Microchemical Journal最新文献

{"title":"Detection of liver cancer serum markers and molecular analysis of metabolites based on electrochemical sensors: Combined targeted immunotherapy","authors":"Yanhui Hu,&nbsp;Qingli Cui,&nbsp;Xu Sun,&nbsp;Dongyang Ma","doi":"10.1016/j.microc.2026.117194","DOIUrl":"10.1016/j.microc.2026.117194","url":null,"abstract":"<div><div>This study aims to compare the clinical efficacy and safety of TACE-HAIC combined with targeted and immunotherapy (quadruple therapy) and TACE combined with targeted and immunotherapy (triple regimen) in advanced hepatocellular carcinoma (HCC). Although progress has been made in the current systemic and local combined treatment strategies for HCC, the dynamic and precise assessment of therapeutic efficacy still highly relies on traditional imaging and intermittent serum marker detection, which has limitations such as delayed response, high cost, and difficulty in achieving high-frequency monitoring. Electrochemical sensor technology, with its advantages of high sensitivity, rapid response, miniaturization and low cost, has shown great potential in the field of medical testing. It is particularly suitable for the ultra-sensitive, real-time and bedside dynamic monitoring of key markers of HCC such as AFP and PIVKA-II, and is expected to provide more precise efficacy feedback and early warning for complex combination therapy. This study adopted a retrospective cohort design, including 102 patients with advanced HCC who received quadruple or triple therapy. The objective response rate (ORR) was evaluated by the mRECIST criteria, and progression-free survival (PFS), overall survival (OS), and adverse reactions were recorded. The results showed that the ORR (52.1% vs. 31.5%), mPFS (10.8 vs. 7.2 months), and mOS (23.5 vs. 18.1 months) in the quadruple group were significantly better than those in the triple group, and the conversion resection rate was higher (25.0% vs. 7.4%). Although the incidence of postoperative pain and nausea and vomiting is slightly higher, the overall safety is controllable. It is worth emphasizing that the results of this study highlight the urgent need for high-frequency and high-sensitivity biomarker monitoring systems, and electrochemical sensor technology can precisely provide an ideal solution for such high-intensity combined treatments. By achieving real-time dynamic tracking of molecules related to tumor burden and drug toxicity, this technology is expected to further optimize the effective regimens verified in this study.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117194"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146147315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of polysaccharides from oenological byproducts by a novel multiple reaction monitoring mass spectrometry method","authors":"Montserrat Dueñas,&nbsp;Diana M. Bosch-Crespo,&nbsp;Natalia Rojo-Nieto,&nbsp;Iván Puerta-García,&nbsp;Elvira Manjón,&nbsp;María Teresa Escribano-Bailón,&nbsp;Ignacio García-Estévez","doi":"10.1016/j.microc.2026.117309","DOIUrl":"10.1016/j.microc.2026.117309","url":null,"abstract":"<div><div>A robust analytical method based on derivatization with 1-phenyl-3-methyl-5-pyrazolone (PMP) and subsequent analysis by HPLC-MS/MS-multiple reaction monitoring (MRM) has been developed and validated for the quantification of monosaccharides in different oenological byproducts (commercial mannoproteins, wine lees and grape pomace extracts). This methodology overcomes most of the limitations associated with the conventional techniques most commonly used in oenology. Method validation demonstrated good precision and accuracy, with low limits of detection (LOD) and quantification (LOQ). Mannose and glucose were identified as the main monosaccharides in commercial mannoprotein extracts and wine lees extracts (53–97%), while galacturonic acid, arabinose, and galactose (∼34% each) dominated in white grape pomace polysaccharide extract, indicating the presence of homogalacturonans (HG) and polysaccharides rich in arabinose and galactose (PRAGs). These results highlight the important structural and compositional variability among oenological extracts, whether commercially available or obtained in the laboratory, reinforcing the need for a robust methodology to determine their composition. Hence, the validated method presented here can be a valuable tool to enhance the understanding of such extracts by providing key chemical information that is crucial for assessing their applicability and technological properties.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117309"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional porous ZnCo-LDH/ZnCo-NH hybrid structure for electro-enhanced thin film microextraction of some acidic red dyes from various cosmetic and food samples","authors":"Maedeh Saadat,&nbsp;Yadollah Yamini","doi":"10.1016/j.microc.2026.117371","DOIUrl":"10.1016/j.microc.2026.117371","url":null,"abstract":"<div><div>A three-dimensional porous nanoheterostructures of ZnCo-LDH/ZnCo-NH were synthesized on a nickel foam substrate. These structures were employed as efficient adsorbents for electro-enhanced thin film microextraction of red dyes from various cosmetic and food samples. The method, followed by high-performance liquid chromatography coupled with a UV detector. The prepared LDH was characterized using various techniques. In addition, effective parameters such as elution solvent (ethanol +0.075% NaNO₃), desorption time (5 min), adsorption time (20 min), sorbent length (2 cm), desorption volume (600 μL), breakthrough volume (10 mL), pH (9), salt addition (0%), adsorption potential (1 V), and desorption potential (1.5 V) were optimized. Under the optimum conditions, the method demonstrated a great linear dynamic range of 0.05–500 μg L⁻¹, with an acceptable limit of detection (LOD) of 0.02 μg L⁻¹. The intra-day and interday relative standard deviations (RSDs) were in the ranges of 2.4%–4.8% and 3.9%–6.1%, respectively. Additionally, R² values were measured to be 0.9948, 0.9970, 0.9901, 0.9976, and 0.9931 for Amaranth, Ponceau 4R, Allura Red, Carmosine, and Erythrosine, respectively. Finally, this method was employed for the extraction and preconcentration of red dyes from various cosmetic and food samples with suitable and satisfactory outcomes.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117371"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyanoethyl cellulose–based molecularly imprinted polymer for selective S-suprofen recognition","authors":"Munirah S.O. Alhar ,&nbsp;Odeh A.O. Alshammari ,&nbsp;Ahmed A. AlOtaibi ,&nbsp;Aljazi Abdullah AlRashidi ,&nbsp;Ahlam F. Alshammari ,&nbsp;Elham A. Alzahrani ,&nbsp;Nadia H. Elsayed ,&nbsp;Khadra B. Alomari ,&nbsp;M. Monier","doi":"10.1016/j.microc.2026.117153","DOIUrl":"10.1016/j.microc.2026.117153","url":null,"abstract":"<div><div>Suprofen (SF) is a chiral nonsteroidal anti-inflammatory drug whose therapeutic activity resides almost exclusively in the S-enantiomer, necessitating efficient enantioselective separation for safe clinical use. Here we report a novel molecularly imprinted polymer (MIP) based on cyanoethyl cellulose (CNCE) chemically modified with 1-amino-1H-pyrrole-2,5-dione (AMA). AMA introduces cationic hydrazidine groups for electrostatic and hydrogen-bonding interactions with anionic S-SF and simultaneously grafts maleimide moieties onto the polymer backbone. Follow-up thiol–maleimide click crosslinking with ethane-1,2-dithiol (ET) sequesters stereospecific recognition cavities to enhance structural fidelity and selectivity. The as-prepared S-SF-imprinted microparticles (S-SF-P) possess high surface area, well-defined porosity, and intense surface roughness, as confirmed by BET and SEM characterizations. Batch adsorption and column experiments showed high chiral selectivity, with S-SF adsorption capacity of 522 ± 3 mg g⁻¹, a selectivity coefficient of ∼13 over R-SF, and eluates reaching 96.9% enantiomeric excess, reflecting the strong performance of the post-imprinted material within its class. Kinetic and thermodynamic examination of the click crosslinking reveals a spontaneous, exothermic reaction that allows for stable network development. This stable, low-cost, renewable cellulose-based MIP with precise post-polymerization crosslinking and dual-functionalization is a platform for high-fidelity drug and other chiral target enantioseparation.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117153"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computation-guided design of a Laccase-COOH-SWCNT/SPCE electrochemical biosensor for selective tyramine detection","authors":"Nurul Hana Mas'od ,&nbsp;Mohammad Nazri Abdul Bahari ,&nbsp;Syaza Azhari ,&nbsp;Mohamad Arif Mohamad Jamali ,&nbsp;Nadrahtul Huda Misral ,&nbsp;Amir Syahir Amir Hamzah","doi":"10.1016/j.microc.2026.117343","DOIUrl":"10.1016/j.microc.2026.117343","url":null,"abstract":"<div><div>Tyramine (TYM) is a key spoilage biomarker in meat products, creating a need for rapid and selective on-site detection technologies. This study presents a computation-guided strategy integrating molecular docking, molecular dynamics (MD), and molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) free-energy analysis with experimental biosensor fabrication to rationalize and enhance TYM recognition by laccase (LAC). Docking and MD simulations revealed that TYM binds within a hydrophobic pocket near the T1 copper site, anchored by a hydrogen bond with Ala80 and stabilized by Phe344, Pro346, Leu112, and Leu459. The LAC–TYM complex remained structurally stable over 100 ns, and MM/PBSA yielded a favorable binding free energy (ΔG_bind ≈ −22.6 kcal/mol), predominantly driven by van der Waals interactions. Guided by these atomistic insights, a LAC–COOH-SWCNT/SPCE biosensor was constructed and characterized by field emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM), confirming uniform enzyme immobilization. Differential pulse voltammetry (DPV) exhibited a linear range of 2.58 × 10⁻⁵ to 1.92 × 10⁻⁴ M with a limit of detection (LOD) of 7.75 × 10⁻⁶ M, a limit of quantification (LOQ) of 2.58 × 10⁻⁶ M, a sensitivity of 0.0136 μA mM⁻¹ and exhibited a high correlation coefficient (R² = 0.984). The sensor demonstrated strong selectivity, minimal interference from structurally unrelated biogenic amines, and good recoveries (78.2–105.8%) in spiked chicken meat samples. This work establishes a unified computation-to-experiment framework for biosensor engineering and highlights the potential of atomistic modelling to guide enzyme–nanomaterial interface design for food safety applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117343"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-floating, self-water-supplying, recyclable cellulose SERS platform with Au@Ag nanocubes for food contaminant detection","authors":"Haoran Zhang ,&nbsp;Guoqiang Fang ,&nbsp;Siqingaowa Han ,&nbsp;Jingkun Yuan ,&nbsp;Bing Zhang ,&nbsp;Wenhao Li ,&nbsp;Jiheng Zhang ,&nbsp;Wuliji Hasi","doi":"10.1016/j.microc.2026.117378","DOIUrl":"10.1016/j.microc.2026.117378","url":null,"abstract":"<div><div>This study developed a self-floating, self-water-supplying cellulose-based surface-enhanced Raman scattering sensing platform with excellent recyclability (FWCSERS). The platform utilized gold-core@silver-shell nanocubes (Au@Ag NCs) as the active substrate, which were modified onto a hydrophilic cellulose filter membrane and fixed on a polystyrene foam float. By leveraging the capillary force of the cellulose membrane to spontaneously transport the test solution to the detection area, real-time analysis was achieved without external pumping. Using crystal violet as a model molecule, the platform's performance was validated, demonstrating a detection limit (LOD) as low as 10⁻⁹ M, good stability, and an analytical enhancement factor (AEF) of 2.22 × 10⁵. The platform also enabled quantitative detection of thiram and rhodamine B over a wide concentration range (10⁻⁹ M to 10⁻⁵ M). It exhibited excellent applicability in practical samples, including lake water, bean sprout extract, and chili powder solution. Furthermore, the substrate could be regenerated for reuse via immersion in pure water after detection. This work provides an efficient and low-cost on-site detection solution for monitoring food and environmental pollutants.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117378"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147386236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symmetric xylylene connected rotatable hydroxy acetophenone fluorescent probes for reversible Ag+ ions and sequential thiosulfate detection: Applications in real samples, Imaging, Fingerprinting, and Logic Operations","authors":"Kavanya Srinivasan ,&nbsp;Narmatha Ganesan ,&nbsp;Elizabeth Antony ,&nbsp;Prince Makarious Paul ,&nbsp;Abiram Angamuthu ,&nbsp;Jan Grzegorz Małecki ,&nbsp;Raju Nandhakumar","doi":"10.1016/j.microc.2026.117316","DOIUrl":"10.1016/j.microc.2026.117316","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Silver is a transition metal ion with unique physiochemical properties, making it more suitable for rapid detection in biological and environmental sectors. In forensic science, development of latent fingerprints using cost- effective silver-based compounds is minimal. However, there is still a lack of sensitive, rapid, and robust fluorescent probes that can detect trace level Ag&lt;sup&gt;+&lt;/sup&gt; ion present in complex matrices. To address the raising concern, the development of symmetric xylylene sensors offers rapid detection Ag&lt;sup&gt;+&lt;/sup&gt; ions in complex matrices such as food, cosmetics and soil. It also shows immaculate application in the field of forensic for the development of Latent fingerprint.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result&lt;/h3&gt;&lt;div&gt;Three symmetric dipodal fluorescent probes based on acetophenone scaffolds, &lt;strong&gt;OHP, MHP,&lt;/strong&gt; and &lt;strong&gt;PHP&lt;/strong&gt; were rationally designed, synthesized and characterized through &lt;sup&gt;1&lt;/sup&gt;H Nuclear Magnetic Resonance (NMR), &lt;sup&gt;13&lt;/sup&gt;C Nuclear Magnetic Resonance (NMR), Infrared (IR), and mass spectrometry. The probes were found to selectively and sensitively detect Ag&lt;sup&gt;+&lt;/sup&gt; and S₂O₃&lt;sup&gt;2−&lt;/sup&gt; ions in a MeOH–H₂O mixture (50 mM HEPES buffer, pH 7.4). Fluorescence experiments revealed that the detection process involves the restriction of rotation of benzylic moieties, inhibition of photoinduced electron transfer (PET), and hypsochromic shifts accompanied with fluorescence enhancement by internal charge transfer (ICT). Job plot analysis supported a 1:1 binding stoichiometry between probes and Ag&lt;sup&gt;+&lt;/sup&gt; ions. The detection limits (LOD) of &lt;strong&gt;OHP, MHP,&lt;/strong&gt; and &lt;strong&gt;PHP&lt;/strong&gt; were found to be 0.68 nM, 0.35 nM, and 0.42 nM, respectively, and their respective limits of quantification (LOQ) were found to be 22.68 nM, 11.79 nM, and 15.76 nM. In addition, density functional theory (DFT) calculations also justified the sensing behavior of these compounds towards Ag&lt;sup&gt;+&lt;/sup&gt; ions. The Ag&lt;sup&gt;+&lt;/sup&gt; ions sensing capability of the probes was effectively realized in multiple real-world matrices, such as water, food, cosmetic, and soil samples, and in latent fingerprint visualization and the fabrication of an INHIBIT molecular logic gate. The probes were also efficiently utilized for bioimaging in &lt;em&gt;E. coli&lt;/em&gt; to detect both Ag&lt;sup&gt;+&lt;/sup&gt; and S₂O₃&lt;sup&gt;2−&lt;/sup&gt; ions.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Significance&lt;/h3&gt;&lt;div&gt;This study presents versatile multifunctional xylylene-bridged symmetric probes (&lt;strong&gt;OHP&lt;/strong&gt;, &lt;strong&gt;MHP&lt;/strong&gt; and &lt;strong&gt;PHP&lt;/strong&gt;) for Ag&lt;sup&gt;+&lt;/sup&gt; ions which mainly focuses on environmental monitoring, forensic significance and biological analysis. The probes achieve nanomolar detection limits and practical applicability in real sample analysis, latent fingerprint visualization and bioimaging highlights their feasibility and efficiency, making them as potent tool for analytical and investigative applications involving trace","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117316"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular diagnosis of renal calculi biomarkers based on electrochemical sensors: Correlation analysis with the risk of obstructive sleep apnea","authors":"Bo Li ,&nbsp;Feng Li ,&nbsp;Xi Xie ,&nbsp;Ying Wang ,&nbsp;Shaoxing Li ,&nbsp;Xiaoyong Liu","doi":"10.1016/j.microc.2026.117352","DOIUrl":"10.1016/j.microc.2026.117352","url":null,"abstract":"<div><div>The intermittent hypoxia, oxidative stress and metabolic disorders caused by OSA may affect the homeostasis of the urinary system, but the clinical connection between them and the formation of kidney stones still requires large-scale population evidence to support. At the level of medical laboratory technology, electrochemical sensors, due to their advantages such as high sensitivity, rapid response, miniaturization and low cost, have become an important tool for detecting biomarkers related to kidney stones (such as calcium ions, oxalic acid, uric acid, citrate and inflammatory factors). They are suitable for bedside testing and dynamic risk monitoring, providing technical support at the molecular level for revealing the common metabolic and inflammatory pathways of OSA and kidney stones. This study adopted a cross-sectional design and included adult participants in the NHANES from 2007 to 2018 who had complete sleep questionnaires and history data of kidney stones. The study did not involve new experiments, and all analyses were completed based on public databases. The results showed that among a total of 34,652 participants, the prevalence of kidney stones in the high-risk OSA group was significantly higher than that in the low-risk group (9.8% vs. 6.2%, <em>P</em> &lt; 0.001). Therefore, there is an independent association between the high-risk of OSA and the increased prevalence of kidney stones.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117352"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratiometric electrochemical quantitation of methyl parathion based on NiHCF/PDDA@rGO nanocomposites","authors":"Xiaolin Jia ,&nbsp;Miaomiao Li ,&nbsp;Zhiguang Liu ,&nbsp;Yujie Han ,&nbsp;Hua-Zhong Yu ,&nbsp;Lifang Fan ,&nbsp;Yujing Guo","doi":"10.1016/j.microc.2026.117344","DOIUrl":"10.1016/j.microc.2026.117344","url":null,"abstract":"<div><div>This work presents an on-off ratiometric electrochemical quantitation study of methyl parathion (MP), one of the most popularly used organophosphorus pesticides, based on electrode modification with a newly developed nanocomposite, i.e., reduced graphene oxide (rGO) functionalized with poly(diallyldimethylammonium chloride) (PDDA) and nickel hexacyanoferrate (NiHCF). It was shown that MP strongly adsorbs on the modified electrodes and produces a distinct reduction signal (-NO₂), which increases proportionally with its concentration; meanwhile, the intrinsic reduction signal (Fe(III)/(II)) from the nanocomposite (NiHCF/PDDA@rGO) decreases due to the inhibited electron-transfer process upon MP binding. Indeed, plotting the ratiometric signal (the ratio of decreased Fe(III)/(II) current and the increased MP current) as a function of the analyte (MP) concentration produces a linear calibration curve in the range of 0.05 μM to 10 μM (R² = 0.9987), with a limit of detection (LOD) of 16 nM. The method was further validated in real water samples, showing recoveries of 96.2–102% with relative standard deviations below 3.3%, which are comparable with standard HPLC results.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117344"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly efficient V2O5@In2O3 nanoflowers for outstanding NO2 gas sensing proficiencies","authors":"Shahid Hussain ,&nbsp;Zhenyu Miao ,&nbsp;Yuanyuan Han ,&nbsp;Adil Shafi Ganie ,&nbsp;Abdul Jalil ,&nbsp;Mohammed Mujahid Alam ,&nbsp;Abdullah G. Al-Sehemi ,&nbsp;Rajesh Kumar Manavalan ,&nbsp;Xiangzhao Zhang ,&nbsp;Guanjun Qiao","doi":"10.1016/j.microc.2026.117359","DOIUrl":"10.1016/j.microc.2026.117359","url":null,"abstract":"<div><div>The global issue of nitrogen dioxide pollution has become a significant environmental concern due to its significant impact on the environment. In this paper, V₂O₅ nanoflowers were successfully prepared by a facile hydrothermal method using ammonium metavanadate as the precursor, representing the fabrication of V₂O₅ with a morphology assembled from numerous fine nanorods into nanoflower-like structures. To enhance the gas-sensitive properties of V₂O₅ nanomaterials, V₂O₅/In₂O₃ nanocomposites were successfully synthesized by a two-step hydrothermal method subsequently. This study presents the first instance in the field of gas-sensing research where the gas sensing performance of V₂O₅ has been enhanced by constructing an n-n heterojunction through composite formation with In₂O₃. In order to further verify the synergistic effect of the nanocomposites on the gas-sensitized performance, the effects of different composite ratios of V₂O₅/In₂O₃ nanocomposites on the gas-sensitized performance were investigated. The results showed that the gas-sensitized performance of V₂O₅/In₂O₃ nanocomposites with a ratio of 3:1 was optimal, and the response of the material to 100 ppm NO₂ at an operating temperature of 200 °C reached 20.4. The material exhibits high response, good selectivity, repeatability and low detection limit, and is moisture resistant. The excellent performance was attributed to the preparation of nanocomposites providing more adsorption sites and the synergistic effect created by the construction of n-n heterojunctions.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"223 ","pages":"Article 117359"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}