Fabricating a sensitive electrochemical aptasensor based on HOF/MXene nanocomposites for monitoring trace ampicillin

Abstract

In this study, a novel hydrogen-bonded organic framework (HOF)/MXene nanocomposite (namely HOF/MXene) was rationally designed and prepared. The HOF can be constructed by the hydrogen bonding self-assembly between organic monomers with abound functional sites and large conjugated systems for immobilizing biological aptamers. Thanks to the advantages of different components, the nanocomposite can be used as a functional material to fabricate an electrochemical aptasensor. The electrochemical aptasensor based on HOF/MXene can quantitatively detect trace ampicillin using differential pulse voltammetry. This work opens a novel idea for constructing HOF/MXene nanocomposites and expanding their applications in the electrical biosensing field.