Microchemical Journal最新文献

{"title":"Detection and classification of microplastics in simulated shoal environments using hyperspectral imaging technology","authors":"Qinchen Yang ,&nbsp;Le Wang ,&nbsp;Yuxian Lu ,&nbsp;Xinrui Xie ,&nbsp;Qian Qian ,&nbsp;Lu Yin","doi":"10.1016/j.microc.2025.114571","DOIUrl":"10.1016/j.microc.2025.114571","url":null,"abstract":"<div><div>Microplastic pollution poses a global environmental threat, yet conventional detection methods suffer from inefficiency and single-point measurement limitations. Hyperspectral imaging (HSI) offers a promising alternative but faces challenges in complex shoal environments where soil-water matrices and variable microplastic concentrations complicate detection. But existing HSI studies focus on single-environment matrices, neglecting shoals and the impact of distribution states on spectral signatures. This study addresses these gaps by developing a non-destructive, efficient HSI-based method to detect and classify 0.5 mm microplastics in simulated shoal environments under two different concentration scenarios. For high-concentration samples, the study employed Otsu image segmentation to obtain binary masks, combined with SG smoothing and SNV preprocessing for spectral feature extraction. Furthermore, density and spectral correlation analysis was performed based on the physical characteristics of the microplastics. This study constructed two types of models based on spectral information and the integration of spatial and spectral information, respectively, with results demonstrating superior performance of the spectral-spatial joint model, achieving an accuracy of 99.52 %. In the detection of low-concentration samples, an improved image segmentation method based on the second principal component was employed. The experiment revealed that the MRCNN model achieved an accuracy of 93.85 % in the detection of low-concentration samples. This accuracy was further enhanced to 96.09 % upon the introduction of the channel attention mechanism. This study demonstrates that hyperspectral imaging technology can effectively classify microplastics in shoal environments, even under varying concentration conditions. By employing a spatial-spectral joint modeling approach in conjunction with a channel attention mechanism, accurate differentiation of three types of microplastic samples was achieved, thereby offering a novel technological means for monitoring microplastic pollution.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114571"},"PeriodicalIF":4.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic solid-phase extraction based on magnetic alginate beads for the extraction and pre-concentration of benzoylurea insecticides in rice samples","authors":"Sujittra Aintharaprasert ,&nbsp;Kittiya Sakhaem ,&nbsp;Dararat Saenkam ,&nbsp;Wannipha Khiaophong ,&nbsp;Norio Teshima ,&nbsp;Kansiri Pakkethati ,&nbsp;Pirom Suwannasom ,&nbsp;Yanawath Santaladchaiyakit ,&nbsp;Orrasa Prasitnok ,&nbsp;Jitlada Vichapong","doi":"10.1016/j.microc.2025.114548","DOIUrl":"10.1016/j.microc.2025.114548","url":null,"abstract":"<div><div>In this study, we synthesized a magnetic alginate beads for the extraction and enrichment of benzoylurea insecticides residues prior to high performance liquid chromatographic analysis. The as-prepared sorbent used for magnetic solid-phase extraction of insecticides in rice samples. Experimental analyses were employed to evaluate the beads' efficiency, utilizing characterization techniques including Fourier-transform infrared spectroscopy (FTIR), Field-emission scanning electron microscope (FE-SEM), thermogravimetric Analysis (TGA), and Brunauer-Emmett-Teller method (BET) to examine the composite's morphology and chemistry. Key parameters affecting the processes of adsorption and desorption process were optimized. Under the optimum condition, good analytical figures of merit through wide liner range with good determination coefficients (R²) higher than 0.99. High enrichment factor with low limit of detection were obtained. They have been successfully applied to the analysis of rice samples with the satisfactory recoveries were obtained. Additionally, the greenness and blueness assessment of the developed method was performed using the Analytical Eco-Scale, AGREE Assessment, ComplexMoGAPI, BAGI and NQS tools to evaluate its environmental impact and analytical practicality. This alternative sorbent was shown good selectivity and cost-effective than commercial sorbent.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114548"},"PeriodicalIF":4.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability-indicating RP-HPLC method development and validation for simultaneous quantification of ciprofloxacin, curcumin, and piperine in a novel topical dosage form","authors":"Alexlivingston Nadar ,&nbsp;Vandana Jain ,&nbsp;Melroy D'Sa","doi":"10.1016/j.microc.2025.114554","DOIUrl":"10.1016/j.microc.2025.114554","url":null,"abstract":"<div><div>An optimized stability-indicating RP-HPLC method has been successfully developed for the concurrent estimation and quantification of Ciprofloxacin, Curcumin, and Piperine. The methodology is strategically optimized with robustness rooted in the principles of sound science. It was validated as per the regulatory guidelines to ascertain its reliability and effectiveness. Analytical conditions provided an incredibly shorter run time of 7 min performed through isocratic elution with acetonitrile: orthophosphoric acid (70:30 % <em>v</em>/v) mobile phase flowing at a<!--> <!-->rate of 1 mL/min. The optimal wavelength (278 nm) was used in chromatographic detection. The temperature of the column was consistently regulated at 30 °C to produce a thermostable response throughout the chromatograms. Additionally, various forced degradation studies were conducted on the selected drug candidates under stress conditions, including thermal, photolytic, oxidative, and acid-base induction. After stress testing, the samples were subjected to HPLC analysis, demonstrating the method's selectivity in discriminating analytes of interest from degradation byproducts. The designed analytical technique was then validated according to ICH guideline Q2(R1). The developed analytical methodology was subsequently corroborated, including a thorough evaluation of relevant performance attributes such as linearity, system suitability, accuracy, precision, robustness, sensitivity, and solution stability. The results demonstrate that quantifying Ciprofloxacin, Curcumin, and Piperine with wide-ranging applications inside a novel topical dosage form is reliable and precise.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114554"},"PeriodicalIF":4.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On-chip microextraction of N-acetylcysteine in water and plasma samples and smartphone-enabled colorimetric determination","authors":"Narges Bastan,&nbsp;Tayyebeh Madrakian,&nbsp;Mazaher Ahmadi,&nbsp;Abbas Afkhami,&nbsp;Abbas Soloki","doi":"10.1016/j.microc.2025.114573","DOIUrl":"10.1016/j.microc.2025.114573","url":null,"abstract":"<div><div>Recent advances in microfluidics have made it possible to carry out expensive tests on a small chip. In this context, the use of smartphones as mainly colorimetric detectors has provided the promise of complete transfer of the analytical chemistry process from sample preparation to detection on microfluidic chips. In this research, a microfluidic chip has been used as a platform for the extraction and smartphone-enabled colorimetric measurement of <em>N</em>-acetylcysteine (NAC). The extraction phase was a deep eutectic solvent based on 1,10-phenanthroline and thymol with a molar ratio of 1:2 (a type V deep eutectic solvent). Analyte determination was done indirectly in this work. NAC reduces Fe³⁺ ions to Fe²⁺ on the chip, and the produced Fe²⁺ selectively forms a red-orange complex with 1,10-phenanthroline in the extraction deep eutectic solvent phase. The results showed that the intensity of red color in the extraction phase depends directly on the analyte concentration. In this way, measuring NAC in the concentration range of 9.0 μg L⁻¹ to 0.5 mg L⁻¹ was possible. The calibration curve was bilinear and the sensitivity of the method was better at the lower concentrations (lower concentration range slope: 29.812, higher concentration range slope: 9.627). The method's detection limit was 3.0 μg L⁻¹ and the quantification limit was 9.0 μg L⁻¹. The method was validated after evaluating the effect of possible interferences in the tap water and plasma matrixes. The results showed that the method provides high accuracy (recovery percentage: 96.6–107.5 %) and high precision (coefficient of variation: 0.46–1.90 %) for determining NAC in the investigated real samples.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114573"},"PeriodicalIF":4.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratiometric electrochemical direct sensing of ciprofloxacin antibiotic via electroless plating of silver on graphynes","authors":"Chaofeng Zhang ,&nbsp;Conglin Zhang ,&nbsp;Yinhui Yi ,&nbsp;Yan Yang ,&nbsp;Gangbing Zhu","doi":"10.1016/j.microc.2025.114565","DOIUrl":"10.1016/j.microc.2025.114565","url":null,"abstract":"<div><div>The abuse of ciprofloxacin (CIP) antibiotic has aroused severe harm to the humans, thus achieving its sensitive and reliable detection is very important. Herein, by using a rising-star material graphynes (GDY) as the substrate, we firstly revealed Ag⁺ can be self-reduced via simple electroless plating process to form tiny silver (Ag⁰) nanoparticles (Ag NPs) and obtained a novel Ag@GDY nanohybrid. For this nanohybrid, the resulted Ag NPs can not only improve the conductivity and resolve the aggregation of GDY, but also can be used as an internal reference to construct a ratiometric electrochemical sensor; meanwhile, GDY can provide the affinity ability to CIP molecules via π-π interaction, and the band theory analysis also demonstrated the Ag@GDY nanohybrid could exhibit the synthetical catalysis advantages from Ag NPs and GDY, showing enhanced greatly catalytical activity compared to the pure GDY. On the basic of these comprehensive superiorities, a sensitive ratiometric electrochemical direct sensing platform for CIP was then developed for the first time by using Ag@GDY modified electrode, which was confirmed to be linear with the CIP concentrations from 0.09 to 5.0 μM via adopting the current ratio between CIP and Ag⁰ as the read-out signal. Under the optimized conditions, the detection limit for CIP is as low as 23.0 nM in this work, and the constructed Ag@GDY sensor for CIP detection in the real samples was also confirmed, which thus showed important potential applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114565"},"PeriodicalIF":4.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive multiplexed detection of cancer biomarker proteins using SPR imaging","authors":"Gulsum Ucak-Ozkaya ,&nbsp;M. Zeki Durak ,&nbsp;Mohamed Sharafeldin ,&nbsp;James F. Rusling","doi":"10.1016/j.microc.2025.114562","DOIUrl":"10.1016/j.microc.2025.114562","url":null,"abstract":"<div><div>While cancer is one of the leading causes of death worldwide, its diagnosis is still lagging behind lengthy procedures that are both expensive and lack specificity. Herein, we investigate the use of surface plasmon resonance imaging (SPRi) for the multiplexed detection of four cancer biomarkers associated with aggressive prostate cancer. This biomarker panel include prostate-specific antigen (PSA), insulin-like growth factor I (IGF-I), vascular endothelial growth factor (VEGF-D), and monocyte surface antigen (CD14). 16 spots SPR chip array functionalized with primary antibodies (Ab₁) against the selected biomarkers, and bovine serum albumin (BSA) as a negative control, was housed in a 3D printed microfluidic channel to control the delivery of sample and reagents. Antigens were first captured, offline, on magnetic beads (MBs) labelled with secondary antibodies (Ab₂), and SPRi signals were collected and analyzed while flowing the MBs on the chip. This enabled the collection of real-time data for the association between antigens, captured on MBs, and Ab₁ immobilized on the SPR chip, and quantification of the target antigens after reaching equilibrium. This assay was capable of achieving dynamic ranges of 10 fg/mL to 100 pg/mL for PSA, 1 to 100 pg/mL for CD14, 1.1 to 110 pg/mL for IGF-I, and 0.5 to 100 pg/mL for VEGF-D. The multiplexed assay limit of detection (LOD) was found to 7.6 pg/mL for CD14, 5.8 pg/mL for IGF-1, and 5.3 pg/mL for VEGF-D with dynamic ranges of four orders of magnitude up to 125 pg/mL. While we could not apply this system in the analysis of real samples, it demonstrates a high throughput analytical approach with strong potential for identifying prostate cancer at an early stage. The system offers high sensitivity (down to few pg/mL) multiplexed detection of a selected panel of prostate cancer biomarkers.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114562"},"PeriodicalIF":4.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving accuracy and interpretability of portable near-infrared spectroscopy via portable mass spectrometry fusion: A case study on the geographical traceability of Angelica sinensis","authors":"Yijing Zhang ,&nbsp;Shamukaer Alimujiang ,&nbsp;Changhao Jia ,&nbsp;Zixuan Yan ,&nbsp;Yuanjian Zhang ,&nbsp;Wenlong Li","doi":"10.1016/j.microc.2025.114564","DOIUrl":"10.1016/j.microc.2025.114564","url":null,"abstract":"<div><div>With growing consumer demand for food quality and safety, rapid and accurate origin traceability has become increasingly important. Portable near-infrared spectroscopy (NIR) and portable mass spectrometry (PMS) have shown respective advantages in food authenticity assessment. However, no study has yet explored the integration of both technologies for origin identification. This study proposes a multilevel data fusion strategy combining NIR and PMS to enhance the traceability accuracy of <em>Angelica sinensis</em> Radix (ASR), a regionally distinctive food ingredient. After applying the mahalanobis distance method to eliminate outliers, classification models based on random forest, radial basis function neural network, and serpent optimization-support vector machine (SO-SVM) were built using both NIR and PMS data. Preprocessing and variable selection techniques were employed to improve model robustness. The SG-MSC-2nd Der-SO-SVM model yielded the best performance on NIR data, while the SS-CMA-ES-SO-SVM model achieved optimal results for PMS data. Among fusion strategies, the Bayesian model averaging-based approach outperformed low-level and mid-level fusion methods, achieving 0.95 accuracy and a Kappa value of 0.91 on the independent validation set. This study demonstrates that the fusion of complementary spectroscopic and spectrometric data offers a powerful solution for improving origin traceability and provides a valuable reference for food quality monitoring.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114564"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a spectrofluorimetric method for MHPG detection in plasma via rhodamine B fluorescence quenching: a Box-Behnken design approach with application to autism spectrum disorder","authors":"Razaz A. Felemban ,&nbsp;Majed A. Algarni ,&nbsp;Ayman A. Abd Al Maksoud ,&nbsp;Adnan Alharbi ,&nbsp;Ahmed K. Bamaga ,&nbsp;Mohammad S. Alzahrani ,&nbsp;Abdulaziz Ibrahim Alzarea ,&nbsp;Ahmed Serag ,&nbsp;Atiah H. Almalki","doi":"10.1016/j.microc.2025.114560","DOIUrl":"10.1016/j.microc.2025.114560","url":null,"abstract":"<div><div>This study presents the development and validation of a sensitive spectrofluorimetric method for detecting 3-methoxy-4-hydroxyphenylglycol (MHPG), a major metabolite of norepinephrine and proxy for central noradrenergic activity, in plasma based on Rhodamine B fluorescence quenching. The spectral characteristics of Rhodamine B and its ion pair complex formation with MHPG were investigated using UV–vis and fluorescence spectroscopy. Mechanistic studies employing Stern-Volmer kinetics, thermodynamic analysis, and Job's method of continuous variation revealed a static quenching mode with 1:1 complex formation stoichiometry. Critical method parameters such as pH, Rhodamine B volume, and incubation time were optimized using a Box-Behnken design of experiments, with desirability function analysis employed to maximize the quenching efficiency and sensitivity. The method was validated according to the ICH M10 guidelines and demonstrated excellent linearity (2–200 ng/mL), precision, accuracy and selectivity, with lower limits of detection and quantification of 0.655 and 1.966 ng/mL, respectively. Application to a pilot cohort of children with ASD and neurotypical controls revealed elevated plasma MHPG levels in the ASD group, although the difference did not reach statistical significance. Notably, age-related trends in MHPG levels differed markedly between groups, with a robust positive correlation observed in controls but absent in the ASD group. Sex-specific analyses further suggested more pronounced sex-related variations in noradrenergic function in ASD compared to controls. These preliminary results provide valuable insights into potential alterations of the noradrenergic system in ASD and highlight the utility of the developed spectrofluorimetric method, warranting further investigations in larger cohorts to elucidate the clinical relevance of disturbed noradrenergic function in ASD.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114560"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen vacancy-rich NiCo2O4 nanoparticles loaded on polyaniline nanowires for highly selective Pb2+ electrochemical sensing","authors":"Xinying Han,&nbsp;Yutong Shan,&nbsp;Rui Wang,&nbsp;Shiyu Wang,&nbsp;Yang Zhao,&nbsp;Huan Wang","doi":"10.1016/j.microc.2025.114568","DOIUrl":"10.1016/j.microc.2025.114568","url":null,"abstract":"<div><div>To satisfy the pressing demands for heavy metal ions (HMIs) detection, A novel sensor was developed to detect lead (Pb²⁺) ions based on oxygen vacancy-rich NiCo₂O₄ (NCO) nanoparticles and polyaniline (PANI) nanowires. The NCO/PANI nanocomposite was synthesized via a synergistic salt-assisted carbonization activation and conductive polymers doping strategy, which simultaneously introduced abundant oxygen vacancies and optimized the heterostructure interface. The NCO nanoparticles coupled with imine functional groups (-N=) on PANI create synergistic adsorption-catalytic sites for Pb²⁺. The sensitivity of the NCO/PANI-modified glassy carbon electrode (GCE) reached an impressive value of 14.96 μA·μM⁻¹, representing increases of 2.5-fold, 4.14-fold, and 24.9-fold compared to that of the NCO-modified GCE (5.99 μA·μM⁻¹), PANI-modified GCE (3.616 μA·μM⁻¹), and bare GCE (0.6 μA·μM⁻¹), respectively. This performance results from oxygen vacancies accelerated electron transfer, redox pair interactions (Co²⁺/Co³⁺, Ni²⁺/Ni³⁺), and enhanced Pb²⁺ adsorption by complexation and pore confinement. The sensing platform achieves an ultralow detection limit of 0.001 μM (S/N = 3) and exhibits robust anti-interference against common coexisting interferences (Cd²⁺, Cu²⁺, Fe²⁺, Ni²⁺, Zn²⁺, Fe³⁺ bisphenol A, catechol, hydroquinone, resorcinol), with satisfactory recovery (101 %–106.2 %) and excellent long-term stability in real water samples. This work not only establishes a robust foundation for optimizing material selection but also expands the horizon for the development of electrochemical sensing platforms.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114568"},"PeriodicalIF":4.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low temperatures and concentrations ethylene glycol sensing based on ultrathin graphene oxide-decorated CuO nanosheets","authors":"Jiahui Lin,&nbsp;Boyan Fu,&nbsp;Leyao Bi,&nbsp;Jiaxing Fu,&nbsp;Junsheng Wen,&nbsp;Wenyue Tian,&nbsp;Chunjie Wang,&nbsp;Yue Wang","doi":"10.1016/j.microc.2025.114542","DOIUrl":"10.1016/j.microc.2025.114542","url":null,"abstract":"<div><div>Ethylene glycol is a toxic contaminant, hence the monitoring of its vapor is crucial for environmental safety and human health. In this study, CuO/GO ultrathin nanosheet composites were successfully synthesized via a one-step chemical precipitation method, and subsequently used for the detection of low concentrations of ethylene glycol at low temperatures. The test results indicate that CuO/0.7GO shows a response of 39.5 at 110 °C for 10 ppm ethylene glycol, which is 19 times greater than that of CuO, and the optimal operating temperature reduced by 20 °C compared to CuO. Notably, CuO/0.7GO still demonstrates a response of 7.02 for 1 ppm ethylene glycol. Furthermore, the CuO/0.7GO sensor exhibits significant selectivity, repeatability, and long-term stability toward ethylene glycol. The morphology, microstructure, and elemental composition of the materials were characterized by XRD, SEM, TEM, EDX, FT-IR, XPS, and UV–Vis. Finally, the gas sensing mechanism of the composite material toward ethylene glycol was discussed in depth, emphasizing that the enhanced gas sensing performance was attributed to the synergistic effect between the abundant chemisorbed oxygen and the hybrid heterojunctions.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"216 ","pages":"Article 114542"},"PeriodicalIF":4.9,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}