Talanta最新文献

{"title":"On-site determination of total dissolved inorganic arsenic in natural waters by a portable atomic fluorescence spectroscopy","authors":"Shuting Pang ,&nbsp;Yao Guan ,&nbsp;Huihua Wei ,&nbsp;Rongkun Wu ,&nbsp;Biqing Xu ,&nbsp;Zhenbin Gong ,&nbsp;Xiong Zhou ,&nbsp;Jie Chen ,&nbsp;Zuhao Zhu","doi":"10.1016/j.talanta.2025.128566","DOIUrl":"10.1016/j.talanta.2025.128566","url":null,"abstract":"<div><div>The determination of total arsenic across diverse environmental matrices remains a significant challenge. To address the spatial and temporal delays and interference from complex field matrices inherent in traditional laboratory analysis methods, this study developed a continuous, automated, and long-term monitoring system for total dissolved inorganic arsenic (TDIAs). The system enables on-line real-time monitoring of TDIAs in natural waters. Through optimizing the instrumental parameters and chemical vapor generation conditions, the reaction kinetic process of As(Ⅴ) pre-reduction process was thoroughly investigated. In addition, a workflow for the on-site determination of TDIAs in natural waters was designed, including on-line filtration, sample acidification, pre-reduction, analytical detection and single-point calibration. The results demonstrated that the limit of detection (LOD) reached as low as 0.005 μg/L, with a linear range of 0.0–5.0 μg/L under the optimal parameter conditions, and the relative standard deviations (RSDs) were in the range of 0.6 %–7.3 %, which demonstrated a good analytical precision. The method validation showed that the recoveries of different matrix samples, such as tap water, lake water and seawater, were stable in the range of 97.8 %–107.8 %, which proved that the method has excellent ability of resisting matrix interference. Finally, the method has been successfully applied to the on-site determination of TDIAs in the Jinjiang River Estuary, Quanzhou Bay.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128566"},"PeriodicalIF":5.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified QuEChERS extraction coupled with LC-MS/MS for the determination of per- and polyfluoroalkyl substances in sediments","authors":"Magdalena Zarębska ,&nbsp;Sylwia Bajkacz ,&nbsp;Ewa Sabura","doi":"10.1016/j.talanta.2025.128567","DOIUrl":"10.1016/j.talanta.2025.128567","url":null,"abstract":"<div><div>A modified QuEChERS-based method combined with liquid chromatography–tandem mass spectrometry was developed for the determination of 25 per- and polyfluoroalkyl substances (PFAS) in sediment samples. The method achieved limits of quantification between 0.003 and 0.56 ng/g dry weight, inter-day precision ranging from 0.3 % to 16.2 %, and recoveries between 72 % and 117 %. The applicability of the procedure was confirmed through analysis of sediments collected from 18 sites along the Oder River. The total concentration of 14 detected PFAS ranged from 1.8 to 9.0 ng/g, indicating limited ecological risk. Short-chain perfluorocarboxylic acids, particularly C4, were the most abundant, while long-chain perfluorosulfonic acids, including C8, accounted for about one-third of the total PFAS burden. Emerging PFAS such as ADONA and GenX, which have been scarcely reported in European sediments to date, were detected, with higher concentrations observed in upstream sections. Elevated pH, TOC, and Na⁺/K⁺ levels upstream of urban areas suggest anthropogenic impact prior to city inflow. Strong correlations among selected PFAS species point to shared sources, likely industrial discharge or degradation products. PFAS retention was strongly influenced by environmental parameters, with positive correlations to TOC and conductivity, and a negative correlation to pH. Partitioning analysis confirmed that long-chain PFAS exhibit greater affinity for sediments, supporting the role of sediments as long-term environmental sinks. The developed analytical procedure, evaluated as moderately green using modern tools for assessing the environmental sustainability of analytical methods, may serve as a useful approach for investigating the distribution and environmental behavior of PFAS in riverine systems.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128567"},"PeriodicalIF":5.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confined electrochemiluminescence at single tissue sections for enhanced imaging of surface antigens","authors":"Chenfeng Fu ,&nbsp;Dongni Han ,&nbsp;Dechen Jiang ,&nbsp;Depeng Jiang","doi":"10.1016/j.talanta.2025.128564","DOIUrl":"10.1016/j.talanta.2025.128564","url":null,"abstract":"<div><div>Spatial analysis of tissue surface molecules demands the imaging methods with high sensitivity and resolution. Here, we present a confined electrochemiluminescence (ECL) at single tissue sections for enhanced imaging of surface antigens. By placing a glass slide in contact with the tissue section at the electrode, a confined space is formed at the tissue to enrich the ECL radicals and boost the ECL emission. Meanwhile, the restricted diffusion of coreactant radicals localizes the ECL emission near the electrode surface, eliminating axial defocus blur and ensuring precise molecular localization. Consequently, this established imaging method with enhanced ECL emission and high spatial resolution is applied to map carcinoembryonic antigen (CEA) at single tissue sections and differentiate cancerous and paracancerous regions at single lung adenocarcinoma tissues. Besides the difference in the amounts of CEA antigen at these two regions, the cancerous regions with a dense structure are observed to have concentrated TPrA radicals resulting in a further enhancement in ECL emission. The clear recognition of cancerous region at the tissue section with a high sensitivity exhibits the potential application of this ECL imaging method for in vitro diagnostics and early cancer diagnosis.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128564"},"PeriodicalIF":5.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separation-free cholesterol detection using an enzyme-doped hydrogel opto-microfluidic hybrid chip via colorimetry and light extinction spectroscopy","authors":"Quoc-Thinh Dinh ,&nbsp;Pei-Yun Yu ,&nbsp;Srishti Sen ,&nbsp;Wen-Chien Chuang ,&nbsp;Wei-Yu Chen ,&nbsp;Cheng-Yang Liu","doi":"10.1016/j.talanta.2025.128570","DOIUrl":"10.1016/j.talanta.2025.128570","url":null,"abstract":"<div><div>Cholesterol levels serve as a critical biomarker for the diagnosis of cardiovascular diseases. However, conventional detection methods are often time-consuming and reliant on specialized laboratory equipment. In this study, we present a novel microfluidic lab-on-a-chip platform designed for the rapid and accurate detection of cholesterol, employing an enzyme-doped agarose hydrogel combined with colorimetric analysis. The chip incorporates sensing zones of varying lengths (4 mm, 5 mm, and 6 mm), enabling multiple optical measurements from a single sample. By integrating optical absorbance with RGB imaging, the system achieves high sensitivity and specificity, with a detection limit as low as 0.0065 mM and a sensitivity of 0.411 absorbance/mM. The chip design features microlenses and optical fibers to enhance light transmission and promote smooth fluid flow. Requiring only 10 μL of sample, the platform is both minimally invasive and highly efficient. Validation experiments using serum and whole blood samples demonstrate excellent recovery rates (95.8 %–110.6 %) and high precision (relative standard deviation, RSD &lt;3.54 %). This portable, cost-effective device offers a reliable solution for routine cholesterol monitoring and early cardiovascular risk assessment.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128570"},"PeriodicalIF":5.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel tissue markers in renal neoplasms using molar-scale quantitative proteomics via the total protein approach normalised with protein deglycase DJ-1 (PARK7)","authors":"André Q. Figueiredo ,&nbsp;Inês F. Domingos ,&nbsp;Luís B. Carvalho ,&nbsp;Jacek R. Wiśniewski ,&nbsp;Dimitrios Korentzelos ,&nbsp;Gabriela Quiroga-Garza ,&nbsp;Rajiv Dhir ,&nbsp;Carlos Lodeiro ,&nbsp;José L. Capelo ,&nbsp;Hugo M. Santos","doi":"10.1016/j.talanta.2025.128558","DOIUrl":"10.1016/j.talanta.2025.128558","url":null,"abstract":"<div><div>Mass spectrometry-based proteomics enables large-scale protein quantification but is hindered by inter- and intra-laboratory variability, complicating data integration and biomarker discovery. This study aims to develop an optimised normalisation strategy using the ubiquitously expressed protein deglycase DJ-1 (PARK7) as an internal standard, combined with the Total Protein Approach (TPA) to improve data comparability in renal neoplasms proteomic datasets. We analysed the MS-based proteomics data of renal tissues from clear cell renal cell carcinoma (ccRCC, n = 7), papillary renal cell carcinoma (pRCC, n = 5), chromophobe renal cell carcinoma (chRCC, n = 5), renal oncocytoma (RO, n = 5), and control normal adjacent tissue (NAT, n = 5). Protein concentrations were calculated using the Total Protein Approach, and the data were normalised to PARK7 expression using a TPA reference value of 34.1 pmol/mg. TPA-PARK7 normalisation showed a trend towards reducing interquartile ranges. After normalisation, 95 % of biomarkers from non-normalised datasets remained statistically significant. Among these, 31 % of previously proposed candidate biomarkers retained their ability to distinguish between conditions, with histologically validated biomarkers (TUBB3, LAMP1, and HK1) showing improved differentiation. Additionally, 322 new statistically significant proteins were identified, and 18 new potential biomarkers for renal neoplasm were detected exclusively after TPA-PARK7 normalisation. Our findings demonstrate that using PARK7 as an internal standard, combined with the TPA, significantly enhances the statistical robustness and reliability of protein quantification in mass spectrometry-based proteomics. This normalisation strategy reduces interlaboratory variability, preserves biomarker differentiation capability, and enables novel biomarker discovery. By reducing variability, this method enhances cross-study comparability and supports the advancement of clinically relevant biomarker discovery.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128558"},"PeriodicalIF":5.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel VOC mixtures classification methods based on GBLinear and TabNet and informative feature selection from gas sensors (E-Nose) data","authors":"Hamed Karami ,&nbsp;Abdolrahman Khoshrou","doi":"10.1016/j.talanta.2025.128554","DOIUrl":"10.1016/j.talanta.2025.128554","url":null,"abstract":"<div><div>The GBLinear and TabNet algorithms have been incorporated with essential feature selection techniques to create a new method of classifying essential oils using e-nose systems. Essential oils, known for their complex chemical compositions and a wide variety of applications in industries such as food, cosmetics, and pharmaceuticals, pose some challenges for e-nose systems due to the high variability and subtle differences in volatile compounds (VOCs). This novel approach, used for the first time for the analysis of electronic nose data, integrates efficient machine-learning models with advanced feature selection techniques and aims to increase the accuracy and interpretability of essential oil classification. This study highlights the potential of integrating interpretable machine learning models with deep learning-based architectures to address challenges in the analysis of complex gas mixtures. Not only was the classification accuracy increased by these methods, but these methods could be used in the future as promising models for analyzing complex mixtures.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128554"},"PeriodicalIF":5.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic solid-phase extraction and HPLC-UV determination of fat-soluble vitamins based on a multifunctional monomer covalent organic frameworks","authors":"Manyan Qiu ,&nbsp;Aiai Nie ,&nbsp;Jinghang Zhang ,&nbsp;Miao Zheng ,&nbsp;Ning Guan ,&nbsp;Sharuna De ,&nbsp;Xiaoyan Pei ,&nbsp;Xinyan Yang ,&nbsp;Yujun Jiang ,&nbsp;Qianyu Zhao ,&nbsp;Chaoxin Man","doi":"10.1016/j.talanta.2025.128569","DOIUrl":"10.1016/j.talanta.2025.128569","url":null,"abstract":"<div><div>The effective separation of fat-soluble vitamins from complex matrices prior to instrumental analysis remains a significant challenge. Herein, a novel magnetic covalent organic framework (Fe₃O₄@tetrakis(4-aminophenyl)methane (TAM)-2,6-dihydroxynaphthalene-1,5-dicarbaldehyde (DHNDA), Fe₃O₄@TAM-DHNDA) was successfully designed and prepared for the efficient separation and enrichment of three fat-soluble vitamins in dairy products. The maximal adsorption efficiency of Fe₃O₄@TAM-DHNDA to fat-soluble vitamin was as high as 26.94 mg/g. Moreover, the adsorption mechanism of Fe₃O₄@TAM-DHNDA for V_A, V_D, and V_E was revealed by molecular simulation techniques. van der Waals forces and hydrogen bonds were the main interactions between Fe₃O₄@TAM-DHNDA and fat-soluble vitamins. Importantly, the magnetic solid phase extraction (MSPE) method based on Fe₃O₄@TAM-DHNDA could be used as an effective sample pretreatment technology for separation and enrichment of fat-soluble vitamins from complex matrices prior to instrumental analysis. When coupled with high-performance liquid chromatography-ultraviolet detector (HPLC-UV), the proposed method enabled the efficient detection of fat-soluble vitamins in dairy products. The limit of detection (S/N = 3) and limit of quantification (S/N = 10) were achieved at 20–50 ng/mL and 55–150 ng/mL, respectively. Good linearity (R² &gt; 0.9998) was obtained within the range of 2–100 μg/mL. The average recoveries of spiked milk samples were determined to be 83 %–101 % and the relative standard deviation (RSD) was 0.83 %–3.46 % (<em>n</em> = 3). This work provided novel insights for the development of novel magnetic adsorbents and the separation and enrichment of fat-soluble vitamins in complex matrices.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128569"},"PeriodicalIF":5.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on a single molecule signal amplification strategy for high risk HPV mRNA based on fluorescent microarray platform","authors":"Mingyuan Zou ,&nbsp;Gulinaizhaer Abudushalamu ,&nbsp;Chuankun Yang ,&nbsp;Guoqiu Wu","doi":"10.1016/j.talanta.2025.128534","DOIUrl":"10.1016/j.talanta.2025.128534","url":null,"abstract":"<div><div>This study introduces a high-sensitivity single-molecule signal amplification approach for detecting high-risk HPV mRNA, utilizing a fluorescent microarray platform (FMP) based on modified entropy-driven chain substitution (EDC). Tailored for the high-throughput detection of 13 high-risk HPV types, the FMP enables concurrent identification of both single and multiple infections, including critical targets HPV16 and HPV18. Clinical validation revealed that the platform achieved over 90 % sensitivity and specificity, with detection sensitivity for HPV16 and HPV18 E6/E7 mRNA surpassing 95 % and specificity nearing 100 %. In samples with multiple HPV infections, the FMP accurately distinguished coexisting types without cross-reactivity, demonstrating its robustness for complex infection profiles. This fluorescence-based platform presents a scalable, precise solution for large-scale HPV screening and diagnostics, especially in resource-constrained environments.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128534"},"PeriodicalIF":5.6,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accurate detection of trace level black powder with miniaturized Fourier deconvolution ion mobility spectrometer","authors":"Binwang Yang ,&nbsp;Xiuqing Zheng ,&nbsp;Feiyu Lu ,&nbsp;Jianna Yu ,&nbsp;Guoxing Jing ,&nbsp;Wen Liu ,&nbsp;Wenshan Li ,&nbsp;Zhaohong Wang ,&nbsp;Wenjie Liu","doi":"10.1016/j.talanta.2025.128559","DOIUrl":"10.1016/j.talanta.2025.128559","url":null,"abstract":"<div><div>Black powder (BP), a low-explosive mixture, is created by mixing sulfur, potassium nitrate, and charcoal, poses significant risks due to its flammability and potential use in illicit activities. Accurate detection of black powder (BP) is crucial for public safety, security, and regulatory compliance. However, the detection of BP is challenging when using miniaturized ion mobility spectrometers because of the sulfur ion peak overlaps heavily with that of the reactant ions (<span><math><mrow><msubsup><mi>O</mi><mn>2</mn><mo>−</mo></msubsup><msub><mrow><mo>(</mo><mrow><msub><mi>H</mi><mn>2</mn></msub><mi>O</mi></mrow><mo>)</mo></mrow><mi>n</mi></msub></mrow></math></span>). A simple method is proposed in this study for accurate and sensitive detection of BP, utilizing a miniaturized Fourier deconvolution ion mobility spectrometer (FD-IMS), which directly improves the resolution between the <span><math><mrow><msubsup><mi>O</mi><mn>2</mn><mo>−</mo></msubsup><msub><mrow><mo>(</mo><mrow><msub><mi>H</mi><mn>2</mn></msub><mi>O</mi></mrow><mo>)</mo></mrow><mi>n</mi></msub></mrow></math></span> peak and the sulfur ion peak without the need to add any chlorinated hydrocarbon modifiers, and avoids the complexities and contamination risks posed by modifiers in the conventional method. The demonstrated device achieved a resolution of up to 2.07 between the <span><math><mrow><msubsup><mi>O</mi><mn>2</mn><mo>−</mo></msubsup><msub><mrow><mo>(</mo><mrow><msub><mi>H</mi><mn>2</mn></msub><mi>O</mi></mrow><mo>)</mo></mrow><mi>n</mi></msub></mrow></math></span> and <span><math><mrow><msubsup><mi>S</mi><mn>3</mn><mo>−</mo></msubsup></mrow></math></span> ion peaks at a drift region voltage and length of 1.54 kV and 42.5 mm, under optimized detection temperature and drift gas humidity, with a minimum detectable quality of sulfur of less than 0.1 ng. It was proven that this miniaturized FD-IMS is qualified to detect trace level BP less than 1 ng as well as other nitro-organic explosives.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128559"},"PeriodicalIF":5.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-sensitive label-free DNA detection based on n-type accumulation mode vertical organic electrochemical transistors","authors":"Kun Xu ,&nbsp;Kejie Zhang ,&nbsp;Bowen Liu ,&nbsp;Lingchao Li ,&nbsp;Li Wang ,&nbsp;Yujing Zhang ,&nbsp;Songcheng Yu ,&nbsp;Yunqing Tang","doi":"10.1016/j.talanta.2025.128561","DOIUrl":"10.1016/j.talanta.2025.128561","url":null,"abstract":"<div><div>Herein, we present an ultrasensitive DNA detection platform based on n-type accumulation-mode vertical organic electrochemical transistors (vOECTs) for the first time. The vOECTs utilize poly(benzimidazobenzophenanthroline) (BBL) as the n-type organic semiconductor channel, operating in accumulation mode with low power consumption and ultrahigh transconductance (up to 53.7 mS). DNA probes were immobilized on Au gate electrodes via Au–S bonds, followed by 6-mercapto-1-hexanol (MCH) blocking to minimize nonspecific adsorption. Target DNA hybridization induces interfacial charge redistribution and electrical double-layer (EDL) modulation, amplifying current responses through the vOECT's high transconductance. The platform achieves an exceptional sensitivity of 155.91 μA/dec—31-fold higher than state-of-the-art DNA sensors—and an ultralow detection limit of 1.07 aM. Notably, the sensor enables label-free, amplification-free detection with rapid response and excellent stability. This work establishes a novel approach for high-precision nucleic acid analysis in biomedical applications.</div></div>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"297 ","pages":"Article 128561"},"PeriodicalIF":5.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}