Microchemical Journal最新文献

{"title":"Enhanced voltammetric detection of chlorogenic acid using a GCE modified with CNTs and ultrasonically assisted synthesized ZrO2 and W nanoparticles: Application to traditional coffee samples","authors":"Tuğçe Teker,&nbsp;Faysal Alhammad,&nbsp;Mehmet Aslanoglu","doi":"10.1016/j.microc.2025.113983","DOIUrl":"10.1016/j.microc.2025.113983","url":null,"abstract":"<div><div>The increasing demand for antioxidant-rich coffee emphasizes the need for sensitive, reliable methods to detect chlorogenic acid (CGA), a key antioxidant in coffee. Accurate CGA quantification is challenging due to variations across different coffee types and preparation methods, posing difficulties for conventional analytical techniques. This study introduces a novel electrochemical platform for CGA detection, utilizing a composite of zirconium oxide (ZrO₂), tungsten (W) nanoparticles, and carbon nanotubes (CNT). The composite was applied to a glassy carbon electrode (GCE) via drop-casting, followed by electrochemical characterization using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The impedance data were interpreted using a R_s + (R_ct + (W‖C₁)) + C₂ equivalent circuit, revealing a low charge transfer resistance and favorable interfacial properties. The developed sensor was used to detect CGA in bitter, Turkish, and turpentine coffee samples via square wave voltammetry (SWV). The ZrO₂@W/CNT/GCE sensor exhibited high performance with an electroactive surface area of 0.368 cm², low charge transfer resistance (113 Ω), a broad detection range (4.0 × 10⁻¹⁰ to 5.0 × 10⁻⁶ M), and a low detection limit (1.4 × 10⁻¹¹ M). It accurately quantified CGA levels in coffee samples: 46.9 ± 0.9 mg/L in bitter coffee, 36.1 ± 0.5 mg/kg in Turkish coffee, and 43.3 ± 0.8 mg/kg in turpentine coffee. The platform demonstrated excellent reproducibility, stability, and selectivity, showing potential for reliable CGA detection in coffee analysis.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113983"},"PeriodicalIF":4.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in flow analysis coupled with liquid waveguide capillary cell for trace analysis in aquatic environments: A systematic review (2012–2024)","authors":"Junxian Pei ,&nbsp;Wenting Zhu ,&nbsp;Kunning Lin","doi":"10.1016/j.microc.2025.113977","DOIUrl":"10.1016/j.microc.2025.113977","url":null,"abstract":"<div><div>Trace substances in aquatic environments play a pivotal role in biogeochemical cycles and public health, necessitating accurate quantification for both scientific research and environmental monitoring. The integration of flow analysis (FA) with liquid waveguide capillary cell (LWCC) technology has emerged as a robust analytical approach, overcoming the sensitivity limitations inherent to conventional spectrophotometric methods. This review systematically evaluates the application of FA-LWCC systems for determining trace nutrients, metals, and other organic/inorganic compounds in aqueous matrices from 2012 to 2024. The present work has three principal objectives: (1) to perform a critical comparative analysis of different FA-LWCC systems, assessing their respective merits and limitations; (2) to comprehensively evaluate FA-LWCC applications for trace quantification of nutrients, metals, and other organic/inorganic compounds in aqueous media; and (3) to identify current methodological challenges and propose future research priorities. This comprehensive review highlights the advancements in FA-LWCC technology for trace analysis in environmental matrices, and aims to stimulate further innovation in this critical field of analytical chemistry. We anticipate that this work will serve as a valuable reference for researchers engaged in trace-level determinations, particularly those focused on aquatic systems.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113977"},"PeriodicalIF":4.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Split Aptamer-Driven CRISPR-Cas12a biosensor with signal amplification for quantitative detection of adenosine deaminase","authors":"Ping Qiu ,&nbsp;Longjian Huang ,&nbsp;Jiayi Zhang ,&nbsp;Wenbo Li ,&nbsp;Xudong Xin ,&nbsp;Luchang Chen ,&nbsp;Qianli Tang ,&nbsp;Kai Zhang ,&nbsp;Xianjiu Liao ,&nbsp;Jihua Wei","doi":"10.1016/j.microc.2025.113975","DOIUrl":"10.1016/j.microc.2025.113975","url":null,"abstract":"<div><div>We report the development of a novel split aptamer-driven electrochemical biosensor integrating entropy-driven Signal amplification (EDSA) and CRISPR-Cas12a technology for the highly sensitive and specific detection of adenosine deaminase (ADA). ADA is an important biomarker involved in immune regulation and purine metabolism, and its accurate quantification is critical for diagnosing various diseases. In our system, ADA catalyzes the deamination of adenosine to inosine, resulting in the release of Aptamer1 from a split aptamer structure. The liberated Aptamer1 initiates a strand displacement reaction within a Blocker/Bandage/Scaffold complex, triggering a cascade of entropy-driven amplification cycles that generate a DNA duplex capable of activating CRISPR-Cas12a. Activated Cas12a exhibits <em>trans</em>-cleavage activity, specifically cleaving a ferrocene-labeled single-stranded DNA (ssDNA) probe immobilized on a gold electrode, leading to a measurable decrease in electrochemical signal. The biosensor operates under isothermal and enzyme-free conditions, providing simplicity, rapid detection, and low cost. It achieves a low detection limit of 0.688 U·L⁻¹ with a wide linear range from 1 to 20,000 U·L⁻¹. The system demonstrates excellent specificity against ADA analogues and common interfering proteins and performs reliably in diluted human serum samples. This strategy represents a versatile and modular platform for point-of-care diagnostics. By altering the aptamer sequence, the biosensor can be adapted for the detection of other clinically relevant proteins and enzymes, contributing to advances in personalized medicine.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113975"},"PeriodicalIF":4.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive and facile photoelectrochemical and colorimetric dual-mode analysis of H2S based on MOF-derived TiO2/C@Au@Cu(II) nanodisk","authors":"Leixia Meng ,&nbsp;Qianqian Wu ,&nbsp;Jinlong Wang ,&nbsp;Zihao Wang ,&nbsp;Zhenzhi Wang ,&nbsp;Bingxin Zhou ,&nbsp;Jianjun Shi ,&nbsp;Ke Xiao","doi":"10.1016/j.microc.2025.113991","DOIUrl":"10.1016/j.microc.2025.113991","url":null,"abstract":"<div><div>Considering the severe toxicity and potential harm of hydrogen sulfide (H₂S) released during agricultural and industrial activities, the development of sensitive and reliable method to measure H₂S is worthwhile for environmental monitoring and human health. Here, the Cu(II) ions were introduced into MIL-125-derived TiO₂/C@Au nanodisk (denoted as TiO₂/C@Au@Cu(II)) and worked as the recognition elements. The H₂S could react with Cu(II) ions to generate CuS, resulting in a reduction in photocurrent and an augment in absorption. Based on this, a sensitive and facile photoelectrochemical (PEC) and colorimetric dual-mode sensing platform was designed for H₂S detection. In PEC mode, the steric hindrance of CuS obstructed the transport of photoexcited charge carriers and the diffusion of electron acceptor/donor between the electrode and electrolyte solution. Thereby, a quenching of the photocurrent signal was observed. For colorimetry, using the peroxidase-mimicking activity of CuS, the color reaction of 3, 3′, 5, 5′-tetramethylbenzidine (TMB) in the presence of H₂O₂ was triggered, causing an obvious absorbance response of colorimetric solution. Noticeably, the dual-mode detection exhibited a wide linear scope of 1 – 5 × 10⁵ nM for H₂S, achieving detection limits of 0.33 and 0.41 nM, respectively. Furthermore, this method presented numerous merits, containing high specificity, remarkable reliability, simplicity, cost-effectiveness and time-efficiency, highlighting its application prospects in environmental analysis and human safety.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113991"},"PeriodicalIF":4.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reusable and In-Situ Electrodeposited SPE-PB-Ag Substrate: Advancing EC-SERS for efficient acetamiprid detection in fruits and vegetables","authors":"Huan Jiang ,&nbsp;Xuemei Tang ,&nbsp;Chengzhen Ji ,&nbsp;Jing Wei ,&nbsp;Jianjun Liao ,&nbsp;Long Wu","doi":"10.1016/j.microc.2025.113971","DOIUrl":"10.1016/j.microc.2025.113971","url":null,"abstract":"<div><div>In agriculture, the spread of pesticides, especially neonicotinoid acetamiprid (AAP), has raised concerns about food residues which are of relevance to public health and safety. To solve this problem, we have developed a high-throughput detection method, electrochemical surface-enhanced Raman Spectroscopy (EC-SERS), which can detect AAP quickly and sensitively in fruit and vegetables. Our method involves the creation of a new label-free substrate, SPE-PB-Ag, by means of an in situ electrodeposition process that is directly applicable to the detection of pesticide residues in EC-SERS. This substrate demonstrated a broad linear range of detection from 0.1 μM to 100 μM at a potential of −0.6 V and a low limit of detection (LOD) of 0.038 μM, which is 10-fold higher than the conventional SERS method (LOD, 0.366 μM). The potential used effectively modulated the stable physical adsorption interactions between the AAP molecules and the substrate surface, thus optimising the EC-SERS detection process. Moreover, the SPE-PB-Ag EC-SERS substrate exhibits the ability to be regenerated through simple washing with pure water, thus sustaining its high enhancement effect over multiple uses. Therefore, this study presents an innovative, convenient, rapid, and reliable strategy for the detection of pesticide residues in fruits and vegetables, advancing the field of food safety and environmental monitoring.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113971"},"PeriodicalIF":4.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Na3CA-assisted post-necking treatment of Bi4TaO8Cl photoelectrode for improved photoelectrochemical sensing of cysteine","authors":"Kai Liang,&nbsp;Jiacheng Xi,&nbsp;Xinghui Hou,&nbsp;Huiyu Yuan,&nbsp;Junyan Cui","doi":"10.1016/j.microc.2025.113980","DOIUrl":"10.1016/j.microc.2025.113980","url":null,"abstract":"<div><div>Bi₄MO₈X-based nanomaterials exhibit promising potential for bioanalytical applications owing to their wide visible light absorption and strong affinity for thiol ligands. However, their photoelectrochemical (PEC) sensing performance is hindered by the low charge separation efficiency. In this study, particulate Bi₄TaO₈Cl photoelectrodes were prepared via a drop-coating method, and their charge separation behavior was optimized through trisodium citrate (Na3CA)-assisted post-necking treatment. This treatment facilitated the substitution of Na⁺ ions for Bi³⁺ ions, which enhanced oxygen vacancy generation. Additionally, it improved inter-particle connectivity. Benefiting from these modifications, the newly fabricated Na-Bi₄TaO₈Cl photoelectrode demonstrated significantly enhanced charge separation and transfer efficiency. Subsequently, a visible-light-driven PEC sensor based on the Na-Bi₄TaO₈Cl electrode was developed for cysteine detection, leveraging the specificity of Bi-S bond. Under visible-light irradiation, the PEC sensor exhibited superior PEC detection performance for cysteine, achieving a sensitivity of 360.00nA·cm⁻²·mM⁻¹ and a linear detection range of 0–3.00 mM. The sensor also demonstrates good selectivity and stability. Moreover, it showed satisfactory recoveries in the detection of cysteine in real samples such as egg white. All these prove the practicability of the PEC sensor. This work provides a novel strategy for designing advanced nanomaterials for biological sensing applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113980"},"PeriodicalIF":4.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical sensors for doping detection: Applicable bio-samples, recognition, and signal amplification","authors":"Yan Pan ,&nbsp;Huaxing Li ,&nbsp;Chunguang Hou","doi":"10.1016/j.microc.2025.113979","DOIUrl":"10.1016/j.microc.2025.113979","url":null,"abstract":"<div><div>Sports doping seriously undermines the fairness of athletic competition and also causes irreversible damage to the athletes’ physical health. Recently, as the types of doping substances have been updated, the methodology for doping control has also evolved. Among them, electrochemical (EC) sensors have gained significant development in the field of doping detection with the advantages of high detection sensitivity, simple operation process, easy integration and portability. This review systematically summarized the types and action manners of common doping agents, and the applicable biological sample matrices, the specific recognition mechanisms, as well as the detection signal cascade amplification strategy during EC assays. Comparison between the EC sensing technology and other mass spectrometry-based doping detection methods was also proposed. Meanwhile, in view of the development drawbacks and practical demands of EC detection of doping, the research perspective on the development direction of EC sensing technology was presented. We expect that this review might advance the development of EC sensing platforms for sensitive detection of low concentrations of exposed doping substances in complex biological matrices.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113979"},"PeriodicalIF":4.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection and classification of lambda-cyhalothrin and iprodione residues in tobacco leaves by SERS combined with supervised machine learning","authors":"Weifan Pan ,&nbsp;Peng Zhang ,&nbsp;Qi Wang ,&nbsp;Liangguang Du ,&nbsp;Xue Yang ,&nbsp;Xiaowei Guo ,&nbsp;Jiamin Yu","doi":"10.1016/j.microc.2025.113959","DOIUrl":"10.1016/j.microc.2025.113959","url":null,"abstract":"<div><div>Surface-enhanced Raman spectroscopy (SERS) is a promising technique for the rapid detection of trace pesticide residues in agricultural produce. Currently, research is predominantly centered on utilizing SERS to discern residues characterized by non-overlapping spectral peaks. Yet, the technology encounters challenges in accurately identifying substances when their Raman spectral peaks overlap. In this paper, a silver nanoparticles (Ag Nps) modified SiO₂ nanoparticles (SiO₂ Nps) arrays composite SERS substrate (SiO₂@Ag Nps-SERS substrate) was prepared for detecting lambda-cyhalothrin (LCT) and iprodione (IPR) residues in tobacco leaves, with detection limits of 0.1 ppm and 1 ppm respectively. And then, supervised machine learning models were used to identify and classify LCT and IPR residues with overlapped Raman characteristic peaks at 1000 cm⁻¹. Support Vector Machine (SVM), Partial Least Squares Discriminant Analysis (PLS-DA) and Decision Tree (DT) models could all accurately classify the spectral data of LCT and IPR residues, and the classification accuracy of SVM model was the highest, reaching 99.74 %. This capability is a testament to the innovative strength of our approach, highlighting its potential for universal applicability in spectral data analysis.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113959"},"PeriodicalIF":4.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic molecular imprinting-restricted access materials combined with luminous boric acid carbon dots for fluorescence monitoring of Tetracycline","authors":"Yinhai Li ,&nbsp;Weilong Zhao ,&nbsp;Xiaofan Tang ,&nbsp;Fei Xu ,&nbsp;Chunmiao Bo","doi":"10.1016/j.microc.2025.113966","DOIUrl":"10.1016/j.microc.2025.113966","url":null,"abstract":"<div><div>In biological samples, the accurate fluorescence detection of tetracycline (TC) affects by not only the interfering molecules but also the nonspecific adsorption of marcromolecules such as proteins. This study developed magnetic molecular imprinting–restricted access materials (MMIP–RAMs) for TC detection. The MMIP–RAMs was synthesized using magnetic poly(chloromethylstyrene-<em>co</em>-divinylbenzene) (Fe₃O₄@P_VBC/DVB) microspheres as the substrate, through two-step surface initiated-atom radical polymerization, TC-molecular imprinting polymers as the recognition sites and zwitterionic phosphorylcholine (MPC) polymers as the anti-protein sites were successively constructed onto Fe₃O₄@P_VBC/DVB surface. The resulting MMIP–RAMs of Fe₃O₄@P_VBC/DVB@MIP@poly(MPC) exhibited a high TC adsorption capacity (138.6 mg g⁻¹) and an anti-protein capacity (above 96.8 %). Meanwhile, boric acid-containing carbon dots (BA-CDs) were prepared by citric acid and 3-aminobenzeneboronic acid precursors through hydrothermal method. In fluorescence detection, MMIP–RAMs could specially recognize TC by its imprinted cavity, after adding luminous BA-CDs, the combined MMIP–RAMs/TC could further bond BA-CDs with aid of boron affinity forces between <em>cis</em>-diol in TC and the boric acid groups in BA-CDs, forming MMIP–RAMs/TC/BA-CDs sandwich particles. The changes of pristine and remaining fluorescence intensity of BA-CDs had a linear relationship to TC content, establishing a simple fluorescence detection method. The fluorescence detection of TC was in the range of 44 − 264 ng mL⁻¹ and low detection limit of 7.1 ng mL⁻¹. When applying this method in milk, the fluorescence interference of background protein was completely eliminated by MMIP–RAMs to guarantee the accuracy of fluorescence determination, the resulting recovery rates of TC in milk were 100.0 − 105.4 % with relative standard deviations of 4.8 − 7.9 %, highlight application potential.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113966"},"PeriodicalIF":4.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tri-mode sensing of Alzheimer’s disease biomarkers mediated by sophisticated Yb/Er co-doped NaGdF4@Au nanocomposites with surface enhanced Raman scattering/up-conversion luminescence/magnetic resonance properties","authors":"Wenting Lan ,&nbsp;Yasheng Dai ,&nbsp;Siqi Chen ,&nbsp;Shiyuan Wang ,&nbsp;Yongling Zhang ,&nbsp;Chenjie Gu ,&nbsp;Tao Jiang ,&nbsp;Yuning Pan","doi":"10.1016/j.microc.2025.113939","DOIUrl":"10.1016/j.microc.2025.113939","url":null,"abstract":"<div><div>Multi-modal sensing techniques based on versatile optical nanocomposites have advanced rapidly, enabling fast and precise diagnosis of biological substances with high sensitivity and resolution. In this study, Yb/Er co-doped NaGdF₄@Au nanocomposites were synthesized using an efficient electrostatic attraction strategy facilitated by surface modification. The quantity of sensitizing Yb ions and the incorporation of Au nanoparticles (NPs) were identified as crucial factors influencing upconversion luminescence (UCL). Notably, concentration-dependent magnetic resonance imaging (MRI) was demonstrated for the Gd-participated nanocomposites, allowing for dual-mode bioimaging of brain neuroma cells. Attributed to the enhanced localized electromagnetic field generated by the Au NPs assembled on the NaGdF₄ matrix, surface enhanced Raman scattering (SERS) were further obtained from the nanocomposites, which demonstrated reliable sensitivity, reproducibility, homogeneity, and stability. Consequently, the proposed nanocomposites were employed in a typical sandwich immunoassay for Amyloid-beta 42, based on a linear dose–response curve established through SERS modality. This multi-modal sensing platform holds significant potential for diverse clinical biomedical diagnostics.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"214 ","pages":"Article 113939"},"PeriodicalIF":4.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}