Microchemical Journal最新文献_第10页

Mapping shared and unique features in spatial transcriptomics through multivariate curve resolution

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-27 DOI: 10.1016/j.microc.2025.113189

Albert Menéndez-Pedriza , Mercedes Blázquez , Laia Navarro-Martín , Joaquim Jaumot

{"title":"Mapping shared and unique features in spatial transcriptomics through multivariate curve resolution","authors":"Albert Menéndez-Pedriza , Mercedes Blázquez , Laia Navarro-Martín , Joaquim Jaumot","doi":"10.1016/j.microc.2025.113189","DOIUrl":"10.1016/j.microc.2025.113189","url":null,"abstract":"<div><div>Spatial biology is poised to play a pivotal role in enhancing our understanding of biological systems. Recent advancements have led to the development of a number of analytical pipelines, particularly within the framework of spatial transcriptomics. However, the analysis of spatial transcriptomic data remains computationally challenging. The Multivariate Curve Resolution Alternating Least Squares (MCR-ALS) model has proven to be a powerful chemometric approach, offering a more interpretable representation of complex spatial data compared to other exploratory approaches such as principal component analysis for not imposing an orthogonality constraint. Despite the growing use of similar models, MCR-ALS has yet to be tested for analyzing spatial transcriptomics data.</div><div>In this study, a critical evaluation of the potential of MCR-ALS-based approaches to complement this key step in spatial transcriptomics analysis is conducted. Specifically, the MCR-ALS evaluation is performed on four samples of European sea bass testis at different early-maturation stages. Our results demonstrate that MCR-ALS is able to provide an accurate interpretation of the data when analyzing tissues both individually and simultaneously. The bilinear resolution effectively identified key spatial regions, which were putatively assigned to specific gonad compartments, in agreement with histological analysis. Furthermore, MCR-ALS models yielded results consistent with those from a standard spatial transcriptomics pipeline, particularly in examining gene expression profiles in specific gonadal regions. Therefore, integrating this chemometric tool into spatial transcriptomics workflow offers significant advantages for unraveling complex biological processes.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113189"},"PeriodicalIF":4.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing a solid-phase extraction method based on a novel polymer-silica composite for analysis of sulfonate genotoxic impurities in drugs

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-27 DOI: 10.1016/j.microc.2025.113182

Wen Zhou , Fucheng Zhu , Yuanlin Li , Chen Liu , Jie Xu , Houmei Liu

{"title":"Developing a solid-phase extraction method based on a novel polymer-silica composite for analysis of sulfonate genotoxic impurities in drugs","authors":"Wen Zhou , Fucheng Zhu , Yuanlin Li , Chen Liu , Jie Xu , Houmei Liu","doi":"10.1016/j.microc.2025.113182","DOIUrl":"10.1016/j.microc.2025.113182","url":null,"abstract":"<div><div>Genotoxic impurities (GTIs), which are present at very small amounts in drugs, can cause severe toxicity. The existence of GTIs poses a significant risk to patients, pharmaceutical companies, and regulatory agencies. Sulfonate compounds, as a typical genotoxic impurity, present a challenge in quantitative analysis because of their low concentration and instability. In this work, by a green, simple and low-cost preparation strategy, a novel polymer was modified on the surface of silica by the reaction of two monomers (1,5-dihydroxynaphthalene and 1,3,5-trimethylhexahydro-1,3,5-triazine). By systematically optimizing the ratio and concentration between the two polymeric monomers and silica, the resultant adsorbent labeled as S-D<sub>1</sub>T<sub>1</sub>/20 was obtained and showed outstanding adsorption performance for sulfonate. Mechanism studies revealed that there are effective hydrogen bond and π-π stacking interactions between S-D<sub>1</sub>T<sub>1</sub>/20 and sulfonate. For the partial sulfonates which are easy to hydrolyze, we proposed to detect the concentration of their hydrolyzed forms. By optimizing the loading and eluting conditions, an SPE-HPLC-DAD method with high sensitivity was developed for the quantitative enrichment and determination of six sulfonates with a wide linear range (0.01 ∼ 3μg mL<sup>−1</sup>), low limits of detection (5 ∼ 25 ng mL<sup>−1</sup>), satisfied inter-day precision, and intra-day precision. Last, this method was successfully applied to various species and forms of commercial drugs and achieved satisfied sulfonate recoveries (91.2 % ∼ 105.8 %). This work provides a unique solution to the frontier scientific problem of accurate determination of trace sulfonate genotoxic impurities in drugs, which is of great significance for ensuring drug quality and clinical safety.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113182"},"PeriodicalIF":4.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous determination of brinzolamide, timolol maleate and its oxidative degradation product using univariate and multivariate green spectrophotometric methods 使用单变量和多变量绿色分光光度法同时测定布林佐胺、马来酸噻吗洛尔及其氧化降解产物

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-27 DOI: 10.1016/j.microc.2025.113185

Asmaa A. Mandour , Nada Nabil , Hala E. Zaazaa , Mohamed A. Ibrahim , Mahmoud A. Tantawy , Ibrahim A. Naguib , Heba-Alla H. Abd-ElSalam

{"title":"Simultaneous determination of brinzolamide, timolol maleate and its oxidative degradation product using univariate and multivariate green spectrophotometric methods","authors":"Asmaa A. Mandour , Nada Nabil , Hala E. Zaazaa , Mohamed A. Ibrahim , Mahmoud A. Tantawy , Ibrahim A. Naguib , Heba-Alla H. Abd-ElSalam","doi":"10.1016/j.microc.2025.113185","DOIUrl":"10.1016/j.microc.2025.113185","url":null,"abstract":"<div><div>Spectrophotometric methods utilizing ratio-spectra were validated for simultaneous determination of Brinzolamide (BRZ) and Timolol maleate (TM) in the presence of the oxidative degradation product of TM (TM deg). TM deg interference was eliminated by dividing the zero-order absorption spectra of TM and BRZ by a concentration 20.00 μg/mL of TM deg. The binary mixture was then analyzed via Method A which determined TM using a ratio difference spectrophotometric approach, where amplitude difference (ΔPA) of the TM spectra at 275.5 nm and 250.0 nm were used, as BRZ (ΔPA) was zero at these wavelengths. Method B involved adjusting the first derivative of the ratio spectra of BRZ and TM in order to determine BRZ selectively. When applying Δλ = 8, scaling factor = 10 and the maximum obtained at 243.8 nm, TM showed no contribution. Method C, involved dividing the total spectrum of the ternary mixture by a double divisor; the sum of the spectra of TM and TM deg. The amplitude of the first derivative of the resulting ratio spectra was measured at 243.7 nm to determine BRZ. Additionally, two multivariate methods, Partial Least Squares and Artificial Neural Networks were applied for determination of BRZ, TM and TM deg. Both models successfully determined BRZ, TM and TM deg. These methods were applied to analyze BRZ and TM in pharmaceutical formulations without matrix interference. Finally, the environmental sustainability of the proposed methods was evaluated. Two methods; National Environmental Methods Index and Eco-Scale assessment metric systems were utilized and revealed greenness of proposed methods.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113185"},"PeriodicalIF":4.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green liquid chromatography mass spectrometry method for determination of n-methyl-n-benzylnitrosamine (carcinogenic impurity) in lacosamide drug substance by advance metrics

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-26 DOI: 10.1016/j.microc.2025.113175

Yerramreddy Srilatha , Kousrali Sayyad , Leela Prasad Kowtharapu , Magapu Ravi Kumar , N. Ramakrishna Reddy , Loka Subramanyam Sarma

{"title":"Green liquid chromatography mass spectrometry method for determination of n-methyl-n-benzylnitrosamine (carcinogenic impurity) in lacosamide drug substance by advance metrics","authors":"Yerramreddy Srilatha , Kousrali Sayyad , Leela Prasad Kowtharapu , Magapu Ravi Kumar , N. Ramakrishna Reddy , Loka Subramanyam Sarma","doi":"10.1016/j.microc.2025.113175","DOIUrl":"10.1016/j.microc.2025.113175","url":null,"abstract":"<div><div>N-Methyl-n-benzylnitrosamine (MBNA) is one of the nitrosamine moiety present in lacosamide, during the manufacturing of lacosamide active pharmaceutical ingredient (API). As a result, a sensitive and reliable technique featuring multi reaction monitoring method has been developed for the quantitative assessment of MBNA impurity in the lacosamide API. The separation of lacosamide and MBNA obtained with a Zorbax SB-Phenyl (250 × 4.6 mm, 5 µm) column under gradient eluent conditions. 0.1 % formic acid in water and 0.1 % formic acid in methanol were used as mobile phases A and B, respectively, in the current study. The mobile phase flow rate is 0.8 mL min<sup>−1</sup>. The multi-reaction monitoring transition for MBNA is 151.00 > 91.20 at a collision energy of −12.0 eV. The limit of detection and limit of quantification concentrations were validated with 0.0015 ppm and 0.0045 ppm, respectively for MBNA impurity in the current study. The accuracy results were lies within the range of 70 %–130 %. Eventually, the developed liquid chromatography tandem mass spectrometry method offers a linear, accurate, suitable, and precise approach to estimate the MBNA impurity present in the lacosamide API.The environmental friendliness of this method was assessed using the national environmental method index (NEMI), the modified green analytical procedure index (MoGAPI), the complex modified green analytical procedure index (Complex MoGAPI),the analytical greenness (AGREE) tool, and the analytical eco-scale. The AGREE score and the eco-scale score of the developed method was found to be0.61 and 67, respectively.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113175"},"PeriodicalIF":4.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A robust electrochemical biosensor with cascade cleavage amplification mediated Pt@CeO2 nanoprobe machine for ultrasensitive microRNA-21 assay

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-26 DOI: 10.1016/j.microc.2025.113172

Huiling Fan , Yuqi Qin , Long Li , Jiansheng Cui , Chenqiang Yang , Zhanhui Wang , Lili Duan , Yihong Wang , Liang Tian

{"title":"A robust electrochemical biosensor with cascade cleavage amplification mediated Pt@CeO2 nanoprobe machine for ultrasensitive microRNA-21 assay","authors":"Huiling Fan , Yuqi Qin , Long Li , Jiansheng Cui , Chenqiang Yang , Zhanhui Wang , Lili Duan , Yihong Wang , Liang Tian","doi":"10.1016/j.microc.2025.113172","DOIUrl":"10.1016/j.microc.2025.113172","url":null,"abstract":"<div><div>Herein, a biosensing system was designed based on tripedal DNAzyme walker integrated nanoprobe signal amplification strategy for realizing ultrasensitive determination of the microRNA-21. In this work, the two-dimensional MoSe<sub>2</sub>/MXene nanocomposite with high electronic conductivity was synthesized as electrode signal amplification materials to immobilize more capture DNA and accelerate electron transport. After adding microRNA-21, the tripedal DNAzyme walker was activated on the surface of the Pt@CeO<sub>2</sub> nanoclusters, which were as nanozyme to construct the high-performance nanoprobe machine. Then, the tripedal DNAzyme strands could cleave the substrate strands and walk onto the nanoprobe for amplifying the signal remarkably. Furthermore, the detectability of the electrochemical biosensor was verified by DPV, acquiring a wide linear response in a range of 0.1 fM to 1 nM, as well as the limit of detection was 0.04 fM. Hence, such double signal amplified strategy could not only provide excellent selectivity and specificity, but also achieve superior repeatability and stability in real complex serum samples. Therefore, the designed biosensing platform detected different microRNA through modulating the recognition sequence, which might provide a general strategy for various cancer analyses and have a promising potential for clinical application.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113172"},"PeriodicalIF":4.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residue analysis and degradation studies of two chiral pyrethroids in cabbage by ultra performance convergence chromatography

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-26 DOI: 10.1016/j.microc.2025.113174

Wenhua Zhang , Qinting Jiang , Fanchao Xiu , Weiqi Bao , Beizhen Hu , Dunming Xu

{"title":"Residue analysis and degradation studies of two chiral pyrethroids in cabbage by ultra performance convergence chromatography","authors":"Wenhua Zhang , Qinting Jiang , Fanchao Xiu , Weiqi Bao , Beizhen Hu , Dunming Xu","doi":"10.1016/j.microc.2025.113174","DOIUrl":"10.1016/j.microc.2025.113174","url":null,"abstract":"<div><div>A novel and accurate method was developed for the determination of the chiral isomers residue of bifenthrin and fluvalinate in cabbage by solid-phase extraction (SPE) in combination with ultra performance convergence chromatography (UPC<sup>2</sup>).</div><div>Four kinds of bifenthrin and fluvalinate isomers were well separated on a CHIRALPAK OJ-H chiral column within 5 min. The method obtained excellent calibration linearity (r<sup>2</sup> > 0.9992) and a satisfactory analysis of the targeted compound, which were evaluated with calibration standards over the range of 0.5–20 mg/mL. The recovery rates ranged from 80.4 % to 102 %, with relative standard deviations below 6.8 %. The limits of quantitation were 0.1–0.2 mg/kg in cabbage leaves. The residual amounts of bifenthrin and cyfluthrin isomers on cabbage were less than 0.5 mg/kg after 3 days of application. The residual half-life of the four pyrethroid isomers was about 2.5 days. There was no obvious enantioselectivity upon degradation between the isomers of bifenthrin and fluvalinate during the growth of cabbage leaves. None of the isomer residues of bifenthrin and fluvalinate were detected in 20 pieces of commercial cabbage samples. The method has the advantages of easy operation, satisfied separation effect and environmental friendly, and can meet the demand of the four kinds of isomers residue analysis of bifenthrin and fluvalinate. The results provided technical support for further research on the residue and degradation of chiral pesticides during vegetable growth.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113174"},"PeriodicalIF":4.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An aptamer/CRISPR electrochemical (ACE) biosensor for Plasmodium falciparum histidine-rich protein II and SARS-CoV-2 nucleocapsid protein

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-26 DOI: 10.1016/j.microc.2025.113176

Young Lo , Ryan H.P. Siu , Chau Tran , Robert G. Jesky , Andrew B. Kinghorn , Julian A. Tanner

{"title":"An aptamer/CRISPR electrochemical (ACE) biosensor for Plasmodium falciparum histidine-rich protein II and SARS-CoV-2 nucleocapsid protein","authors":"Young Lo , Ryan H.P. Siu , Chau Tran , Robert G. Jesky , Andrew B. Kinghorn , Julian A. Tanner","doi":"10.1016/j.microc.2025.113176","DOIUrl":"10.1016/j.microc.2025.113176","url":null,"abstract":"<div><div>The <em>trans</em>-cleavage activity of CRISPR Cas12 and Cas13 on single-stranded DNA has been widely applied for biosensing and diagnostic applications. Typically, such approaches have traditionally been limited to the sensing of nucleic acids. Here, we have combined CRISPR Cas12 with nucleic acid aptamers to enable protein recognition by an electrochemical approach. To demonstrate the versatility of this approach, we have successfully detected two important protein disease biomarkers: <em>Plasmodium falciparum</em> histidine-rich protein II (<em>PfHRP2)</em> as a biomarker of malaria, and SARS-CoV-2 nucleocapsid (N) protein as a biomarker of COVID. We designed activable aptasensors by annealing aptamers to a complementary locking strand. CRISPR Cas12 <em>trans</em>-cleavage is initiated by strand displacement upon protein binding, thereby cleaving a redox reporter conjugated to DNA on an electrode, transducing into an electrochemical signal. The limits of detection for <em>PfHRP2</em> and COVID N protein are 45.5 nM and 8.18 nM respectively with high specificity towards their targets. Protein detection by such CRISPR-assisted ACE biosensors can be potentially expanded and multiplexed across several critical biomarkers in parallel.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113176"},"PeriodicalIF":4.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A greener approach for analysis of tafenoquine succinate in presence of their potential degradation impurities with comprehensive characterization of degradation products by Orbitrap-LCMS and NMR

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-26 DOI: 10.1016/j.microc.2025.113141

Pravin Wasure, Niraj Rajput, Tarang Jadav, Pinaki Sengupta

{"title":"A greener approach for analysis of tafenoquine succinate in presence of their potential degradation impurities with comprehensive characterization of degradation products by Orbitrap-LCMS and NMR","authors":"Pravin Wasure, Niraj Rajput, Tarang Jadav, Pinaki Sengupta","doi":"10.1016/j.microc.2025.113141","DOIUrl":"10.1016/j.microc.2025.113141","url":null,"abstract":"<div><div>Establishment of a stability-indicating analytical method (SIAM) is crucial for analysis of pharmaceutical substances in presence of degradation impurities. This study aimed to establish a green analytical approach for quantifying tafenoquine in presence of its degradation products (DP) which formed via chemical breakdown of the drug. The objective was also to characterize various unknown DPs using Orbitrap-LCMS and NMR. Tafenoquine was exposed to hydrolytic, thermal, photolytic, and oxidative stress conditions. The drug exhibited susceptibility under acidic, neutral, oxidative, and photolytic conditions, leading to the formation of 10 new DPs. To characterize them, the fragmentation of tafenaquine was first studied using a multistage Orbitrap-LCMS system. Degradation impurities in each stress sample were then separated using a newly developed, green, sensitive, and specific RP-HPLC method, employing Eclipse plus-C18 column and ammonium formate as buffer. This method was subsequently adapted to an Orbitrap-LCMS system with an extended runtime for further characterization. Mechanistic explanations were provided for each impurity generated under different stress conditions. Among the 10 degradation products, DP7 was identified as major impurity which was isolated, and characterized using <sup>1</sup>H NMR spectroscopy. The toxicity potential of identified DPs was evaluated <em>in silico</em> using ProTox 3.0 software. Greenness of developed SIAM was assessed through Analytical GREEness metric and Green Analytical Procedure Index, demonstrating its eco-friendly nature. These findings will aid pharmaceutical industry in optimizing storage conditions and improving stability and safety profile of tafenoquine formulations. The developed SIAM can be used by analytical laboratories and pharmaceutical industries for tafenoquine stability testing.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113141"},"PeriodicalIF":4.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced low-temperature sensitivity of H2S gas sensing via oxygen vacancy-rich NiO-SnO2 heterojunction nanostructures 通过富氧空位 NiO-SnO2 异质结纳米结构提高 H2S 气体传感的低温灵敏度

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-26 DOI: 10.1016/j.microc.2025.113177

Yan Qian , Haibang Zhang , Yan Xiong , Yinzuo Wu , Ziyue Fu , Pingchun Guo , Hedong Jiang , Jiake Li , Yanxiang Wang , Shijin Yu , Hua Zhu

{"title":"Enhanced low-temperature sensitivity of H2S gas sensing via oxygen vacancy-rich NiO-SnO2 heterojunction nanostructures","authors":"Yan Qian , Haibang Zhang , Yan Xiong , Yinzuo Wu , Ziyue Fu , Pingchun Guo , Hedong Jiang , Jiake Li , Yanxiang Wang , Shijin Yu , Hua Zhu","doi":"10.1016/j.microc.2025.113177","DOIUrl":"10.1016/j.microc.2025.113177","url":null,"abstract":"<div><div>The detection of low concentration hydrogen sulfide (H<sub>2</sub>S) gas is of paramount importance for environmental safety and human health, given its colorless, toxic, and flammable nature. In this study, heterostructure material composed of SnO<sub>2</sub> nanorods modified with NiO nanosheets were synthesized, which significantly improved the detection performance of the sensor for hydrogen sulfide (H<sub>2</sub>S) gas at low temperatures by combining the interaction between oxygen vacancies and built-in electric fields. The formation of heterojunctions was verified using X-ray diffraction (XRD) and transmission electron microscopy (TEM), and the existence of oxygen vacancies was further confirmed through electron paramagnetic resonance (EPR) spectroscopy. The heterojunction sensor, when modified with 3 mol% NiO, exhibited an exceptional response value of 386 towards 10 ppm H<sub>2</sub>S at 125 °C, with a rapid response time of 6 s, surpassing that of the pristine SnO<sub>2</sub> sensor. This superior performance can be attributed to the synergistic effect of oxygen vacancies between SnO<sub>2</sub> and NiO, along with the inherent electric field present in the heterojunction. The study showcases the remarkable selectivity and long-term stability of this sensor in detecting hydrogen sulfide gas, offering innovative insights for the advancement of low-temperature and highly sensitive H<sub>2</sub>S gas sensors.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"212 ","pages":"Article 113177"},"PeriodicalIF":4.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degradation of eosin Y complexes during natural ageing: Spectroscopic markers and parameters that affect their stability

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-02-26 DOI: 10.1016/j.microc.2025.113178

Victoria Beltran , Andrea Marchetti , Steven de Meyer , Margje Leeuwestein , Christophe Sandt , Ferenc Borondics , Ligia Maria Moretto , Karolien De Wael

引用次数: 0