Talanta最新文献

{"title":"An integrated and multifunctional homemade cell sensor platform based on Si-d-CQDs and CRISPR-Cas12a for CD31 detection during endothelial-to-mesenchymal transition","authors":"Guolin Yuan ,&nbsp;Dongliang Cheng ,&nbsp;Jian Huang ,&nbsp;Meifang Wang ,&nbsp;Xianru Xia ,&nbsp;He An ,&nbsp;Fei Xie ,&nbsp;Xiandong Li ,&nbsp;Jiayi Chen ,&nbsp;Yijun Tang ,&nbsp;Chunyan Peng","doi":"10.1016/j.talanta.2025.127612","DOIUrl":"10.1016/j.talanta.2025.127612","url":null,"abstract":"<div><div>Endothelial-to-mesenchymal transition (EndMT) plays a crucial role in the initiation and progression of atherosclerosis and various disease processes. Cluster of differentiation 31 (CD31) is a significant marker in EndMT. Detecting CD31 is essential for early-stage monitoring of EndMT and diagnosing atherosclerosis. Herein, we propose a homemade electrochemical array sensor comprising four electrodes, applied for cell cultivation, electrical stimulation, and simultaneous electrochemical detection, offering a three-in-one approach for CD31 detection during EndMT. To enhance the analytical performance of the cell sensor, indium tin oxide/chitosan-MXene/polyaniline (ITO/CS-MXene/PANI) composites were synthesized. The synthesis process involved the polymerization of PANI on the surface of the CS-MXene-modified ITO electrode, resulting in the creation of highly biocompatible active sites for cell immobilization. Si-d-CQDs@acDNA-Apt_CD31-Fc, with exceptional photophysical and chemical properties, was integrated into the array sensor setup, which enabled the dual-mode detection of fluorescent and electrochemical signals in cultured cells. A CRISPR-Cas12a system was employed to cleave Si-d-CQDs@acDNA-Apt_CD31-Fc. Subsequently, the fragmented Fc molecules were enriched via electrochemistry to further amplify the electrochemical signals. Through the unique combination of programmable Si-d-CQDs@acDNA-Apt_CD31-Fc, the CRISPR-Cas12a system, and voltage enrichment, a novel “signal-on-off-super on” signal amplification strategy was developed. The cell sensor exhibited a wide linear range from 1 × 10¹ particles mL⁻¹ to 1 × 10⁶ particles mL⁻¹ (<em>R</em>² = 0.9912) and a detection limit of 4 particles mL⁻¹. The proposed strategy presents a promising approach for developing CRISPR-Cas12a-based tools for detecting various stages of EndMT and opens a new window for dual-mode analysis applications.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127612"},"PeriodicalIF":5.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient enrichment and sensitive determination of endocrine disruptors in PPCPs by novel magnetic covalent organic framework extraction coupled with HPLC-MS/MS","authors":"Zheng Hu ,&nbsp;Yuhang Yang ,&nbsp;Zhe Li ,&nbsp;Qiuying Tao ,&nbsp;Yinghong Huang ,&nbsp;Xian Wang","doi":"10.1016/j.talanta.2025.127667","DOIUrl":"10.1016/j.talanta.2025.127667","url":null,"abstract":"<div><div>Endocrine-disrupting chemicals (EDCs) are a growing class of pollutants commonly found in environmental matrices due to their extensive use in pharmaceuticals and personal care products (PPCPs). In this study, a novel magnetic covalent organic framework (COF), Fe₃O₄–COOH@TFP-BHBD, was successfully synthesized and utilized as an adsorbent for magnetic solid-phase extraction (MSPE) of EDCs from PPCPs. The core-shell structured adsorbent demonstrated a high specific surface area, strong magnetic responsiveness and excellent stability. A COF-MSPE-high-performance liquid chromatography-tandem mass spectrometry (COF-MSPE-HPLC-MS/MS) method was developed for the quantitative analysis of EDCs in PPCPs. Under the optimized condition, the detection and quantification limits of this method reached as low as 0.001–0.007 ng/mL and 0.004–0.025 ng/mL, respectively. This method was validated and proven capable to analyze real PPCP samples, while the spiked recovery rates in ranged from 85.62 to 107.83 % with RSD of 2.28–8.58 %. Moreover, the adsorption mechanism was investigated using density functional theory (DFT) calculations. The DFT results revealed that the efficient enrichment capacity of Fe₃O₄–COOH@TFP-BHBD for EDCs can be attributed to π-π interactions and hydrogen bondings. This proposed method provides excellent adsorption ability and sensitivity for the extraction and precise detection of EDCs in PPCPs.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127667"},"PeriodicalIF":5.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorimetry/fluorescence dual-signal sensing system based on peptide nanotubes activating hemin and PPIX for sensitive detection of tannic acid","authors":"Rong Tang,&nbsp;Chenglin Zhang,&nbsp;Baolian Liu,&nbsp;Yujie Kang,&nbsp;Ya Wang,&nbsp;Xiupei Yang","doi":"10.1016/j.talanta.2025.127663","DOIUrl":"10.1016/j.talanta.2025.127663","url":null,"abstract":"<div><div>Recently, it has become valuable to develop strategies based on multi-mode sensors to detect analytes related to human health, food safety and environmental pollution. In this study, KL@PPIX-hemin composite prepared by immobilizing hemin and protoporphyrin IX (PPIX) on self-assembled peptide nanotubes (PNTs) through multiple non-covalent interactions were used for colorimetric/fluorescent dual-mode sensing of tannic acid (TA). PNTs as a carrier can provide the hydrophobic microenvironment for hemin and PPIX to protect them from dimerization, thus activating their respective peroxidase-mimicking activity and fluorescence emission. Further experiments show that the composite could catalyze H₂O₂ to oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to generate blue ox-TMB, which could exactly quench the emission of PPIX by inner filter effect. The added TA can reduce ox-TMB to TMB and further turn on the fluorescence of system. A colorimetric/fluorescent dual-mode sensing system for TA was thus constructed and a low limit of detection (13.2 nM) was obtained. In addition, the analytical strategy has been successfully applied to accurate TA determination in actual tea samples. The method was also combined with smartphone to achieve visual detection of TA, which provides a broad prospect for portable and rapid tannic acid analysis.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127663"},"PeriodicalIF":5.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CuSeO3@f-CNFs: A superoxide nanozyme for the selective nanomolar determination of the key cardiovascular biomarker, Glutathione","authors":"M.G. Gopika ,&nbsp;Beena Saraswathyamma ,&nbsp;Mani Govindasamy","doi":"10.1016/j.talanta.2025.127621","DOIUrl":"10.1016/j.talanta.2025.127621","url":null,"abstract":"<div><div>Nanocomposites that mimic the characteristics of enzymes, commonly as nanozymes, can function as an efficient sensing material with high selectivity towards the targeted biological macromolecule. These nanozymes overcome of the challenges that arise when using natural enzymes as sensing material. This study presents a novel nanozyme, Copper Selenite (CuSeO₃) nanoparticles mounted on f-CNF, to electrochemically determine a potential cardiovascular biomarker, Glutathione (GSH). The choice of this material is due to the well-known ability of GSH to form a complex with copper. When a Cu ion enters a healthy cell, it quickly forms a complex with GSH, which then moves to another storage molecule: either a metalloprotein or a chelator. CNF was functionalized using acid to generate functionalized-CNF to enhance biocompatibility and boost conductivity. This was done to provide many active sites for effective integration of CuSeO₃ in the nanocomposite preparation. The glassy carbon electrode (GCE) surface was enhanced by introducing CuSeO₃@f-CNF nanocomposite, resulting in a significant increase in the current response for GSH in comparison to prior research. CuSeO₃@f-CNF/GCE sensor has shown excellent sensing properties, like enhanced stability, selectivity, sensitivity, and reproducibility, for detecting and quantifying GSH. The sensor demonstrated an extensive linear detection range from 62.5 nM to 7785.0 μM, signifying one of the most comprehensive ranges documented to date. It attained a remarkable detection limit (LOD) of 17.6 nM. The sensor's performance was further tested by analyzing genuine biological fluid samples. The nanozyme-modified GCE demonstrated exceptional electrocatalytic efficiency for GSH detection, making it extremely appropriate for real-time monitoring applications.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127621"},"PeriodicalIF":5.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-laser fabrication of nitrogen-doped porous graphene from chitosan/polyimide for the electrochemical determination of dextromethorphan","authors":"Natthakarn Chanjamsri ,&nbsp;Supatinee Kongkaew ,&nbsp;Suparat Cotchim ,&nbsp;Yudtapum Thipwimonmas ,&nbsp;Warakorn Limbut","doi":"10.1016/j.talanta.2025.127643","DOIUrl":"10.1016/j.talanta.2025.127643","url":null,"abstract":"<div><div>A simple and effective disposable electrode was developed for the electrochemical detection of dextromethorphan (DEX) in pharmaceutical and forensic samples. Polyimide was treated with chitosan before being used to create the electrode through single-laser fabrication of nitrogen-doped porous graphene. The laser power and speed were optimized to achieve optimal performance. Scanning electron microscopy, energy dispersive X-ray, Raman and Fourier transform infrared spectroscopy were used to characterize the morphology of fabricated materials. The electrochemical characterization of electrodes was studied by using cyclic voltammetry and electrochemical impedance spectroscopy. The electrochemical behavior of DEX was investigated using cyclic voltammetry and analytical measurements were performed using differential pulse voltammetry. Differential pulse voltammetry was optimized in terms of buffer type, buffer pH, potential pulse, time pulse, potential step, scan rate, deposition potential, and deposition time. In the optimal condition, two linear ranges were observed, ranging from 2.5 to 25 μmol L⁻¹ and 25 to 400 μmol L⁻¹. The limit of detection (LOD) was 1.8 μmol L⁻¹. The developed method produced a statistically significant agreement with high-performance liquid chromatography for the determination of DEX.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127643"},"PeriodicalIF":5.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of electrode body material on the analytical behaviour of solid-contact ion-selective electrodes","authors":"Ville Yrjänä ,&nbsp;Zekra Mousavi ,&nbsp;Tomasz Sokalski ,&nbsp;Narender Joon ,&nbsp;Ivo Leito ,&nbsp;Johan Bobacka","doi":"10.1016/j.talanta.2025.127651","DOIUrl":"10.1016/j.talanta.2025.127651","url":null,"abstract":"<div><div>Different materials such as PVC, PTFE, or PEEK are commonly used as the external body of solid-contact ion-selective electrodes (SC-ISEs). So far, the possible effect of these electrode body materials on the analytical behaviour of SC-ISEs has not been considered. In this study, we demonstrate that the selectivity of SC-ISEs can be strongly influenced by the type of the material used as the electrode body. To investigate this effect, different characterization techniques such as potentiometry, optical microscopy, NMR, and FTIR were used. Interestingly, the electrode body material significantly influences the selectivity in the case of bicarbonate SC-ISEs (anionic ISE), while the effect is negligible in the case of potassium SC-ISEs (cationic ISE).</div><div>Results from NMR and FTIR indicate that some additives or compounds may migrate into the plasticised PVC membrane thereby influencing the selectivity of SC-ISEs. However, one cannot exclude the opposite process where membrane components will diffuse into the PVC electrode body. This can be quite a complex process as not only the chemical composition of the PVC rod would play a role but also its physical properties such as porosity or tortuosity.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127651"},"PeriodicalIF":5.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143179435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel separated OPECT aptasensor based on MOF-derived BiVO4/Bi2S3 type-II heterojunction for rapid detection of bacterial quorum sensing signal molecules","authors":"Peng Ju ,&nbsp;Siyu Wen ,&nbsp;Shiliang Wang ,&nbsp;Chuan Zhou ,&nbsp;Jinquan Wang ,&nbsp;Long Xiao ,&nbsp;Fubin Ma ,&nbsp;Shuai Wang","doi":"10.1016/j.talanta.2025.127635","DOIUrl":"10.1016/j.talanta.2025.127635","url":null,"abstract":"<div><div>Quorum sensing signal molecules released by microorganisms serve as critical biomarkers regulating the attachment and aggregation of marine microbes on engineered surfaces. Hence, the development of efficient and convenient methods for detecting quorum sensing signal molecules is crucial for monitoring and controlling the formation and development of marine biofouling. Advanced optoelectronic technologies offer increased opportunities and methods for detecting quorum sensing signal molecules, thereby enhancing the accuracy and efficiency of detection. This study proposes a CAU-17-derived BiVO₄/Bi₂S₃ gated organic photoelectrochemical transistor (OPECT), and applies it to the detection of a typical quorum sensing signal molecule, N-(3-oxodecanoyl)-<span>l</span>-homoserine lactone (3-O-C10-HL). A strategy of signal amplification and separate detection process was employed. Specifically, BiVO₄/Bi₂S₃ type-II heterojunction photoanode was fabricated and successfully utilized for effective gating of the poly (ethylene dioxythiophene): poly (styrene sulfonate) channel. Using the previously screened 3-O-C10-HL adaptor, rapid and sensitive recognition of 3-O-C10-HL was achieved by effectively enhancing the response of the photoanode and regulating the overall performance of the device. The designed device demonstrated excellent specificity and sensitivity with a detection limit of 2.85 pM. This work not only provides an effective OPECT biosensing approach for detecting 3-O-C10-HL, but also reveals the application potential of semiconductor MOFs-derived materials in future optoelectronics.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127635"},"PeriodicalIF":5.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“On-plant” wearable electrochemical sensor for atmospheric lead monitoring","authors":"Sumeyye Seker ,&nbsp;Ozge Surucu ,&nbsp;Anastasios Economou ,&nbsp;Joseph Wang","doi":"10.1016/j.talanta.2025.127654","DOIUrl":"10.1016/j.talanta.2025.127654","url":null,"abstract":"<div><div>Considering the extremely high toxicity of lead (Pb), early detection of atmospheric Pb levels is paramount for the implementation of preventive measures, to contain sources of emission, to minimize both human and plant exposure and to prevent accumulation in the biosphere. This work demonstrates a wearable “on-plant” sensor for electrochemical Pb detection in atmospheric aerosol samples. The sensor is screen-printed onto a flexible self-adhesive vinyl-based matte substrate which enables its attachment on plant leaves. It features a bismuth/Nafion-coated carbon working electrode transducer covered with a polyvinyl alcohol (PVA) membrane which serves as a passive <em>in-situ</em> gas collection layer and as an electrolyte-containing matrix. The Pb collected at the interface between the sample in the gas phase and the acetate buffer solution (ABS) embedded within the PVA membrane is measured by square wave anodic stripping voltammetry (SWASV). Different steps of the fabrication process were optimized and the detection of on plant leaves was demonstrated. Simulation experiments were conducted with a Pb-containing aerosol sprayed on the leaves to evaluate the effect of various operational parameters such as long-term stability, spraying time, accumulation time, or sensor/leaf bending. The “on-plant” sensor allows remote near real-time monitoring of Pb levels as low as 50 μg L⁻¹ in ambient air using a portable miniaturized potentiostat, and can be expanded to other target metals, forming the basis of an early warning system for atmospheric heavy metals exposure.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127654"},"PeriodicalIF":5.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An ultrasensitive flexible biosensor enabled by high-performance graphene field-effect transistors with defect-free van der Waals contacts for breast cancer miRNA fast detection","authors":"Mingyuan Sun ,&nbsp;Shuai Wang ,&nbsp;Yunhong Zhang ,&nbsp;Zheng Zhang ,&nbsp;Shun Wang ,&nbsp;Zhenhua Wang ,&nbsp;Xiaoshuang Chen ,&nbsp;Hong Liu ,&nbsp;Yu Zhang ,&nbsp;Lin Han","doi":"10.1016/j.talanta.2025.127637","DOIUrl":"10.1016/j.talanta.2025.127637","url":null,"abstract":"<div><div>MicroRNAs (miRNAs) present in bodily fluids such as blood, saliva, and urine hold significant potential for both diagnosing and prognosing breast cancer. However, the development of flexible wearable field-effect transistor (FET) breast cancer miRNA biosensors still faces many challenges. Herein, we developed an ultrasensitive flexible biosensor based on a high-performance FET with defect-free van der Waals contacts for breast cancer miRNA fast detection. The flexible biosensor achieves a limit of detection (LOD) as low as 1.92 fM, a wide linear detection range of 10 fM–100 pM, and a short detection time of 10 min for fast detection of miRNA-155, which is approximately a 5-fold lower LOD compared to conventional graphene FET biosensors. Additionally, the sensor maintains stable sensing performance even after 100 bending/relaxation cycles. The defect-free graphene channel and excellent electrical properties of the flexible FET contribute to the high performance of the biosensor. The biosensor effectively differentiates miRNA levels in serum between breast cancer patients and healthy individuals, proving the possibility of practical application. It also successfully detects miRNA in sweat by attaching the biosensor to the human body, demonstrating its promise for non-invasive health monitoring as a wearable device. This easy-to-fabricate, high-performance flexible biosensor advances cancer biomarker analysis and wearable health monitoring technology.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127637"},"PeriodicalIF":5.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced chemiluminescence of luminol via In2S3/MXene composite as a novel Co-reactant accelerator for UV-filter Benzophenone-3 determination","authors":"Guanghui Zhang ,&nbsp;Longjie Li ,&nbsp;Zhenjie Yuan ,&nbsp;Quandong Li ,&nbsp;Junjie Wan ,&nbsp;Yongping Lin ,&nbsp;Yingchun Li","doi":"10.1016/j.talanta.2025.127642","DOIUrl":"10.1016/j.talanta.2025.127642","url":null,"abstract":"<div><div>In this study, a novel In₂S₃/MXene composite was developed as a co-reactant accelerator to enhance the chemiluminescence (CL) performance of the classical luminol-H₂O₂ system. The In₂S₃ and MXene heterojunction catalyzed the CL reaction through synergistic effect, facilitating the generation of reactive oxygen species and increasing CL intensities. This enhanced system was applied for the first time to detect an ultraviolet (UV) filter-benzophenone-3 (BP-3) by leveraging its light absorption property. The proposed CL method exhibited excellent sensitivity, with a linear detection range for BP-3 spanning from 1 × 10⁻¹¹ mol/L to 1 × 10⁻⁹ mol/L and a detection limit of 5.28 × 10⁻¹² mol/L (S/N = 3). The method was validated by successfully detecting BP-3 in real water samples, demonstrating its potential in monitoring UV-absorbing pollutants in environments.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"287 ","pages":"Article 127642"},"PeriodicalIF":5.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}