days at 4 °C (96.5 % ± 0.35, n = 3), with only marginal signal attenuation observed. Clinical validation using constructed serum samples revealed excellent agreement in glioma concentration calculated by the proposed sensing platform and added glioma cell concentrations. Collectively, our findings demonstrate that this sensing platform represents a rapid, sensitive, specific, and portable technology for the detection of U251 glioblastoma cells, with potential applications in clinical diagnostics of glioma.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 Pt A","pages":"128903"},"PeriodicalIF":6.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photoelectrochemical biosensors for cardiovascular disease biomarkers: Advances, challenges, and clinical prospects 用于心血管疾病生物标志物的光电化学生物传感器:进展、挑战和临床前景
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-30 DOI: 10.1016/j.talanta.2025.128929
Xiangmei Wang , Pei Song , Yuqi Ni , Ai-Jun Wang , Yadong Xue , Li-Ping Mei , Jiu-Ju Feng
{"title":"Photoelectrochemical biosensors for cardiovascular disease biomarkers: Advances, challenges, and clinical prospects","authors":"Xiangmei Wang ,&nbsp;Pei Song ,&nbsp;Yuqi Ni ,&nbsp;Ai-Jun Wang ,&nbsp;Yadong Xue ,&nbsp;Li-Ping Mei ,&nbsp;Jiu-Ju Feng","doi":"10.1016/j.talanta.2025.128929","DOIUrl":"10.1016/j.talanta.2025.128929","url":null,"abstract":"<div><div>With the aging of the population and changes in modern lifestyles, the prevalence of cardiovascular diseases (CVDs) continues to rise globally, posing a serious threat to human health. The optimal therapeutic window for treating severe CVDs such as acute myocardial infarction (AMI) is extremely narrow, limiting the treatment outcomes. The emergence of in vitro diagnostic technology has significantly improved the diagnostic compliance rate of AMI and elevated the treatment effects. In recent years, an emerging analytical method, photoelectrochemical (PEC) biosensor, has drawn much attention because of its excellent sensitivity, good stability, and easy operation. Their clinical translation is expected to shorten the screening and diagnosis cycle, extend the therapeutic window, and significantly benefit patients. Despite rapid progress in the past decade, existing reviews mainly focus on general PEC sensing principles or material innovations, while comprehensive analyses of disease-specific biomarker detection and translational challenges remain limited. This review addresses these gaps by systematically summarizing recent advances of PEC biosensors for CVDs biomarker detection, critically comparing detection strategies, and discussing opportunities for clinical application. We also look ahead at the key research needs, including multiplex detection, integration with wearable devices, and real-world validation, thereby offering new perspectives for advancing the practical application of PEC biosensors in CVDs diagnostics.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 ","pages":"Article 128929"},"PeriodicalIF":6.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145236276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review on advances in DNA-intercalators for sensor technologies: Mechanisms, applications, and innovations 传感器技术中dna插入器的研究进展:机制、应用和创新
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-30 DOI: 10.1016/j.talanta.2025.128926
Ruonan Wang, Baoshan He, Wenhong Zhao, Huali Jin, Min Wei, Ligen Wu
{"title":"A review on advances in DNA-intercalators for sensor technologies: Mechanisms, applications, and innovations","authors":"Ruonan Wang,&nbsp;Baoshan He,&nbsp;Wenhong Zhao,&nbsp;Huali Jin,&nbsp;Min Wei,&nbsp;Ligen Wu","doi":"10.1016/j.talanta.2025.128926","DOIUrl":"10.1016/j.talanta.2025.128926","url":null,"abstract":"<div><h3>Background</h3><div>DNA intercalators have attracted considerable attention in the field of sensor technology due to their unique ability to insert between base pairs of nucleic acids, resulting in measurable optical or electrochemical changes. Recent advancements in molecular biology, nanotechnology, and optoelectronic sensing have expanded the applications of DNA intercalators beyond anticancer drug development to include biosensing and environmental monitoring. They enable highly sensitive and specific detection of target molecules through fluorescence, colorimetric, and electrochemical signal transduction. However, comprehensive reviews on their role in sensing remain limited. This review summarizes their classification, mechanisms, recent biosensing applications, and future research directions.</div></div><div><h3>Results</h3><div>DNA-intercalators, a class of molecules capable of inserting between and specifically binding to DNA double-helix base pairs, have attracted attention for their wide range of applications in molecular biology, drug discovery, and detection technologies. This paper reviews the origin and mechanisms of action of DNA intercalators, with a particular focus on their classification and recent advances in analytical and biomedical applications. DNA-intercalators have shown significant value in sensor development, especially in heavy metal ion detection, specific nucleic acid sequence recognition, and drug screening through fluorescence, colorimetric, and electrochemical signal transduction. Finally, the article summarizes the limitations of current research and looks forward to the development of novel low-toxicity insertion agents and multi-target detection platforms.</div></div><div><h3>Significance</h3><div>This review is significant for promoting the development of DNA-intercalators and provide a reference for the research and application of DNA-intercalators.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 ","pages":"Article 128926"},"PeriodicalIF":6.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantifying endogenous and tracer-derived ketone bodies using a dual-label UHPLC-MS/MS method. 采用双标签UHPLC-MS/MS方法定量内源性和示踪衍生酮体。
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-30 DOI: 10.1016/j.talanta.2025.128919
Sandra Adámez-Rodríguez, Eric D Queathem, Abdirahman Hayir, María Luisa Marina, María Castro-Puyana, Patrycja Puchalska
{"title":"Quantifying endogenous and tracer-derived ketone bodies using a dual-label UHPLC-MS/MS method.","authors":"Sandra Adámez-Rodríguez, Eric D Queathem, Abdirahman Hayir, María Luisa Marina, María Castro-Puyana, Patrycja Puchalska","doi":"10.1016/j.talanta.2025.128919","DOIUrl":"https://doi.org/10.1016/j.talanta.2025.128919","url":null,"abstract":"<p><p>Acetoacetate (AcAc) and β-hydroxybutyrate (βOHB) are ketone bodies involved in energy metabolism, particularly during physiological states of glucose scarcity, such as fasting, exercise, and the implementation of a ketogenic diet. The production (ketogenesis) and utilization (ketolysis) of ketone bodies are dynamic processes that can be quantified using stable isotope-labeled tracers in metabolic tracing studies, necessitating precise and sensitive analytical methods for accurately measuring both labeled and unlabeled pools. Although UHPLC-MS/MS has recently emerged as a reliable tool for quantifying ketone bodies, its dependence on <sup>13</sup>C-labeled internal standards limits its utility in <sup>13</sup>C-based tracer studies. AcAc, in particular, poses challenges due to its chemical instability and the scarcity of authentic, stable, isotopically labeled internal standards. While the chemical reduction of AcAc to βOHB provides a solution, this necessitates a cumbersome desalting step. To overcome these limitations, we developed a novel approach using deuterated AcAc (d<sub>3</sub>-AcAc) and [3,4,4,4-d<sub>4</sub>]βOHB as internal standards for the simultaneous quantification of <sup>13</sup>C-labeled and unlabeled ketone bodies in biological samples. We optimized the synthesis of AcAc from ethyl-AcAc via base-catalyzed hydrolysis, achieving 99.2 ± 0.2 % purity at 60 °C for 3 h, as confirmed by <sup>1</sup>H NMR. Stability assessments in the extraction buffer and post-extraction serum samples confirmed the robustness of newly synthesized d<sub>3</sub>-AcAc for at least 5 h. A comparative analysis against the labor-intensive conventional method demonstrated superior precision, accuracy, and ease of application, enabling high-throughput metabolic and clinical studies. The optimized UHPLC-MS/MS method substantially improves metabolic tracing capabilities, enabling rapid and accurate investigation of ketone body tracing studies across various physiological and pathological conditions.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 Pt A","pages":"128919"},"PeriodicalIF":6.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target-silent self-driven DNA walker for small molecule detection with antibody immobilized on gold nanoparticles. 靶向沉默自驱动DNA行走器,用于金纳米颗粒固定抗体的小分子检测。
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-30 DOI: 10.1016/j.talanta.2025.128932
Han Pang, Qiang Zhao
{"title":"Target-silent self-driven DNA walker for small molecule detection with antibody immobilized on gold nanoparticles.","authors":"Han Pang, Qiang Zhao","doi":"10.1016/j.talanta.2025.128932","DOIUrl":"https://doi.org/10.1016/j.talanta.2025.128932","url":null,"abstract":"<p><p>A three-dimensional DNA walker offers an efficient strategy for sensitive detection of analytes with signal amplification. In this study, we report a target-silent, self-driven DNA walker for detecting small molecules (SMs). The DNA walker is composed of the Mg<sup>2+</sup>-dependent 8-17E DNAzyme walking strand conjugated with an SM (W-SM) and the three-dimensional walking track on gold nanoparticle (AuNP). The AuNP surface is functionalized with monoclonal antibody (mAb) and fluorescently labeled substrate of DNAzyme. Without target molecules, the W-SM is attached to the surface of AuNP via the antigen-antibody interaction. The DNAzyme catalytically cleaves the substrate, driving the W-SM autonomously moving along the walking track and generating high fluorescence. In the presence of SM target, the SM target competes with the W-SM in binding with the antibody on AuNP, and the DNA walker becomes inactive, causing fluorescence decline. This DNA walker enabled detection of digoxin and folic acid at concentrations as low as 0.2nM and 1 nM, respectively. It also performed well in diluted serum samples in responding to targets. This proposed strategy provides a new approach for constructing a DNA walker with a simple design for sensitive detection of small molecules in solution phase, showing promise in applications.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 Pt A","pages":"128932"},"PeriodicalIF":6.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recycling noble metal waste into catalytic wealth: In-situ SERS monitoring catalytic systems based on microporous hydrazone covalent organic frameworks materials. 将贵金属废物转化为催化财富:基于微孔腙共价有机骨架材料的原位SERS监测催化系统。
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-30 DOI: 10.1016/j.talanta.2025.128930
Qiuwen Huang, Yushi Chen, Rui Tan, Jiwei Tang, Yu Zeng, Panjie Li, Guoqi Zhang, Xiaojun Luo
{"title":"Recycling noble metal waste into catalytic wealth: In-situ SERS monitoring catalytic systems based on microporous hydrazone covalent organic frameworks materials.","authors":"Qiuwen Huang, Yushi Chen, Rui Tan, Jiwei Tang, Yu Zeng, Panjie Li, Guoqi Zhang, Xiaojun Luo","doi":"10.1016/j.talanta.2025.128930","DOIUrl":"https://doi.org/10.1016/j.talanta.2025.128930","url":null,"abstract":"<p><p>This study focuses on the development of an integrated analytical platform with in situ surface-enhanced Raman spectroscopy (SERS) monitoring capabilities, achieved through the design of a dual-functional, two-dimensional microporous covalent organic framework (COF). The hydrazone-functionalized COF not only exhibits selective recognition for Au(III)/Pt(IV) ions but also achieves efficient recovery of Au(III) from the leachate of waste electronic components, with a recovery efficiency of 95.73 %. By harnessing the enzyme-like catalytic activity of the COF@Au composite and the synergistic combination of COF's confinement effects with the localized surface plasmon resonance of Au nanoparticles, we created enhanced electromagnetic field regions on the material surface. This configuration enables real-time SERS tracking of reactant-product evolution during the reduction of 4-nitrothiophenol (4-NTP), with a reaction rate constant of 0.0181 s<sup>-1</sup>. This integrated platform combines precious metal recovery reactions, catalytic processes and in-situ SERS monitoring (\" recovery - catalysis - monitoring \"), establishing a new paradigm of green and real-time tracking analysis.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 Pt A","pages":"128930"},"PeriodicalIF":6.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lighting up the gold/silver nanoclusters via confinement effect for the quantification and discrimination of sulfur-containing compounds. 利用约束效应点亮金/银纳米团簇,用于含硫化合物的定量和鉴别。
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-30 DOI: 10.1016/j.talanta.2025.128935
Jin Mu, Xiqian Li, Yunjing Zang, Qiong Jia
{"title":"Lighting up the gold/silver nanoclusters via confinement effect for the quantification and discrimination of sulfur-containing compounds.","authors":"Jin Mu, Xiqian Li, Yunjing Zang, Qiong Jia","doi":"10.1016/j.talanta.2025.128935","DOIUrl":"https://doi.org/10.1016/j.talanta.2025.128935","url":null,"abstract":"<p><p>Sulfur-containing compounds (SCCs) play critical roles in physiological and pathological processes, but their abnormal levels are linked to diseases such as cancer and neurodegenerative diseases. Consequently, the development of accurate quantification and discrimination methods for SCCs is of great significance, providing a powerful tool for the early diagnosis of diseases. In the present study, we designed a confinement-enhanced fluorescence strategy utilizing zirconium-layered double hydroxide microspheres (ZrLDHMs) to encapsulate bimetallic AuAg nanoclusters (AuAgNCs), achieving remarkable enhancement in fluorescence properties including emission intensity, quantum yield, and fluorescence lifetime. Capitalizing on the redox activity of 2,6-dichlorophenol indophenol (DCIP) and the reducing ability of SCCs, a novel dual-mode (fluorescence/colorimetry) sensing platform was constructed based on ZrLDHMs@AuAgNCs for rapid SCCs detection. The fabricated sensor exhibited high sensitivity toward five SCCs (GSH, Cys, MPA, Na<sub>2</sub>S, and Na<sub>2</sub>SO<sub>3</sub>). Taking GSH as a representative, the sensor demonstrated limit of detection of 0.64 μM (fluorescence) and 0.09 μM (colorimetry) with a linear range of 2-70 μM at pH 7.0. Furthermore, by leveraging the differences in the reduction capabilities of DCIP among various types of SCCs, different responses are generated on the sensor array, thereby forming \"fingerprint\" features. Based on the extracted fingerprint features, the sensor array enabled rapid discrimination of multiple SCCs with high specificity. It was successfully applied to discriminate different types of SCCs in real serum and urine samples. Notably, this work not only demonstrates ZrLDHMs as effective confinement matrices for metal nanoclusters fluorescence enhancement, but also establishes a versatile sensing platform for the quantification and discrimination of SCCs, offering a versatile tool for clinical diagnostics.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 Pt A","pages":"128935"},"PeriodicalIF":6.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface-doped Ru over WO3 nanocubes for highly selective and ppb-concentration 1-octen-3-ol sensing. 表面掺杂钌在WO3纳米立方体上的高选择性和ppb浓度1-辛烯-3-醇传感。
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-30 DOI: 10.1016/j.talanta.2025.128933
Tingting Wang, Xinhua Zhao, Zhenxu Li, Yi Zhang, Zhu Zhang, Dachi Yang
{"title":"Surface-doped Ru over WO<sub>3</sub> nanocubes for highly selective and ppb-concentration 1-octen-3-ol sensing.","authors":"Tingting Wang, Xinhua Zhao, Zhenxu Li, Yi Zhang, Zhu Zhang, Dachi Yang","doi":"10.1016/j.talanta.2025.128933","DOIUrl":"https://doi.org/10.1016/j.talanta.2025.128933","url":null,"abstract":"<p><p>The newly-emerged gas sensing detection of 1-octen-3-ol biomarker is expected to indirectly monitor foodborne illnesses caused by Salmonella-contaminated meat, which requires high selectivity and a ppb-concentration detection limit. Here, surface-doped ruthenium over tungsten oxide nanocubes (Ru/WO<sub>3</sub> NCBs) have been synthesized by a wet-chemical approach for highly selective and ppb-concentration 1-octen-3-ol sensing. As-prepared Ru/WO<sub>3</sub> NCBs exhibit a polycrystalline structure and consist of NCBs that have an average side length of ∼131 nm, and the Ru/WO<sub>3</sub> NCBs show a high sensing response toward 5 ppm 1-octen-3-ol (R<sub>a</sub>/R<sub>g</sub> = 406), excellent selectivity, 50 ppb detection limit, 70 % relative humidity tolerance, and 54 days stability at 220 °C. The excellent sensing performance might be attributed to the electronic and chemical sensitization of Ru, which thickens the electron depletion layer and increases adsorbed oxygen to promote interfacial electron transfer and 1-octen-3-ol oxidation. Practically, Ru/WO<sub>3</sub> NCBs have been integrated into a sensing device to simulate detecting 1-octen-3-ol, which has the potential for Salmonella detection in the future.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 Pt A","pages":"128933"},"PeriodicalIF":6.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated chemometric and machine learning approaches to study the properties of pure and adulterated edible oils. 综合化学计量学和机器学习方法研究纯和掺假食用油的性质。
IF 6.1 1区 化学
Talanta Pub Date : 2025-09-29 DOI: 10.1016/j.talanta.2025.128925
Shruti O Varma, Ajay L Vishwakarma, M R Sonawane, Ajay Chaudhari
{"title":"Integrated chemometric and machine learning approaches to study the properties of pure and adulterated edible oils.","authors":"Shruti O Varma, Ajay L Vishwakarma, M R Sonawane, Ajay Chaudhari","doi":"10.1016/j.talanta.2025.128925","DOIUrl":"https://doi.org/10.1016/j.talanta.2025.128925","url":null,"abstract":"<p><p>The adulteration of pure edible oils, particularly with cost-effective oils like palm oil, has become a significant concern due to its detrimental impact on oil quality and human health. This study examines how palm oil adulteration affects the dielectric, physical, and chemical properties of groundnut and sunflower oils. Additionally, this study explores the nutritional differences between pure and adulterated oils, highlighting potential risks to consumers. Microwave analysis showed decreased dielectric constant and loss in groundnut and sunflower oils after palm oil blending. Chemical parameters and fatty acid composition confirmed adulteration effects and potential health risks. To ensure the accuracy and reliability of our findings, we applied several chemometric methods, including Hierarchical Cluster Analysis (HCA), Principal Component Analysis (PCA), Multiple Linear Regression (MLR), and Artificial Neural Networks (ANN) to detect adulteration in oils. Among these, ANN and MLR were compared for predicting the dielectric constant. The results showed that ANN performed much better than MLR, explaining R<sup>2</sup> value of 0.94 in groundnut oil and 0.96 in sunflower oil, proving it to be a more accurate method for assessing oil quality. The features that made the ANN model work better were found using SHAP analysis. The result of the SHAP value shows that the refractive index (RF) in groundnut oil and the saponification (SAP) value in sunflower oil are the most influential predictors of dielectric constant, as both parameters vary significantly with adulteration. This finding demonstrates a powerful and accurate approach for detecting adulteration and assessing the quality of edible oils.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"298 Pt A","pages":"128925"},"PeriodicalIF":6.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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