Süleyman Bodur , Sezin Erarpat Bodur , Selim Gürsoy , Merve Fırat Ayyıldız , Bedrihan Kartoğlu , Hilal Akbıyık , Ömer Tahir Günkara , Sezgin Bakırdere
{"title":"Dispersive solid phase extraction and quadruple isotope dilution–mass spectrometry combination for the accurate and sensitive quantification of capsaicin in pepper, domestic wastewater and human saliva samples by GC–MS system","authors":"Süleyman Bodur , Sezin Erarpat Bodur , Selim Gürsoy , Merve Fırat Ayyıldız , Bedrihan Kartoğlu , Hilal Akbıyık , Ömer Tahir Günkara , Sezgin Bakırdere","doi":"10.1016/j.microc.2024.112246","DOIUrl":"10.1016/j.microc.2024.112246","url":null,"abstract":"<div><div>In the presented study, reduced graphene oxide/Fe<sub>3</sub>O<sub>4</sub> (rGO/Fe<sub>3</sub>O<sub>4</sub>) nanocomposites based dispersive solid phase extraction (DSPE) – gas chromatography–mass spectrometry (GC–MS) method was developed for the determination of capsaicin in domestic wastewater (DW), pepper (PP) and human saliva (HS) samples. All important parameters of the DSPE method affected the preconcentration factor were carefully optimized to achieve high signal to noise ratio for the analyte. After the optimization studies, the system analytical performance of DSPE-GC–MS system was evaluated using the aqueous standard solution of capsaicin. Limit of detection (LOD), limit of quantitation (LOQ) and dynamic range were figured out to be 0.54 µg/kg, 1.80 µg/kg and 2.66 – 487.35 µg/kg, respectively. Under the optimum experimental conditions, recovery studies were conducted with the spiked DW, PP and HS samples, and percent recovery results were recorded between 52.6 % and 183.6 % via matrix matching calibration strategy. After the implementation of ID<sup>4</sup> strategy, percent recovery results for the spiked DW, PP and HS samples were calculated as 98.2 %–99.3 %, 99.7 %–100.7 % and 99.4 %–99.8 %, respectively. In addition, capsaicin content in Sivri (S)-PP, Kıl (K)-PP and Samandağ (SA)-PP samples were found to be 309.5 ± 11.8 mg/kg, 873.7 ± 26.7 mg/kg and 165.3 ± 5.1 mg/kg via DSPE-GC-ID<sup>4</sup>-MS method, respectively. As a result, the combination of quadruple isotope dilution (ID<sup>4</sup>) strategy and the DSPE-GC–MS method were successfully performed to boost the accuracy and precision of developed DSPE-GC–MS method.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112246"},"PeriodicalIF":4.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tingting Liu , Mizero Gloria , Xiaofeng Hou , Siyu Shen , Wondimu Andualem Ayele , Hongbing Qin , Qinqin Ma , Hailong Gong , Xuedong Wang
{"title":"Recent advances regarding development of effervescence reaction-assisted microextraction techniques for determination of organic pollutants in complex media","authors":"Tingting Liu , Mizero Gloria , Xiaofeng Hou , Siyu Shen , Wondimu Andualem Ayele , Hongbing Qin , Qinqin Ma , Hailong Gong , Xuedong Wang","doi":"10.1016/j.microc.2024.112249","DOIUrl":"10.1016/j.microc.2024.112249","url":null,"abstract":"<div><div>The effervescence reaction-assisted microextraction (EAM) technology can enhance the efficiency of dispersion technology. The in-situ generation of CO<sub>2</sub> resulting from the reaction between a CO<sub>2</sub> donor and a proton donor forms the basis for the EAM process, effectively dispersing the extractant phase into the sample through the gas produced. After being developed in 2011, EAM technology quickly gained much popularity. Numerous studies have employed it to improve pretreatment procedures. Due to its practical application, low operational cost, reduced solvent usage, excellent extraction efficiency, and environmental friendliness, the EAM technique has garnered significant attention. This article provides a comprehensive overview of the fundamental principles, influencing factors, and methodologies involved in the development of EAM technology in conjunction with large-scale instruments. It specifically focuses on the construction of diverse extractant-based methods for detecting organic pollutants in complex matrices such as environmental samples, food products, and biological specimens. The advantages and disadvantages of these methods are discussed in relation to their practical applications. Furthermore, this review elucidates the effective utilization of this approach for enriching and detecting pollutants within intricate matrices. By conducting a systematic analysis of recent advancements and research cases, this review serves as a valuable reference for advancing environmentally friendly, rapid, and convenient sample pretreatment techniques.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112249"},"PeriodicalIF":4.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deciphering versatile electrode materials in the electrochemical progressive processes for flutamide detection: A systematic review","authors":"Chellapandi Bhuvaneswari , Karuppaiya Palpandi , Boopathi Shagunthala Hariprasad , Chettipalayam Arunasalam Dhayanithi , Natarajan Raman , Periakaruppan Prakash , Sundaram Ganesh Babu","doi":"10.1016/j.microc.2024.112244","DOIUrl":"10.1016/j.microc.2024.112244","url":null,"abstract":"<div><div>Excess of flutamide causes diseases, therefore excess of anything is undesirable. In order to safeguard human health and the environment, the scientific community battled to monitor hazardous and deadly substances, bacteria, gases, and radiation. So, we focus on the detection of Flutamide (FLT), a non-steroidal anti-androgen drug that is widely used in the treatment of prostatic carcinoma are rapidly attracted interest in the field of medical sciences because it is cherished in monitoring health and environmental conditions and their absurd negative effects when used in excess. This review article focuses on the important advancement in developing mixed and clinical nano samples-based on electrochemical sensors for simultaneous electrochemical sensing of FLT. The fabrication of different electrodes such as Diamond Electrode, Screen Printed Carbon Electrodes (SPCE), Glassy Carbon Electrode (GCE), Gold Electrode (AuE), Carbon Paste Electrode (CPE), and Graphite Pencil Lead Electrode used to detect FLT are highlighted. Furthermore, the challenges of translating different kinds of electrodes with supported nanomaterials-based sensors from the laboratory to the market are considered in future perspectives. This review discusses the selective reports on the different kinds of electrodes to discuss the application of FLT sensors during the period from 2012 to 2024. This review will be a useful tool for researchers, providing new perspectives and ideas for exciting new directions to explore.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112244"},"PeriodicalIF":4.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milena do Prado Ferreira , Felipe Augusto Gorla , Mariana Gava Segatelli , Sueli Fumie Yamada Ogatta , Eduardo Costa Figueiredo , César Ricardo Teixeira Tarley
{"title":"Development of method for SARS-CoV-2 spike protein determination in saliva samples at fg mL−1 levels using electrochemically controlled preconcentration and molecularly imprinted polypyrrole sensor","authors":"Milena do Prado Ferreira , Felipe Augusto Gorla , Mariana Gava Segatelli , Sueli Fumie Yamada Ogatta , Eduardo Costa Figueiredo , César Ricardo Teixeira Tarley","doi":"10.1016/j.microc.2024.112236","DOIUrl":"10.1016/j.microc.2024.112236","url":null,"abstract":"<div><div>The present study describes a novel approach for designing a highly sensitive and selective electrochemical sensor for the detection of SARS-CoV-2 in saliva samples by sensing the S-protein, using an electrochemically controlled preconcentration. The sensor is based on electropolymerized molecularly imprinted polypyrrole (PPy) onto a screen-printed carbon electrode (MIP/PPy). The morphology of the MIP/PPy sensor was evaluated by SEM and AFM. The selectivity of the MIP/PPy compared to NIP/PPy was assessed by rebinding S-protein, followed by the monitoring of the redox probe ([Fe(CN)<sub>6</sub>]<sup>3−/4−</sup>). A substantial decrease in the anodic peak current of the redox probe was noticed when using the MIP/PPy. The detectability of the sensor was greatly improved (c.a 1,000,000 fold) by using controlled electrochemical preconcentration of S-protein at +0.6 V for 1.0 min in the rebinding process. Under this condition, a low limit of detection of 6.8fg mL<sup>−1</sup> and an analytical curve in the range of 50.0–125.0 fg mL<sup>−1</sup> (R<sup>2</sup> = 0.996) was obtained. The reproducibility for 10 authentic sensors was highly satisfactory with a relative standard deviation (%,RSD) of 2.8 %. Upon preparation, the sensor can be stored for up to 14 days under refrigeration, with a response efficiency greater than 85 %. The MIP/PPy exhibited high selectivity toward S-protein compared to antitrypsin, human serum albumin (HAS), transferrin, HIgG, and lysozyme. The sensor was applied for detecting SARS-CoV-2 virus through S-protein in infected patients’ saliva samples and validated by RT-PCR. In addition, the satisfactory recovery (91 to 103 %) in S-protein spiked negative samples attested to the free-interference analysis.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112236"},"PeriodicalIF":4.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alisson Geraldo Alves Ferreira, William Xavier Paula Lima, Rafael Cardoso Rial
{"title":"Nuclear magnetic resonance (NMR) applications in biodiesel characterization and quality – A review","authors":"Alisson Geraldo Alves Ferreira, William Xavier Paula Lima, Rafael Cardoso Rial","doi":"10.1016/j.microc.2024.112226","DOIUrl":"10.1016/j.microc.2024.112226","url":null,"abstract":"<div><div>This manuscript highlights the role of nuclear magnetic resonance (NMR) in assessing the quality and purity of biodiesel. NMR has proven to be an indispensable tool for biodiesel characterization, allowing for precise identification of key physicochemical properties such as methyl ester content, oxidative stability, free fatty acids, and glycerin residues. The ability of 1H NMR to detect impurities, adulterants, and structural changes during production and storage ensures compliance with international standards like ASTM D6751 and EN 14214, which are essential for maintaining biodiesel quality and performance. The study comprehensively compares the application of NMR in analyzing biodiesel from various feedstocks, including vegetable oils, animal fats, and waste oils. NMR’s capacity to discriminate biodiesel sources through specific chemical shifts, such as the methoxy group at 3.6 ppm, and identify contaminants, like water and residual catalysts, highlights its superiority over other analytical techniques like gas chromatography (GC) and Fourier-transform infrared spectroscopy (FTIR). Additionally, the manuscript underscores the importance of NMR in optimizing production processes by evaluating conversion efficiency and identifying by-products. The key contributions of this study lie in its detailed comparison of biodiesel from different feedstocks and its focus on the role of impurities and additives in affecting biodiesel quality. This work confirms NMR’s effectiveness as a reliable, non-destructive tool for ensuring biodiesel purity, making it an essential technique in advancing biodiesel production, improving process efficiency, and promoting the use of sustainable biofuels.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112226"},"PeriodicalIF":4.9,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noorfatimah Yahaya , Nur Nadhirah Mohamad Zain , Ahmad Husaini Mohamed , Grasianto , Sazlinda Kamaruzaman , Mazidatulakmam Miskam , Rajeev Jain , Muggundha Raoov , Wan Nazwanie Wan Abdullah
{"title":"Nanosorbents in solid-phase extraction techniques for bioanalysis: A review","authors":"Noorfatimah Yahaya , Nur Nadhirah Mohamad Zain , Ahmad Husaini Mohamed , Grasianto , Sazlinda Kamaruzaman , Mazidatulakmam Miskam , Rajeev Jain , Muggundha Raoov , Wan Nazwanie Wan Abdullah","doi":"10.1016/j.microc.2024.112170","DOIUrl":"10.1016/j.microc.2024.112170","url":null,"abstract":"<div><div>In this article, we provide an in-depth review of the application of nanosorbents for bioanalytical sample preparation. Based on the reported literature, researchers are increasingly interested in using nanomaterials to enhance conventional sorptive extraction methods and develop innovative techniques in bioanalysis. The properties, advantages, and disadvantages of various classes of nanosorbents used in bioanalytical sample preparation were discussed in this study. Detailed mechanisms of separation, green metrics evaluation, and the challenges and potential of nanosorbents in solid-phase extraction techniques are also elaborated. It is hoped that this review will assist researchers in the development of ideal techniques for selective, fast, green, simple, sensitive, and accurate analytical methodologies for bioanalysis.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112170"},"PeriodicalIF":4.9,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hany Abd El-Raheem , Rabiaa Helim , Rabeay Y.A. Hassan , Ahmed F.A. Youssef , H. Korri-Youssoufi , Charoenkwan Kraiya
{"title":"Electrochemical methods for the detection of heavy metal ions: From sensors to biosensors","authors":"Hany Abd El-Raheem , Rabiaa Helim , Rabeay Y.A. Hassan , Ahmed F.A. Youssef , H. Korri-Youssoufi , Charoenkwan Kraiya","doi":"10.1016/j.microc.2024.112086","DOIUrl":"10.1016/j.microc.2024.112086","url":null,"abstract":"<div><div>Naturally occurring heavy metals (HMs) present a serious risk to human health and the environment because of their toxicity, persistence, and tendency to bioaccumulate. Their presence in air, water, soil, and food can lead to a multitude of adverse effects, from acute poisoning to chronic health problems. The rapid expansion of industrialization and technology has increased HMs contamination from industrial emissions, mining, agriculture, urbanization, and e-waste, posing serious risks to ecosystems and public health. To tackle this increasing challenge, it is essential to develop highly robust, sensitive, and selective electrochemical detection methods for the rapid identification of heavy metal ions (HMIs) contaminants. This review investigates a variety of electrochemical sensors and biosensors utilizing voltammetric techniques for HMIs detection. It covers voltammetric methods such as cyclic voltammetry (CV), square wave voltammetry (SWV), differential-pulse voltammetry (DPV), normal pulse voltammetry (NPV), staircase voltammetry (SV), linear sweep voltammetry (LSV), hydrodynamic voltammetry (HV), anodic stripping voltammetry (ASV), cathodic stripping voltammetry (CSV), and adsorptive stripping voltammetry (AdSV). The review also emphasizes recent advancements in the electrochemical detection of HMIs through various sensor and biosensor platforms, including different nanomaterials and DNA aptamers. These innovations have potential applications in environmental monitoring, food and water safety, industrial waste management, and public health protection, making them vital tools for safeguarding human health and the environment from HMIs contamination.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112086"},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent advances in zearalenone clean-up approaches from polluted food and feed: A mini-review of the State-of-the-art developments","authors":"M.A. Diab , Heba A. El-Sabban , Kwang-Hyun Baek","doi":"10.1016/j.microc.2024.112182","DOIUrl":"10.1016/j.microc.2024.112182","url":null,"abstract":"<div><div>Zearalenone (ZEN), a mycotoxin generated by fusarium species, is often found in food and feed and can be extremely harmful to human and animal health. Warranting food safety requires effective extraction of ZEN from contaminated matrices. This mini-review concisely summarizes the most recent ZEN extraction techniques from contaminated food and feed. It highlights firstly various extraction techniques, including liquid–liquid extraction (LLE), solid phase extraction using molecularly imprinted polymers (SPE-MIPs), [Quick, Easy, Cheap, Effective, Rugged, and Safe method (QUEChERS)], green extraction methods such as ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE) to improve extraction approaches. Secondly, it discusses recent advanced methods of ZEN detection. This review also discusses the challenges associated with ZEN extraction such as matrix effects, co-contaminants, and the need for standardization method. It emphasizes the importance of continued research to refine existing techniques and develop novel strategies that ensure high efficiency, specificity, and environmental sustainability.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112182"},"PeriodicalIF":4.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahdi Ghorbani , Ava Saghafi , Nahid Afshar Lahoori , Sara Sarabyar , Parisa Mohammadi , Mojgan Ojaghzadeh Khalil Abad
{"title":"Comprehensive review of sample preparation strategies for phthalate ester analysis in various real samples","authors":"Mahdi Ghorbani , Ava Saghafi , Nahid Afshar Lahoori , Sara Sarabyar , Parisa Mohammadi , Mojgan Ojaghzadeh Khalil Abad","doi":"10.1016/j.microc.2024.112072","DOIUrl":"10.1016/j.microc.2024.112072","url":null,"abstract":"<div><div>Phthalate esters (PAEs), ubiquitous plasticizers in diverse consumer products, pose significant environmental and human health risks due to their persistence and endocrine-disrupting properties. Accurately determining PAEs in various environmental matrices is crucial for evaluating exposure levels, assessing risks, and implementing effective mitigation strategies. This review comprehensively examines sample preparation techniques for PAE analysis, focusing on methodologies. We categorize these techniques into traditional methods (solid phase extraction, liquid–liquid extraction, QuEChERS), advanced techniques (liquid phase microextraction, solid phase microextraction, and their modifications), and hybrid approaches combining multiple techniques. The strengths, limitations, and recent advancements of each method are thoroughly discussed. This compilation not only summarizes current knowledge but also highlights emerging trends and research gaps, providing valuable insights for future investigations. By fostering scientific progress and innovation in PAE analysis, we aim to support the development of robust analytical methods that contribute to environmental monitoring and risk assessment, ultimately safeguarding human health and the environment.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112072"},"PeriodicalIF":4.9,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Supramolecular luminescent sensors for explosive detection: Current trends and future directions","authors":"Abhirami R.B. , Mahesh Vasava , Manaswini Karsharma , Riya Khandelwal , Prasenjit Maity","doi":"10.1016/j.microc.2024.112063","DOIUrl":"10.1016/j.microc.2024.112063","url":null,"abstract":"<div><div>The imperative of global security amidst persistent threats of terrorism, organized crimes, and accidental events underscores the critical role of explosive detection in safeguarding public safety. While effective, traditional detection methods are often time- and resource-intensive and may not always be suitable for on-site applications in specific scenarios. Consequently, there has been a concerted research effort to develop fluorescent materials with diverse sensing mechanisms to achieve heightened sensitivity, selectivity, and rapid response times in explosive detection. This review explores the exploration of supramolecular systems, including cucurbit[n]uril, pillar [n]arenes, cyclodextrin, calixarenes, electron-rich supramolecules, and related complexes, designed to enhance the efficiency of explosive detection. Recent advancements and emerging technologies in this field are discussed in the review, intending to stimulate further inquiry and innovation in synthesizing and applying supramolecular complexes for explosive detection, addressing the urgent demand for heightened security measures.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 112063"},"PeriodicalIF":4.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}