Microchemical Journal最新文献

{"title":"Applications of nanosorbents in dispersive solid phase extraction/microextraction approaches for monitoring of synthetic dyes in various types of samples: A review","authors":"Wajid Ali Khan ,&nbsp;Pakorn Varanusupakul ,&nbsp;Hameed Ul Haq ,&nbsp;Muhammad Balal Arain ,&nbsp;Grzegorz Boczkaj","doi":"10.1016/j.microc.2024.112419","DOIUrl":"10.1016/j.microc.2024.112419","url":null,"abstract":"<div><div>Nanosorbents are frequently used in analytical chemistry for their various applications, including extraction and microextraction of synthetic dyes. Synthetic dyes pose a threat to living organisms, particularly humans, due to their worldwide use in a variety of industries. The removal and quantification of synthetic dyes from various matrices is becoming increasingly important. The use of nanosorbents in dispersive solid phase extraction/microextraction (DSPE/DSPME) based approaches are considered the most sensitive and effective techniques for the preconcentration of synthetic dyes due to its high sample clean-up capability, low usage of solvents, high enrichment (preconcentration) factors assuring low detection limits (LOD) of the overall analytical procedures. This review describes widely used nanosorbents, their key properties, and sorption capability, as well as progress and challenges in popular DSPE/DSPME methods and their types, including magnetic solid phase extraction/microextraction (MSPE/MSPME), dispersive micro-solid phase extraction (D-µ-SPE), and ultrasound-assisted dispersive solid phase extraction/microextraction (UA-DSPE/UA-DSPME) for extraction and quantification of dyes. Nanomaterials synthesis methods are typically divided into bottom-up and top-down methods. Bottom-up techniques include hydrothermal, sol–gel, laser pyrolysis, sonochemical, chemical reduction, inert gas condensation (IGC), co-precipitation, and chemical vapor deposition (CVD). Hydrothermal and CVD are the most commonly used. These methods have several advantages, including low cost, the ability to synthesize with a more controlled design, and the release of low waste. However, suffers from ensuring reproducibility and large-scale production. Top-down techniques involve reducing the size of the bulk material to create nanomaterials. The top-down approaches include electrospinning, laser ablation, etching, mechanical milling, thermal decomposition, and sputtering. Top-down techniques yield high-quality nanostructures with precise shapes. However, costly setup and inefficiency in the case of soft materials are considered the major limitations of these approaches. The analytical instrumental technique is used to perform the final quantitative analysis step in these microextraction-based methods. The most common analytical instruments used with these sorbent-based microextraction techniques are UV–visible spectrophotometers, high performance liquid chromatography (HPLC) with UV or diode array detectors (DADs), and liquid chromatography with mass spectrometers. Among the available methods, dedicated procedures for analysis of popular dyes such as Sudan dyes, sunset yellow, malachite green, methylene blue, crystal violet, tartrazine, and azo dye were developed. These methods provide limit of detection (LOD) values at the ppb range, thus meeting the sensitivity demands for environmental analysis and monitoring.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112419"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple and rapid paper-based colorimetric spot test for promethazine screening in recreational drug beverages and pharmaceuticals","authors":"Apichai Phonchai ,&nbsp;Sunisa Pon-in ,&nbsp;Sirirat Resan ,&nbsp;Pavinee Chuayyok ,&nbsp;Duangjai Nacapricha ,&nbsp;Prapin Wilairat ,&nbsp;Korbua Chaisiwamongkhol","doi":"10.1016/j.microc.2024.112353","DOIUrl":"10.1016/j.microc.2024.112353","url":null,"abstract":"<div><div>This study introduces a paper-based colorimetric spot test for the rapid and cost-effective detection of promethazine, featuring enhanced stability and user-friendliness. The developed device employs a potassium persulfate reagent encapsulated in a xerogel matrix, facilitating a simple chemical oxidation reaction that produces a pink color upon promethazine detection. Color quantification is efficiently achieved using a digital camera, with image analysis performed through ImageJ software to convert color image into a blue intensity scale. Under optimized conditions, the method demonstrates a linear calibration curve within the range of 100–600 mg/L and a detection limit of 20 mg/L. The paper-based colorimetric spot test exhibited good intra-day and inter-day accuracy of the recoveries of 98–102 % and 99–101 %, respectively. Good precision of measurement was also achieved (5.6 % RSD). The xerogel matrix ensures the long-term storage stability of the reagent for three months when stored at both 25 °C and 4 °C, making the device suitable for field applications. When applied to detection of promethazine in recreational drug beverage samples and pharmaceutical formulations, the performance of the proposed method showed no significant statistical differences compared to gas chromatography–flame ionization detection (GC–FID). This low-cost, portable, and disposable tool is suited for onsite screening of promethazine, representing a significant advancement in rapid drug detection methodologies.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112353"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and application of tungsten oxide nanostructure for ascorbic acid sensing","authors":"Sakeena Masrat ,&nbsp;Rafiq Ahmad ,&nbsp;Abdullah ,&nbsp;Md.Tabish Rehman ,&nbsp;Mohamed F. AlAjmi ,&nbsp;Prabhash Mishra ,&nbsp;Byeong-Il Lee","doi":"10.1016/j.microc.2024.112337","DOIUrl":"10.1016/j.microc.2024.112337","url":null,"abstract":"<div><div>Engineered nanomaterials that exhibit enzyme-like activity are highly sought after for designing enzymeless sensors, which circumvent the need for costly enzymes. In this context, we synthesized tungsten oxide (WO₃) nanostructures via the hydrothermal method and characterized them using various techniques. A slurry of the resulting WO₃ nanostructure was prepared and drop-cast onto a screen-printed carbon electrode (SPCE) to construct an enzymeless sensor. The electrochemical characteristics of the WO₃/SPCE sensor were evaluated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). An optimized WO₃/SPCE sensor was electrochemically evaluated for ascorbic acid (AA) detection at varying concentrations employing CV analysis. The CV response exhibited a significant oxidation peak for AA, which gradually intensified with an increment in the AA concentration. The sensor demonstrated a linear response up to 1000 μM, high sensitivity (5.62 μA/μM-cm²), and a detection limit (DL) of 0.6 μM. Moreover, the engineered enzymeless WO₃/SPCE sensor displayed excellent selectivity, stability (94.5 % over 6 weeks), and fabrication reproducibility (RSD of 9.2 % across 7 devices). Thus, this WO₃ nanostructure proves to be a promising candidate for the large-scale, cost-effective sensor development for AA detection and holds potential for the fabrication of enzyme-based biosensors.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112337"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidant-assisted preparation of carbon dots pairs for construction of a dual-channel fluorescence sensor array for tetracyclines discrimination","authors":"Jing Li ,&nbsp;Su Li ,&nbsp;Ya-Lan Duan ,&nbsp;Yan-Ting Song ,&nbsp;Lu-Shuang Li","doi":"10.1016/j.microc.2024.112372","DOIUrl":"10.1016/j.microc.2024.112372","url":null,"abstract":"<div><div>The improper or excessive use of tetracyclines (TCs) can lead to residues in the environment and food, posing a global environmental concern. It is imperative to explore simple and economical methods for detecting and discriminating multiple TCs simultaneously. In this work, oxidant-doping carbon dots (OCDs) and reference carbon dots without oxidant-doping (RCDs) were synthesized in the presence and absence of ammonium persulphate (APS), resulting in distinct compositions of functional groups. TCs can quench the fluorescence of the two CDs to different extents, thus a two-channel fluorescence sensor array for five kinds of TCs was constructed. The discrepancies in fluorescence response of the two CDs towards various TCs were maximized through regulating the spiked concentration of APS. Under optimal sensing conditions, each of the five TCs produced unique fluorescence response patterns, allowing for differentiation within concentration ranges of 0.5 ∼ 50 μg mL⁻¹ based on linear discriminant analysis. Discrimination of binary, ternary and quaternary mixtures of TCs was achieved through the sensor array. The sensor array was successfully applied to tap water, lake water, and milk samples, yielding satisfactory recovery rates ranging from 85.1 % to 114.4 %. Additionally, molecular docking was initially employed to investigate the interaction modes and strengths between different TCs and the CDs. Overall, this study provides a viable detection platform for multiple TCs, demonstrating significant potential for environmental monitoring and food quality control.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112372"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionic liquids in dispersive liquid–liquid microextraction for environmental aqueous samples","authors":"Leonardo R. Amaral,&nbsp;Mariana R. Gama,&nbsp;Tânia M. Pizzolato","doi":"10.1016/j.microc.2024.112254","DOIUrl":"10.1016/j.microc.2024.112254","url":null,"abstract":"<div><div>Dispersive liquid–liquid microextraction (DLLME) is considered an environmentally friendly sample preparation technique due to its few steps and the low consumption of solvents and reagents, as well as the smaller amounts of waste generated. Since its first description in 2006, several advances and variations of DLLME have emerged. With the development of more sensitive and selective methods for determining environmental contaminants, the use of ionic liquids has contributed to improving the extraction step. Herein, this review presents a discussion on the use of ionic liquids as extraction solvents for the DLLME technique and its applications for aqueous environmental samples, as well as the challenges demanded by this analytical sample preparation.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112254"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical carbon-based sensors for non-enzymatic uric acid sensing","authors":"Anju Joshi ,&nbsp;Gymama Slaughter","doi":"10.1016/j.microc.2024.112331","DOIUrl":"10.1016/j.microc.2024.112331","url":null,"abstract":"<div><div>Given the clinical importance of uric acid (UA) in various metabolic and cardiovascular disorders, there is an urgent need for the development of reliable monitoring methods. Biosensors have emerged as a promising diagnostic platform for continuous bedside UA monitoring. Recent advancements in novel electrocatalysts, enzyme immobilization strategies, and flexible sensing platforms have significantly enhanced these biosensors’ sensitivity, specificity, and portability. A key area of focus is the development of smart nanomaterials that mimic enzyme action without compromising the electrochemical response for UA detection. This review explores the current landscape of nanomaterials, particularly carbon-based nanomaterials such as carbon nanotubes, graphene, carbon dots, and carbon black, for non-enzymatic UA sensing. It offers comprehensive insights into the latest progress in carbon-based nanomaterials, their performance in point-of-care analysis systems for UA monitoring, the challenges faced, and future directions for clinical implementation.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112331"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fast-response and high-sensitive 8-amidoquinoline-based fluorescent probe for naked-eye selective detection of Zn(II) and its photophysical and bioimaging applications","authors":"Xuan Zhou ,&nbsp;Tianjiao Hou ,&nbsp;Yang Zheng ,&nbsp;Lei Wang ,&nbsp;Fang Wang ,&nbsp;Yu Zhang ,&nbsp;Jun Luo ,&nbsp;Xuan Shen","doi":"10.1016/j.microc.2024.112313","DOIUrl":"10.1016/j.microc.2024.112313","url":null,"abstract":"<div><div>Zinc levels in living organisms and the environment are vital to human health and the environment. Therefore, rapid and highly sensitive methods for detecting Zn²⁺ are required. Herein, a novel fluorescent probe (APYQ) was synthesized by a simple Schiff base reaction. APYQ exhibited high selectivity to detect Zn²⁺ without interference from other metal ions. The limit of detection (LOD) as low as 1.87 nM, and response time as fast as 5 s. These two indicators had the best overall performance compared to other Zn²⁺ probes over the past five years. Single crystals of APYQ and APYQ-Zn²⁺ complex were successfully obtained, indicating that the fluorescence enhancement induced by the large conjugated rigid plane structure of the complex may rationalize the superb detection limit. The intramolecular charge transfer (ICT) and chelation-enhanced fluorescence (CHEF) mechanism was proposed based on Job’s plot, ESI-MS, NMR titration and DFT calculation. Moreover, APYQ possessed the capability to detect Zn²⁺ in water samples and test strips in a qualitative and quantitative manner. Furthermore, APYQ has been effectively used to detect Zn²⁺ intracellularly in Hela cells. This work provides a substantially enriched probe arsenal for the detection of Zn²⁺ with high sensitivity and fast response.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112313"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile one-step synthesis of multifunctional carbon dots for rapid fingerprint recognition, information encryption, and Fe3+ ion detection","authors":"Zhi-Wei Pan ,&nbsp;Qiao-Qiao He ,&nbsp;Ting-Ting Du ,&nbsp;Yu-Dan Deng ,&nbsp;QinMei Zhong ,&nbsp;Qiang Liu ,&nbsp;Wen-Jing Yi","doi":"10.1016/j.microc.2024.112392","DOIUrl":"10.1016/j.microc.2024.112392","url":null,"abstract":"<div><div>Fingerprint recognition plays a crucial role due to its uniqueness. However, conventional detection methods suffer from significant drawbacks, including high consumption, health risk and sample contamination, which restrict their practical application in the crime investigations and forensic analysis. This necessitates the development of simple, rapid, safe and environmentally-friendly alternative methods for fingerprints detection. In this work, we report the synthesis of novel cyan-emitting carbon dots (CDs) via a facile one-step hydrothermal reaction using polyethyleneimine and coumarin as precursors. The CDs enabled the clear visualization of fingerprint patterns on various substrates through immersion and spraying methods with pure water solutions, without the need for any cosolvents. Level 2 and level 3 details of fingermarks were evidently visible for individual identification within a short exposure time under 365 nm UV light irradiation. Additionally, fluorescent 3D fingerprint images revealed direct and specific evidence regarding pressing habits. Interestingly, the fluorescence intensity of CDs was tunable by adjusting the pH. We further fabricated invisible CDs ink for information encryption and decryption via UV irradiation and acid/alkali treatment. Moreover, CDs have the specific ability to sense Fe³⁺ ions in actual water samples, with a detection limit of 0.613 μM and a linear range of 0–27 μM. We conducted an in-depth study on the fluorescence quenching mechanism of CDs caused by Fe³⁺ ions, proposing a plausible mechanism based on a synergistic effect of dynamic quenching, static quenching and inner filter effect. Therefore, this study provides a promising multifunctional nanomaterial for fingerprint recognition, data encryption, and Fe³⁺ detection.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112392"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of deep eutectic solvents as alternate solvents in the microextraction and estimation of pesticide, insecticide, fungicide residues and metal contaminants in tea (Camellia sinensis)","authors":"Lingamallu Jaganmohanrao","doi":"10.1016/j.microc.2024.112515","DOIUrl":"10.1016/j.microc.2024.112515","url":null,"abstract":"<div><div>Teas are produced scientifically in well organised plantation industry This review discusses the microextraction and estimation of metal contaminants, residues of pesticides, insecticides and fungicides from various tea samples using deep eutectic solvents (DES) in different microextraction techniques. DESs are considered as green/safe solvents as these are easily decomposable biologically and eco-friendly, when compared to traditional organic solvents. Homogeneous DES liquids are formed by mixing hydrogen bond donor and hydrogen bond acceptor under appropriate conditions. Natural Deep Eutectic Solvents (NADES) are produced from the components existing in the nature as primary metabolites. Versatility of DES/NADES is good, as these are useful in different varieties of microextraction techniques. Various and suitable parameters are optimised for microextraction techniques to separate maximum metal contaminants as well as residues of phthalates, benzotriazoles, benzothiazoles, bisphenols, endocrine disrupting phenols, polycyclic aromatic hydrocarbons, general insecticides, pesticides and fungicides from variety of tea samples. Appropriate estimation techniques are developed. Micro quantities of samples and solvents are used in these techniques. Selected modern techniques [Liquid-liquid microextraction (LLME), Liquid phase microextraction (LPME), Solid phase extraction (SPE), Solid phase microextraction (SPME), Cloud point extraction (CPE), Magnetic multiwall carbon nano tubes (MMWCNT), Metal Organic Frames (MOFs)] are reported for exclusive and complete separation of contaminants and residues from tea sample using minimum amount of DES/NADES in shorter time. Bioenergy is saved due to minimum use of solvents as well as shorter estimation periods. Lower LODs and LOQs are reported using different chromatographic and spectroscopic techniques. Greenness of the techniques using DESs is improved, when compared to toxic conventional organic solvents.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112515"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating the analytical chemistry Profile: A Three-Decade comprehensive review of fluorometric quantitation in pharmaceutical formulations","authors":"Rajendra Kotadiya","doi":"10.1016/j.microc.2024.112568","DOIUrl":"10.1016/j.microc.2024.112568","url":null,"abstract":"<div><div>Owing to its high sensitivity and specificity, fluorescence spectroscopy has emerged as a critical analytical tool for pharmaceutical formulations. Over the last three decades, it has been widely used to quantify active pharmaceutical ingredients across various drug formulations owing to its ability to detect trace amounts, even in complex matrices. This review synthesizes the applications of fluorescence spectroscopy in pharmaceutical formulations from 1990 to the present, focusing on advancements in methods, solvents, wavelengths, linearity, and sensitivity metrics, such as LODs and LOQs. The data was compiled from studies involving spectrofluorometric methods for pharmaceutical formulations. The key parameters included the excitation and emission wavelengths, solvents, linearity ranges, LODs, and LOQs, with a comprehensive analysis of the trends and developments in these metrics over time. This review highlights substantial variations in excitation (220–419 nm) and emission wavelengths (292–800 nm), reflecting the diverse chemical structures of the drugs analyzed. Water and methanol are the most commonly used solvents for this purpose. Linearity ranges extended from 0.05--600 ng/mL (e.g., amulpride to etodolac), demonstrating the versatility of fluorescence spectroscopy. The LOD values ranged from 0.007 µg/mL (methocarbamol) to 60 ng/mL (fluvoxamine), indicating high sensitivity. Fluorescence spectroscopy remains an indispensable tool for pharmaceutical quantitation, offering enhanced precision and adaptability to a wide range of drug formulations. Its evolution, characterized by increased sensitivity and methodological refinement, ensures its continued relevance in drug quality assurance and regulatory compliance.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112568"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}