Talanta最新文献_第10页

Highly efficient and broad-spectrum antibacterial carbon dots combat antibiotic resistance. 高效、广谱的抗菌碳点可对抗抗生素耐药性。

IF 5.6 1区化学

Talanta Pub Date : 2025-01-01 Epub Date: 2024-09-19 DOI: 10.1016/j.talanta.2024.126926

Huimin Miao, Panyong Wang, Jie Wu, Xinlu Li, Yuwei Du, Haiyang Yan, Qiannan You, Wenfei Dong, Li Li

{"title":"Highly efficient and broad-spectrum antibacterial carbon dots combat antibiotic resistance.","authors":"Huimin Miao, Panyong Wang, Jie Wu, Xinlu Li, Yuwei Du, Haiyang Yan, Qiannan You, Wenfei Dong, Li Li","doi":"10.1016/j.talanta.2024.126926","DOIUrl":"10.1016/j.talanta.2024.126926","url":null,"abstract":"Bacterial infections have become a major global public health issue, particularly with the emergence of multidrug-resistant strains. Therefore, developing non-antibiotic antimicrobial agents is crucial for treating drug-resistant bacterial infections. Building on previous research into natural products as novel antibacterial agents, this study synthesized curcumin-derived carbon dots using curcumin and ethylenediamine as raw materials through a hydrothermal method. The resulting carbon dots not only improved the water solubility and stability of curcumin but also exhibited highly efficient broad-spectrum antibacterial activity. Detailed investigations into the antibacterial performance and mechanisms of the carbon dots were conducted through experiments such as minimum inhibitory concentration (MIC) determination, live/dead bacterial staining, morphological studies, nucleic acid concentration detection, and reactive oxygen species (ROS) detection. The results indicated that the carbon dots significantly damaged the structural integrity of bacteria and generated large amounts of ROS. They exhibited remarkable antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and effectively inhibited drug-resistant MRSA. Their antibacterial efficacy was notably superior to that of broad-spectrum antibiotics such as chloramphenicol and Sulfadiazine. This study highlights the potential application of curcumin-derived carbon dots in combating bacterial infections and provides valuable insights for developing novel antibacterial agents derived from natural products.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"281 ","pages":"126926"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ultrasensitive electrochemical sensor for the simultaneous detection of baicalin and baicalein in pharmaceuticals and serum samples.

IF 5.6 1区化学

Talanta Pub Date : 2024-12-18 DOI: 10.1016/j.talanta.2024.127414

Xin Zhang, Rui Liu

{"title":"An ultrasensitive electrochemical sensor for the simultaneous detection of baicalin and baicalein in pharmaceuticals and serum samples.","authors":"Xin Zhang, Rui Liu","doi":"10.1016/j.talanta.2024.127414","DOIUrl":"https://doi.org/10.1016/j.talanta.2024.127414","url":null,"abstract":"Developing an accurate and ultrasensitive method for the simultaneous detection of baicalin and baicalein, two key flavonoid from Scutellaria baicalensis, is critical, particularly in the context of traditional Chinese medicine. This study focuses on an innovative electrochemical approach, utilizing a biochar (BC)/ZIF-67/MnCo2O4 composite, which was fabricated via a combination of ultrasonic, calcination, and hydrothermal treatments. The resulting BC/ZIF-67/MnCo2O4 electrode exhibits exceptional sensitivity, with linear response ranges of 0.01 μM-400 μM. The limits of detection (LOD) for baicalein and baicalin were as low as 0.056 nM and 0.49 nM, respectively. The practical evaluations in serum and Scutellaria baicalensis demonstrate high recovery rates of 93.65 %-95.25 % for baicalein and 98.23 %-101.52 % for baicalin, with relative standard deviations below 3.99 % and 2.92 %, respectively. This study not only presents a promising technique for quality control in traditional Chinese medicine but also expands the potential applications of BC/ZIF-67/MnCo2O4 composites in electrochemical sensing, paving the way for applications in food safety monitoring and herbal medicine standardization.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127414"},"PeriodicalIF":5.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A mitochondrial targeted fluorescent probe for imaging nitroreductase activity and photodynamic therapy in tumor cells.

IF 5.6 1区化学

Talanta Pub Date : 2024-12-18 DOI: 10.1016/j.talanta.2024.127392

Ya-Ting Bao, Hai-Bo Mao, Ke-Wei Lei, Jing-Bo Hu, Jing Huang

{"title":"A mitochondrial targeted fluorescent probe for imaging nitroreductase activity and photodynamic therapy in tumor cells.","authors":"Ya-Ting Bao, Hai-Bo Mao, Ke-Wei Lei, Jing-Bo Hu, Jing Huang","doi":"10.1016/j.talanta.2024.127392","DOIUrl":"https://doi.org/10.1016/j.talanta.2024.127392","url":null,"abstract":"The hypoxic environment in tumors is closely linked to tumor structure, function, dissemination, invasion, metastasis, and drug resistance. Nitroreductase (NTR) is often recognized as a biomarker to evaluate the hypoxia degree for tumor cells. Traditional detection methods such as PET, MRI and multispectral photoacoustic tomography have limitations. Fluorescent probes have garnered attention due to their high sensitivity, rapid response, specificity, and non-invasive nature. In this study, we introduced a novel small molecule fluorescent probe, T-TPE-NO2, designed with an AIE molecular framework TPE and successfully targeted to the mitochondria of tumor cells. The probe had high selectivity and could detect NTR activity in a broad pH range. Additionally, the probe exhibits high sensitivity with a LOD of 46.3 ng/mL. Under tumor NTR, the probe emitted strong fluorescence signals and generated a substantial amount of reactive oxygen species upon laser irradiation, thereby inducing tumor cell death and enabling photodynamic therapy. The synthesis, structural and morphological characterization of the probe were rigorously validated. Experimental results demonstrate that T-TPE-NO2 exhibited high sensitivity and selectivity for tumor cells, highlighting its potential application in photodynamic therapy. This research offers a new approach for the detection and treatment of tumor hypoxia.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127392"},"PeriodicalIF":5.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient extraction and analysis method for lead-containing nanoparticles in complex biological samples to eliminate "false" interferences by using SP-ICP-MS.

IF 5.6 1区化学

Talanta Pub Date : 2024-12-17 DOI: 10.1016/j.talanta.2024.127372

Qinfei Zhou, Lihong Liu, Junhui Zhang, Haozhong Tian, Hua Guo, Zhenhua Wang, Yong Liang, Bin He, Ligang Hu, Guibin Jiang

{"title":"Efficient extraction and analysis method for lead-containing nanoparticles in complex biological samples to eliminate \"false\" interferences by using SP-ICP-MS.","authors":"Qinfei Zhou, Lihong Liu, Junhui Zhang, Haozhong Tian, Hua Guo, Zhenhua Wang, Yong Liang, Bin He, Ligang Hu, Guibin Jiang","doi":"10.1016/j.talanta.2024.127372","DOIUrl":"https://doi.org/10.1016/j.talanta.2024.127372","url":null,"abstract":"Metal-containing nanoparticles (MNPs) ubiquitously exist in the environment and organisms, playing distinct roles in the fate and toxicity of metals. However, the extraction and analysis of the MNPs in biological samples is still a great challenge and the interferences of other metal species and complex matrices remains unclear. In this work, we established a method for efficient extraction and accurate analysis of MNPs in biological samples to eliminate the interference caused by metal ions and biological matrices based on the alkali extraction and single particle mode inductively coupled plasma mass spectrometry (SP-ICP-MS). Obvious interference signals of lead-containing nanoparticles (PbNPs) were found in various biological matrices (liver, brain, bile, intestine, stomach), causing false positive results or overestimation of PbNPs. Then, a novel strategy using EDTA and ultrasonic during the TMAH extraction process were proposed to successfully eliminate the interferences due to the strong and competitively binding of EDTA to Pb ions, which was identified as ionic signals in SP-ICP-MS and resulted in the elimination of interferences. Finally, this method was successfully applied for the extraction, characterization and quantification of PbNPs in different biological tissues collected near a power plant, revealing the occurrence of PbNPs in stomach, intestine and liver tissues and indicating their oral exposure and potential translocation. This method could be universally applied for the efficient extraction and accurate analysis of MNPs in biological samples and thus provided a reliable and powerful tool for the investigation of the occurrence, fate and toxicity of MNPs in environmental and organisms.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127372"},"PeriodicalIF":5.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The coordination effect of organic ligands in Ce-MOF brings about atomically dispersed Fe in CeO₂ for TAC detection in commercial samples. Ce-MOF 中有机配体的配位效应使 Fe 原子分散在 CeO2 中，用于检测商业样品中的 TAC。

IF 5.6 1区化学

Talanta Pub Date : 2024-12-16 DOI: 10.1016/j.talanta.2024.127405

Lulu Cui, Houshen Li, Weijie Shi, Yingying Jing, Shuhong Sun, Shiyun Ai, Zeyi Guo

引用次数: 0

Eco-sustainable point-of-care devices: Progress in paper and fabric based electrochemical and colorimetric biosensors.

IF 5.6 1区化学

Talanta Pub Date : 2024-12-16 DOI: 10.1016/j.talanta.2024.127397

P Lingadharini, Debashis Maji

{"title":"Eco-sustainable point-of-care devices: Progress in paper and fabric based electrochemical and colorimetric biosensors.","authors":"P Lingadharini, Debashis Maji","doi":"10.1016/j.talanta.2024.127397","DOIUrl":"https://doi.org/10.1016/j.talanta.2024.127397","url":null,"abstract":"Monitoring real-time health conditions is a rinsing demand in a pandemic prone era. Wearable Point-of-Care (POC) devices with paper and fabric-based sensors are emerging as simple, low-cost, portable, and disposable analytical tools for development of green POC devices (GPOCDs). Capabilities of passive fluid transportation, compatibility with biochemical analytes, disposability and high degree of tunability using vivid device fabrication strategies enables development of highly sensitive and economically feasible POC sensors in particularly post COVID-19 pandemic outbreak. Herein we focus mainly on development of biosensors for testing body fluids in the last 5 years using microfluidic technique through electrochemical and colorimetric principle which forms the two most competing sensing techniques providing quantitative and qualitative assessment modalities respectively and forms almost 80 % of the diagnostic platform worldwide. Present review highlights use of these popular substrates as well as various fabrication strategies for realization of GPOCDs ranging from costly and highly sophisticated photolithography to low cost, non conventional techniques like use of correction ink or marker based devices to even novel pop-up/origami induced patterning techniques. Insights into the advancements in colorimetric technique like distance, count or even text based semi-quantitative read-out modality as a on-hand diagnostic information has also been provided. Finally, future outlooks with other interdisciplinary modalities like use of novel materials, incorporation of digital tools like artificial intelligence (AI), machine learning (ML) and strategies for sensitivity and reliability improvement of future GPOCDs have also been discussed.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127397"},"PeriodicalIF":5.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic photoelectrochemical transistor based on titanium dioxide nanorods for detection of Microcystin-LR.

IF 5.6 1区化学

Talanta Pub Date : 2024-12-16 DOI: 10.1016/j.talanta.2024.127401

Jiahe Chen, Jiaxin Lv, Yue Liu, Jia-Hao Chen, Xue Wang, Hong Zhou

引用次数: 0

Covalent organic framework-based solid phase microextraction coupled with electrospray ionization mass spectrometry for the quantitative assessment of abnormal bile acids by triclosan exposure in mice.

IF 5.6 1区化学

Talanta Pub Date : 2024-12-16 DOI: 10.1016/j.talanta.2024.127398

Xinye Shi, Yuandi Xue, Yuxin Tu, Canrong Chen, Yajing Zhang, Zian Lin, Zongwei Cai

{"title":"Covalent organic framework-based solid phase microextraction coupled with electrospray ionization mass spectrometry for the quantitative assessment of abnormal bile acids by triclosan exposure in mice.","authors":"Xinye Shi, Yuandi Xue, Yuxin Tu, Canrong Chen, Yajing Zhang, Zian Lin, Zongwei Cai","doi":"10.1016/j.talanta.2024.127398","DOIUrl":"https://doi.org/10.1016/j.talanta.2024.127398","url":null,"abstract":"Bile acids, a representative diagnostic indicator of liver function, are used to visualize the extent of liver injury. Numerous studies have shown that triclosan (TCS) exposure leads to abnormal bile acid metabolism. As a result, there is a requirement to develop a fast and smart means to quantitatively monitor abnormal bile acids from exposure to triclosan in bio-sample. In this work, solid-phase microextraction (SPME) probes of sea urchin-like covalent organic frameworks (COF) were in situ synthesized on steel needles by using 1,3,5-tris(4-aminophenyl)benzene (TAPB) and 2,5-dimethoxybenzene-1,4-dicarboxaldehyde (DMTP) as two organic units and employed for extraction of bile acids. This TAPB-DMTP-COF-SPME possessed an excellent specified surface area (3351 m2 g-1) and a high regular porosity (∼3.6 nm), which was an ideal adsorbent to concentrate bile acids efficiently. The created probe, together with electrospray ionization mass spectrometry (ESI/MS), proved to be a fast and specific assay for the detection of bile acids in bio-samples. The proposed method had a low limitation of detection (0.03 μg L-1), good linearity (R2 ≥ 0.9931), wide linear range (0.10-1000.00 μg L-1) and excellent enrichment factor (63.60-252.00). Based on these excellent properties, it was successful application for the analyzing of bile acids in mice liver and feces, demonstrating the great potential of TAPB-DMTP-COF-SPME-ESI/MS in bile acids detection and liver injury diagnosis.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127398"},"PeriodicalIF":5.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemiluminescence immunosensor using a lanthanum-based metal-organic framework as signal probe and Cu₂MoS₄ as a co-reaction promoter for the sensitive detection of anti-Müllerian hormone.

IF 5.6 1区化学

Talanta Pub Date : 2024-12-16 DOI: 10.1016/j.talanta.2024.127406

Jing Li, Shenglan Hu, Lingling Zheng, Lixin Xu, Yusheng Wu, Biyang Deng

{"title":"Electrochemiluminescence immunosensor using a lanthanum-based metal-organic framework as signal probe and Cu2MoS4 as a co-reaction promoter for the sensitive detection of anti-Müllerian hormone.","authors":"Jing Li, Shenglan Hu, Lingling Zheng, Lixin Xu, Yusheng Wu, Biyang Deng","doi":"10.1016/j.talanta.2024.127406","DOIUrl":"https://doi.org/10.1016/j.talanta.2024.127406","url":null,"abstract":"In this study, we used meso-tetra (4-carboxyphenyl) porphyrin (TCPP) as an organic ligand to modify a lanthanide-based metal-organic framework as an electrochemiluminescence (ECL) platform to sensitively detect anti-Müllerian hormone (AMH). La-MOF amplified the ECL signal by suppressing the aggregation-caused quenching created by TCPP self-aggregation. Utilizing the reversible cycling of the mixed-valence transition metal ion (Cu+/Cu2+ and Mo4+/Mo6+) and the electrical conductivity of Cu2MoS4 and silver nanoparticle (AgNP), Cu2MoS4-AgNP as a dual co-reaction promoter constantly generated sulfate radical anions (SO4•-) and thus amplified the ECL signal. Based on this strategy, we built a sandwich-type ECL immunosensor for the sensitive detection of AMH with a linear range of 1 × 10-4 to 50 ng/mL and a limit of detection of 24 fg/mL. This study provides a novel approach for the sensitive and selective detection of AMH, demonstrating its high potential and practical value for the sensitive detection of AMH.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127406"},"PeriodicalIF":5.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrothermal desolvation-enhanced microplasma optical emission spectrometry for sensitive determination of Cd, Zn Pb and Mn in environmental water samples. 电热去溶增强微等离子体光发射光谱法灵敏测定环境水样中的镉、锌、铅和锰。

IF 5.6 1区化学

Talanta Pub Date : 2024-12-16 DOI: 10.1016/j.talanta.2024.127373

Ji-Ying Cai, Jia-Min Xu, Hao Shen, Jian-Hua Wang, Yong-Liang Yu

{"title":"Electrothermal desolvation-enhanced microplasma optical emission spectrometry for sensitive determination of Cd, Zn Pb and Mn in environmental water samples.","authors":"Ji-Ying Cai, Jia-Min Xu, Hao Shen, Jian-Hua Wang, Yong-Liang Yu","doi":"10.1016/j.talanta.2024.127373","DOIUrl":"https://doi.org/10.1016/j.talanta.2024.127373","url":null,"abstract":"Herein, a novel electrothermal desolvation (ED) introduction approach is developed to enhance the analytical sensitivity of the point discharge (PD)-based microplasma-optical emission spectrometric (PD-MIP-OES) system for detecting trace Cd, Zn, Pb and Mn in environmental water samples. Liquid samples are converted into aerosols through a miniature ultrasonic nebulizer, and subsequently desolvated by electric heating at 350 °C. The analytes obtained after condensation (referring to the smaller apertures aerosols and volatile analytes after ED and condensation) are excited and detected by PD-MIP-OES. For a 160 μL liquid sample, analysis is completed within 10 s, achieving a desolvation efficiency of 93 %. Under the optimized conditions, the detection limits for Cd, Zn, Pb and Mn are 1.3, 1.2, 2.4 and 2.1 μg L-1, respectively. Compared to traditional direct ultrasonic nebulization introduction, sensitivity increases by 17, 12, 10 and 14 times, respectively. The accuracy and practicality of the proposed method are verified by measuring certified reference material and several real water samples. The ED-enhanced PD-MIP-OES device presented is compact, easy to operate, and capable of rapid analysis, which provides a convenient and reliable tool for the field analysis of Cd, Zn, Pb and Mn in environmental water samples.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127373"},"PeriodicalIF":5.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0