Microchemical Journal最新文献

{"title":"Utility of cauliflower waste/garlic biomass admixture for green synthesis of multi-doped CQDs as a fluorescent optosensor for Fe3+ in different matrices","authors":"Raneem Hesham ,&nbsp;Heba Abd El-Aziz ,&nbsp;Rania El-Shaheny","doi":"10.1016/j.microc.2024.112322","DOIUrl":"10.1016/j.microc.2024.112322","url":null,"abstract":"<div><div>A simple method for the synthesis of multi-doped carbon quantum dots (CQDs) has been developed via a fast, affordable, and green pathway from natural, nontoxic, and inexpensive substrates as garlic and cauliflower leaves and stalk as a plant by-product by the aid of microwave. The synthesized fluorescent CQDs have excellent quantum yield of 42 % at λ_ex/λ_em of 330/411 nm with superb stability. The CQDs were fully described using energy-dispersive X-ray, X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, Zeta potential, UV–visible spectroscopy, and fluorescence spectroscopy which demonstrate that CQDs are doped with multiple elements including sulfur, nitrogen, phosphorus, potassium, sodium, and calcium. It has been noted that Fe³<strong>⁺</strong> specifically quenches the CQDs’ fluorescence, unlike other heavy metals. Based on this phenomenon, the produced CQDs revealed outstanding results as a fluorescent optosensor for iron determination over the concentration range of 10.0–400.0 μM with a limit of detection of 3.29 μM. The proposed method is effective for determining Fe³⁺ in pharmaceutical dosage form with mean % recovery of 98.73 ± 0.75 %. Additionally, the synthesized CQDs also showed a significant promising potential in environmental applications for detection of Fe³<strong>⁺</strong> in tap, irrigation, and river water with mean % recovery of 99.45 ± 1.71, 100.57 ± 1.32, and 101.49 ± 2.44 %, respectively. Several greenness measures and software approved the greenness of the designed optosensor. This approach proved that green synthesis could furnish CQDs from natural low-cost substrates with distinct outstanding characteristics that are suited for certain uses without consuming hazard materials unlike traditional methods.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112322"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidic paper-based analytical devices and miniaturized systems to detect sugar adulteration in honey: A mini-review","authors":"Hany Abd El-Raheem ,&nbsp;Abdulsalam kabiru saidu ,&nbsp;Ali Zazoua ,&nbsp;Muggundha Raoov ,&nbsp;Sibel A. Ozkan ,&nbsp;Waleed Alahmad","doi":"10.1016/j.microc.2024.112469","DOIUrl":"10.1016/j.microc.2024.112469","url":null,"abstract":"<div><div>Honey is a natural sweetener widely used in food products and as a daily dietary ingredient, providing a valuable source of carbohydrates, energy, and medicinal properties. However, the increasing demand for honey has led to its adulteration with various sugar syrups. Ensuring honey authentication is crucial for maintaining consumer confidence and for developing sensitive, accurate, rapid, and cost-effective methods for the frequent and convenient detection of adulterants. Microfluidic paper-based analytical devices (µPADs) and miniaturized detection systems not only fulfill these requirements but also offer advantages such as simplicity, portability, minimal use of reagents and materials, and accessibility compared to traditional methods. These tools facilitate rapid, on-site analysis, thereby obviating the need for costly laboratory techniques such as high-performance liquid chromatography or gas chromatography. This article reviews and summarizes recent advancements in the detection of sugar adulteration in honey using µPADs and miniaturized detection systems. The future prospects of these tools are discussed, as they are expected to become more accurate, adaptable, and applicable across various domains.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112469"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Handling non-linearities and pre-processing in multivariate calibration of vibrational spectra","authors":"Alejandro C. Olivieri","doi":"10.1016/j.microc.2024.112323","DOIUrl":"10.1016/j.microc.2024.112323","url":null,"abstract":"<div><h3>Background</h3><div>several automatic pre-processing methods are available for coping with scattering effects in vibrational spectra (near and mid infrared, Raman) when linear multivariate models are applied for calibration. In contrast, almost no methods have been developed for data sets showing a non-linear relationship between instrumental signals and analyte concentrations or target properties.</div></div><div><h3>Results</h3><div>several data sets are studied, both simulated and experimental, showing different degrees of non-linearity: very low, intermediate, and high. For each of them, three multivariate models have been applied: classical partial least-squares (PLS), sequential pre-processing through orthogonalization (SO-PLS) and Kernel partial least-squares (K-PLS). The success of these models depends on the degree of non-linearity presented by each data set. The results are discussed in terms of the model structures.</div></div><div><h3>Significance</h3><div>the need of developing new automatic pre-processing techniques for non-linear vibrational data sets is highlighted, in order to reach a similar status as the linear counterparts.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112323"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the internal alteration mechanism of marble jade artifacts from Sanxingdui ritual Pit no. 3, Sichuan","authors":"Haoze Wu ,&nbsp;Jiancheng Liu ,&nbsp;Hui Fang ,&nbsp;Yunpeng Wang ,&nbsp;Qinglin Ma","doi":"10.1016/j.microc.2024.112338","DOIUrl":"10.1016/j.microc.2024.112338","url":null,"abstract":"<div><div>The Sanxingdui site holds significant archaeological value within the upper reaches of the Yangtze River in China, representing a key center of civilization. Jade was emblematic of status and rank in this society, playing an essential role in significant rituals and funerary practices. Over an extended burial period, most jade artifacts have undergone varying degrees of alteration. This study analyzed marble jade artifacts excavated from the Sanxingdui site with an ultra-deep field microscope, SEM-EDS, a Raman spectrometer, and XRD to investigate changes in chemical composition and physical phases. The study confirms the presence of a distinct layered structure characteristic of internal hollow alteration. Furthermore, it establishes that the presence of bronze and ivory alteration products notably influenced the alteration process. These interactions resulted in the generation of libethenite [Cu₂(PO₄)(OH)] within the hollow regions of the jade artifacts. Since the exothermic reactions during generation occur in a buried environment, this can increase the temperature of the surrounding aqueous environment and the formation of a hydrothermal environment. Within this environment, the libethenite undergoes further reactions, leading to the generation of cornetite [Cu₃(PO₄)(OH)₃] and pseudomalachite [Cu₅(PO₄)₂(OH)₄]. In the interim, the hydrothermal conditions facilitated a gradual dissolution of libethenite in groundwater, allowing it to infiltrate the interior of the jade. Subsequent crystallization, triggered by a decrease in temperature, induced stress damage to the internal structure of the jade. This process alters the internal hollowing, destroying the crystal structure of the jade and eventually causing a complete loss of its mechanical properties, transforming the jade into an internal powder. The results of this study indicate that the alteration products from bronze and ivory significantly impact jade. Therefore, this factor should be carefully considered in the conservation and preservation of jade, with appropriate measures taken accordingly.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112338"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CRISPR/Cas system-mediated function of Hg2+ on urease activity for colorimetric detection of the tumor biomarker in clinical samples","authors":"Xin Jin ,&nbsp;Jiankang Zhu ,&nbsp;Yun Zhang ,&nbsp;Shuaichen Jin ,&nbsp;Xinxin Zhao ,&nbsp;Qian Xu ,&nbsp;Dexu Zhang ,&nbsp;Linchuan Li ,&nbsp;Qiongzheng Hu ,&nbsp;Guangyong Zhang","doi":"10.1016/j.microc.2024.112317","DOIUrl":"10.1016/j.microc.2024.112317","url":null,"abstract":"<div><div>Detecting tumor biomarkers in blood samples is essential in cancer diagnosis and prognosis. This study proposes a CRISPR/Cas system-mediated colorimetric assay to detect the tumor biomarker in human serum samples. It involves using the tumor biomarker as a switch of the CRISPR/Cas system to modulate the function of Hg²⁺, which is a typical urease inhibitor. The detection of carcinoembryonic antigen (CEA) is demonstrated as an example. The CEA aptamer is used to activate the CRISPR/Cas system, allowing for the cleavage of a single-stranded DNA (ssDNA) rich in thymine (T) nucleotides, thereby causing the inhibition of the urease activity by Hg²⁺. However, in the presence of CEA, the CRISPR/Cas system cannot be activated due to the specific binding of CEA to its aptamer, which leads to the capture of Hg²⁺ owing to the formation of a DNA hairpin structure with T-Hg²⁺-T coordination bonds. Thus, the urease activity is remained. Since the enzymatic hydrolysis of urea by urease increases the pH of the urea solution containing phenol red and changes the solution from yellow to pink, CEA can be detected with the assistance of the colorimetric assay. This method shows high sensitivity and selectivity for CEA with a detection limit of 0.028 ng/mL. In addition, serum samples from patients with normal and abnormal levels are tested to verify the validity of the proposed method for practical applications. Overall, this study provides a simple, fast, and stable colorimetric assay to detect the tumor biomarker in human serum and has great potential for early cancer screening and prognostic determination.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112317"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly sensitive determination of perfluorooctanoic acid in food and river samples with an electrochemical platform based on MIP and modified MWCNTs","authors":"Ting Liu ,&nbsp;Chunyan Sang ,&nbsp;Bolu Sun ,&nbsp;Hua Cai ,&nbsp;Hong Liu ,&nbsp;Yuwei Liu ,&nbsp;Gengsheng He","doi":"10.1016/j.microc.2024.112328","DOIUrl":"10.1016/j.microc.2024.112328","url":null,"abstract":"<div><div>Perfluorooctanoic acid (PFOA), one of the emerging persistent organic pollutants, has received great concern due to high resistance to degradation and potential health risks. Numerous reports have revealed its presence in environment (soil, water, air), multiple foods and human blood with certain levels. In this study, a selective electrochemical molecularly imprinted sensor (MIP/CMC-MWCNTs@GCE) based on a template molecule of PFOA and a functional monomer of methacrylic acid (MAA) was developed via electro-polymerization on the surface of a glassy carbon electrode modified with carboxymethyl cellulose (CMC) and multiwalled carbon nanotubes (MWCNTs) for PFOA detection. The composite electrode was characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) to investigate its microstructure and surface groups. Cyclic voltammetry (CV) results and electrochemical impedance spectroscopy (EIS) also showed its excellent electrochemical performance. After optimizing the experimental conditions by differential pulse voltammetry (DPV), the obtained sensor quantified PFOA in a wide range of 0.1–2000 ng mL⁻¹ with a low detection limit (LOD) of 0.1287 ng mL⁻¹. Finally, this rapid sensing method has been successfully applied in chicken, peach, tomato and river samples with a recovery rate of 92.00–113.19 %. These results present that the composite sensor has good selectivity, stability and high sensitivity for PFOA determination, which may be a promising alternative for on-site and real-time monitoring in complex samples.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112328"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of solid-phase microextraction methods for determination of non-steroidal anti-inflammatory drugs","authors":"Farah Al-Hammashi ,&nbsp;Behjat Deiminiat ,&nbsp;Gholam Hossein Rounaghi","doi":"10.1016/j.microc.2024.112340","DOIUrl":"10.1016/j.microc.2024.112340","url":null,"abstract":"<div><div>The non-steroidal anti-inflammatory drugs (NSAIDs) with antipyretic, anti-inflammatory and analgesic characteristics have become one of the most extensively used drugs all over the world. The residues of these pharmaceuticals can penetrate the ecosystem and cause a serious concern because of the environmental and health implication. Hence, the accurate analytical determination of these drugs in different samples is necessary. The sensitive measurement of NSAIDs depends on an effective and efficient extraction process. In recent years, various extraction techniques including solid-phase microextraction and liquid-phase microextraction have been introduced. This review summarizes the development of new solid-phase micro extraction techniques for determination of non-steroidal anti-inflammatory drugs and also compares their merits and demerits.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112340"},"PeriodicalIF":4.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and application of a non-targeted analysis method using GC-MS and LC-MS for identifying chemical contaminants in drinking water via point-of-use filters.","authors":"John T Sloop, Jonathan S Casey, Hannah Liberatore, Alex Chao, Kristin K Isaacs, Seth R Newton","doi":"10.1016/j.microc.2024.112223","DOIUrl":"10.1016/j.microc.2024.112223","url":null,"abstract":"<p><p>While many chemicals are regulated and routinely monitored in drinking water, they represent just a portion of all contaminants that may be present. Typical drinking water analyses involve sampling one liter or less of water, which could lead to trace level contaminants going undetected. In this study, a method was developed for using point-of-use activated carbon block drinking water filters as sampling devices. The filters were extracted to remove chemicals that were collected, and then analyzed by non-targeted analysis via liquid chromatography and gas chromatography high-resolution mass spectrometry. Extraction efficiencies were assessed by spiking and recovery experiments to better understand the chemical space coverage. To test the method's applicability to real-world samples, filters from a small-scale pilot study were collected from individuals in New York, NY and Atlanta, GA and analyzed. Twenty tentatively identified chemical candidates were confirmed by comparison to chemical standards. Principal components analysis was performed on the full set of filtered chemical features to explore how geographic and temporal differences in samples impact drinking water composition. Product use categories for confirmed chemicals were explored to determine potential sources of contaminants.</p>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycatechol coated cigarette filter as a sorbent for microextraction by packed sorbent of acidic non-steroidal anti-inflammatory drugs (NSAIDs) from wastewater samples","authors":"Farah Al-Hammashi,&nbsp;Fariborz Momenbeik","doi":"10.1016/j.microc.2024.112298","DOIUrl":"10.1016/j.microc.2024.112298","url":null,"abstract":"<div><div>In this study, we employed microextraction by packed sorbent (MEPS) using polycatechol-coated cigarette filters (PCCFs) as a sorbent to extract acidic non-steroidal anti-inflammatory drugs (NSAIDs) from water samples, followed by high-performance liquid chromatographic analysis. The formation of coating on cigarette filter was confirmed by Fourier transform infrared (FT-IR) spectroscopy, UV–vis diffuse reflectance spectroscopy (DRS) and scanning electron microscopy (SEM). The effect of coating parameters on extraction efficiency of acidic NASIDs were investigated and 106.0 mg of Na₂CO₃, 30.0 mg of catechol and 3 h coating time were selected as optimum conditions. Additionally, other factors affecting the analyte extraction efficiency were optimized including a sample solution pH of 2.0, 700.0 µL of methanol as the elution solvent, 3 sorption cycles, 2 desorption cycles, and a 1.5 ml sample volume. Under the optimum conditions the calibration curves for all three analytes were draw and the analytical performance parameters including linear dynamic range (50.0–1000.0 µg.L⁻¹ for naproxen and diclofenac and 100.0–500.0 µg.L⁻¹ for ibuprofen) with R² &gt; 0.9982, limit of detection (LOD &lt; 45.3 µg.L⁻¹), precision (RSD% &lt; 6.5), accuracy (recovery% &gt; 90.1) and enrichment factor (EF &gt; 2.7) were evaluated. Finally, this method was successfully used to extract and determine the amount of selected acidic NSAIDs in wastewater samples. The sorbent was cheap, easily prepared, efficient, and even reusable.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112298"},"PeriodicalIF":4.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Competitive adsorption of two phenolic pollutants compounds using a novel biosorbent: Analytics (HPLC), Statistical (experimental design), and theoretical studies (DFT)","authors":"Taoufiq Bouzid ,&nbsp;Aicha Naboulsi ,&nbsp;Abdelali Grich ,&nbsp;Hicham Yazid ,&nbsp;Julien Vieillard ,&nbsp;Abdelmajid Regti ,&nbsp;Mamoune El Himri ,&nbsp;Mohammadine El Haddad","doi":"10.1016/j.microc.2024.112281","DOIUrl":"10.1016/j.microc.2024.112281","url":null,"abstract":"<div><div>In this study, we focused on a novel agricultural waste material, specifically a plant known as Nicotiana glauca Graham (NgG), which is highly abundant in Morocco. The investigation involved testing four activating agents H₃PO₄, H₂SO₄, NaOH, and ZnCl₂ on Nicotiana glauca Graham (NgG) to assess their effects. By employing an experimental design, we successfully determined the optimal conditions for this activation process. The resulting activated carbon was then evaluated for its effectiveness in removing two phenolic pollutants, Bisphenol A (BPA) and β-naphthol (BNL). Analysis using FTIR revealed various functional groups on the activated carbon surface, including P = O, P-O-C aromatics, and O-H groups, which played a crucial role in the adsorption of BPA and BNL. XRD analysis indicated that the optimal adsorbent was amorphous, while Zeta potential measurements showed a significant decrease in pollutant removal rates after reaching a pH level of nearly 10. The activated carbon produced from H₃PO₄ exhibited a surface area of 1078 m²/g. Experimental adsorption results at the highest removal rate showed q_BPAs = 125.82 mg/g for BPA and q_BNLs = 62.82 mg/g for BNL in individual mode, while in the mixed mode, q_BPAm = 16.22 mg/g for BPA and q_BNLm = 16.04 mg/g for BNL were observed. To enhance our study, we utilized Density Functional Theory (DFT) calculations to identify the most electrophilic and nucleophilic regions on BPA and BNL. The analysis highlighted the hydroxyl groups (–OH) of BNL and BPA as the most significant negative zones, crucial for understanding the underlying mechanisms and explaining the experimental observations. In the isotherm analysis, we identified the Temkin model in a singular mode and the Langmuir model in a mixture mode, showcasing a notable distinction between the two modes.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"208 ","pages":"Article 112281"},"PeriodicalIF":4.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}