Microchemical Journal最新文献

{"title":"Fluorescence polarization assays: Another mainstream in detection of biohazards","authors":"Chang Yeol Lee ,&nbsp;Juyeon Jung","doi":"10.1016/j.microc.2025.113523","DOIUrl":"10.1016/j.microc.2025.113523","url":null,"abstract":"<div><div>Infectious pathogens such as virus and drug-resistant bacteria are widespread, incurring high incidence, mortality rates, and significant socioeconomic burdens. Standard diagnostic methods such as bacterial culture, nucleic acid testing (NAT), and immunoassays have been used for containment. These methods, however, face technical challenges. Procedures are complicated, time/labor-intensive, and depend on bulky, expensive instruments. NAT systems based on quantitative polymerase chain reaction (qPCR) and clustered regular interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) use fluorescence readouts, relying on costly fluorophore (F)-quencher (Q) reporter probes. In addition, the fluorescence readout is susceptible to external noises, affecting the sensitivity and reliability of the analysis.</div><div>Attributed to an underlying principle in signal readout, a fluorescence polarization (FP) system outperforms the fluorescent ones. It interrogates the polarization of emitted light from Fs upon excitation with linearly polarized light. Fs’ rotational behaviors that mainly rely on their molecular weights govern the degree of polarization of emitted light, resulting in corresponding FP signal change. Thus, FP system works with a simpler, cost-effective Q-free reporter probe. In addition, it provides robust signals with ratiometric nature of the readout.</div><div>This review discusses diagnostic systems for biohazards that leverage FP readout and novel molecular/immuno-assays. We will explore the assay designs, principles, and practical features of these systems, while addressing current challenges. A critical discussion will suggest future directions for further advancements, aiming to make FP-based diagnostic systems a standard tool for clinical care.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113523"},"PeriodicalIF":4.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical review of recent progress on lithium ion batteries: Challenges, applications, and future prospects","authors":"Harish Sharma ,&nbsp;Shivangi Sharma ,&nbsp;Pankaj Kumar Mishra","doi":"10.1016/j.microc.2025.113494","DOIUrl":"10.1016/j.microc.2025.113494","url":null,"abstract":"<div><div>Li-based batteries are significantly advanced in both the commercial and research spheres during the past 30 years. The history of lithium-based batteries is rife with innovations and backtracking steps, from the earliest lithium metal anode interactions of the modern commercial lithium-ion batteries (LIBs). However, in the early twentieth century, research on LIBs places more emphasis on solid-state physics, and researchers started paying more attention to the morphology of electrode materials. Different performance parameters – energy, electricity, cycle life, safety, costs and environmental impact-often need to be compensated depending on application and are linked to difficult material chemistry problems. Cell phones and a number of other portable electrical devices are currently employing Li-ion rechargeable batteries as their power source &amp; demand for them seems to be rising quickly. The Li-ion rechargeable battery has become developed in the growth sector with significant momentum for its research as a result of the concern over the energy sources, either for large-scale batteries for electricity power storage or for electric vehicles (EV). The current study of the materials that design anode, electrolyte, and cathode is presented here, along with the state-of-the-art of Li-ion battery technology, &amp; the underlying issues related with their development, benefits, and drawbacks are explored. In this review, we will conclude the research on the current modern battery as well as a brief discussion of battery chemistry other than lithium-ion. The paper finally identifies practically workable near-term strategies which considered the significant difficulties with some major techniques.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113494"},"PeriodicalIF":4.9,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-step electrodeposition of gold nanospheres/reduced graphene oxide for adsorptive stripping voltammetric determination of iron in seawater","authors":"Cuncun Ma ,&nbsp;Ying Li ,&nbsp;Haitao Han","doi":"10.1016/j.microc.2025.113499","DOIUrl":"10.1016/j.microc.2025.113499","url":null,"abstract":"<div><div>An effective voltammetric method for determination of iron (Fe) in seawater was proposed based on the gold nanospheres (AuNSs)/electrochemically reduced graphene oxide (E-rGO) modified glassy carbon electrode (GCE). The AuNSs/E-rGO/GCE was prepared through a simple one-step electrodeposition method. E-rGO provides perfect conductivity, larger electrode surface, and more active sites for AuNSs which possess the ability to accelerate electron transfer and excellent electro-catalytic performance for the voltammetric determination of Fe³⁺. Benefiting from the synergistic effects of E-rGO and AuNSs, the AuNSs/E-rGO/GCE exhibited excellent performance for the voltammetric determination of Fe³⁺. Adsorptive stripping voltammetry was adopted for Fe³⁺ determination using the fabricated AuNSs/E-rGO/GCE with 1-(2-Pyridylazo)-2-naphthol as the complexing ligand. Under the optimal conditions, the AuNSs/E-rGO/GCE showed a limit of detection was 1.5 nM and linear range was 5 ∼ 450 nM for Fe³⁺ determination. In addition, the AuNSs/E-rGO/GCE has been successfully applied to determine the total dissolved Fe in real seawater samples.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113499"},"PeriodicalIF":4.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on hydrophobic materials in oil–water separation","authors":"Xunan Zhang ,&nbsp;Wenjie Liu ,&nbsp;Bixue Gao ,&nbsp;Wei Zong","doi":"10.1016/j.microc.2025.113455","DOIUrl":"10.1016/j.microc.2025.113455","url":null,"abstract":"<div><div>With the rapid development of industry, the emission of oil-containing waste has increased significantly, causing serious damage to the ecological environment. Inspired by the typical biological surface superhydrophobic phenomenon in nature, hydrophobic materials have gained widespread attention from scientists in the oil–water separation field due to their advantages of high separation efficiency, simple preparation methods, eco-friendliness, and low cost. In this review, the inspiration, properties and commonly used methods for constructing hydrophobic substances are first introduced. Next, research results of hydrophobic substances in the field of oil–water separation are reviewed. Last but not least, the challenges and future development direction in the field of hydrophobic substances are discussed.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113455"},"PeriodicalIF":4.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable glucose sensors based on substrate material: A review","authors":"Yu-Zhu Zhao ,&nbsp;Nian-Cui Liu ,&nbsp;Moldir Rustem ,&nbsp;Guo-Cheng Han ,&nbsp;Xiao-Zhen Feng ,&nbsp;Heinz-Bernhard Kraatz","doi":"10.1016/j.microc.2025.113446","DOIUrl":"10.1016/j.microc.2025.113446","url":null,"abstract":"<div><div>Diabetes mellitus is increasingly prevalent, necessitating regular sweat glucose (SG) monitoring for effective disease management. Sweat holds significant promise in disease diagnosis and health monitoring because of its easy collection method and the abundant biochemical information it provides. Glucose is a primary energy source for cellular activity, and precise measurement of its concentration in sweat can estimate SG levels effectively. Non-invasive continuous glucose monitoring through sweat sensors makes wearable electronic devices increasingly desirable for personal health monitoring, given their non-intrusive nature.</div><div>This review starts by providing a thorough overview of sweat-based wearable sensors, focusing on their importance in glucose monitoring. The sensors are categorized according to the materials used in their substrates. Next, we summarize and discuss the challenges and opportunities facing researchers and clinicians in wearable glucose biosensors. We also envision the future of epidermal glucose monitoring, aiming to maximize its diagnostic potential in diabetes management.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113446"},"PeriodicalIF":4.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly features in molecularly imprinted polymers for applications in electrochemical and optical sensing","authors":"Hany Abd El-Raheem ,&nbsp;Abdullah S. Alawam ,&nbsp;Hassan A. Rudayni ,&nbsp;Ahmed A. Allam ,&nbsp;Rabiaa Helim ,&nbsp;Rehab Mahmoud ,&nbsp;Niluh Indria Wardani ,&nbsp;Waleed Alahmad","doi":"10.1016/j.microc.2025.113443","DOIUrl":"10.1016/j.microc.2025.113443","url":null,"abstract":"<div><div>Synthetic receptors embedded in polymeric matrices can be fabricated using molecularly imprinted polymers (MIPs), a novel methodology designed to mimic the biological lock-and-key interactions of antibodies with their target antigens. These artificial receptors exhibit high binding efficiencies and exceptional selectivity, enabling them to recognize target molecules even in complex matrices with interfering species. MIPs facilitate seamless integration between artificial materials and natural systems, offering significant versatility across various applications. Traditionally, MIP synthesis has relied heavily on organic solvents. However, increasing regulatory restrictions on chemical use, growing environmental concerns, and the demand for higher product purity are driving the transition toward greener and more sustainable synthesis methods. These advancements align with green chemistry and engineering principles, promoting environmentally friendly practices. This review highlights recent developments in green materials and their applications in (bio) sensing technologies, particularly electrochemical and optical (bio) sensors. Moreover, the analytical greenness assessment tool for molecularly imprinted polymers synthesis (AGREEMIP) was involved in this review. Additionally, it discusses existing challenges in the field and explores future research directions aimed at fostering sustainable innovations in molecular imprinting and sensor development.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113443"},"PeriodicalIF":4.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive optical analysis of aqueous dissolved organic Matter: From sampling techniques to analytical interpretation","authors":"Binessi Edouard Ifon ,&nbsp;Azhar Rashid ,&nbsp;Fidèle Suanon ,&nbsp;Yeyuan Xiao ,&nbsp;Anyi Hu","doi":"10.1016/j.microc.2025.113437","DOIUrl":"10.1016/j.microc.2025.113437","url":null,"abstract":"<div><div>Ultraviolet–visible spectroscopy (UV–Vis) and fluorescence spectroscopy have been used widely to study dissolved organic matter (DOM), however, it is scarce to find a relatively complete and detailed protocol together with analytical methods for the characterization of DOM in aquatic environments. This warrants a review of materials and methods as well as the applications of DOM optical parameters from a wider range of research topics along with a critical comparison of the individual parameters. In this review we provide a comprehensive optical analysis of aqueous DOM, focusing on refining sampling techniques and advancing analytical interpretation to enhance water quality assessments. The study systematically compares various sampling methods, including <em>in-situ</em> and continuous monitoring, to determine their impact on the optical properties of DOM. Key optical techniques, such as fluorescence excitation-emission matrix (EEM) spectroscopy and UV–visible absorbance, were employed to characterize the molecular composition, sources, and transformation processes of DOM. Additionally, given the constraints of closed-source tools like MATLAB, an alternative open-source StaRdom package in RStudio for DOM characterization was discussed. Results demonstrate that sampling techniques significantly influence DOM optical signatures, affecting the accuracy of source tracking and environmental monitoring. Moreover, a detailed interpretation of spectral data revealed correlations between specific fluorescence indices and DOM origin, including terrestrial, microbial, and anthropogenic sources. The review offers a reliable approach for interpreting optical data and integrating multivariate statistical tools to improve the identification of DOM patterns across different aquatic environments. This analysis provides critical insights into the optical behavior of DOM and underscores the importance of selecting appropriate sampling techniques for accurate environmental assessment and water treatment applications. The review presents wide opportunities for the enhanced monitoring and management of water quality.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113437"},"PeriodicalIF":4.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next-generation microfluidics based on artificial intelligence: Applications for food sample analysis","authors":"Sara Movahedi ,&nbsp;Farshad Bahramian ,&nbsp;Mahnaz Ahmadi ,&nbsp;Niki Pouyanfar ,&nbsp;Reyhane Masoudifar ,&nbsp;Masoumeh Ghalkhani ,&nbsp;Chaudhery Mustansar Hussain ,&nbsp;Rüstem Keçili ,&nbsp;Saeed Siavashy ,&nbsp;Fatemeh Ghorbani-Bidkorpeh","doi":"10.1016/j.microc.2025.113395","DOIUrl":"10.1016/j.microc.2025.113395","url":null,"abstract":"<div><h3>Background</h3><div>Microfluidics has transformed research across science, offering advantages like reduced sample waste and costs over traditional methods. Despite these benefits, microfluidics generates large datasets, posing analysis challenges with conventional tools. To address this, researchers integrate artificial intelligence (AI) with microfluidics. In food safety research, a critical area for human health, precise and reliable platforms are essential. AI-integrated microfluidics platforms show promise, attracting attention for their unique advantages in food sample analysis.</div></div><div><h3>Scope and approach</h3><div>This review explores recent advancements in integrating artificial intelligence (AI) with microfluidics for food sample analysis. It introduces AI and microfluidics principles, discusses their synergistic applications, and examines various algorithms and microfluidic chip designs. It highlights AI-microfluidics integration to enhance food analysis through data processing, pattern recognition, and predictive modeling. It then discusses progress, challenges, and opportunities in this interdisciplinary approach and its potential impact on food analysis.</div></div><div><h3>Key findings and conclusions</h3><div>Integrating AI and microfluidics creates a powerful platform for rapid detection in food analysis, enhancing accuracy, sensitivity, and real-time data processing. This interdisciplinary approach unlocks new possibilities in food safety, quality control, and environmental assessment. Future research should prioritize refining AI algorithms, integrating advanced sensors, addressing scalability, and developing regulatory frameworks to support widespread adoption.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113395"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable paper-based platforms for cellular studies: A review","authors":"Praveen Kumar ,&nbsp;Harikrishnan Ravikumar ,&nbsp;Anjali Awasthi ,&nbsp;Muthukumar Raghunathan ,&nbsp;Ashish Kapoor","doi":"10.1016/j.microc.2025.113409","DOIUrl":"10.1016/j.microc.2025.113409","url":null,"abstract":"<div><div>Paper-based microchemical systems have emerged as transformative and sustainable technologies for biological studies, offering affordability, biodegradability, and portability. Paper, with its multiscale porous structure and tunable properties, provides an ideal platform for replicating cellular microenvironments and facilitating biointerfaces for cell-related applications. Recent innovations have successfully integrated cellular analysis with paper-based platforms, enhancing functionality and expanding their potential. This review explores advances in paper-based platforms, emphasizing their role in enabling precise and accessible cellular analyses for both fundamental and applied research. These innovations broaden the potential of paper-based platforms for healthcare applications, including diagnostics, drug screening, and point-of-care testing, particularly in resource-limited settings. The review also discusses advances in fabrication techniques, material modifications, and surface functionalization to enhance cell adhesion, proliferation, and viability. Integration with image processing techniques is highlighted as a powerful tool for gaining insights into cellular behavior. Additionally, the versatile applications of paper-based platforms in various cellular studies are presented. Sustainable solutions, including hybrid platforms and automated systems, are examined to address challenges such as maintaining cellular microenvironments, enhancing assay sensitivity, and ensuring clinical reliability. This review underscores the potential of paper-based platforms to revolutionize clinical and biomedical analysis through sustainable and innovative technologies.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113409"},"PeriodicalIF":4.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionary carbon quantum dots and their applications: A theoretical computations perspective","authors":"Fanyong Yan ,&nbsp;Tingting Meng ,&nbsp;Jinxia Xu ,&nbsp;Yating Li ,&nbsp;Yang Fu","doi":"10.1016/j.microc.2025.113392","DOIUrl":"10.1016/j.microc.2025.113392","url":null,"abstract":"<div><div>Carbon quantum dots (CQDs) are considered very promising zero-dimensional nanomaterials in the fields of catalysis, optoelectronic materials, sensing and bioimaging. Nevertheless, its complex framework and variable photovoltaic effects pose challenges for its synthesis and design. Theoretical computations play an important role in materials science as a predictive tool, especially in understanding the structure and properties of materials. This review summarizes the progress made in modeling CQDs with GGA, LDA and SHE + U. According to the CQDs used in different domains, the structure–property relationships of the CQDs models are analysed in the areas of catalysis, optoelectronic materials, sensing and bio-imaging. Moreover, challenges and opportunities for theoretical computations in the application of CQDs are discussed.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113392"},"PeriodicalIF":4.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}