Mahdi Ghorbani , Ava Saghafi , Nahid Afshar Lahoori , Sara Sarabyar , Parisa Mohammadi , Mojgan Ojaghzadeh Khalil Abad
{"title":"Comprehensive review of sample preparation strategies for phthalate ester analysis in various real samples","authors":"Mahdi Ghorbani , Ava Saghafi , Nahid Afshar Lahoori , Sara Sarabyar , Parisa Mohammadi , Mojgan Ojaghzadeh Khalil Abad","doi":"10.1016/j.microc.2024.112072","DOIUrl":"10.1016/j.microc.2024.112072","url":null,"abstract":"<div><div>Phthalate esters (PAEs), ubiquitous plasticizers in diverse consumer products, pose significant environmental and human health risks due to their persistence and endocrine-disrupting properties. Accurately determining PAEs in various environmental matrices is crucial for evaluating exposure levels, assessing risks, and implementing effective mitigation strategies. This review comprehensively examines sample preparation techniques for PAE analysis, focusing on methodologies. We categorize these techniques into traditional methods (solid phase extraction, liquid–liquid extraction, QuEChERS), advanced techniques (liquid phase microextraction, solid phase microextraction, and their modifications), and hybrid approaches combining multiple techniques. The strengths, limitations, and recent advancements of each method are thoroughly discussed. This compilation not only summarizes current knowledge but also highlights emerging trends and research gaps, providing valuable insights for future investigations. By fostering scientific progress and innovation in PAE analysis, we aim to support the development of robust analytical methods that contribute to environmental monitoring and risk assessment, ultimately safeguarding human health and the environment.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112072"},"PeriodicalIF":4.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Supramolecular luminescent sensors for explosive detection: Current trends and future directions","authors":"Abhirami R.B. , Mahesh Vasava , Manaswini Karsharma , Riya Khandelwal , Prasenjit Maity","doi":"10.1016/j.microc.2024.112063","DOIUrl":"10.1016/j.microc.2024.112063","url":null,"abstract":"<div><div>The imperative of global security amidst persistent threats of terrorism, organized crimes, and accidental events underscores the critical role of explosive detection in safeguarding public safety. While effective, traditional detection methods are often time- and resource-intensive and may not always be suitable for on-site applications in specific scenarios. Consequently, there has been a concerted research effort to develop fluorescent materials with diverse sensing mechanisms to achieve heightened sensitivity, selectivity, and rapid response times in explosive detection. This review explores the exploration of supramolecular systems, including cucurbit[n]uril, pillar [n]arenes, cyclodextrin, calixarenes, electron-rich supramolecules, and related complexes, designed to enhance the efficiency of explosive detection. Recent advancements and emerging technologies in this field are discussed in the review, intending to stimulate further inquiry and innovation in synthesizing and applying supramolecular complexes for explosive detection, addressing the urgent demand for heightened security measures.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112063"},"PeriodicalIF":4.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohd Shoab Ali , Saurav Kumar Jha , Garima Gupta , Amirhossein Sahebkar , Prashant Kesharwani
{"title":"Frontiers of nanozymes: Enhancing cancer diagnosis and therapeutic strategies","authors":"Mohd Shoab Ali , Saurav Kumar Jha , Garima Gupta , Amirhossein Sahebkar , Prashant Kesharwani","doi":"10.1016/j.microc.2024.112043","DOIUrl":"10.1016/j.microc.2024.112043","url":null,"abstract":"<div><div>Scientists are intrigued by the enzyme-like characteristics of nanozymes, which connect nanotechnology and biology. In 2007, nanozyme research exploded with the discovery of enzyme-mimicking magnetic nanoparticles (NPs). Over the last decade, nanozymes have revealed their catalytic secrets and expanded their applications. Biocatalytic tumor treatment uses nanozymes as a tiny enzyme mimics, to treat various cancers. This method combines nanotechnology and enzyme-driven biocatalysis. In addition, novel nanocatalysts usually employ multivalent ions as catalyst centres and are widely reported to outperform enzymes in catalysis. They also have better stability in living organisms, functional versatility, and lower production costs. A recent study suggests that nanozymes for biocatalytic tumor treatment could be promising because malignant tumors can change or alter numerous enzymes. Furthermore, the current research in this domain focuses more on iron-based nanostructures because they are simple to make, biocompatible, have promising physical properties, and can catalyze biological processes efficiently; and largely increase tumor hypoxia and reactive oxygen species (ROS)-mediated damage <em>via</em> ferroptosis. Apart from the above-mentioned properties, nanozymes can increase chromogenic or fluorogenic chemical oxidation with certain analytes. This colour change or fluorescence signal can identify and quantify the target biomarker. This review covers nanozyme research for the medical purposes, including their inherent enzymatic properties, biosensing applications for biomarker detection, and other intriguing potential. We also addressed major issues that might impact their clinical use and future progress.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112043"},"PeriodicalIF":4.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arnavaz Keikavousi Behbahan, Iman Al Yahyai, Haider A.J. Al Lawati, Javad Hassenzadeh, FakhrEldin O. Suliman
{"title":"Implementation of the metal organic frameworks on paper-based devices: A review on current applications and future sights","authors":"Arnavaz Keikavousi Behbahan, Iman Al Yahyai, Haider A.J. Al Lawati, Javad Hassenzadeh, FakhrEldin O. Suliman","doi":"10.1016/j.microc.2024.112011","DOIUrl":"10.1016/j.microc.2024.112011","url":null,"abstract":"<div><div>Paper-based analytical devices (PADs) can be considered as the latest regression of lab-on-a-chip devices and have attracted the attention of many researchers. Recently, noteworthy progress has been made in various fields regarding the introduction of metal–organic frameworks (MOFs). Due to the intrinsic advantages of both PADs and MOFs, there has been a rapid growth in their fields confirmed by the large number of publications and citations. The integration of various MOFs within PADs is anticipated to fabricate state-of-the-art devices for several applications in a wide range of fields. This manuscript aims to review the recent 5 years of published studies based on the coupling of MOFs on PADs, outlining their potential application in different fields. Furthermore, challenges and obstacles as well as prospects related to this combination have been discussed.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112011"},"PeriodicalIF":4.9,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent electrochemical applications of Two-Dimensional nanoclays based materials","authors":"Hadi Beitollahi , Zahra Dourandish , Somayeh Tajik , Peyman Mohammadzadeh Jahani , Reza Zaimbashi , Fariba Garkani Nejad , Sayed Zia Mohammadi","doi":"10.1016/j.microc.2024.111908","DOIUrl":"10.1016/j.microc.2024.111908","url":null,"abstract":"<div><div>Naturally-occurring mineral substances called clays are available at a low cost and are ecologically beneficial. These clays are composed of two-dimensional (2D) nanoclays, layered silicates made up of platelets with nanoscale thickness joined together by van der Waals forces. There are various types of nanoclays frequently cited in the literature, such as montmorillonite (MMT), kaolinite, vermiculite (VMT), laponite, and illite. These nanoclays possess distinct physical and chemical characteristics, which make them useful for a variety of applications in scientific and industrial fields. This study includes the development of electrochemical sensors that employ modified electrodes with 2D nanoclays and their composites to detect drugs, diagnose medical conditions, monitor environmental pollutants, and ensure food safety. This article discusses these applications in detail. Furthermore, we explored the uses of 2D nanoclays in various electrochemical applications, such as serving as cathodes in Li-sulfur batteries, separators in batteries and supercapacitors, and acting the role of catalysts in the processes of water electrolysis and oxygen reduction reaction. Finally, we assessed the current challenges related to the use of 2D nanoclays in electrochemistry.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111908"},"PeriodicalIF":4.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surface functionalized gold nanoclusters based on optical biosensors for detecting pesticide residues in agricultural foods: A critical review","authors":"Zahra Abbaszadeh , Mir-Michael Mousavi , Mansour mahmoudpour","doi":"10.1016/j.microc.2024.111988","DOIUrl":"10.1016/j.microc.2024.111988","url":null,"abstract":"<div><div>Pesticides play a crucial role in modern agriculture for managing pests; however, their indiscriminate application raises concerns regarding food safety. It is, therefore, necessary to advance effective and rapid techniques for detecting pesticide residues in food products and water. Gold nanoclusters (AuNCs) are considered a versatile group due to their diverse functionality and attractive optoelectronic and photoluminescence characteristics, indicating significant promise in food safety. Specifically, AuNCs optical biosensors have been featured as universal and versatile tools for manufacturing new-generation recognizing approaches with enhanced sensitivity, stability, and specificity. In this review, we explore the latest tests and tools that utilize optical sensors with AuNCs for detecting pesticides. The review explores the evolution of these sensors and their innovative strategies for attaching recognition elements to AuNCs, both chemically and physically. Additionally, the article explores the synthesis principle, sensing mechanism, and recent advancements in using AuNCs as optical biosensors to detect pesticides. Furthermore, it explores the utilization of optical AuNC probes in ensuring food safety and the obstacles that may arise during their incorporation, drawing from the latest developments in this area.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111988"},"PeriodicalIF":4.9,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nutan Shukla , Carol Yazbleydy Cárdenas Rodriguez , Ratnesh Das , Elizaveta Mukhanova , Alexander Soldatov
{"title":"Innovative biomedical applications of micro/nano channel technologies in microfluidics","authors":"Nutan Shukla , Carol Yazbleydy Cárdenas Rodriguez , Ratnesh Das , Elizaveta Mukhanova , Alexander Soldatov","doi":"10.1016/j.microc.2024.111819","DOIUrl":"10.1016/j.microc.2024.111819","url":null,"abstract":"<div><div>The development of microfluidic devices represents a major breakthrough in biological research. These devices, referred to as analytical microsystems, are engineered for high sensitivity and are adept at analyzing complex biological materials. This innovation has significantly advanced biotechnology, allowing researchers to perform more accurate and efficient analyses of biological samples.Microfluidic devices function at the micron and nanoscale, utilizing precisely designed micro-channels to separate, analyze, and modify the behaviour of fluids and particles across various applications, including drug development, environmental monitoring, biohazard detection, and clinical diagnostics. The increasing interest in microfluidics has revealed numerous advantages associated with the materials used in this technology. By harnessing the distinct properties of fluids at the micro scale, these devices improve automation, control, and high-throughput processing capabilities, potentially replacing some traditional biological analytical and diagnostic methods.Moreover, microfluidic devices tend to be more cost-effective, require shorter bioassay times, and utilize smaller quantities of chemicals and sample volumes. This makes them a highly efficient solution for advanced research in biotechnology. This review article focuses on the compatibility, benefits, and applications of various materials—both inorganic and organic material fabrication of microfluidic devices. We highlight the enhanced performance of micro/nano channels achieved through hybrid manufacturing techniques that integrate advanced functionalization or modification methods. Additionally, we discuss recent advancements in specific applications of microfluidics, including their integration with Raman spectroscopy, mass spectrometry, and optical detection techniques to enhance biomedical applications and sensing capabilities.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111819"},"PeriodicalIF":4.9,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lukman Iddrisu , Evodia Moses Mkulo , Felix Danso , Mpwaga Alatwinusa Yohana , Yinyan Chen , Zhijia Fang , Ravi Gooneratne
{"title":"Biomarker for the toxicity evaluation of cadmium based on Glutathione: Recent Progress and challenges","authors":"Lukman Iddrisu , Evodia Moses Mkulo , Felix Danso , Mpwaga Alatwinusa Yohana , Yinyan Chen , Zhijia Fang , Ravi Gooneratne","doi":"10.1016/j.microc.2024.111935","DOIUrl":"10.1016/j.microc.2024.111935","url":null,"abstract":"<div><div>There is growing global concern regarding the prevalence of heavy metal ions, such as cadmium, which pose increasing risks to both the environment and human health. Exposure to metals such as mercury, lead, cadmium, and manganese, can result in serious neurological impairments, including Parkinson’s disease, epilepsy, and olfactory dysfunction, particularly affecting olfactory neurons. Recent research has focused on developing accurate and precise methods for detecting Cd, as there is an increasing demand for cost-effective, sensitive, specific, and rapid detection techniques. One promising approach is the use of glutathione (GSH) biomarker, which offer timely, affordable, and user-friendly detection. These biomarkers have been integrated with various transducers such as electrochemical, optical, and fluorescent platforms to enhance detection sensitivity. Electrochemical biosensors leverage the redox properties of GSH to achieve low detection limits and quick response times, whereas optical biosensors rely on the GSH-Cd<sup>2+</sup> complexation process to produce observable spectral changes. Fluorescent biosensors utilize GSH-mediated fluorescence quenching or amplification to detect trace amounts of Cd with high sensitivity. To address the challenges in detection, researchers are exploring the use of nanomaterials to enhance signal transmission and sensor durability, as well as to incorporate selective membranes to improve specificity. GSH-based biosensors are continuously evolving and hold promise for applications in environmental monitoring, food safety, and biomedical fields, with the aim of identifying the health risks associated with Cd exposure.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111935"},"PeriodicalIF":4.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salah M. Tawfik , Mirkomil Sharipov , Mohamed R. Elmasry , Shavkatjon Azizov , Dong-Hwan Kim , Abbaskhan Turaev , Yong-Ill Lee , Hoon Eui Jeong
{"title":"Smart Polythiophenes: Pioneering imprinted and functionalized materials in biosensor technology","authors":"Salah M. Tawfik , Mirkomil Sharipov , Mohamed R. Elmasry , Shavkatjon Azizov , Dong-Hwan Kim , Abbaskhan Turaev , Yong-Ill Lee , Hoon Eui Jeong","doi":"10.1016/j.microc.2024.111947","DOIUrl":"10.1016/j.microc.2024.111947","url":null,"abstract":"<div><div>Smart designs beyond the limitations of the biosensors present fascinating opportunities for portable, flexible, versatile, and effective performance that allow for the rapid in-vivo, and real-time detection of potential targets. Conjugated polythiophenes (CPTs) are particularly valuable as biosensors because of their remarkable brightness, excellent photostability, and low toxicity. CPTs potentially molecularly self-assemble using an imprinted method resulting in imprinted conjugated polythiophenes (ICPTs). ICPTs combined the distinctive characteristics of CPTs with the excellent selectivity arising from robustly particular binding sites of molecular imprinting. ICPT-based biomimetic sensors represent a specialized subset within this extensive field. An overview of various types of CPT-based sensors was described to achieve a systematic analysis. These included biosensors based on printing technologies, microfluidic systems, film transistors, colorimetric methods, and electrochemical approaches. Additionally, we discussed the optical-electrical properties, and sub-types of polythiophene derivatives examining their specific applications and advantages in biosensor technology. The final section provided an in-depth exploration of the imprinted techniques employed in developing ICPTs-based sensors, with particular emphasis on applications in biochemical sensing.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111947"},"PeriodicalIF":4.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A.M. Elbasiony , Sarah Alharthi , Mohamed Mohamady Ghobashy , Waleed E. Boraie , Mohamed S. Attia , Mohamed Madani , Samera Ali Al-Gahtany , Reem Darwesh , Mohamed Shaban , A.I. Sharshir
{"title":"Development and application of novel biosensors for enhanced detection in medical diagnostics","authors":"A.M. Elbasiony , Sarah Alharthi , Mohamed Mohamady Ghobashy , Waleed E. Boraie , Mohamed S. Attia , Mohamed Madani , Samera Ali Al-Gahtany , Reem Darwesh , Mohamed Shaban , A.I. Sharshir","doi":"10.1016/j.microc.2024.111938","DOIUrl":"10.1016/j.microc.2024.111938","url":null,"abstract":"<div><div>Biosensors have emerged as crucial medical diagnostics and environmental monitoring tools, offering high sensitivity, specificity, and rapid detection capabilities. This review highlights recent advancements in biosensor technologies, mainly focusing on integrating nanomaterials such as carbon nanotubes (CNTs), graphene oxide, and gold nanoparticles. These nanomaterials enhance biosensor performance by increasing surface area, facilitating electron transfer, and providing tunable functionalization options essential for capturing and detecting analytes. The review explores applications of biosensors in the early detection of diseases, where detecting biomarkers at low concentrations is critical for timely medical intervention. Furthermore, the application of biosensors in environmental monitoring is discussed, emphasizing their role in detecting pollutants and ensuring safety standards. Special attention is given to epidermal biosensors for non-invasive monitoring and their distinguishing features compared to other biosensors. Despite the significant progress in biosensor development, challenges such as stability, reproducibility, and real-world integration remain. Addressing these challenges is crucial for the widespread adoption of biosensors in clinical and environmental settings.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111938"},"PeriodicalIF":4.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}