Microchemical Journal最新文献_第10页

An environmentally friendly cucurbit[7]uril-mediated magnetic-assisted matrix solid-phase dispersion extraction combined with HPLC-MS/MS for multiple analysis of pharmaceuticals and personal care products in aquatic organisms 一种环境友好的瓜类脲介导的磁辅助基质固相分散萃取结合高效液相色谱-质谱联用技术用于水生生物中药物和个人护理用品的多重分析

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115146

Huiyu He, Rui Wang, Rongbin Nie, Nan Dong

{"title":"An environmentally friendly cucurbit[7]uril-mediated magnetic-assisted matrix solid-phase dispersion extraction combined with HPLC-MS/MS for multiple analysis of pharmaceuticals and personal care products in aquatic organisms","authors":"Huiyu He, Rui Wang, Rongbin Nie, Nan Dong","doi":"10.1016/j.microc.2025.115146","DOIUrl":"10.1016/j.microc.2025.115146","url":null,"abstract":"<div><div>Trace amounts of pharmaceuticals and personal care products (PPCPs) in aquatic environment poses a non-negligible risk to human health. Here, an environmentally friendly cucurbit[7]uril-mediated magnetic-assisted matrix solid phase dispersion (Q[7]-<em>m</em>-MSPD) extraction method was developed for extracting PPCPs from complex aquatic organisms. The extraction of PPCPs were achieved via the host-guest interaction between Q[7] and targets, significantly reducing the matrix interference. Gold magnetic nanoparticles (AuMNPs) were chelated to Q[7]-target complexes and used for purification and enrichment via magnetic solid-phase extraction (MSPE), effectively replacing the complex operation of sample loading and elution on SPE columns in MSPD. Coupled with high performance liquid chromatography-tandem mass spectrometry, multiple analysis of 14 PPCPs in 3 aquatic plants and an aquatic animal were achieved, with detection limits ranging from 0.0015 to 0.0179 μg/kg, recoveries ranging from 71.06 to 113.6 %, and enrichment factors within 46 to 152. The green chemistry assessment confirmed the environmental friendliness, economic feasibility, and application potential of the Q[7]-<em>m</em>-MSPD, with an AGREE score of 0.63 and a BAGI score of 72.5. By integrating the merits of MSPD and MSPE, the proposed approach exhibited high sensitivity and anti-interference capability, simple operation, and great environmental friendliness. Therefore, the approach provided a green method for simultaneously detecting multiple hazardous residues in complex matrices owing to the broad-spectrum molecular recognition capability of Q[7] , which has a good application prospect in food safety and environmental monitoring.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115146"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smartphone-assisted dual-mode turn-off-on red-emission AuNCs/WS2 FRET sensor for detection of carbendazim 用于检测多菌灵的智能手机辅助双模关闭红色发射aunc /WS2 FRET传感器

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115159

Sheng Gong , Fan Nie , Lingxuan Ma , Jiali Wan , Yu Yang , Wensheng Zhang , Jinchao Wei , Peng Li

{"title":"Smartphone-assisted dual-mode turn-off-on red-emission AuNCs/WS2 FRET sensor for detection of carbendazim","authors":"Sheng Gong , Fan Nie , Lingxuan Ma , Jiali Wan , Yu Yang , Wensheng Zhang , Jinchao Wei , Peng Li","doi":"10.1016/j.microc.2025.115159","DOIUrl":"10.1016/j.microc.2025.115159","url":null,"abstract":"<div><div>The overuse of pesticides poses a significant threat to human health, driving the need for accurate and rapid strategies to identify various pesticides. A fluorescent nano-sensor (R-AuNCs@Aptamer) was developed by integrating an amino-modified carbendazim aptamer with red-colored gold nanoclusters (R-AuNCs). We subsequently engineered an aptamer-triggered turn-off-on Förster resonance energy transfer (FRET) platform, employing R-AuNCs@Aptamer in conjunction with tungsten disulfide nanosheets (WS<sub>2</sub> NS). In this setup, the carbendazim aptamer-stabilized red-emitting R-AuNCs (∼655 nm) served as the energy donor, while WS<sub>2</sub> NS acted as a fluorescence quencher. Upon the introduction of carbendazim, alterations in fluorescence intensity were monitored at 655 nm, facilitating the recognition of carbendazim. The resulting fluorescent nano-sensor displayed outstanding selectivity towards carbendazim, exhibiting a broad detection range of 0.1 to 1000 μg/L and remarkable sensitivity with a low limit of detection. It demonstrated reliability and practicality when applied to <em>Notoginseng Radix et Rhizoma</em> and <em>Ginseng Radix et Rhizoma</em> samples, with recoveries ranging from 90 % to 110 %. By changing the aptamer sequence, this sensor can be customized to detect different pollutants, exhibiting excellent tailorability and broad application potential.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115159"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bimetallic MOF-derived hierarchical porous carbon spheres for electrochemical Cu2+ sensing 电化学感应Cu2+的双金属mof衍生的分层多孔碳球

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115107

Yaqi Yang , Zhewei Zhang , Li Zhang , Zijian Zhao

{"title":"Bimetallic MOF-derived hierarchical porous carbon spheres for electrochemical Cu2+ sensing","authors":"Yaqi Yang , Zhewei Zhang , Li Zhang , Zijian Zhao","doi":"10.1016/j.microc.2025.115107","DOIUrl":"10.1016/j.microc.2025.115107","url":null,"abstract":"<div><div>The development of detection devices with rapid response, high sensitivity, and precise detection capabilities for heavy metal ions remains a research hotspot in environmental protection and food safety. In this study, a facile and efficient synchronous doping/etching strategy was employed to synthesize hierarchically porous bimetallic MOF-derived CeSn@C-10 material. Comprehensive characterization techniques, including X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) revealed that the incorporation of Sn species significantly enhanced oxygen vacancy concentration in the CeO<sub>2</sub> lattice while stabilizing low-valent Ce<sup>3+</sup> species, thereby boosting the electrocatalytic activity for CeSn@C-10. The hierarchical porous architecture endowed the material with an enlarged specific surface area and improved accessibility to active sites. When fabricated into an electrochemical sensor (CeSn@C-10/GCE), it exhibited exceptional Cu<sup>2+</sup> detection performance with dual linear ranges of 0.2–5 μM and 5–60 μM, achieving a low detection limit of 38 nM (S/N = 3). The sensor demonstrated remarkable anti-interference capability and promising applicability in real-sample analysis. This work provides a novel strategy for designing hierarchically porous bimetallic electrochemical sensors through synergistic enhancement mechanisms.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115107"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid and selective SERS detection of trace norfloxacin in water using inorganic imprinted Fe3O4@mTiO2 and self-correcting substrate Au@4-NTP@Ag 无机印迹Fe3O4@mTiO2和自校正底物Au@4-NTP@Ag快速选择性SERS检测水中痕量诺氟沙星

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115132

Wenlong Liao , Li Zheng , Junling Shao , Juan Wu , Qian Long , Lingpu Jia , Huiming Li , Kunping Liu , Yixiang Duan

{"title":"Rapid and selective SERS detection of trace norfloxacin in water using inorganic imprinted Fe3O4@mTiO2 and self-correcting substrate Au@4-NTP@Ag","authors":"Wenlong Liao , Li Zheng , Junling Shao , Juan Wu , Qian Long , Lingpu Jia , Huiming Li , Kunping Liu , Yixiang Duan","doi":"10.1016/j.microc.2025.115132","DOIUrl":"10.1016/j.microc.2025.115132","url":null,"abstract":"<div><div>Norfloxacin (NOR) contamination in aquatic systems poses significant risks to ecological safety and human health, driving urgent needs for efficient and accurate monitoring solutions to enable timely risk intervention. This study presented a rapid and selective surface-enhanced Raman spectroscopy (SERS) platform for ultrasensitive NOR detection by integrating inorganic molecularly imprinted Fe<sub>3</sub>O<sub>4</sub>@mTiO<sub>2</sub> (MIFT) with a self-correcting SERS substrate. The MIFT materials, synthesized via sol-gel and microwave-assisted methods using NOR as the template, exhibited minimal residual template and background interference while selectively enriching NOR via imprinting sites. Au@Ag core–shell nanoparticles incorporating 4-nitrothiophenol (Au@4-NTP@Ag), prepared by seed-mediated growth, served as an internal standard-based SERS substrate, enhancing quantitative accuracy (R<sup>2</sup> = 0.9932) through signal normalization (I<sub>740</sub>/I<sub>1075</sub>) and offering improved activity and stability from Au<img>Ag synergy. The integrated platform demonstrated high specificity with <10 % response to structural analogs (e.g., enrofloxacin, ofloxacin) and negligible interference from non-analog antibiotics, and a detection limit of 2.02 nM was achieved—nearly three orders of magnitude lower than direct SERS or HPLC-DAD methods. This sensitive and selective integrated SERS platform shows great potential for on-site monitoring of trace antibiotics in environmental water samples.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115132"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ag/AgCl nanocubes-regulated Fe2O3/CuO Z-scheme heterojunction for sensitive differential signal photoelectrochemical detection of oxytetracycline Ag/AgCl纳米立方调控Fe2O3/CuO z -方案异质结对土环素敏感差分信号的光电检测

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115138

Wenchao Geng , Linsheng Xue , Liming Qiang , Zhiyi Yan , Jiarui Wei , Fei Wang , Ruiying Yang

{"title":"Ag/AgCl nanocubes-regulated Fe2O3/CuO Z-scheme heterojunction for sensitive differential signal photoelectrochemical detection of oxytetracycline","authors":"Wenchao Geng , Linsheng Xue , Liming Qiang , Zhiyi Yan , Jiarui Wei , Fei Wang , Ruiying Yang","doi":"10.1016/j.microc.2025.115138","DOIUrl":"10.1016/j.microc.2025.115138","url":null,"abstract":"<div><div>Differential signal strategy has become an attractive tool for designing high-performance sensor. However, antibiotic sensor still possesses a lot of room for development in terms of sensitivity, economy, and matrix impact. Herein, using plasmonic Ag/AgCl nanocubes-regulated Fe<sub>2</sub>O<sub>3</sub>/CuO <em>Z</em>-scheme heterojunction, a new differential signal PEC sensor is reported for oxytetracycline (OTC) detection. We first synthesized Ag/AgCl nanocubes as efficient signal amplifiers. MOFs-derived Fe<sub>2</sub>O<sub>3</sub>/CuO <em>Z</em>-scheme heterojunction with the electron lifetime of 1.67 Hz and incident photon-to-current efficiency (IPCE) of 43.9 %, is used as an excellent photoelectrode. When target OTC is captured, Ag/AgCl nanocubes is further bound on the sensor to quench the photocurrent signal of Fe<sub>2</sub>O<sub>3</sub>/CuO <em>Z</em>-scheme heterojunction. The differential PEC sensor combining signals from two independent and related events significantly improves the detection limit (6 nM) compared with the conventional PEC assay using a single binding event. The developed PEC sensor not only provides a basis for exploring an innovative detection mode, but also offers a promising application in analysis of food and environmental antibiotics residues.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115138"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photothermal ATP detection by competitive displacement of ZIF-67 adsorbed G4-dHemin DNAzyme ZIF-67吸附G4-dHemin DNAzyme的竞争置换光热ATP检测

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115147

Lijie Lin , Xiaotao He , Xiaoting Xu , Qian Xiao , Qiuyi Li , Yi Zou , Danqing Lu

{"title":"Photothermal ATP detection by competitive displacement of ZIF-67 adsorbed G4-dHemin DNAzyme","authors":"Lijie Lin , Xiaotao He , Xiaoting Xu , Qian Xiao , Qiuyi Li , Yi Zou , Danqing Lu","doi":"10.1016/j.microc.2025.115147","DOIUrl":"10.1016/j.microc.2025.115147","url":null,"abstract":"<div><div>Adenosine triphosphate (ATP) is the primary energy currency in biological system. Abnormal ATP levels are closely related to physical disease. There are series of shortcomings of traditional ATP detection methods, such as complex sample preparation, expensive analysis cost, lack of specificity. Therefore, it is extremely important to establish a convenient and simple ATP monitoring method. Herein, we propose a photothermal biosensing strategy utilizing zeolitic imidazolate framework-67 (ZIF-67) and G4-dHemin DNAzyme for both precise and selective ATP quantification. This platform enables the detection of ATP through a novel competitive displacement mechanism, and achieves higher specificity and lower costs than the traditional method without relying on the aptamer. ZIF-67 has ultrahigh selectivity for recognizing ATP, and G4-dHemin DNAzyme exhibits oxidase-like activity which can effectively oxidize TMB. In this work, G4-dHemin DNAzyme was adsorbed by ZIF-67 due to the electrostatic effect. As a result, the oxidase-like activity of G4-dHemin DNAzyme was greatly reduced. The presence of ATP released the G4-dHemin DNAzyme from ZIF-67, allowing the restore of oxidase-like activity of G4-dHemin DNAzyme. Thus, the colorless TMB could be effectively oxidized to blue substrates (ox TMB). ox TMB, as an excellent photothermal agent, converted the optical signal into a thermal signal (temperature increasing) driven by an 808 nm laser (2.45 W). Then, the photothermal and color signal variations were easily monitored by a portable thermometer and a smartphone. The minimum detection limit of this method was calculated to be 0.41 μM, which could meet the detection of ATP in real samples.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115147"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-in-one portable hydrogel microneedle patch for colorimetric monitoring meat freshness 用于肉类新鲜度比色监测的一体化便携式水凝胶微针贴片

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115143

Fangli Gang, Wanlin Liu, Rui Shi, Lei Zhang, Shaobo Yu, Jing Yang

{"title":"All-in-one portable hydrogel microneedle patch for colorimetric monitoring meat freshness","authors":"Fangli Gang, Wanlin Liu, Rui Shi, Lei Zhang, Shaobo Yu, Jing Yang","doi":"10.1016/j.microc.2025.115143","DOIUrl":"10.1016/j.microc.2025.115143","url":null,"abstract":"<div><div>A portable, visual and pH-responsive hydrogel microneedle patch was developed that integrates sampling and detection functions to provide an intuitive and rapid assessment of meat freshness. Polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) served as the hydrogel matrix, while the mixed dyes of methyl red (MR) and bromothymol blue (BB) were selected as the colorimetric indicators. The prepared BM/PVA/PVP microneedle patches exhibited satisfactory mechanical strength (up to 3.22 N per tip) and water absorption capacity (achieving a swelling rate of 189 %), enabling effective tissue penetration and tissue fluid extraction. Throughout the three defined stages of meat freshness (fresh, less fresh and spoiled), the BM/PVA/PVP microneedle patch demonstrated distinct color transitions from red to yellowish green to green as the pH value of the tissue fluid increased. Moreover, the patch efficiently extracted tissue fluid and provided a clear colorimetric response within 15 min. Therefore, the BM/PVA/PVP hydrogel microneedle patch holds promise for food safety applications as a portable, rapid and visual method for monitoring meat freshness.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115143"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zn/Co bimetallic zeolite imidazole framework electrocatalysts and its application in constructing cathodic luminol electrochemiluminescence system Zn/Co双金属沸石咪唑骨架电催化剂及其在构建阴极发光胺电化学发光体系中的应用

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115070

Waner Hou , Xun Lei , Zhimin Liu , Xuanxuan Hao , Jintao Cheng , Yaxin Li , Leqian Hu , Peng Li

{"title":"Zn/Co bimetallic zeolite imidazole framework electrocatalysts and its application in constructing cathodic luminol electrochemiluminescence system","authors":"Waner Hou , Xun Lei , Zhimin Liu , Xuanxuan Hao , Jintao Cheng , Yaxin Li , Leqian Hu , Peng Li","doi":"10.1016/j.microc.2025.115070","DOIUrl":"10.1016/j.microc.2025.115070","url":null,"abstract":"<div><div>Herein, ZnCo bimetallic zeolite imidazole framework (ZnCo-ZIF) nanocubes were synthesized and used as 2e<sup>−</sup> oxygen reduction reaction (2e-ORR) electrocatalysts. ZnCo-ZIFs showed excellent ORR catalytic activity, which was benefit for producing reactive oxygen species (ROS) efficiently and enhancing the electrochemiluminescence (ECL) emission from luminol/H<sub>2</sub>O<sub>2</sub> system. The reaction mechanism investigation implied that ORR reaction could produce ROS, and the ECL response exhibited a positive correlation with the catalytic activity of ZnCo-ZIFs promoter. In addition, the electrocatalytic activity of different Zn/Co molar ratio (1/ 9, 1/5, 1 /1, 5/1 and 9/1) were investigated, the results showed that ZnCo-ZIF-IV with Zn/Co molar ratio of 5/1 displayed the highest ORR electrocatalytic performance, and the onset potential, H<sub>2</sub>O<sub>2</sub> production rate, the faraday efficiency were 0.67 V (vs. RHE), 67.17 % and 50.74 %, respectively. Finally, an ECL immunosensor based on the promoting effect of ZnCo-ZIF-IV nanocubes on the luminol/H<sub>2</sub>O<sub>2</sub> ECL system was proposed for the sensitive zearalenone assay. This strategy offers a new way to study the luminol-cathodic ECL system.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115070"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn-Mo@sulfur-dopped carbon xerogel based lamotrigine sensitive electrochemical sensor: Characterization and applications Mn-Mo@sulfur-dopped碳干凝胶基拉莫三嗪敏感电化学传感器：表征和应用

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115157

Hind A.M. Noureldin , Abdalla Abdelwahab , Ali M. Abdel-Aziz , Ghada M. El-Sayed , Azza A. Moustafa , Ibrahim H.A. Badr

{"title":"Mn-Mo@sulfur-dopped carbon xerogel based lamotrigine sensitive electrochemical sensor: Characterization and applications","authors":"Hind A.M. Noureldin , Abdalla Abdelwahab , Ali M. Abdel-Aziz , Ghada M. El-Sayed , Azza A. Moustafa , Ibrahim H.A. Badr","doi":"10.1016/j.microc.2025.115157","DOIUrl":"10.1016/j.microc.2025.115157","url":null,"abstract":"<div><div>A novel low-cost voltammetric sensor based on a glassy carbon electrode (GCE) modified with sulfur-doped carbon xerogel/manganese/molybdenum (Mn-Mo@SCX/GCE) was designed for the determination of lamotrigine (LTG). The prepared nanocomposite was characterized using high-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), X-ray Diffraction (XRD), Energy Dispersive X-ray spectroscopy (EDX), X-ray Photoelectron Spectroscopy (XPS), and N<sub>2</sub>-adsorption/desorption isotherm. Using electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV), the behavior of the proposed sensor for the oxidation of LTG was investigated. The obtained data revealed that Mn-Mo@SCX/GCE increased the anodic peak of LTG compared to the pristine GCE. The influence of various parameters was investigated, including nanocomposite volume, electrode surface area, scan rate, pH, and accumulation time. The optimal conditions were determined to be 12.5 μL nanocomposite, 0.13 cm<sup>2</sup> surface area, pH 4.5, and 30 s accumulation time. Under the optimal conditions, the developed sensor exhibited a linear response toward LTG in the range of 20 nM to 43.04 μM, with a correlation coefficient of 0.9901, a limit of detection of 15 pM, and a limit of quantification of 47 pM. The analytical method validation parameters were investigated, and the developed sensor showed good accuracy, selectivity, excellent repeatability and reproducibility, and high sensitivity. Finally, the proposed analytical method was successfully applied for the quantification of LTG in its dosage forms as well as spiked human serum and urine samples, with high recovery results.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115157"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-enzymatic multiplexed detection of glucose and high-density lipoprotein cholesterol using the nanocomposites-based electrochemical microfluidic platform 基于纳米复合材料的电化学微流控平台对葡萄糖和高密度脂蛋白胆固醇的非酶复用检测

IF 4.9 2区化学

Microchemical Journal Pub Date : 2025-09-02 DOI: 10.1016/j.microc.2025.115154

Chanjin Ko , Seonyeop Kim , Taeha Lee , Gyudo Lee , Wonseok Lee

{"title":"Non-enzymatic multiplexed detection of glucose and high-density lipoprotein cholesterol using the nanocomposites-based electrochemical microfluidic platform","authors":"Chanjin Ko , Seonyeop Kim , Taeha Lee , Gyudo Lee , Wonseok Lee","doi":"10.1016/j.microc.2025.115154","DOIUrl":"10.1016/j.microc.2025.115154","url":null,"abstract":"<div><div>Metabolic syndrome is a group of conditions that together raise the risk of various diseases such as diabetes, stroke, cardiovascular diseases, and other serious health disorders. Herein, we developed a non-enzymatic electrochemical sensor platform for the simultaneous detection of glucose and high-density lipoprotein cholesterol which are known as metabolic syndrome biomarkers. We fabricated two sensing layers using nanocomposites comprising multi-walled carbon nanotubes and nanoparticles (<em>e.g.,</em> gold titanium dioxide and zinc oxide) for non-enzymatic detection. At the glucose sensing part, the linear detection range was from 1 nM to 100 mM and the limit of detection was 1 nM. Meanwhile, the linear detection range was from 1 nM to 100 μM and the limit of detection was 1 nM at the high-density lipoprotein cholesterol sensing layer. Additionally, the non-enzymatic electrochemical sensor platform could selectively detect glucose and high-density lipoprotein cholesterol, and the detection capability of the sensor was maintained for 3 weeks. Moreover, we demonstrated sensitive and selective detection of spiked glucose and high-density lipoprotein cholesterol in human plasma and ion sports drinks.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115154"},"PeriodicalIF":4.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0