Microchemical Journal最新文献

{"title":"Distinct plasma metabolic signature and potential biomarkers in female sigmoid Colon Cancer: A mass spectrometry-based untargeted metabolomics study","authors":"Qinyu Xiao ,&nbsp;Zining Wu ,&nbsp;Jiamin Yang ,&nbsp;Qing Liu ,&nbsp;Yang Zhao ,&nbsp;Hongbo Huang ,&nbsp;Yiwen Tao ,&nbsp;Bo Ding","doi":"10.1016/j.microc.2026.117290","DOIUrl":"10.1016/j.microc.2026.117290","url":null,"abstract":"<div><div>The annotation of potential metabolic biomarkers for female sigmoid colon cancer (SCC) is crucial for advancing personalized disease prevention and treatment through precision medicine. In this study, we employed mass spectrometry-based metabolomics and SIRIUS to analyze venous and arterial plasma samples from female SCC patients. An integrated approach combining Volcano and S-Plot analyses was used to identify discriminative metabolic biomarkers. A total of 23 significant metabolites, primarily classified as phosphatidylcholines, carbohydrates, and organic acids, were annotated especially two new compounds of N-(4-methyl-1-((2-(3-methylbutanamido)ethyl)amino)-1-oxopentan-2-yl)cyclobutanecarboxamide and 3,4,5-trihydroxy-6-((3-mercapto-2-(4-(2-(methylamino)ethoxy)-2-propylphenoxy)propanoyl)oxy)tetrahydro-2H-pyran-2-carboxylic acid. These included 12 characteristic metabolic biomarkers differentiating preoperative SCC from healthy controls, 8 biomarkers distinguishing preoperative and postoperative arterial/venous plasma samples, and 3 biomarkers differing between arterial and venous sampling sites. SIRIUS annotated 797 metabolites from arterial and venous samples. These annotated metabolites differed from previously reported SCC-associated metabolites. Finally, this study screened a unique set of metabolic biomarkers in female SCC, enhancing our understanding of its pathogenesis. The integration of volcano and S-plot analyses proved to be an effective strategy for metabolite screening. These findings provide potential therapeutic targets for precision medicine approaches in female SCC.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117290"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanism of nano sustained-release prokinetic drugs based on electrochemical sensors: effects on the gut microbiome and metabolome of patients with gastroparesis","authors":"Cheng Chen ,&nbsp;Yaoye Tao","doi":"10.1016/j.microc.2026.117293","DOIUrl":"10.1016/j.microc.2026.117293","url":null,"abstract":"<div><div>Gastric dyskinesia, as a functional gastrointestinal disorder characterized by delayed gastric emptying, involves neuro-muscular dysfunction and intestinal flora imbalance. Traditional assessment methods have limitations such as complex operation and low temporal resolution. In recent years, electrochemical sensors have shown significant application value in the field of medical testing due to their high sensitivity, rapid response, miniaturization, and good biocompatibility. This technology converts biological recognition events into quantifiable electrical signals, enabling real-time, label-free detection of key metabolites such as short-chain fatty acids, lipopolysaccharides, and neurotransmitters in feces, breath, or body fluids. It provides a new technical path for the precise classification of gastric dyskinesia, dynamic monitoring of therapeutic effects, and mechanism analysis. The study adopted a prospective cohort design, including patients diagnosed with gastric dyskinesia who received intervention with nano-sustained motility-promoting drugs. 16S rRNA sequencing and metabolomics analysis were used to evaluate changes in intestinal flora structure and metabolites before and after treatment. Although data were not directly obtained using electrochemical sensing equipment, the identified key biomarkers (such as acetic acid, propionic acid, butyric acid, indole, 5-hydroxytryptamine, etc.) are all current key targets for the development of electrochemical sensors. Existing studies have shown that electrochemical platforms based on carbon nanomaterials, molecularly imprinted polymers, or field-effect transistors can achieve nanomolar-level detection of these metabolites, demonstrating good clinical translation potential. The results showed that after intervention, patients' gastric emptying function improved, accompanied by an increase in specific beneficial bacteria abundance and a decrease in pro-inflammatory metabolite levels, suggesting that the drug has a dual effect of regulating the interaction between the microbiota and the host. These metabolic changes provide clear molecular evidence for the application of electrochemical sensors in the management of gastric dyskinesia.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117293"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering aptasensor based on DNAzyme-aptamer switch and loop-mediated isothermal amplification for ultrasensitive contaminant detection","authors":"Zanlin Chen ,&nbsp;HaiMing Li ,&nbsp;Yian Chen ,&nbsp;Shuangyan Han","doi":"10.1016/j.microc.2026.117196","DOIUrl":"10.1016/j.microc.2026.117196","url":null,"abstract":"<div><h3>Background</h3><div>Small-molecule contaminants in food are associated with over 200 types of diseases and pose a significant threat to public health. Conventional detection techniques, such as high-performance liquid chromatography (HPLC), are time-consuming, labor-intensive, and require well-equipped laboratory settings, making them unsuitable for rapid, high-throughput on-site screening. Consequently, the development of sensitive, efficient, and field-deployable detection methods for small-molecule contaminants remains a persistent yet critical challenge in food safety monitoring.</div></div><div><h3>Results</h3><div>Herein, an aptasensor has been developed utilizing DNA tetrahedron (DT) scaffold, DNAzyme-aptamer switch and loop-mediated isothermal amplification (LAMP) for sensitive and quantitative detection of small molecular contaminants. The tetrahedral scaffold precisely orients the DNAzyme-aptamer complex in an optimal conformation, granting the aptamer enhanced conformational flexibility for rapid target capture. Critically, target binding induces allosteric activation of the DNAzyme, triggering Mg²⁺-dependent self-cleavage that programmatically converts biorecognition events into a signal-off electrochemical response via controlled ferrocene (Fc) tag and methylene blue (MB) release. This aptasensor exhibits excellent linearity for detecting Bisphenol A within a range of 8.8 pM to 109.5 nM, with a limit of detection (LOD) of 8.0 pM. For the detection of malachite green and trichlorfon, the LOD is 2.7 pM and 36.9 pM, respectively. Simultaneously, the short DNA fragments cleaved by DNAzyme are utilized built-in primers for LAMP. Following the LAMP reaction, the LOD for bisphenol A was determined to 10.0 fM.</div></div><div><h3>Significance</h3><div>This sensor represents the first dual-channel aptasensor that integrates LAMP with DNAzyme and tetrahedron nanostructures. It offers simple operation, achieves a detection limit as low as 10 fM for bisphenol A (BPA), and enables the detection of various contaminants through interchangeable aptamer sequences, demonstrating strong versatility and broad applicability.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117196"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on chitosan-based hydrogels with conductive and stimulus - responsive properties for smart sensing and food packaging","authors":"Jing Xu,&nbsp;Shenghua Lv,&nbsp;Ying Chen,&nbsp;Xiangyi Liu,&nbsp;Tingxiang He,&nbsp;Leipeng Liu","doi":"10.1016/j.microc.2026.117339","DOIUrl":"10.1016/j.microc.2026.117339","url":null,"abstract":"<div><div>Chitosan (CS) is a naturally derived polysaccharide containing amino and hydroxyl groups. Due to its excellent biocompatibility, biodegradability, antibacterial activity, hydrophilicity and environmental friendliness, it has important applications in many fields. In recent years, the research and application of chitosan in hydrogel flexible sensing materials and smart food packaging materials have received extensive attention. This paper systematically reviews the preparation methods, functionalization strategies of chitosan hydrogels, and the research progress of their applications in flexible sensing materials and smart packaging materials. The design principles and implementation approaches of sensing hydrogels and stimulus-responsive chitosan hydrogels were analyzed and summarized. Meanwhile, the latest breakthroughs, main challenges and future opportunities in chitosan-based hydrogel sensing materials and the field of intelligent food packaging were emphasized. The research results are intended to provide guidance for the innovation and application development of chitosan-based sensing materials and smart packaging materials.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117339"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of ternary novel Mg@Cr/ZnO nanocomposite based electrochemical non-enzymatic sensor for uric acid detection in biomedical application","authors":"Hadi M. Marwani ,&nbsp;Mohsin Saeed ,&nbsp;Muhammad Fazle Rabbee ,&nbsp;Saeed D. Alahmari ,&nbsp;Moayad M. Khashoqji ,&nbsp;Nouf M. Alourfi ,&nbsp;Roaa A. Tayeb ,&nbsp;O. Madkhali ,&nbsp;Mohammed Muzibur Rahman","doi":"10.1016/j.microc.2026.117306","DOIUrl":"10.1016/j.microc.2026.117306","url":null,"abstract":"<div><div>The accurate detection of uric acid (UA) is crucial in clinical diagnostics monitoring, as abnormal UA levels are associated with various health disorders, including gout and kidney dysfunction. Developing cost-effective and highly sensitive electrochemical sensors remains a significant challenge due to the need for fast electron transfer and selective detection in complex media. In this study, we report a novel ternary magnesium and chromium co-doped zinc oxide nanocomposite (Mg@Cr/ZnO NCs) synthesized via a simple, single-step solid-state method. The strategic incorporation of Mg and Cr into the ZnO lattice enhances its electrical conductivity, catalytic activity, and surface area, making it an excellent candidate for electrochemical applications. The synthesized nanocomposite was thoroughly characterized using FESEM-EDS, XPS, UV–Vis, FTIR, and XRD analyses to confirm its morphology, composition, and crystalline structure. A glassy carbon electrode (GCE) modified with Mg@Cr/ZnO NCs was fabricated with 5% Nafion and employed for UA sensing using linear sweep voltammetry (LSV) in phosphate buffer (pH 7.0). The sensor exhibited a wide linear range (50.0 – 2500.0 μM), high sensitivity (2.33 μAμM^-1cm^-2), and a low detection limit (2.69 μM), along with excellent stability and selectivity. The combination of a facile synthesis approach and superior electrochemical performance demonstrates the novelty and potential of Mg@Cr/ZnO NCs based non-enzymatic electrodes for reliable and efficient biomedical and healthcare sensing applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117306"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomass-derived multi-emissive carbon dots-based ratiometric fluorescence and visual detection of residual chlortetracycline hydrochloride and hemin chloride in food matrix","authors":"Hui Wang ,&nbsp;Chengqian Li ,&nbsp;Xiaoyu Luo ,&nbsp;Chenxi Jiang ,&nbsp;Fei Shang ,&nbsp;Zhonghong Li ,&nbsp;Yong Han","doi":"10.1016/j.microc.2026.117350","DOIUrl":"10.1016/j.microc.2026.117350","url":null,"abstract":"<div><div>Multi-emissive red fluorescence carbon dots (R-CDs) were synthesized using <em>Stellaria pallida</em> and urea precursors through a solvothermal method, based on which a ratiometric fluorescent sensor was constructed and integrated into a portable dual-mode sensing platform for determining the residual levels of Chlortetracycline Hydrochloride (CTC) and Hemin Chloride (Hemin) in food products. The ratiometric fluorescent sensor achieved limits of detection (LODs) were 13.00 × 10⁻³ μM for CTC and 0.74 × 10⁻³ μM for Hemin, while the visual detection platform provided LODs of 1.50 × 10⁻³ μM and 0.53 × 10⁻³ μM, respectively. The relative standard deviation of the spike recovery tests ranged from 0.69% to 1.12%. This work presents a green, low-cost, and highly sensitive dual-analyte sensing strategy combined with a visual readout, offering a reliable platform for on-site food safety monitoring.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117350"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147382003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issues related to methanol quantification with electron-ionization mass spectrometry","authors":"Gregorio Marbán,&nbsp;Katia Tamargo-Martínez","doi":"10.1016/j.microc.2026.117304","DOIUrl":"10.1016/j.microc.2026.117304","url":null,"abstract":"<div><div>This work analyses some issues that arise when using the electron-impact ionization quadrupole mass spectrometry technique for the quantitative analysis of methanol in gas streams. The mass spectrum of methanol has been found to strongly depend on the type of carrier gas (argon or helium) and the concentration/partial pressure of methanol within the low methanol concentration range. Rigorous mathematical tools have been used to determine reliable values of relative intensity of cations produced by electron-ionization of methanol. The relative intensity of cations such as <em>m/z</em> 2, 15, 18 or 28 grows exponentially with decreasing methanol concentration values for below 2 vol%. This could lead to errors when measuring the concentration of gases like hydrogen, methane, water or carbon monoxide alongside methanol. This effect is increased by the use of helium as the carrier gas instead of argon, although the relative intensity values in both gases tend to converge for increasing values of methanol concentration. A tentative explanation for this phenomenon is proposed, based on the different ionization energies of argon and helium, and how this difference affects the ionization of neutral fragments and the ionization equilibria in which these fragments are involved.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117304"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An adapted new cyano-assisted salting out CASO-HPLC method for simultaneous determination of linagliptin and metformin hydrochloride binary mixture in pure and tablet dosage form","authors":"Yahya Abduh Salim Mohamed,&nbsp;Teshreen Nagy Ahmed Dammaj","doi":"10.1016/j.microc.2026.117308","DOIUrl":"10.1016/j.microc.2026.117308","url":null,"abstract":"<div><div>An adapted, new, efficient, simple, and reproducible cyano-assisted salting out high-performance liquid chromatographic (CASO-HPLC) method was developed for the simultaneous determination of metformin hydrochloride (MET) and linagliptin (LINA) binary mixture in pure and tablet dosage form. The chromatographic conditions were optimized using an isocratic elution mode to obtain a rapid and efficient separation of the cited drugs. A mobile phase mixture composed of 0.02 M aq. ammonium sulphate and methanol in the ratio of 85: 15 (<em>v</em>/v) respectively was used, buffered at pH 3.0 and adjusted at a flow rate of 1 mL min⁻¹. The effluent was monitored at ƛ _max 230 nm. The analytes exhibited retention times of 3.7 min for metformin HCl and 7.4 min for linagliptin. The linearity of the proposed method was evaluated over the concentration range of 0.3–40.0 μg mL⁻¹ for both cited drugs. MET and LINA showed excellent correlation coefficients of 0.9998 and 0.9992 respectively. Limits of detection (LOD) were 0.049,0.053 μg mL⁻¹ and limits of quantitation (LOQ) were 0.147, 0.159 μg mL⁻¹ for MET and LINA, respectively. The method was validated according to USP and ICH guidelines. The proposed CASO-HPLC method offered superior separation efficiency and peak shape compared to conventional HILIC and reversed-phase chromatography and was successfully applied for the simultaneous determination of MET and LINA in both pure and combined tablet dosage forms.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117308"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable sweat electrochemical biosensors for monitoring biomarkers of acute exercise injury: A review","authors":"Yuanye Hu,&nbsp;Xingjun Zhou,&nbsp;Zixuan Yang","doi":"10.1016/j.microc.2026.117414","DOIUrl":"10.1016/j.microc.2026.117414","url":null,"abstract":"<div><div>Acute exercise and strenuous occupational tasks can trigger complex pHysiological stress responses and tissue damage that are often monitored using blood based biomarkers. Sweat offers a promising alternative medium for continuous non invasive assessment, but the diversity of sweat composition and sensing technologies complicates translation into practice. This review synthesizes current knowledge on sweat accessible indicators of inflammatory activation, skeletal muscle injury, metabolic strain, and hydration status that are relevant to early detection of exercise related complications. Particular attention is given to the evidence for concordance between sweat and blood for cytokines, creatine kinase, myoglobin, lactate, and key electrolytes, highlighting both encouraging correlations and important inconsistencies. We then critically analyze electrochemical sensing strategies, including amperometric and potentiometric formats, and discuss how electrode materials, biorecognition layers, and antifouling interfaces shape analytical sensitivity, selectivity, and operational stability on the skin. Recent advances in flexible substrates and wearable microfluidic architectures for fresh sample delivery are summarized in terms of their impact on temporal resolution and sampling accuracy. Finally, we examine system level challenges such as calibration, motion induced artifacts, interindividual variability, and integration with wireless electronics and data analytics. By linking physiological context with micro scale sensing principles, this review outlines key design considerations and validation requirements needed to move sweat based electrochemical monitoring of exercise stress from proof of concept devices toward robust tools for sports science and occupational health. In addition, it identifies opportunities for multi analyte sensing panels, standardized exercise testing protocols, and longitudinal human studies to establish clinical utility.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117414"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential of 1D to 2D transformation in visible and near-infrared (VIS/NIR) spectroscopy for improved plant disease and stress detection: A review","authors":"Mas Ira Syafila Mohd Hilmi Tan ,&nbsp;Lai-Kuan Wong ,&nbsp;Yuen Peng Loh ,&nbsp;Chih-Yang Pee","doi":"10.1016/j.microc.2026.116932","DOIUrl":"10.1016/j.microc.2026.116932","url":null,"abstract":"<div><div>Visible and near-infrared (VIS–NIR) spectroscopy has been widely recognized for non-destructive plant disease detection and species classification, traditionally utilizing one-dimensional (1D) spectral data. However, the potential of transforming 1D spectral data into two-dimensional (2D) formats such as images, spectrograms, and wavelets remains largely underexplored. This review was performed through a structured literature search of major scientific databases, applying predefined inclusion and exclusion criteria to identify studies on VIS–NIR spectroscopy and 1D-to-2D spectral transformation techniques. This review explores the various transformation techniques with their integration with machine learning and deep learning algorithms, highlighting the ability of 2D spectral data to significantly enhance classification accuracy, capture complex features, and reveal intricate patterns that are not discernible in 1D data. By examining a variety of transformation techniques and their applications in plant disease detection, soil classification, and other agricultural domains, this paper demonstrates how 2D spectral representations enhance model accuracy and interpretability. In addition, it discusses the practical implications of integrating 2D VIS–NIR spectroscopy into precision agriculture workflows, emphasizing its potential for field-deployable real-time diagnostics. Overall, this review highlights 2D transformation as a promising advancement over traditional 1D chemometric techniques, unlocking new opportunities in agriculture and smart farming.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 116932"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}