All-in-one portable hydrogel microneedle patch for colorimetric monitoring meat freshness

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal Pub Date : 2025-09-02 DOI:10.1016/j.microc.2025.115143

Fangli Gang, Wanlin Liu, Rui Shi, Lei Zhang, Shaobo Yu, Jing Yang

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Abstract

A portable, visual and pH-responsive hydrogel microneedle patch was developed that integrates sampling and detection functions to provide an intuitive and rapid assessment of meat freshness. Polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) served as the hydrogel matrix, while the mixed dyes of methyl red (MR) and bromothymol blue (BB) were selected as the colorimetric indicators. The prepared BM/PVA/PVP microneedle patches exhibited satisfactory mechanical strength (up to 3.22 N per tip) and water absorption capacity (achieving a swelling rate of 189 %), enabling effective tissue penetration and tissue fluid extraction. Throughout the three defined stages of meat freshness (fresh, less fresh and spoiled), the BM/PVA/PVP microneedle patch demonstrated distinct color transitions from red to yellowish green to green as the pH value of the tissue fluid increased. Moreover, the patch efficiently extracted tissue fluid and provided a clear colorimetric response within 15 min. Therefore, the BM/PVA/PVP hydrogel microneedle patch holds promise for food safety applications as a portable, rapid and visual method for monitoring meat freshness.

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用于肉类新鲜度比色监测的一体化便携式水凝胶微针贴片

开发了一种便携式，视觉和ph响应水凝胶微针贴片，集成了采样和检测功能，以提供直观和快速的肉类新鲜度评估。以聚乙烯醇（PVA）和聚乙烯吡咯烷酮（PVP）为水凝胶基质，以甲基红（MR）和溴百里酚蓝（BB）混合染料为比色指示剂。制备的BM/PVA/PVP微针贴片具有令人满意的机械强度（每个针尖高达3.22 N）和吸水能力（达到189%的溶胀率），能够有效地渗透组织并提取组织液。在肉类新鲜度的三个确定阶段（新鲜、不新鲜和变质）中，随着组织液pH值的增加，BM/PVA/PVP微针贴片呈现出明显的颜色转变，从红色到黄绿色再到绿色。此外，该贴片有效地提取组织液，并在15分钟内提供清晰的比色响应。因此，BM/PVA/PVP水凝胶微针贴片作为一种便携式、快速和可视化的肉类新鲜度监测方法，有望用于食品安全应用。

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来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.