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Recent progress in noble metal-based single-atom nanozymes for biomedical applications 用于生物医学应用的贵金属基单原子纳米酶的最新进展
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-21 DOI: 10.1016/j.microc.2024.111731
Jingyu Zhao , Fangqin Han , Chunfang Cheng , Huixin Wang , Guanhui Zhao , Peng Jia , Nuo Zhang , Yaoguang Wang , Jie Zhang , Qin Wei
{"title":"Recent progress in noble metal-based single-atom nanozymes for biomedical applications","authors":"Jingyu Zhao ,&nbsp;Fangqin Han ,&nbsp;Chunfang Cheng ,&nbsp;Huixin Wang ,&nbsp;Guanhui Zhao ,&nbsp;Peng Jia ,&nbsp;Nuo Zhang ,&nbsp;Yaoguang Wang ,&nbsp;Jie Zhang ,&nbsp;Qin Wei","doi":"10.1016/j.microc.2024.111731","DOIUrl":"10.1016/j.microc.2024.111731","url":null,"abstract":"<div><div>Nanozymes are nanomaterials with enzymatic properties designed to overcome the inherent limitations of natural enzymes. They can mimic various enzyme activities with durability, low cost, and tunable catalytic properties. With the rapid development of nanotechnology, biotechnology, catalytic science, and computational chemistry, remarkable progress has been made in the research of nanozymes. However, compared with natural enzymes, the reported nanozymes possess lower catalytic activity, which limits their further application. Single-atom nanozymes (SAzymes) are a new type of nanozymes that have been widely explored in recent years. With their maximum active site density and well-defined coordination environment, SAzymes have demonstrated excellent catalytic performance, showing broad application prospects in many fields such as biosensing, antibacterial, and tumor therapy. Furthermore, the well-defined atomic coordination and electron configuration of SAzymes provide strong support to reveal the complex mechanism of their catalytic reaction. Particularly, the noble metal-based SAzymes precisely synthesized on the atomic scale, inherit the advantages of SAzymes, while combining the excellent electronic conductivity, high stability and good catalytic activity of noble metals. This effectively reduces the production cost and gives the noble metal-based SAzymes a great potential for practical applications. In this review, we focus on the recent advances of noble metal-based SAzymes in biomedicine and discuss their underlying challenges as well as future prospects.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111731"},"PeriodicalIF":4.9,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescence-based determination of tobramycin using a portable smartphone-based device 使用基于智能手机的便携式设备,基于荧光测定妥布霉素
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111713
Karolina Mermer , Justyna Paluch , Julia Fudali , Kamil Strzelak , Joanna Kozak
{"title":"Fluorescence-based determination of tobramycin using a portable smartphone-based device","authors":"Karolina Mermer ,&nbsp;Justyna Paluch ,&nbsp;Julia Fudali ,&nbsp;Kamil Strzelak ,&nbsp;Joanna Kozak","doi":"10.1016/j.microc.2024.111713","DOIUrl":"10.1016/j.microc.2024.111713","url":null,"abstract":"<div><div>The study presents the development of a robust portable smartphone-based device for determining tobramycin in drugs and urine by a fluorescence-based method. As existing analytical methods for the determination of tobramycin often require complex equipment and time-consuming procedures, the proposed approach offers simplicity, portability and real-time monitoring capabilities. The spectrofluorimetric method is based on the reaction of tobramycin and fluorescamine in an alkaline medium. The measurement of analytical signals was enabled with a specially designed device integrating a 3D printed adapter, LEDs, a macro lens, an Arduino-based microcontroller, and a<!--> <!-->smartphone. The traditional spectrofluorimetry was used as a reference method. Preliminary and optimisation studies were conducted to select the most suitable experimental conditions (e.g. reagent concentration and reaction time) as well as instrumental parameters (e.g. selection of the appropriate RGB model component, ISO, and white balance). The performance of the method was validated, and then verified against conventional spectrofluorimetry, showing comparable accuracy and precision. The method implemented in a smartphone-based device showed a linear range of 0.10–1.00 <!--> <!-->mg<!--> <!-->L<sup>-1</sup> with a detection limit of 0.03 <!--> <!-->mg<!--> <!-->L<sup>-1</sup>. Synthetic samples were tested to verify analytical usability, followed by analysis of pharmaceutical and urine samples. The method showed good precision (CV&lt;3.4 %) and recovery values (92.3–114.1 %), consistent with spectrofluorimetric results (CV&lt;5.9 %, recovery 92.3–119.8 %). Comparison with other methods highlighted the simplicity and efficiency of the developed approach. The research reveals that it is competitive with existing well-established methods. The proposed device offers reliable results with low reagent and sample consumption, making it<!--> <!-->suitable for on-the-go analysis in non-laboratory conditions.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111713"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzyme-responsive aptasensing based on the ATP aptamer and benzothiazole-coumarin G-quadruplex fluorescent probe for label-free detection of adenosine deaminase activity and its inhibitor 基于 ATP aptamer 和苯并噻唑-香豆素 G-四倍体荧光探针的酶响应式适配传感技术,用于无标记检测腺苷脱氨酶活性及其抑制剂
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111714
Yuxiang Xia , Hongyu Li , Yating Lu , Yanfei Zhang , Kaixin Xue , Jiaheng Zhang , Yujie Zhao , Xingyu Luo
{"title":"Enzyme-responsive aptasensing based on the ATP aptamer and benzothiazole-coumarin G-quadruplex fluorescent probe for label-free detection of adenosine deaminase activity and its inhibitor","authors":"Yuxiang Xia ,&nbsp;Hongyu Li ,&nbsp;Yating Lu ,&nbsp;Yanfei Zhang ,&nbsp;Kaixin Xue ,&nbsp;Jiaheng Zhang ,&nbsp;Yujie Zhao ,&nbsp;Xingyu Luo","doi":"10.1016/j.microc.2024.111714","DOIUrl":"10.1016/j.microc.2024.111714","url":null,"abstract":"<div><div>Adenosine deaminase (ADA) is a vital enzyme for regulating the biological process in humans and its abnormal expression level is related to various severe diseases. Nevertheless, conventional approaches for detecting ADA activity are hindered by the drawbacks of complexity and limited detection performances. To address these challenges, we here designed an ADA-responsive aptasensing strategy based on a synthesized benzothiazole-coumarin G-quadruplex (G4) fluorescent probe, which can bind to the G-rich ATP aptamer (G-APA) and form the high-contrast fluorescent complex (S1/G-APA). While the fluorescence of S1/G-APA could be quenched by ATP competition due to the allosteric process, the deamination in ATP catalyzed by ADA would recover the fluorescence of S1/G-APA and allow a facile, turn-on, label-free, and selective detection of ADA activity. This proposed method exhibits favorable detection performances for ADA activity analysis with a wide detection linear range varied from 1 to 100 U/L and a detection limit of 0.82 U/L. Meanwhile, it can be applied for ADA inhibitor (DCF) evaluation and provide a turn-off and sensitive detection performances. Inspired by these detection efficacies, the serum samples spiked with ADA and DCF have been investigated to present the satisfied recovery rates and detection reliability. Collectively, this method will provide a promising way for portable and efficient ADA activity quantification and evaluating the inhibition efficiencies of ADA inhibitors, which hold the potential in promoting ADA-related sensing and pharmaceutical research.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111714"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142319270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real time monitoring of heavy metal adulteration in biodiesel using Arduino UNO platform@A promising multi-purpose stimuli-responsive azomethine based chemoreceptor for hierarchical tri-ionic sensing 利用 Arduino UNO 平台实时监测生物柴油中的重金属掺假@一种用于分层三离子传感的前景广阔的多用途刺激响应型偶氮金属化学感受器
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111739
Rajeshwari Pal , Riyanka Das , Adwitiya Pal , Bishwajit Singh Kapoor , Krishnendu Kundu , Arunabha Thakur , Sudit Sekhar Mukhopadhyay , Priyabrata Banerjee
{"title":"Real time monitoring of heavy metal adulteration in biodiesel using Arduino UNO platform@A promising multi-purpose stimuli-responsive azomethine based chemoreceptor for hierarchical tri-ionic sensing","authors":"Rajeshwari Pal ,&nbsp;Riyanka Das ,&nbsp;Adwitiya Pal ,&nbsp;Bishwajit Singh Kapoor ,&nbsp;Krishnendu Kundu ,&nbsp;Arunabha Thakur ,&nbsp;Sudit Sekhar Mukhopadhyay ,&nbsp;Priyabrata Banerjee","doi":"10.1016/j.microc.2024.111739","DOIUrl":"10.1016/j.microc.2024.111739","url":null,"abstract":"<div><div>The presence of metallic adulteration even in very trace level may lead to deleterious impact on the biodiesel quality and ultimately may be responsible for the dropping down of system efficiency, which necessitates the trace level recognition of heavy metal adulteration from biodiesel. In this context, herein using an azomethine functionalized chromogenic chemoreceptor, 1-((E)-(4-hydroxyphenylimino) methyl) napthalen-2-ol (<strong>HMN</strong>) has been reported for the selective chemodosimetric recognition of Cu<sup>2+</sup> with a lower detection threshold of 7.8 ppb <em>via</em> distinct chromogenic variation of <strong>HMN</strong>. In addition to this, it has also exhibited selective and reversible naked eye chromogenic sensing behaviour towards F<sup>−</sup> (LOD=160 ppb) and Al<sup>3+</sup> (LOD=48 ppb) at very trace level, which is quite lower than the WHO permissible limit. Distinct chromogenic recognition of F<sup>−</sup> by <strong>HMN</strong> proceeds <em>via</em> strong intermolecular hydrogen bonding mediated improved intramolecular charge transfer. The spectroscopic response of <strong>HMN</strong> in alternate presence and absence of the targeted analytes made it suitable to formulate AND-NOT-XNOR-NAND-OR gate based ‘<em>Castle-like</em>’ complicated logic circuitry. <em>In-vitro</em> cell imaging study using A549, human lung carcinoma cell line attests intracellular recognition capability of <strong>HMN</strong>, demonstrating its effectual bio-medicinal applications. Interestingly, inspired by the capability of <strong>HMN</strong> towards recognition of copper from biodiesel specimen, an RGB-assisted device comprised of TCS color sensor and an Arduino UNO 8-bit microcontroller has been developed for real-time quantitative analysis of the biodiesel adulteration. Going one step further, utilization of lab-on-a-box based prototype to monitor the concentration-dependent chromogenic fluctuation <em>via</em> RGB analysis is undoubtedly beneficial for the determination of copper adulteration in biodiesel sample. The presently developed chemoreceptor can thus be regarded as a valuable addition in the field of supramolecular chemistry as well as a significant initiative towards regular monitoring of the biodiesel quality control parameters as a part of sustainable environment.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111739"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptide-based fluorescent probe with large Stokes shift for specific sequential detection of copper (II) ions and histidine: Smartphone device, real samples, test strips and bioimaging applications 基于多肽的荧光探针具有大斯托克斯位移,可用于特异性连续检测铜 (II) 离子和组氨酸:智能手机设备、真实样品、试纸和生物成像应用
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111728
Peng Wang , Xinlin Cao , Shirui Xue , Zhijie Wang , Yi Zhou , Jiang Wu
{"title":"Peptide-based fluorescent probe with large Stokes shift for specific sequential detection of copper (II) ions and histidine: Smartphone device, real samples, test strips and bioimaging applications","authors":"Peng Wang ,&nbsp;Xinlin Cao ,&nbsp;Shirui Xue ,&nbsp;Zhijie Wang ,&nbsp;Yi Zhou ,&nbsp;Jiang Wu","doi":"10.1016/j.microc.2024.111728","DOIUrl":"10.1016/j.microc.2024.111728","url":null,"abstract":"<div><div>A novel and facile fluorescent probe, <strong>DNH</strong>, was developed based on a dipeptide backbone (Asn-His-NH<sub>2</sub>) labelled with a dansyl fluorophore. <strong>DNH</strong> exhibited significant advantages in detecting Cu<sup>2+</sup> based on the paramagnetic quenching mechanism, including satisfactory water solubility (100 % aqueous medium), a large Stokes shift (230 nm), excellent anti-interference capability (no interference), a low detection limit (19.6 nM), rapid response time (within 30 s) and a wide pH range (7–12). Employing a displacement approach, the <strong>DNH</strong>-Cu<sup>2+</sup> ensemble showed strong fluorescence enhancement upon recognition of <sub>L</sub>-His with outstanding selectivity, and the detection limit for the <strong>DNH</strong>-Cu<sup>2+</sup> ensemble with respect to <sub>L</sub>-His was calculated at 22.8 nM. Notably, <strong>DNH</strong> demonstrated favourable reversibility for at least seven cycles with minor changes in fluorescence intensity when Cu<sup>2+</sup> and <sub>L</sub>-His were added alternately. Moreover, <strong>DNH</strong> exhibited excellent low cytotoxicity and good biocompatibility, and was utilised as an outstanding probe for the sequential determination of Cu<sup>2+</sup> and <sub>L</sub>-His in living cells and zebrafish. <strong>DNH</strong> was successfully used to determine Cu<sup>2+</sup> and <sub>L</sub>-His in three actual water samples with good recovery and accuracy. In addition, <strong>DNH</strong> was applied to filter paper to develop visual test strips for the rapid and high-efficiency analysis of Cu<sup>2+</sup> and <sub>L</sub>-His. Furthermore, the semi-quantitative visual monitoring of Cu<sup>2+</sup> and <sub>L</sub>-His was achieved by developing a smartphone colour recogniser into a portable analytical device, achieving low detection limits of 0.49 μM and 0.63 μM, respectively. Given these attributes, <strong>DNH</strong> presents itself as a promising peptide-based fluorescent probe, showcasing considerable potential for real-time visual monitoring of Cu<sup>2+</sup> and <sub>L</sub>-His in various environmental and biological settings.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111728"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A focused review on organic electrochemical transistors: A potential futuristic technological application in microelectronics 聚焦有机电化学晶体管:微电子学中一种潜在的未来技术应用
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111737
Ahsan Raza , Umar Farooq , Khalida Naseem , Sarfaraz Alam , Mohammad Ehtisham Khan , Akbar Mohammad , Waleed Zakri , Muhammad Yasir Khan
{"title":"A focused review on organic electrochemical transistors: A potential futuristic technological application in microelectronics","authors":"Ahsan Raza ,&nbsp;Umar Farooq ,&nbsp;Khalida Naseem ,&nbsp;Sarfaraz Alam ,&nbsp;Mohammad Ehtisham Khan ,&nbsp;Akbar Mohammad ,&nbsp;Waleed Zakri ,&nbsp;Muhammad Yasir Khan","doi":"10.1016/j.microc.2024.111737","DOIUrl":"10.1016/j.microc.2024.111737","url":null,"abstract":"<div><h3>Background</h3><div>An organic electrochemical transistor (OECT) is an important device in an area of the art in bioelectronics that can convert ionic and biological inputs into electronic outputs with its aqueous environment. The OECTs use a combination of electronic and ionic charges to leverage the mixed conduction properties of materials within their channel. As bioelectronics applications become popular in OECTs, there is a need to standardize the material channel mixed insulation characteristics, however there is some variation in conditions. This review provides an in-depth formulation of OECTs, including their selection mechanisms, use of organic materials, fabrication methods, and applications to bioelectronics devices. Moreover, it offers a critical assessment of OECT’s research and development in the future.</div></div><div><h3>Results</h3><div>The review is organized as follows: First, we provide an overview of the construction and operation of an OECT device in section 2. Next, in section 3, we describe how OECT behavior differs from conventional metal oxide semiconductor field effect transistor (MOSFET), and we discuss how electronic charge transport in the channel by Bernard’s Model. In section 4, we discuss several materials for the transient behavior of OECTs. In section 5, we deal with the recent advances in OECT device fabrication. Then, in section 6, we consider the current applications of OECTs in the fields of biosensing, circuits and logic, neuromorphic computing, and prosthetic and human–machine interfaces. In section 7, we describe limitations concerning the OECT device with expert suggestions to address these limitations. Finally, in section 8, we close the Review with a brief conclusion.</div></div><div><h3>Significance</h3><div>A significant advancement has been made in this field through the development of innovative approaches, such as spray coating for uniform channel deposition and screen printing for large-scale production. The full potential of OECTs in revolutionizing bioelectronics and healthcare applications will be realized only through collaborative efforts between researchers, engineers, and industry stakeholders.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111737"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142317836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AuNP@Self-assembled 4H-Chromene-Enhanced colorimetric detection of ganciclovir using smartphone Technology: Portable solutions for healthcare 利用智能手机技术对AuNP@自组装的4H-Chromene-增强型更昔洛韦进行比色检测:便携式医疗解决方案
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111734
Geetika Bhardwaj , Randeep Kaur , Sanjeev Saini , Narinder Singh , Navneet Kaur
{"title":"AuNP@Self-assembled 4H-Chromene-Enhanced colorimetric detection of ganciclovir using smartphone Technology: Portable solutions for healthcare","authors":"Geetika Bhardwaj ,&nbsp;Randeep Kaur ,&nbsp;Sanjeev Saini ,&nbsp;Narinder Singh ,&nbsp;Navneet Kaur","doi":"10.1016/j.microc.2024.111734","DOIUrl":"10.1016/j.microc.2024.111734","url":null,"abstract":"<div><div>Any substance, radiation, or radionuclide in our environment that promotes carcinogenesis is a cancerogen. In the current work, we modified the <em>4H</em>-chromene derivative by covering its surface with a shell of gold nanoparticles. Interestingly, ganciclovir (GCV) formed a bridge between the Nap-group of <em>4H</em>-chromene and gold nanoparticles to display surface charge reduction properties in <strong>AuNP@Self-assembled <em>4H</em>-Chromene</strong>. The surface charge of AuNPs is reduced as a result of the electron transfer mechanism brought on by the creation of the Nap-GCV-AuNP link, which leads to agglomeration. This led to the development of a dual-mode colorimetric sensor for GCV that incorporates solution form and portable sensor strip. The probe showed a linear range of 0–74 nM under ideal circumstances, with a detection limit of 4 nM in solution and 3 nM on paper strip detection. An evaluation of the practical utility in human serum using a portable visual read-out produced satisfactory findings, with a recovery percentage of 102.1 % and a standard deviation of ± 4 %. Surprisingly, this is the first work on the colorimetric detection of Ganciclovir that we are aware of.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111734"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective separation of polyphenols with a novel azo porous organic polymer: Ultrahigh adsorption capacity and superfast adsorption rate 利用新型偶氮多孔有机聚合物选择性分离多酚:超高吸附容量和超快吸附速率
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111696
Xian Cheng , Miao-Miao Long , Sheng-Nan Li , Peng-Fei Li , Pan-Pan Li , Liang-Wu Bi , Yu-Xiang Chen
{"title":"Selective separation of polyphenols with a novel azo porous organic polymer: Ultrahigh adsorption capacity and superfast adsorption rate","authors":"Xian Cheng ,&nbsp;Miao-Miao Long ,&nbsp;Sheng-Nan Li ,&nbsp;Peng-Fei Li ,&nbsp;Pan-Pan Li ,&nbsp;Liang-Wu Bi ,&nbsp;Yu-Xiang Chen","doi":"10.1016/j.microc.2024.111696","DOIUrl":"10.1016/j.microc.2024.111696","url":null,"abstract":"<div><div>For the first time, a novel porous organic polymer (POP), namely Cin-POP, was constructed under normal temperature and pressure using less toxic basic fuchsin and natural cinnamic acid. Cin-POP was synthesized through the diazo-coupling reaction between the diazonium salts of basic fuchsin and cinnamic acid. The FT-IR spectra and XPS analysis prove the successful construction of the Cin-POP, and the BET analysis demonstrates the high-surface-area (166.42–202.56 m<sup>2</sup> g<sup>−1</sup>) and suitable pore sizes (11.00–18.63 nm). Owing to the advantages of porous structures, abundant aromatic groups, good thermal stability, and good dispersity, Cin-POP exhibits remarkable adsorption rates and capacities towards polyphenols, including procyanidine and rutin. Especially for procyanidine, the extraction efficiency can arrive at nearly 98.1 % after 2.5 min adsorption, and the pseudo-second-order rate constant (k<sub>2</sub>) of Cin-POP is 0.0257 g mg<sup>−1</sup> min<sup>−1</sup>. The maximum adsorption capacities of Cin-POP towards procyanidine and rutin are 2500.00 mg g<sup>−1</sup> and 1814.83 mg g<sup>−1</sup>, outpacing all reported adsorbents. In addition, Cin-POP can selectively adsorb polyphenol among the mixtures of polyphenols and alkaloids. More importantly, Cin-POP can be used for polyphenols separation from complex cinnamon extract. All the above advantages make Cin-POP comparable porous adsorbent for polyphenol separation.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111696"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemoglobin-Capped carbon dots synthesized via microwave green approach as a biosensor for specific cholesterol detection 通过微波绿色方法合成的血红蛋白封接碳点作为特异性胆固醇检测生物传感器
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111652
Nahid Shahabadi , Kobra Omidfar , Saba Zendehcheshm
{"title":"Hemoglobin-Capped carbon dots synthesized via microwave green approach as a biosensor for specific cholesterol detection","authors":"Nahid Shahabadi ,&nbsp;Kobra Omidfar ,&nbsp;Saba Zendehcheshm","doi":"10.1016/j.microc.2024.111652","DOIUrl":"10.1016/j.microc.2024.111652","url":null,"abstract":"<div><div>This study explores the potential of hemoglobin-capped green-synthesized carbon dots (g-CD) as a biosensor for the specific detection of cholesterol. The CDs, synthesized using an environmentally friendly and convenient microwave green approach, derived from Wood Extract of Wild Cherry Shrub and utilizing hemoglobin as a capping agent, offer promising characteristics for cholesterol detection. This green synthesis method avoids the use of toxic precursors, making the process safer and more sustainable. Additionally, microwave (MW) heating, being volumetric in nature, reduces the synthesis time and energy consumption, resulting in a uniform and unique microstructure, offering a substantial advantage over traditional methods. Through fluorescence spectroscopy, the interaction between the g-CD/Hb complex and cholesterol was investigated. The results demonstrate that the fluorescence intensity of the g-CD/Hb complex increases with the concentration of cholesterol, suggesting a potential application for cholesterol detection. Notably, the calculated limit of detection (LOD) was found to be 9.22 μM, significantly lower than previously reported sensors, indicating higher sensitivity. Moreover, the biosensor exhibits high selectivity towards cholesterol over other biomolecules commonly found in human serum. Additionally, the biosensor shows excellent performance with real human blood samples, indicating its practical utility in clinical settings. Overall, the g-CD/Hb biosensor presents a promising approach for the specific detection of cholesterol, offering potential applications in biomedical research and clinical diagnostics. The key innovations include the use of a green and rapid synthesis method, improved detection limit, and validation of performance in real samples, distinguishing this sensor from previous research.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111652"},"PeriodicalIF":4.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-time detection of cerebral edema in mice based on low-field nuclear magnetic resonance 基于低场核磁共振的小鼠脑水肿实时检测
IF 4.9 2区 化学
Microchemical Journal Pub Date : 2024-09-20 DOI: 10.1016/j.microc.2024.111738
Yu He , Xiaoyong Rao , Yang Zhan , Qing Tao , Yan He , Xiaoming Fu , Yan Zeng , Xiaojian Luo , Haowei Lu , Wei Liu
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