Microchemical Journal最新文献

Magnetic Fe3O4@rGO-Ag SERS platform for rapid sub-micromolar detection of triazophos in complex food matrices 磁性Fe3O4@rGO-Ag SERS平台快速亚微摩尔检测复杂食品基质中三唑磷

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-10-08 DOI: 10.1016/j.microc.2025.115660

Jiawei Liu , Chengzhen Ji , Long Wu , Yu Han , Jing Wei , Sihang Zhang , Yongxin Pan , Jinhua Li

{"title":"Magnetic Fe3O4@rGO-Ag SERS platform for rapid sub-micromolar detection of triazophos in complex food matrices","authors":"Jiawei Liu , Chengzhen Ji , Long Wu , Yu Han , Jing Wei , Sihang Zhang , Yongxin Pan , Jinhua Li","doi":"10.1016/j.microc.2025.115660","DOIUrl":"10.1016/j.microc.2025.115660","url":null,"abstract":"<div><div>Triazophos (Tri), a persistent organophosphorus pesticide, poses significant risks on the ecosystems and food safety. Though chromatography-mass spectrometry achieves excellent sensitivity, its cost, training demands and long sample work-up preclude on-site use. Herein, we introduce a magnetic solid-phase micro-extraction SERS platform (Fe₃O₄@rGO-Ag) that couples superparamagnetic isolation (<1 s) with rGO pre-concentration and Ag-nanoparticle plasmonic enhancement. Tri is quantified in 40 min with a limit of detection (LOD) of 0.012 μM (10× lower than direct SERS) and linearity from 1 to 100 μM (R<sup>2</sup> = 0.9932). Kinetic modeling and X-ray photoelectron spectroscopy confirm that reversible physisorption dominates Tri enrichment. In complex food matrices (e.g., <em>Brassica campestris</em> L. and mango), the method delivers recoveries of 99–117 % with relative standard deviation (RSD) less than 6.8 % and retains 97 % of the SERS signal in the presence of common interferents. This work bridges the critical gap between laboratory-grade sensitivity and field-deployable practicality in pesticide monitoring. The protocol's magnetic isolation, reversible enrichment mechanism, and user-friendly optical readout make it easier to perform rapid, on-site quantitative screening at farms and markets, thereby reducing the risk of contaminated produce reaching consumers and mitigating ecological exposure to persistent organophosphorus residues.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115660"},"PeriodicalIF":4.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress of sandwich-type electrochemical immunosensors for the detection of protein markers of lung cancer in human serum 三明治型电化学免疫传感器检测人血清中肺癌蛋白标志物的研究进展

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-10-05 DOI: 10.1016/j.microc.2025.115576

Ziyu Zeng , Weiyu Zhao , Wen Liu , Lina Qiu , Jinchao Song

{"title":"Research progress of sandwich-type electrochemical immunosensors for the detection of protein markers of lung cancer in human serum","authors":"Ziyu Zeng , Weiyu Zhao , Wen Liu , Lina Qiu , Jinchao Song","doi":"10.1016/j.microc.2025.115576","DOIUrl":"10.1016/j.microc.2025.115576","url":null,"abstract":"<div><div>Lung cancer is the leading cause of cancer-related mortality worldwide, e underscoring the urgent need for effective early detection methods. The potential of sandwich-type electrochemical immunosensors for the detection of lung cancer protein markers in human serum has been established. The protein markers include Carcinoembryonic Antigen, Cytokeratin-19 fragment, Neuron-specific Enolase and Pro-gastrin-releasing peptide. These immunosensors capitalize on the high specificity of antibody-antigen interactions and employ various signal amplification strategies, including non-bioactive materials and enzyme-based labels. The utilization of labeling techniques has the capacity to enhance sensitivity, reduce detection limits, and improve stability. This article reviews the labels of sandwich-type electrochemical immunosensors for lung cancer protein markers, focusing on design principles, signal transduction mechanisms, and analytical performance. Despite the initial promise demonstrated in laboratory settings, challenges persist in the domains of multi-marker detection, interference resistance in complex samples, and clinical validation. Future efforts should aim toward multiplexed detection, improved real-sample accuracy, and translation into More portable diagnostic devices to facilitate early lung cancer diagnosis and staging.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115576"},"PeriodicalIF":4.9,"publicationDate":"2025-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single cell analysis for medicine research: A review 单细胞分析用于医学研究：综述

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-10-04 DOI: 10.1016/j.microc.2025.115648

Song Zhang , Lin Qian , Mingxin Lu , Haoya Mou , Jinhong Guo , Peiyang Gao , Jie Cheng

引用次数: 0

Graphene Based Nanocomposites: A State of the Art in Heavy Metal Detection 石墨烯基纳米复合材料：重金属检测的最新进展

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-30 DOI: 10.1016/j.microc.2025.115587

Anuradha Biswal , Susobhan Swain , Rajaram Mishra , Abhisikta Biswal , Sarat K. Swain

{"title":"Graphene Based Nanocomposites: A State of the Art in Heavy Metal Detection","authors":"Anuradha Biswal , Susobhan Swain , Rajaram Mishra , Abhisikta Biswal , Sarat K. Swain","doi":"10.1016/j.microc.2025.115587","DOIUrl":"10.1016/j.microc.2025.115587","url":null,"abstract":"<div><div>A massive rise in anthropogenic activities in the last few decades has substantially exposed human life to different heavy metal (HM) with high toxicological implications, when present over permissible limits. Hence, detection of these elements, even in trace amounts, becomes pivotal for maintaining quality of life. Several materials have been employed to serve this purpose, out of which graphene and its nanocomposites have exhibited true potential in detection of HM ions present in various environmental and food samples with very minimal limit of detection (LOD). The excellent large surface area, optical, electrical, thermal, and mechanical properties of graphene bestow the hybrid materials with true potential to serve as appropriate sensing platforms for HM ions. This review provides a concise view towards graphene, its derivatives, detection methods, and utilization of graphene in sensing of mercury, arsenic, cadmium, lead, and copper ions in different media. Latest development of smart graphene-based nanostructured biosensors in the last decade, which reveal extraordinary selectivity and sensitivity towards these hazardous substances with unparalleled stability enabling them an essential tool in the field of environmental remediation, are also highlighted in this review.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115587"},"PeriodicalIF":4.9,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of magnetic nanomaterials in virus detection: A mini-review 磁性纳米材料在病毒检测中的应用综述

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-29 DOI: 10.1016/j.microc.2025.115565

Xing-yu Long , Ting-mei Wang , Meng Hu , Zi-han Chang , Jing-wen Gu , Yan Zhang , Yang Li

{"title":"Application of magnetic nanomaterials in virus detection: A mini-review","authors":"Xing-yu Long , Ting-mei Wang , Meng Hu , Zi-han Chang , Jing-wen Gu , Yan Zhang , Yang Li","doi":"10.1016/j.microc.2025.115565","DOIUrl":"10.1016/j.microc.2025.115565","url":null,"abstract":"<div><div>The swift and precise identification of viral pathogens plays a pivotal role in epidemic containment and public health protection. With the rapid development of nanotechnology, the application of magnetic nanomaterials (MNMs) in the epidemiological research field is becoming increasingly widespread. MNMs have emerged as powerful tools in virus detection, prevention, and treatment. Their unique magnetic properties, excellent stability, good biocompatibility, high specific surface area, and ease of functionalization make them highly suitable for these applications. These characteristics also provide new ideas and innovative methods for combating viruses. This mini-review highlights the recent advancements in applying MNMs for virus detection. It focuses on their roles in magnetic nanoparticle biosensing technology, magnetic immunoassay/fluorescence and luminescence enhanced detection, multifunctional nanocarriers and electrochemical catalytic signal amplification. The review also covers innovations in colorimetric and thermosensitive sensing. We also explored the obstacles and potential advancements of MNMs in this research area.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115565"},"PeriodicalIF":4.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced ferrite hybrid nanostructures for electrochemical sensing: a review of biomedical diagnostic applications 用于电化学传感的先进铁氧体杂化纳米结构：生物医学诊断应用综述

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-29 DOI: 10.1016/j.microc.2025.115507

Murat Çelik , Ipek Kucuk , Selenay Sadak , Bengi Uslu

{"title":"Advanced ferrite hybrid nanostructures for electrochemical sensing: a review of biomedical diagnostic applications","authors":"Murat Çelik , Ipek Kucuk , Selenay Sadak , Bengi Uslu","doi":"10.1016/j.microc.2025.115507","DOIUrl":"10.1016/j.microc.2025.115507","url":null,"abstract":"<div><div>Ferrite hybrid structures are compounds classified as magnetic metal oxides, often denoted by the formula MFe₂O₄. M usually refers to divalent metal ions, including Mn, Fe, Co, Ni, Cu or Zn. Hybrid nanostructures provide both high conductivity and large surface area, offering more sensitive and reliable sensing in electrochemical sensors. The physical and chemical properties of ferrihybrids vary depending on synthesis methods and processing conditions. Recently, ferrihybrid materials have come to the forefront with their catalytic and magnetic properties and are widely preferred for their ability to increase the selectivity and sensitivity of the developed sensor. The application of ferri-hybrid nanosensors in diagnostics is examined in this comprehensive review under four main headings: cancer, neurodegenerative, renal and diabetes mellitus diseases. Under these headings, metals that form a hybrid structure with ferrite are examined, the synthesis of these structures is reviewed and the reasons for their preference in electrochemical diagnosis are investigated and organized in tables.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115507"},"PeriodicalIF":4.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Programmable prokaryotic Argonautes-assisted sensitive diagnosis of foodborne bacteria: functionalities and multiplexing applications 可编程原核argonautas辅助食源性细菌敏感诊断的进展：功能和多路应用

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-29 DOI: 10.1016/j.microc.2025.115561

Sofiene Mansouri , Yousef Alharbi , Abdulrahman Alqahtani

{"title":"Advancements in Programmable prokaryotic Argonautes-assisted sensitive diagnosis of foodborne bacteria: functionalities and multiplexing applications","authors":"Sofiene Mansouri , Yousef Alharbi , Abdulrahman Alqahtani","doi":"10.1016/j.microc.2025.115561","DOIUrl":"10.1016/j.microc.2025.115561","url":null,"abstract":"<div><div>The global spread of infectious diseases caused by pathogenic microorganisms poses significant challenges to public health. Therefore, it is imperative to develop diagnostic techniques that are sensitive, selective, and user-friendly to effectively control the transmission and progression of these infections. The Argonaute system, recognized as an advanced technique, has been successfully employed in biosensing applications beyond the extensively studied CRISPR/Cas system. While CRISPR/Cas has been widely explored, its reliance on PAM sequence recognition remains relatively limited. Argonaute, recognized for its role as a target-activated nuclease and its programmability, is being repurposed to develop novel sensing techniques. By leveraging its design versatility, the stability of guide DNA, its capacity for multiple-turnover activity, superior nucleic acid cleavage efficiency, and high specificity, Argonaute has been employed in biosensing applications, thereby opening new horizons in analytical chemistry. This paper primarily presents the working mechanism and structure of common Argonaute proteins. The advantages of Argonaute compared to the CRISPR/Cas system in bacterial analysis are outlined and examined. Subsequently, Argonaute-derived sensing approaches for the diagnosis of pathogenic bacteria are comprehensively reviewed, with an emphasis on their design principles. Finally, the prospects and current challenges in this field are critically discussed.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115561"},"PeriodicalIF":4.9,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile synthesis of aluminum based metal-organic frameworks for high adsorption of artificial sweeteners in beverages and seasonings: Integrating experimental and computational study 用于饮料和调味料中人工甜味剂高吸附的铝基金属有机骨架的简易合成：实验与计算相结合的研究

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-27 DOI: 10.1016/j.microc.2025.115536

Xing-Wei Luo , Fu-Shuai Kang , Xiao-Li Wang , Da-Feng Jiang , Yun-Liang Lin , Hai-Long Jiang , Ru-Song Zhao

{"title":"Facile synthesis of aluminum based metal-organic frameworks for high adsorption of artificial sweeteners in beverages and seasonings: Integrating experimental and computational study","authors":"Xing-Wei Luo , Fu-Shuai Kang , Xiao-Li Wang , Da-Feng Jiang , Yun-Liang Lin , Hai-Long Jiang , Ru-Song Zhao","doi":"10.1016/j.microc.2025.115536","DOIUrl":"10.1016/j.microc.2025.115536","url":null,"abstract":"<div><div>In this study, a metal organic frameworks named MIL-53(Al) was designed and constructed via a facile one-pot route for the efficient capture artificial sweeteners (ASs). Capitalizing on its high stability, large specific surface area and π-conjugated backbone, the material showed excellent adsorption capacity and repeatability. Then a solid-phase extraction (SPE) column founded on MIL-53(Al) was fabricated, and it was applied to enriching and analyzing ASs in combination with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The developed method showed good linearity (<em>r</em> ≥ 0.996), low limit of detection (0.22 ng/L), high precision (RSD < 7.81 %). The applicability of the method was evaluated by analyzing six samples (water, beverages and seasonings). The spiked recoveries of ASs in samples ranged from 78.3 to 105 %, and ASs (11.2–24.1 ng/L) were detected in beverage samples. The potential adsorption mechanism was also elucidated based on integrated adsorption experiments and simulation calculations. In summary, this study establishes a precise method for determining ASs in complex matrices, offering reliable solutions for environmental monitoring and food safety assessment.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115536"},"PeriodicalIF":4.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical sensors for the detection of macrolide antibiotics: a review 电化学传感器检测大环内酯类抗生素的研究进展

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-26 DOI: 10.1016/j.microc.2025.115373

Ioan-Adrian Stoian , Bogdan-Cezar Iacob , Ede Bodoki

{"title":"Electrochemical sensors for the detection of macrolide antibiotics: a review","authors":"Ioan-Adrian Stoian , Bogdan-Cezar Iacob , Ede Bodoki","doi":"10.1016/j.microc.2025.115373","DOIUrl":"10.1016/j.microc.2025.115373","url":null,"abstract":"<div><div>Antibiotics have transformed medicine by effectively treating infectious diseases in humans and livestock. However, their misuse has led to the rise of antibiotic-resistant bacteria, making antimicrobial resistance a significant public health challenge of the 21st century. Among the various antibiotic families, macrolides are one of the most frequently prescribed antibiotics. The recent increase in research on electrochemical sensors for macrolide antibiotics (MAs) detection highlights the need for a critical review to summarize recent developments, address current challenges, and outline future research directions, filling a notable gap in literature. While existing reviews have addressed electrochemical detection of other antibiotic classes, there is a conspicuous gap regarding MAs, likely due to historical focus shifts stemming from concerns over serious side effects associated with macrolide derivatives. However, recent advancements have reignited interest in this class, suggesting a macrolide renaissance with potential for novel, safe antibiotics.</div><div>This review outlines various electrochemical techniques employed for MAs detection, focusing on surface modifications and detection mechanisms. Electrode surface modifications have enhanced the electroanalytical performance of sensors, enabling the detection of trace levels of MAs in complex samples such as pharmaceuticals, biological fluids, and food matrices. However, the extent of these improvements is often debated in real-world applications. Further advancements are essential to address specific limitations and validate the reliability of electrochemical methods over traditional separation-based techniques. Despite these hurdles, electrochemical sensing offers significant potential for managing and monitoring MAs across various samples, with integration of smartphones and communication devices enhancing the accessibility of point-of-care testing.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115373"},"PeriodicalIF":4.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent development in polysaccharide-based conductive hydrogels and their potential applications in sensing: An extensive review 多糖基导电水凝胶的研究进展及其在传感领域的应用前景

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-26 DOI: 10.1016/j.microc.2025.115470

Wilson M. Seleka, Edwin Makhado

{"title":"Recent development in polysaccharide-based conductive hydrogels and their potential applications in sensing: An extensive review","authors":"Wilson M. Seleka, Edwin Makhado","doi":"10.1016/j.microc.2025.115470","DOIUrl":"10.1016/j.microc.2025.115470","url":null,"abstract":"<div><div>Reducing toxic petroleum emissions from fossil fuel burning is a critical worldwide issue, directly linked to safeguarding human health and environmental sustainability. Greenhouse gases emitted from energy production not only harm ecosystems but also provide significant threats to human health. Consequently, there is an immediate need for sophisticated gas sensors that provide elevated sensitivity, quick reaction times, and minimal detection thresholds—particularly those functional at ambient temperature. Conventional sensing materials, including metal and metal oxide adsorbents, have potential but often need high temperatures for optimal performance. To address this constraint, researchers have used conducting polymers—specifically polyaniline and its derivatives—incorporated into hydrogel composites. These materials provide a unique amalgamation of conductivity, flexibility, and performance under ambient conditions, making them ideal candidates for next-generation gas sensors. This study provides a thorough examination of current developments in the synthesis, characterization, and use of conductive hydrogel composites. Particular attention is given to their function in identifying harmful gases, highlighting advancements over the last five years. The paper examines the essential sensing principles, identifies existing obstacles, and delineates future trajectories for this potential category of materials in electrochemical sensing technologies.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115470"},"PeriodicalIF":4.9,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0