Advances in small-molecule fluorescent probes for imaging epilepsy biomarkers: A review

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal Pub Date : 2025-09-08 DOI:10.1016/j.microc.2025.115238

Yan Rong , Jiaqi Zhou , Yuqing Hu , Xianzhi Chai , Hai-Hao Han , Xiao-Peng He

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Abstract

Epilepsy is a common neurodegenerative disorder. Despite the rapid development of diagnostic and therapeutic strategies for epilepsy, one-third of patients still suffer from a low diagnostic efficiency due to the substantial heterogeneity of this disease. Therefore, it is imperative to create efficient tools to identify biomarkers expressed during different epileptic states, thereby increasing the number of patients that could benefit from surgical intervention. Fluorescent imaging is an efficient, non-invasive, and high-resolution technique that has emerged as a powerful tool for disease diagnosis. Numerous fluorescent small-molecule probes have been designed for the diagnosis of epilepsy. This review summarizes currently identified biomarkers relevant to epilepsy, and highlights fluorescent probes developed to detect these biomarkers. The use of the probes for fluorescence-based imaging of epilepsy in vivo will also be discussed. Finally, this review discusses the challenges of currently developed fluorescent probes in terms of clinical translation.

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小分子荧光探针用于癫痫生物标志物成像的研究进展

癫痫是一种常见的神经退行性疾病。尽管癫痫的诊断和治疗策略发展迅速，但由于该病的异质性，仍有三分之一的患者的诊断效率较低。因此，必须创建有效的工具来识别在不同癫痫状态下表达的生物标志物，从而增加可以从手术干预中受益的患者数量。荧光成像是一种高效、无创、高分辨率的技术，已成为疾病诊断的有力工具。许多荧光小分子探针已被设计用于癫痫的诊断。本文综述了目前发现的与癫痫相关的生物标志物，并重点介绍了用于检测这些生物标志物的荧光探针。探针用于荧光成像的癫痫在体内也将讨论。最后，本综述讨论了目前开发的荧光探针在临床翻译方面的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.