Boron/nitrogen co-doped reticulated porous carbon frameworks encapsulating cobalt selenide: An advanced nanomaterial for ultrasensitive simultaneous detection of xanthine and uric acid in human serum

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal Pub Date : 2025-09-04 DOI:10.1016/j.microc.2025.115188

Mingyuan Li , Zhenyu Ma , Tong Zhang , Wenshuo Wang , Lijuan Xue , Di Zhu

{"title":"Boron/nitrogen co-doped reticulated porous carbon frameworks encapsulating cobalt selenide: An advanced nanomaterial for ultrasensitive simultaneous detection of xanthine and uric acid in human serum","authors":"Mingyuan Li , Zhenyu Ma , Tong Zhang , Wenshuo Wang , Lijuan Xue , Di Zhu","doi":"10.1016/j.microc.2025.115188","DOIUrl":null,"url":null,"abstract":"<div><div>A novel assembly and self-templating approach was developed for synthesizing cobalt selenide nanoparticles (CoSe) embedded within boron/nitrogen co-doped interconnected reticulated porous carbon frameworks (denoted CoSe@B,N-IRPC). This methodology employs polyacrylonitrile (PAN) as the carbon precursor and boron nitride as the heteroatom source for B/N co-doping, achieved through hydrothermal processing. The resultant CoSe@B,N-IRPC integrates a distinctive 3D porous architecture with hierarchical connectivity, establishing efficient pathways for electron transfer, ion diffusion, and mass transport. The B,N-co-doped carbon matrix effectively confines nanostructured CoSe within the carbon microstructure, preventing nanoparticle aggregation, enhancing electrical conductivity, and mitigating substantial volume changes during electrochemical operation. These characteristics collectively yield superior electrochemical performance and cycling stability. Leveraging these structural advantages, the CoSe@B,N-IRPC based sensor demonstrates exceptional capability for simultaneous detection of xanthine (XA) and uric acid (UA). It exhibits wide linear ranges of 0.0142–4719 μM (XA) and 0.0316–2587 μM (UA), with ultralow detection limits of 0.011 μM (XA) and 0.028 μM (UA), respectively. This unique combination of an ultra-wide linear range and highly competitive detection limits distinguishes it from most previously reported target-specific sensors. Furthermore, the electrode displays superior interference resistance against common electroactive species, outstanding repeatability, and excellent reproducibility. Critically, the sensor achieves accurate quantification of target analytes in spiked real biological samples, yielding excellent recovery rates. This performance confirms its strong potential for practical diagnostic applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"218 ","pages":"Article 115188"},"PeriodicalIF":4.9000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microchemical Journal","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0026265X25025366","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

A novel assembly and self-templating approach was developed for synthesizing cobalt selenide nanoparticles (CoSe) embedded within boron/nitrogen co-doped interconnected reticulated porous carbon frameworks (denoted CoSe@B,N-IRPC). This methodology employs polyacrylonitrile (PAN) as the carbon precursor and boron nitride as the heteroatom source for B/N co-doping, achieved through hydrothermal processing. The resultant CoSe@B,N-IRPC integrates a distinctive 3D porous architecture with hierarchical connectivity, establishing efficient pathways for electron transfer, ion diffusion, and mass transport. The B,N-co-doped carbon matrix effectively confines nanostructured CoSe within the carbon microstructure, preventing nanoparticle aggregation, enhancing electrical conductivity, and mitigating substantial volume changes during electrochemical operation. These characteristics collectively yield superior electrochemical performance and cycling stability. Leveraging these structural advantages, the CoSe@B,N-IRPC based sensor demonstrates exceptional capability for simultaneous detection of xanthine (XA) and uric acid (UA). It exhibits wide linear ranges of 0.0142–4719 μM (XA) and 0.0316–2587 μM (UA), with ultralow detection limits of 0.011 μM (XA) and 0.028 μM (UA), respectively. This unique combination of an ultra-wide linear range and highly competitive detection limits distinguishes it from most previously reported target-specific sensors. Furthermore, the electrode displays superior interference resistance against common electroactive species, outstanding repeatability, and excellent reproducibility. Critically, the sensor achieves accurate quantification of target analytes in spiked real biological samples, yielding excellent recovery rates. This performance confirms its strong potential for practical diagnostic applications.

Abstract Image

查看原文本刊更多论文

包覆硒化钴的硼/氮共掺杂网状多孔碳框架：用于人血清中黄嘌呤和尿酸超灵敏同时检测的先进纳米材料

开发了一种新的组装和自模板方法，用于合成嵌入硼/氮共掺杂互连网状多孔碳框架（表示CoSe@B，N-IRPC）的硒化钴纳米颗粒（CoSe）。该方法以聚丙烯腈（PAN）为碳前驱体，氮化硼为杂原子源，通过水热处理实现B/N共掺杂。由此产生的CoSe@B，N-IRPC集成了具有分层连接的独特3D多孔结构，建立了电子转移，离子扩散和质量传递的有效途径。B， n共掺杂碳基体有效地将纳米结构的CoSe限制在碳微观结构内，防止纳米颗粒聚集，提高导电性，并减轻电化学操作过程中的大量体积变化。这些特性共同产生了优异的电化学性能和循环稳定性。利用这些结构优势，CoSe@B，N-IRPC为基础的传感器显示出同时检测黄嘌呤（XA）和尿酸（UA）的卓越能力。线性范围为0.0142 ~ 4719 μM （XA）和0.0316 ~ 2587 μM (UA)，超低检出限分别为0.011 μM （XA）和0.028 μM （UA）。这种超宽线性范围和极具竞争力的检测极限的独特组合将其与以前报道的大多数目标特定传感器区分开来。此外，该电极对常见电活性物质具有优异的抗干扰性，突出的可重复性和优异的再现性。至关重要的是，该传感器在加标的真实生物样品中实现了目标分析物的准确定量，产生了极好的回收率。这一性能证实了其在实际诊断应用中的强大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.