Microchemical Journal最新文献

{"title":"Novel selective ionic liquid membrane-coupled microfluidic chip for heavy metal separation and analytical strategies","authors":"Yang Yuan ,&nbsp;Hui Jia ,&nbsp;Jibao Liu ,&nbsp;Fei Gao ,&nbsp;Xu Zhu ,&nbsp;Zihan An ,&nbsp;Jie Wang","doi":"10.1016/j.microc.2024.112321","DOIUrl":"10.1016/j.microc.2024.112321","url":null,"abstract":"<div><div>The development of new low-cost, highly selective and efficient methods for the separation and detection of heavy metal ions in aqueous environments is of great importance for water safety and biological health. In this study, a novel ion separation membrane was prepared for the separation of copper ions in cadmium ion detection solution. Compared with the commercial membrane, the ion mobility was increased by 64.02 %, and further separated by selective complexation of thiacalix[4]arene-p-tetrasulfonate (TCAS), and the separation factor for Cu/Cd reached 34.66. This allowed Cd to be detected preferentially, and reduced the interference of other ions in the detection. The joint electric field environment was regulated to separate the organics and reduce the interference to the detection. The sensing performance was enhanced by modifying the screen-printed electrodes. The proposed sensing platform allows for simultaneous pre-processing and detection and has a detection limit of 0.19 μg-L⁻¹ (S/N = 3) for Cd²⁺.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112321"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-assemblies of porphyrin tubular cage/polylysine based 1D nanoribbons with controllable handedness for enantioselective detection of theanine and mechanism revealing","authors":"Yuying Jiang,&nbsp;Jingxiu Bi,&nbsp;Rui Gao,&nbsp;Pingxiang Liu,&nbsp;Chao Zhang,&nbsp;Tong Zhao,&nbsp;Xuexia Yuan,&nbsp;Yutao Wang","doi":"10.1016/j.microc.2024.112365","DOIUrl":"10.1016/j.microc.2024.112365","url":null,"abstract":"<div><div>1D nanoribbons with supramolecular controllable handedness are constructed by the co-assemblies of porphyrin tubular cage (PTC) with polylysine (PL) upon multiple intermolecular forces at the air/water interface. Depending on the outstanding stimuli-responsive performance of aggregating hierarchical nanoribbons, the enantiomers of theanine are clearly discriminated through the relative fluorescence intensity of co-assembling system. It is revealed that the enantioselective mechanism originate from the quite disparate intermolecular interactions between co-assemblies and theanine isomers induced selective adsorption by means of experimental characterization combined with molecular simulations. This study not only helps to further understand the multiple interaction within co-assembling system, but also provides a novel strategy for enantioselective sensing platform with controllable handedness.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112365"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal-organic frameworks: Biosensor applications for diagnosis of cancers","authors":"Mojtaba Hosseine ,&nbsp;Seyed Morteza Naghib ,&nbsp;Navid Rabiee","doi":"10.1016/j.microc.2024.112341","DOIUrl":"10.1016/j.microc.2024.112341","url":null,"abstract":"<div><div>For early cancer diagnosis and therapy, development of sensitive and selective methods for cancer biomarker detection is crucial. One of the most powerful technologies for cancer early detection in development is biosensor technology based on nanostructures. Recently, researchers are becoming more interested in porous materials, especially metal–organic frameworks (MOFs). This is because of their unique physicochemical properties, high surface area, tunable pore scales, and good adsorption abilities, which makes them an innovative class of porous materials. Consequently, MOFs have been proposed for various applications as biosensors as well as biomedical applications, such as tissue engineering, drug delivery, and imaging agents. Because of their high porosity, analytes can be adsorbed effectively, which makes them suitable for sensing applications. MOF can be fabricated by three main methods, i.e., solid, liquid, and gas phase approaches. The unique aspect of this review is the thorough explanation of three different methods used to fabricate MOFs, as well as the further used techniques/methods. Additionally, this review article provides an in-depth discussion of the different cancer biosensor applications, including lung, breast, and prostate. Ultimately, the article explores potential future directions, highlighting promising avenues for further research involving MOFs. It emphasizes the importance of developing cost-effective, fast production methods and leveraging cutting-edge technology. This comprehensive review is a valuable tool that can aid in the development of future research projects using comparable nanomaterials.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112341"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced biosensing technologies for cardiac troponin I Detection: Challenges and future directions in personalized heart health management","authors":"Akanksha Shrivastav ,&nbsp;Garima Singh ,&nbsp;Annu Mishra ,&nbsp;Pankaj Kumar ,&nbsp;Ajeet Kaushik ,&nbsp;Ashish Mathur","doi":"10.1016/j.microc.2024.112462","DOIUrl":"10.1016/j.microc.2024.112462","url":null,"abstract":"<div><div>Acute myocardial infarction (AMI) is the leading cause of death worldwide. Cardiac troponin I (cTnI) an imperative biomarker for AMI, plays a vital role in the early diagnosis. Conventional cTnI detection techniques are well established and support diagnostics in relation to heart diseases; however, their time-consuming operations leads to delayed decision-making. Thus, there is a need to innovate novel sensing approaches that provide timely diagnosis, and even point-of-care (PoC) capabilities. In the past few years, wearable biosensors have emerged as better alternatives than conventional methods, showing enhanced sensitivity, selectivity, and the ability to detect PoC biomarkers toward managing personalized heart health. These biosensors have properties that include ease of use, a high sensitivity response time, compatibility with established cTnI detection methods, and PoC applications that position them nicely for integration into optical and electrochemical platforms. This review further explores challenges and prospects envisioned in biosensing technology for cTnI detection from advanced technological features and integration into healthcare systems. With real-time data derived from these biosensors, healthcare providers can improve the accuracy of diagnosis, and further, they can encourage proactive interventions that greatly improve outcomes for patients with AMI. It explains the potential that lies in biosensors toward rapid, accurate, and cost-effective detection, revolutionizing the management and diagnosis of AMI.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112462"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review: Strategies for enhancing the performance of SnO2-based formaldehyde gas sensors","authors":"Chun-sen He,&nbsp;Jia-cheng Ye,&nbsp;Hao-hao Zhang,&nbsp;Xiaoran Gong,&nbsp;Xue Li","doi":"10.1016/j.microc.2024.112591","DOIUrl":"10.1016/j.microc.2024.112591","url":null,"abstract":"<div><div>Formaldehyde (HCHO) is a harmful volatile organic compound (VOC) that presents significant environmental and health risks even at low concentrations, thus it needs to be accurately and efficiently detected. The development of high-performance HCHO sensors featuring higher sensitivity, selectivity, and rapid response is crucial for applications in environmental monitoring and public health protection. SnO₂-based gas sensors have drawn considerable attention due to their low cost, high sensitivity, and good stability. Nevertheless, challenges such as enhancing sensitivity, lowering operating temperatures, and ensuring long-term stability persist. In this article, the sensing mechanism of SnO₂ is initially introduced. Subsequently, the strategies for enhancing the gas sensitivity of SnO₂ HCHO sensors are reviewed, including morphological engineering, metal doping, forming heterojunctions with metal oxides, and composites with carbon-based materials or new materials. Finally, the challenges and future research directions are prospected.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112591"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acrylic molecularly imprinted polymer-based electrochemical sensor for precise nanomolar quantification of daclatasvir dihydrochloride in Daclavirdin®, Serum, and Urine","authors":"Abanoub Naseef ,&nbsp;Fatehy M. Abdel-Haleem ,&nbsp;Magdy Kandil Zahran ,&nbsp;Ahmed Barhoum","doi":"10.1016/j.microc.2024.112389","DOIUrl":"10.1016/j.microc.2024.112389","url":null,"abstract":"<div><div>Monitoring the concentration of daclatasvir dihydrochloride (DCT), an anti-HCV drug, in pharmaceutical formulations and biological fluids is essential for patients undergoing liver treatment. This study details the fabrication of a highly sensitive potentiometric sensor based on a carbon paste electrode (CPE) modified with molecularly imprinted polymers (MIPs) for DCT quantification. The MIPs were synthesized using acrylic acid or acrylamide as monomers, cross-linked with ethylene glycol dimethacrylate as the crosslinker, creating selective recognition sites for DCT. The optimal sensor (Sensor 6) is composed of 2.00 % graphite, 68.25 % tricresyl phosphate (TCP) as a plasticizer, and 0.50 % sodium tetraphenyl borate (Na-TPB) as an ion exchanger. The sensor demonstrated a slope of 30.32 ± 0.51 mV/decade, a broad dynamic ranges from 10^-8 to 10^-2 M, and a low detection limit of 6.9 nM and a low quantification limit of 21.0 nM. The sensor also demonstrated excellent sensitivity, precision, and reproducibility, with a correlation coefficient (R²) of 0.999 and a relative standard deviation (RSD) of 1.70 %, making it highly suitable for accurate DCT quantification. The proposed sensor displayed excellent selectivity towards DCT in the presence of various metal cations, as well as other compounds, including benzoate, alanine, glycine, glucose, lactose, starch, ascorbic acid, uric acid, egg albumin, and sofosbuvir. Furthermore, it was successfully applied to bulk solutions, pharmaceutical formulations, and human urine and plasma samples, achieving recovery values of 98.2 % to 102.1 %, confirming its accuracy and reliability.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112389"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triethylamine regulated MOFs-derived peroxidase-like nanozymes for colorimetric analysis of glyphosate with boosted catalytic activity","authors":"Xue Zou ,&nbsp;Qiumeng Chen ,&nbsp;Qian Liu ,&nbsp;Xiaoying Huang ,&nbsp;Yuanjun Tong ,&nbsp;Zhengjun Gong","doi":"10.1016/j.microc.2024.112314","DOIUrl":"10.1016/j.microc.2024.112314","url":null,"abstract":"<div><div>Developing accurate and rapid methods for analyzing organophosphorus pesticides is essential to ensure water quality and food safety due to their significant chemical and biological toxicity. This study presents a novel colorimetric sensor for glyphosate based on inhibiting Fe/ZnO nanozyme activity. By doping with iron and modulating the growth process of Fe/Zn MOFs precursors with triethylamine (TEA), Fe/ZnO nanozymes with substantial active surfaces and abundant Fe active sites were derived. The Fe/ZnO possessed excellent peroxidase-like activities, measuring 15.3 and 7.5 times higher than those of the materials synthesized without iron doping (ZnO) and the use of TEA (Fe/ZnO-w), respectively. Glyphosate inhibited the enzyme-like activity of Fe/ZnO by adsorbing on its surface through electrostatic interaction and occupying its catalytic active site. Based on this mechanism, a colorimetric sensing assay was created to directly and selectively detect glyphosate. The linear range for glyphosate detection was 0.02 to 10 mg L⁻¹, with a detection limit (3σ) of 15.6 μg L⁻¹. The proposed method has been successfully applied to the analysis of real samples. Metal oxides derived from well-designed MOFs provide a simple and effective strategy for creating high-performing pesticide detection platforms.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112314"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handling non-linearities and pre-processing in multivariate calibration of vibrational spectra","authors":"Alejandro C. Olivieri","doi":"10.1016/j.microc.2024.112323","DOIUrl":"10.1016/j.microc.2024.112323","url":null,"abstract":"<div><h3>Background</h3><div>several automatic pre-processing methods are available for coping with scattering effects in vibrational spectra (near and mid infrared, Raman) when linear multivariate models are applied for calibration. In contrast, almost no methods have been developed for data sets showing a non-linear relationship between instrumental signals and analyte concentrations or target properties.</div></div><div><h3>Results</h3><div>several data sets are studied, both simulated and experimental, showing different degrees of non-linearity: very low, intermediate, and high. For each of them, three multivariate models have been applied: classical partial least-squares (PLS), sequential pre-processing through orthogonalization (SO-PLS) and Kernel partial least-squares (K-PLS). The success of these models depends on the degree of non-linearity presented by each data set. The results are discussed in terms of the model structures.</div></div><div><h3>Significance</h3><div>the need of developing new automatic pre-processing techniques for non-linear vibrational data sets is highlighted, in order to reach a similar status as the linear counterparts.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112323"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the internal alteration mechanism of marble jade artifacts from Sanxingdui ritual Pit no. 3, Sichuan","authors":"Haoze Wu ,&nbsp;Jiancheng Liu ,&nbsp;Hui Fang ,&nbsp;Yunpeng Wang ,&nbsp;Qinglin Ma","doi":"10.1016/j.microc.2024.112338","DOIUrl":"10.1016/j.microc.2024.112338","url":null,"abstract":"<div><div>The Sanxingdui site holds significant archaeological value within the upper reaches of the Yangtze River in China, representing a key center of civilization. Jade was emblematic of status and rank in this society, playing an essential role in significant rituals and funerary practices. Over an extended burial period, most jade artifacts have undergone varying degrees of alteration. This study analyzed marble jade artifacts excavated from the Sanxingdui site with an ultra-deep field microscope, SEM-EDS, a Raman spectrometer, and XRD to investigate changes in chemical composition and physical phases. The study confirms the presence of a distinct layered structure characteristic of internal hollow alteration. Furthermore, it establishes that the presence of bronze and ivory alteration products notably influenced the alteration process. These interactions resulted in the generation of libethenite [Cu₂(PO₄)(OH)] within the hollow regions of the jade artifacts. Since the exothermic reactions during generation occur in a buried environment, this can increase the temperature of the surrounding aqueous environment and the formation of a hydrothermal environment. Within this environment, the libethenite undergoes further reactions, leading to the generation of cornetite [Cu₃(PO₄)(OH)₃] and pseudomalachite [Cu₅(PO₄)₂(OH)₄]. In the interim, the hydrothermal conditions facilitated a gradual dissolution of libethenite in groundwater, allowing it to infiltrate the interior of the jade. Subsequent crystallization, triggered by a decrease in temperature, induced stress damage to the internal structure of the jade. This process alters the internal hollowing, destroying the crystal structure of the jade and eventually causing a complete loss of its mechanical properties, transforming the jade into an internal powder. The results of this study indicate that the alteration products from bronze and ivory significantly impact jade. Therefore, this factor should be carefully considered in the conservation and preservation of jade, with appropriate measures taken accordingly.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112338"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CRISPR/Cas system-mediated function of Hg2+ on urease activity for colorimetric detection of the tumor biomarker in clinical samples","authors":"Xin Jin ,&nbsp;Jiankang Zhu ,&nbsp;Yun Zhang ,&nbsp;Shuaichen Jin ,&nbsp;Xinxin Zhao ,&nbsp;Qian Xu ,&nbsp;Dexu Zhang ,&nbsp;Linchuan Li ,&nbsp;Qiongzheng Hu ,&nbsp;Guangyong Zhang","doi":"10.1016/j.microc.2024.112317","DOIUrl":"10.1016/j.microc.2024.112317","url":null,"abstract":"<div><div>Detecting tumor biomarkers in blood samples is essential in cancer diagnosis and prognosis. This study proposes a CRISPR/Cas system-mediated colorimetric assay to detect the tumor biomarker in human serum samples. It involves using the tumor biomarker as a switch of the CRISPR/Cas system to modulate the function of Hg²⁺, which is a typical urease inhibitor. The detection of carcinoembryonic antigen (CEA) is demonstrated as an example. The CEA aptamer is used to activate the CRISPR/Cas system, allowing for the cleavage of a single-stranded DNA (ssDNA) rich in thymine (T) nucleotides, thereby causing the inhibition of the urease activity by Hg²⁺. However, in the presence of CEA, the CRISPR/Cas system cannot be activated due to the specific binding of CEA to its aptamer, which leads to the capture of Hg²⁺ owing to the formation of a DNA hairpin structure with T-Hg²⁺-T coordination bonds. Thus, the urease activity is remained. Since the enzymatic hydrolysis of urea by urease increases the pH of the urea solution containing phenol red and changes the solution from yellow to pink, CEA can be detected with the assistance of the colorimetric assay. This method shows high sensitivity and selectivity for CEA with a detection limit of 0.028 ng/mL. In addition, serum samples from patients with normal and abnormal levels are tested to verify the validity of the proposed method for practical applications. Overall, this study provides a simple, fast, and stable colorimetric assay to detect the tumor biomarker in human serum and has great potential for early cancer screening and prognostic determination.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112317"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}