Microchemical Journal最新文献

{"title":"Kinetics, chemical composition, and network pharmacology of Camphora officinarum essential oils using lithium salt-ultrasonic pretreatment","authors":"Hao Jin, Shengxiang Xu, Tianhao Ma, Qiuyu Chen, Jiahui Li, Yahui Zhang, Qiang Zhang, Fengli Chen","doi":"10.1016/j.microc.2026.118798","DOIUrl":"https://doi.org/10.1016/j.microc.2026.118798","url":null,"abstract":"","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 1","pages":"118798-118798"},"PeriodicalIF":0.0,"publicationDate":"2026-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148408622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue fluorescent molecularly imprinted chitosan gel beads for rapid on-site determination of diazinon in environmental water","authors":"Chaojie Yu, Jie Yang, Yuxin Sang, Congmin Liu, Yi-Xiang Wang, Zuwei Song, Fansheng Cheng, Weina Li","doi":"10.1016/j.microc.2026.118779","DOIUrl":"https://doi.org/10.1016/j.microc.2026.118779","url":null,"abstract":"","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 1","pages":"118779-118779"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salt-promoted homogenization-ultrasonic synergistic extraction of saponins from fresh leaves of Acanthopanax trifoliatus: process optimization, composition analysis and anti-inflammatory activity","authors":"Qingfen Zhang, X J Liu, Zhi Wang, Xuke Chen, Zhiqiang He, W Wang, Minghua Zhu, Zhixin Sun, Qi Lu","doi":"10.1016/j.microc.2026.118684","DOIUrl":"https://doi.org/10.1016/j.microc.2026.118684","url":null,"abstract":"","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 1","pages":"118684-118684"},"PeriodicalIF":0.0,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous colorimetric detection of four bacteria in blood by an integrated multifunctional microfluidic chip","authors":"Tao Jiang, J Liu, Xin Du, Xi Zhang, Yan Xu","doi":"10.1016/j.microc.2026.118729","DOIUrl":"https://doi.org/10.1016/j.microc.2026.118729","url":null,"abstract":"","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 1","pages":"118729-118729"},"PeriodicalIF":0.0,"publicationDate":"2026-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratiometric dual-mode sensing of nitrite in pickled vegetables based on red fluorescent carbon dots as a single signaling element","authors":"Wanling Zheng, Ying Tan, Xiaomin Zhang, Jingru Chen, Liangqia Guo, Fengfu Fu","doi":"10.1016/j.microc.2026.118697","DOIUrl":"https://doi.org/10.1016/j.microc.2026.118697","url":null,"abstract":"","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 1","pages":"118697-118697"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The monitoring and control of carboxymethyl lysine in foods based on fluorescent imprinting composite membrane","authors":"Lizhi Luo, Yong Shao, Le Song, Xun Jiao, Yinjie Bai, Yajie Liu, Jinlong Zhao, Maojun Jin, Sheng Yin, Yingli Liu, Baoguo Sun, Yahui He","doi":"10.1016/j.microc.2026.118725","DOIUrl":"https://doi.org/10.1016/j.microc.2026.118725","url":null,"abstract":"","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 1","pages":"118725-118725"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymatic construction of carbon nanotubes-polydopamine molecularly imprinted electrochemical sensor for ultra-trace creatinine detection","authors":"Fanxing Meng, Ruiting Yao, Palihan Turhanjiang, Chao Feng, Tongpan Liu, Mingping Shen, Zongda Li, Haoqiang Liu, Minwei Zhang","doi":"10.1016/j.microc.2026.118709","DOIUrl":"https://doi.org/10.1016/j.microc.2026.118709","url":null,"abstract":"","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 1","pages":"118709-118709"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silver-doped cobalt ferrite nanowires (Ag:CoFe2O4) as high-sensitivity non-enzymatic electrochemical biosensors for glucose detection in diabetic serum","authors":"Ali Umar ,&nbsp;Noman Nazeer ,&nbsp;Faiz Mahmood ,&nbsp;Vipulkumar M. Dabhi ,&nbsp;N. Raghu ,&nbsp;Ramandeep Kaur ,&nbsp;Kamlajeet Kaur ,&nbsp;Mahnur Jafarli ,&nbsp;Nasiba Jumaniyazova ,&nbsp;Shekhar Singh","doi":"10.1016/j.microc.2026.118523","DOIUrl":"10.1016/j.microc.2026.118523","url":null,"abstract":"<div><div>This study reported the synthesis, structural characterization, and electrochemical biosensing performance of silver-doped cobalt ferrite nanowires (Ag:CoFe₂O₄ NWs, Co₁₋ₓAgₓFe₂O₄, x = 0–0.15) as a non-enzymatic platform for selective and sensitive glucose detection. Nanowires (diameter 25–42 nm, length 800–1200 nm) were synthesized via a co-precipitation–hydrothermal route and characterized by XRD (Rietveld refinement), FESEM, TEM, FTIR, XPS, TGA/DTG, and BET analysis. The optimally doped electrode (x = 0.05, GCE/Ag:CoFe₂O₄/Nafion) exhibits a sensitivity of 1438 μA mM⁻¹ cm⁻², a linear range of 0.5 μM–8.2 mM, and a LOD of 0.12 μM (S/N = 3) in 0.1 M NaOH. The sensor shows negligible interference from uric acid, ascorbic acid, dopamine, fructose, and serum ions, retains &gt;93% response after 30 days, and gives 97.4–102.1% recovery in spiked human serum. The enhanced performance is attributed to maximized BET surface area (87.4 m² g⁻¹), oxygen vacancy density, surface Fe³⁺/Fe²⁺ redox sites, and metallic Ag⁰ co-catalyst coverage at x = 0.05.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 ","pages":"Article 118523"},"PeriodicalIF":4.9,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainability-designed RP-HPLC for comprehensive profiling of pharmaceutical impurities using a model drug substance and its formulations","authors":"Hadeel Alabdulmonem ,&nbsp;Afnan Ali Hussain Hakami ,&nbsp;MaymounahN. Alharthi ,&nbsp;Tahani Y.A. Alanazi ,&nbsp;Hoda A. Ahmed ,&nbsp;Mahmoud A. Mohamed","doi":"10.1016/j.microc.2026.118504","DOIUrl":"10.1016/j.microc.2026.118504","url":null,"abstract":"<div><h3>Objective</h3><div>A comprehensive impurity profiling of Cefixime was carried out using a stability-indicating reversed-phase HPLC method with the purpose of developing a sustainable method. In this work, thirteen pharmacopeial-related substances, such as the isomers of cefazolinic acid, the isomers of cefazoloic acid, and stereoisomers, are separated and quantified simultaneously with minimum environmental impact, following the Green Analytical Chemistry (GAC) principles.</div></div><div><h3>Methods</h3><div>We achieved chromatographic separation on an Inertsil ODS-3 V (250 × 4.6 mm, 5 μm) column maintained at 40 °C. The mobile phase was an ethanol-aqueous solution (pH 4.2) that was acidified with phosphoric acid, and a programmed gradient system at a flow rate of 1.5 mL min⁻¹ was used with UV detection at 254 nm. The studies of forced degradation were carried out under acidic, alkaline, oxidative, thermal, and photolytic stresses to assess the stability-indicating capacity.</div></div><div><h3>Results</h3><div>Without matrix co-elution, the method demonstrated excellent baseline resolution (<em>Rs</em> &gt; 2.0) for Cefixime and all thirteen impurities, confirming high specificity. The method validation was successfully carried out following the ICH Q2(R2) guidelines, with excellent linearity, precision, accuracy, and robustness. Forced degradation studies showed that alkaline (15.7%) and acidic (14.5%) hydrolysis were very prevalent, and detailed chemical mechanisms were suggested for the degradation products. The sustainability of the method has been carefully quantified by four comprehensive metrics, resulting in very high green scores: AGREE, ComplexGAPI, BAGI and RAPI.</div></div><div><h3>Significance</h3><div>This green analytical approach is replacing the use of acetonitrile (hazardous reagent) in analytical methods, using an ethanol bio-renewable system instead. Provides an easy-to-use, high-resolution, and field-ready instrument for routine quality control and stability monitoring of β-lactam antibiotics.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 ","pages":"Article 118504"},"PeriodicalIF":4.9,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cascade amplification with an exonuclease-III (exo-III)-triggered target-reconstructed DNAzyme walker for ultrasensitive multiplex analysis of cervical cancer radiotherapy prognosis related microRNAs by ICP-MS","authors":"Beili Wang ,&nbsp;Wei Gao ,&nbsp;Liang Yang","doi":"10.1016/j.microc.2026.118490","DOIUrl":"10.1016/j.microc.2026.118490","url":null,"abstract":"<div><div>Cervical cancer remains a leading cause of cancer-related mortality among women, and the prognosis of patients after radiotherapy varies considerably due to differences in tumor radiosensitivity and treatment response. Reliable biomarkers for post-radiotherapy prognosis are therefore critically needed. MicroRNAs (miRNAs) have emerged as promising non-invasive indicators, yet accurate detection is hindered by their low abundance and the lack of multiplexing capability in conventional methods. Herein, we report a highly sensitive and specific platform for simultaneous detection of three cervical cancer radiotherapy-associated miRNAs (miR-21, miR-1246, and miR-20a) by integrating an Exo-III-triggered target-reconstructed DNAzyme walker with inductively coupled plasma mass spectrometry (ICP-MS). The strategy employs a structurally locked DNA walker that is sequentially activated through Exo-III-mediated target recycling and DNA polymerase/endonuclease-assisted cyclic amplification, ultimately unleashing a DNAzyme walker to cleave element-labeled substrates. Using orthogonal platinum group element tags (Pt, Ir, Rh), the released tags are quantified by ICP-MS without spectral cross-talk. The method achieves detection limits as low as 0.15 fM, 0.32 fM, and 0.26 fM for miR-21, miR-1246, and miR-20a, respectively, with excellent single-nucleotide discrimination and negligible cross-reactivity. Successful spike-recovery experiments in diluted human serum validate its practical feasibility. This cascade amplification strategy offers a robust, multiplex, and ultrasensitive tool for non-invasive liquid biopsy-based prognostic assessment of post-radiotherapy cervical cancer, and can be readily adapted for other disease-related miRNA panels.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"227 ","pages":"Article 118490"},"PeriodicalIF":4.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148060033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}