Microchemical Journal最新文献

{"title":"A different application of the Aliquat® 336 loaded poly(vinylidene fluoride-co-hexafluoropropylene) based electrospun nanofibers disks for the preconcentration followed by flame atomic absorption spectrometry detection of low-level Bi(III)","authors":"Jamal-Addin Rajabi-Orhani ,&nbsp;Leila Dolatyari ,&nbsp;Mohammad Reza Yaftian","doi":"10.1016/j.microc.2024.111703","DOIUrl":"10.1016/j.microc.2024.111703","url":null,"abstract":"<div><div>It is the first report on the potential of electrospun nanofiber disks inserted in a filtration apparatus as a preconcentration strategy for the analysis of low-level metals. The nanofibers included 60 wt% of poly(vinylidene fluoride-<em>co</em>-hexafluoropropylene) (PVDF-HFP) and 40 wt% of ionic liquid Aliquat<strong>®</strong> 336. The electrospinning process was done by applying a voltage of 16 kV, an injection rate of 1 mL h⁻¹, and 10 cm distance of the needle tip location from the drum collector. A circular piece of the prepared nanofiber disks was placed in a filtration apparatus, and 200 mL solution containing 1 mg of Bi(III) adjusted to 0.5 mol/L of hydrochloric acid was transmitted from inside the nanofiber disk by controlling the flowrate (3.3 mL s⁻¹). The adsorbed Bi(III) was eluted by 10 mL of 0.2 mol/L solution of ethylendiaminetetraacetic acid and ammonium hydroxide mixture, and then was analyzed by flame atomic absorption spectrometry. The introduced technique (nanofiber disks-based solid phase extraction) can be used in the bismuth concentration range of 4–2000 µg/L, with a limit of detection 1.2 µg/L. The determined inter- and intra-day relative standard deviations (3 days and n = 7) for a solution of 100 µg/L of bismuth were 1.1 % and 2.4 %, respectively. The method offers a preconcentration factor of 200-fold. The fabricated nanofiber disks were used at least in 7 consecutive preconcentration experiments. The proposed method was selective towards Bi(III) and can be used satisfactory for its determination in real samples.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111703"},"PeriodicalIF":4.9,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on quantification of various biomarkers for the detection of oral carcinoma via electrochemical biosensors","authors":"Ekta Daweshar ,&nbsp;Pankaj ,&nbsp;Rajvee Mewada,&nbsp;Suveen Kumar","doi":"10.1016/j.microc.2024.111741","DOIUrl":"10.1016/j.microc.2024.111741","url":null,"abstract":"<div><div>Oral carcinoma ranks sixth among the most fatal carcinomas, projecting a threat to the entire world, affecting the head and neck region. It is predominant in men due to several causative agents like tobacco, drinking, and HPV (human papillomavirus). Despite various diagnostic methods and treatments available, high rates of morbidity and mortality pose a significant challenge for oncologists toward its early detection. Conventional methods of diagnosis include biopsy, histopathology, and ELISA, which are time-consuming and non-compliant towards the patient. Therefore, developing an accurate, sensitive, selective, and cost-effective biosensing technology is imperative for timely prognosis, diagnosis, and treatment. Various electrochemical biosensors have been developed to ensure rapid and non-invasive /minimally invasive diagnosis of oral carcinoma. Nanomaterials have been extensively researched and utilized to develop invasive, minimally invasive, and non-invasive platforms for biosensor fabrication in oral carcinoma detection. This review aims to summarize various electrochemical biosensors developed for detecting oral carcinoma including the advantages and limitations of nanomaterials (metals, metal oxides and hydroxides, carbon, etc.), and other nanocomposite materials based on electrochemical biosensors. Finally, it also addresses the current challenges and prospects for developing handheld devices for oral carcinoma detection.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111741"},"PeriodicalIF":4.9,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entropy-driven DNA nanomachine with magnetic assistance manipulating the aggregation of Au nanoparticles for label-free photothermal Aptasensing","authors":"Hongbo Li ,&nbsp;Jingling Zhang ,&nbsp;Ye Cao ,&nbsp;Qin Xu ,&nbsp;Jing Li","doi":"10.1016/j.microc.2024.111751","DOIUrl":"10.1016/j.microc.2024.111751","url":null,"abstract":"<div><div>Photothermal sensing has attracted increasing attention as a fast and portable detection method. However, photothermal sensors with excellent comprehensive performance still face challenges. Herein, a unique photothermal biosensor for bisphenol A as a model target is successfully constructed based on aptamer recognition coupled with the programmable entropy-driven DNA nanomachine cascaded strand displacement manipulating the aggregation of gold nanoparticles. In this protocol, the exposed bases of two DNA probes released from the DNA amplification network can anchor gold nanoparticles by van der Waals attraction. This allows gold nanoparticles to resist aggregation induced by a certain concentration of sodium chloride. Based on this exclusive mechanism, target-induced visual detection can be achieved by reading temperature changes. The two probes that are fully utilized to improve the atomic economy of the reaction and enhance the detection sensitivity. Also, label-free gold nanoparticles save time in the fabrication of the photothermal sensor. Moreover, visualized photothermal sensors with multi-color gradients enable self-verification of detection results, increasing sensor reliability. In particular, the splitting mode of magnetic-assisted extraction gives the designed photothermal sensor excellent specificity, which can meet the needs of real sample detection with high background noise. Additionally, this programmable and robust photothermal sensor has advantages of portability, replicability, rapid response, and simple operation.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111751"},"PeriodicalIF":4.9,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early detection for carbohydrate antigen-19-9 based on surface enhanced Raman spectroscopy aptamer sensor","authors":"Ji Xia ,&nbsp;Yan Li ,&nbsp;Yue Xin ,&nbsp;Luyao Kang ,&nbsp;Dan Lu","doi":"10.1016/j.microc.2024.111750","DOIUrl":"10.1016/j.microc.2024.111750","url":null,"abstract":"<div><h3>Background</h3><div>Incipient screening for cervical cancer is crucial for treatment and improving prognosis. In this work, SERS based aptamer sensor (aptasensor) has been developed and applied to high-sensitivity detection of cervical cancer tumor marker (Carbohydrate antigen19-9 (CA19-9)) with a microporous chip, which was used as surface enhanced Raman scattering (SERS) analysis platform.</div></div><div><h3>Methods</h3><div>The aptamer of CA19-9 was immobilized on the gold nanodumbbell as a capture probe and the gold nanobipyramid containing complementary aptamer chains of the signal molecule Cy5 was modified as a signal probe. SERS aptasensor was constructed by combining signal probes and capture probes. It caused signal molecule Cy5 were sandwiched between the signal probes and capture probes; the constructed SERS aptasensor generated a strong SERS signal of Cy5. Based on the strong specificity of the aptamer, the CA19-9 aptamer binds specifically to CA19-9 when CA19-9 exist in the detection environment. The signal probe was released, resulting in a decrease in the SERS signal of the detection environment.</div></div><div><h3>Results</h3><div>Under the optimal detection conditions, the detection limit of the aptasensor was calculated to be 1.16 × 10⁻³ U/mL and limit of quantification is equal to 3.87 × 10⁻³ U/mL. In addition, a standard cervical cancer bearing mouse model was constructed and the SERS spectra of the serum of mice at different stages were measured. The CA19-9 content in the serum of mice at different stages was calculated. Compared with the results of enzyme-linked immunosorbent assay (ELISA), relative error (RE) values (2.54 %, −6.093 %, −4.922 %, and 3.04 %) of the CA19-9 concentrations detected by the two methods on the day of 0, 7, 14 and 28.</div></div><div><h3>Conclusion</h3><div>The proposed SERS aptasensor provides a new and reliable platform for early cervical cancer screening, and its low RE value proves that it will be a promising CA19-9 detection method.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111750"},"PeriodicalIF":4.9,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of proteins in hypoxic Müller glia cells by single-cell ICP-MS: The use of a Rh-DNA intercalator for enhanced cell detection","authors":"Alicia Villa-Vázquez ,&nbsp;Paula Menero-Valdés ,&nbsp;Lydia Álvarez ,&nbsp;Héctor González-Iglesias ,&nbsp;Beatriz Fernández ,&nbsp;Rosario Pereiro","doi":"10.1016/j.microc.2024.111745","DOIUrl":"10.1016/j.microc.2024.111745","url":null,"abstract":"<div><div>Single cell − inductively coupled plasma-mass spectrometry (sc-ICP-MS) enables the identification and quantification of elements and biomolecules within individual cells. Target proteins can be analyzed by sc-ICP-MS using metal nanoclusters (MNCs)-based immunoprobes, facilitating the detection of low amounts of proteins in each cell. However, for the full implementation of sc-ICP-MS, an effective strategy to enhance the detection of cellular events is required. In this work, the measurement of endogenous elements and two external tags (ruthenium red and Rh-DNA intercalator) was investigated for cell detection. As a proof of concept, the sequential determination of two proteins (hypoxia inducible factor-1α and vascular endothelial growth factor; HIF-1α and VEGF, respectively) in individual human Müller glia cells (MIO-M1) was pursued. Specific antibodies against HIF-1α and VEGF were labelled with AuNCs and IrNCs, respectively. The results demonstrated the advantages of using Rh-DNA intercalator for the detection and discrimination of cellular events by sc-ICP-MS for quadrupole (Q) mass spectrometers. Additionally, applying this analytical method to cultured MIO-M1 cells under hypoxic and to normoxic conditions showcased the ability of sc-ICP-QMS to study hypoxia-induced changes in the cell-to-cell distributions of HIF-1α and VEGF levels.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111745"},"PeriodicalIF":4.9,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A highly sensitive sandwich-type electrochemical sensor for detection glypican-3 based on H-rGO-CMC@Pt NPs and aptamers","authors":"Xiaohong Tan ,&nbsp;Wenzhan Li ,&nbsp;Wei He ,&nbsp;Tingting Yu ,&nbsp;Bingbing Wan ,&nbsp;Yong Huang ,&nbsp;Jintao Liang ,&nbsp;Guiyin Li","doi":"10.1016/j.microc.2024.111747","DOIUrl":"10.1016/j.microc.2024.111747","url":null,"abstract":"<div><div>Glypican-3 (GPC3), which is a surface heparan sulfate proteoglycan, has been widely known the ideal biomarker for diagnosis and treatment of hepatocellular carcinoma (HCC). Accurate and sensitive detection of serum GPC3 level is an important and challenging task. In this paper, a sandwich electrochemical aptasensor was designed to specifically detect serum GPC3 level through aptamer-target-aptamer recognition. A GPC3 aptamer (GPC3_Apt) immobilized on the surface of gold nanoparticles@reduced graphene oxide modified screen-printed electrode (Au NPs@rGO/SPCE) was used as the capture probe. Hemin-reduced graphene oxide-carboxymethyl chitosan@platinum nanoparticles (H-rGO-CMC@Pt NPs), with good mimicking peroxidases activity, were labeled with amination GPC3 aptamer, which was employed as the signal probe. Once the target GPC3 was anchored on the surface of GPC3_Apt/Au NPs@rGO/SPCE, the H-rGO-CMC@Pt NPs-GPC3_Apt was further specifically bound to the GPC3, forming the aptamer-target-aptamer sandwich structure, which can catalyze the oxidation of hydroquinone (HQ) to benzoquinone (BQ) and lead the oxidation current of HQ recorded by DPV to changing. The linear relationship between the current signal of oxidation of HQ and GPC3 concentration range of 0.0001–3.0 µg/mL and 3.0–60.0 µg/mL, with a low detection limit (LOD) of 0.0685 ng/mL. Additionally, the electrochemical aptasensor was successfully applied for the detection of GPC3 in human serum samples with the recovery of 99.95–104.06 % and relative standard deviation (RSD) of 1.31–5.22 %. Thus, the sandwich aptasensor could provide a new strategy for detection of serum GPC3 level and improve the early diagnosis rate of HCC.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111747"},"PeriodicalIF":4.9,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanozymes in environmental remediation: A bibliometric and comprehensive review of their oxidoreductase-mimicking capabilities","authors":"Vasundra Nagendran ,&nbsp;Louella Concepta Goveas ,&nbsp;Ramesh Vinayagam ,&nbsp;Thivaharan Varadavenkatesan ,&nbsp;Raja Selvaraj","doi":"10.1016/j.microc.2024.111748","DOIUrl":"10.1016/j.microc.2024.111748","url":null,"abstract":"<div><div>Nanozymes mimic enzyme-like properties and possess unique characteristics inherent to nanomaterials, combining catalytic functionality with distinct nanostructure features. This class of emerging materials has garnered significant attention for their potential applications in environmental remediation. A bibliometric analysis was conducted to map research trends and identify key areas of focus in this rapidly evolving field. This review comprehensively examines the types and catalytic mechanisms of oxidoreductase nanozymes, and their diverse environmental applications with specific attention to detection and degradation of various pollutants such as dyes, pesticides, antibiotics and toxic ions. The intricate mechanisms of oxidoreductases mimicked by nanozymes and their roles in catalysing reactions for environmental remediation are discussed. Furthermore, their versatility and efficacy in addressing environmental challenges are elaborated with recent literature. Through a thorough analysis of recent advancements and case studies, this review provides valuable insights into the potential of nanozymes as efficient tools for sustainable environmental management.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111748"},"PeriodicalIF":4.9,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142322198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printing and MATLAB assisted ratiometric-sensing platform for visual on-site sensing of tetracycline using color conversion strategy","authors":"Ruimei Zhang ,&nbsp;Dong Zeng ,&nbsp;Yuxin Guo ,&nbsp;Jiawei Huang ,&nbsp;Ruizhi Wen ,&nbsp;Hongchang Li","doi":"10.1016/j.microc.2024.111730","DOIUrl":"10.1016/j.microc.2024.111730","url":null,"abstract":"<div><div>In this research, a ratiometric-sensing platform (ZIF-8/CDs) that combines non-fluorescence metal–organic frameworks (ZIF-8) with blue-green fluorescent carbon dots (CDs) has been developed for the determination of tetracycline (TC) with high sensitivity and selectivity in real samples. For this purpose, ZIF-8 with polyhedral structure was synthesized, which could form aggregation-induced emission (AIE) effect through electrostatic, hydrogen bonding, π-π stacking, and coordination interactions in the presence of TC, leading to enhanced intensity with a bright yellow fluorescence at 516 nm, acting as a response signal. However, the fluorescence intensity of blue-green fluorescent CDs maintained practically constant at 466 nm, serving as a reference signal. Furthermore, we integrate MATLAB algorithm and 3D-printing technology with the ZIF-8/CDs complex into a ratiometric-sensing platform for semi-quantitative detection of TC, in which 3D-printing technology is responsible for engineering an integrated dark chamber to achieve the fluorescence images of real samples, whereas MATLAB with the image processing functions and data processing capabilities utilizes to develop a mini program for calculating the RGB values of the obtained images. Consequently, the ratiometric-sensing platform in a simple, rapid, and economic way without any complicated process and expensive instruments could be used for visual/onsite detection of TC in real samples.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111730"},"PeriodicalIF":4.9,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142317845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cutting edge potentiometric determination of baricitinib in synthetic wastewater and in tablet dosage form using modified carbon paste ion-selective membrane","authors":"Heba T. Elbalkiny ,&nbsp;Mona S. Elshahed ,&nbsp;Dalia Mohamed ,&nbsp;Azza A. Ashour ,&nbsp;Rasha Th. El-Eryan","doi":"10.1016/j.microc.2024.111727","DOIUrl":"10.1016/j.microc.2024.111727","url":null,"abstract":"<div><div>After the recent hit of COVID-19, many drugs were successively administered to save patients’ lives and those drugs reached aquatic sources, one of those drugs was Baricitinib. Driven by the current situation, a potentiometric technique using an ion-selective membrane (ISM) recipe drop cast on a modified carbon paste electrode was optimized for the superior determination of Baricitinib (BAR). The molecular docking was customized to optimize the proper ionophores incorporated in the ISM, revealing that beta-cyclodextrin (β-CD) is the most compatible ionophore with the studied drug. A multivariate optimization experimental design was employed to optimize the best experimental condition for the analytical method. To this end; dual nanoparticles (multi-walled carbon nanotubes and copper oxide nanoparticles) were incorporated in the carbon paste electrode, and the ISM recipe was enriched with β-CD and cation-exchanger (phosphotungstic acid) in a polyvinylchloride matrix plasticized with dibutyl phthalate. A Nernstian slope equal to 19.97 mV/decade with a linearity range of 7.99 × 10⁻⁷–1.00 × 10⁻³ M was obtained. The validated sensor exhibited good recovery when used to determine the studied drug in synthetic wastewater and tablet dosage form. The greenness of the method was evaluated using the Complementary Green Analytical Procedure Index and Blue Applicability Grade Index.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111727"},"PeriodicalIF":4.9,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescent sensing platform based on two-dimensional layered double hydroxides and exonuclease I for DNA and microRNA detection","authors":"Yuanyi Wu ,&nbsp;Yan Yang ,&nbsp;Shihao Yang ,&nbsp;Yang Ju ,&nbsp;Yang Jiang ,&nbsp;Yumei Xiao ,&nbsp;Jialin He ,&nbsp;Tian Liu ,&nbsp;Leyao Tang ,&nbsp;Kaiyong Wang ,&nbsp;Yi Yang","doi":"10.1016/j.microc.2024.111740","DOIUrl":"10.1016/j.microc.2024.111740","url":null,"abstract":"<div><div>Interfacial and interlayer interactions between layered double hydroxides (LDHs) and nucleic acids offer LDHs great potential to absorb and detect nucleic acids. Herein, we demonstrate a simple, rapid, and versatile fluorescent sensing platform based on two-dimensional LDHs and exonuclease I (Exo I) for the selective analysis of DNA and microRNA. ZnNiAl-LDHs were utilized as quenchers for FAM labelled on single-stranded DNA (ssDNA) probes via dynamic quenching with high fluorescence quenching ability. The quenching mechanism was explored by means of spectral analysis, characterization experiments, DNA adsorption and desorption studies, zeta potential analysis, and molecular dynamics simulations. The driving forces for the adsorption of LDHs toward fluorophore-labelled nucleic acids were confirmed to be electrostatic interaction, van der Waals force, and anion exchange for the first time. In order to distinguish the formed target/probe duplexes from FAM-ssDNA probes, Exo I was introduced to specifically hydrolyze FAM-ssDNA probes. The fabricated fluorescent sensing platform for nucleic acids detection shows a low detection limit of 0.08 nM. Finally, this sensor was effectively utilized for the detection of DNA and microRNA in actual biological and environmental samples, achieving recoveries ranging from 96.4 % to 105 %, indicating high accuracy. This work proposed a promising sensing platform for sequence-specific nucleic acids detection, and provides a new perspective on two-dimensional LDHs as structural supports and biomolecular reservoirs for biomedical applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111740"},"PeriodicalIF":4.9,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142317844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}