Iranian Journal of Pathology最新文献_第7页

Primary Follicular Lymphoma of Thyroid: A Rare Case Report with Review of the Literature. 甲状腺原发性滤泡性淋巴瘤1例报告并文献复习。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-10-02 DOI: 10.30699/ijp.2024.562997.2985

Shruthi K P, Lincy Joseph, Jeena V Chimmen

{"title":"Primary Follicular Lymphoma of Thyroid: A Rare Case Report with Review of the Literature.","authors":"Shruthi K P, Lincy Joseph, Jeena V Chimmen","doi":"10.30699/ijp.2024.562997.2985","DOIUrl":"10.30699/ijp.2024.562997.2985","url":null,"abstract":"Background & objective: Thyroid lymphomas are predominantly secondary to lymphoma at other sites, and primary follicular lymphoma of the thyroid is a very rare entity.Case presentation: Here, we report a case of a 62-year-old female who presented with swelling in the front of her neck for one month. The clinical diagnosis was a multinodular goiter. Fine needle aspiration cytology was done and reported as nodular colloid goiter with lymphocytic thyroiditis. The system examination was unremarkable. Histopathological assessments of the right hemithyroidectomy specimen revealed the effacement of thyroid architecture by abnormal and extensive lymphoid follicles. Immunohistochemistry revealed CD20, CD10, BCL2, and BCL6 positivity in the lymphoid follicles. FDG-PT CT scan demonstrated no evidence of lymphoma elsewhere. So, a e final diagnosis of follicular lymphoma of the thyroid was made.Conclusion: Due to the rarity and low prevalence of primary follicular lymphoma of the thyroid and challenging in its differentiation from Hashimoto's thyroiditis with dense lymphoplasmacytic infiltration and formation of lymphoid follicles, histopathologic diagnosis should be confirmed by immunohistochemical studies.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 4","pages":"447-452"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologic and Prognostic Significance of Tumor Budding in Colorectal Adenocarcinoma: A Retrospective Cohort Study Conducted in Shiraz, Iran. 结直肠腺癌肿瘤发生的组织病理学和预后意义：在伊朗设拉子进行的一项回顾性队列研究。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2021-12-15 DOI: 10.30699/IJP.2023.1999329.3090

Mohammad Hossein Anbardar, Nadia Rahimizadeh

{"title":"Histopathologic and Prognostic Significance of Tumor Budding in Colorectal Adenocarcinoma: A Retrospective Cohort Study Conducted in Shiraz, Iran.","authors":"Mohammad Hossein Anbardar, Nadia Rahimizadeh","doi":"10.30699/IJP.2023.1999329.3090","DOIUrl":"10.30699/IJP.2023.1999329.3090","url":null,"abstract":"Background & objective: Colorectal cancer is the second reason for cancer-associated death. The prognosis of the malignancy is defined by TNM scoring. However, tumor grading, lymphovascular invasion, perineural invasion, and tumor buddings may affect its prognosis. This study aimed to assess the prognostic and histologic impact of tumor budding in colorectal adenocarcinoma.Methods: This study is a retrospective cohort of 192 patients with colorectal adenocarcinoma. All four stages of colorectal adenocarcinoma patients were included, but the patients in stages I and II were also analyzed separately. We used pathology reports to extract the histopathologic data. The prognostic values were extracted by calling the patients.Results: Less than half of the patients were in stages I and II of the disease. According to our analysis, tumor extension and lymphovascular invasion were correlated with tumor budding count in patients in stages I and II, and lymphovascular invasion, tumor grade, tumor stage, lymph node involvement, tumor extension, tumor site, metastasis, and five-year survival were correlated with tumor budding within all stages.Conclusion: It is recommended that tumor budding count should be assessed and reported in pathology reports of adenocarcinomas due to its high correlation with poor prognosis.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 1","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Understanding of PCSK9 and Its Relevance to Cancer Prognosis and Immune Therapy: A Review. 目前对 PCSK9 及其与癌症预后和免疫疗法相关性的了解：综述。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2023-12-29 DOI: 10.30699/IJP.2023.1999459.3093

Morteza Hassandokht Mashhadi, Fahime Taheri, Sadaf Irani, Arshiya Mesbah Mousavi, Ali Mehri, Hossein Javid

{"title":"Current Understanding of PCSK9 and Its Relevance to Cancer Prognosis and Immune Therapy: A Review.","authors":"Morteza Hassandokht Mashhadi, Fahime Taheri, Sadaf Irani, Arshiya Mesbah Mousavi, Ali Mehri, Hossein Javid","doi":"10.30699/IJP.2023.1999459.3093","DOIUrl":"10.30699/IJP.2023.1999459.3093","url":null,"abstract":"The effectiveness of immunotherapy for most cancer patients remains low, with approximately 10-30% of those treated surviving. Thus, much effort is being put into finding new ways to improve immune checkpoint therapy. Our review concludes that inhibition of proprotein convertase subtilisin/Kexin type 9 (PCSK9), which plays a critical role in regulating cholesterol metabolism, can cause movement of T cells toward tumors, with increased sensitivity to immune checkpoint therapies. We searched PubMed, NCBI, Scopus, and Google Scholar for the published articles without limitations on publication dates. We used the following terms: \"PCSK9\", \"Cancer\", \"Immune Checkpoint\", and \"Cancer Prognosis\" in the title and/or abstract. Our search initially revealed 600 records on the subject and stored them in the used databases under EndNote X8 management software. A total of 161 articles were selected and through a careful review, 76 were included in our research. We concluded that PCSK9 reduces the number of LDL receptors (LDL-R) on the cell surface, which is linked to its ability to regulate cholesterol levels in the body. Also, we discuss how suppressing PCSK9 leads to the MHC-1 accumulation on the surface of cancer cells, which results in T lymphocyte invasion. Finally, we believe that inhibiting PCSK9 may be an effective strategy for improving cancer immunotherapy.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Structural, Cytological and Biomarker Expression in Carcinoma in situ and Invasive Components in Breast Carcinoma. 乳腺癌原位癌和浸润性成分结构、细胞学和生物标志物表达的比较。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-04-07 DOI: 10.30699/IJP.2024.2025907.3285

Azar Naimi, Niloufar Mohaghegh

{"title":"Comparison of the Structural, Cytological and Biomarker Expression in Carcinoma in situ and Invasive Components in Breast Carcinoma.","authors":"Azar Naimi, Niloufar Mohaghegh","doi":"10.30699/IJP.2024.2025907.3285","DOIUrl":"10.30699/IJP.2024.2025907.3285","url":null,"abstract":"Background & objective: Breast cancer is thought to arise from non-invasive breast lesions, such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). DCIS is considered a direct precursor of invasive carcinoma. The morphological features alone do not reflect the biological truth of this disease. Therefore, we investigated features of carcinoma in situ and the invasive components in women diagnosed with breast cancer.Methods: This study was a cross-sectional study. The corresponding IHC slides were selected from the pathology archive and examined by the pathologist. Fifty-one samples which showed both in situ and invasive components confirmed immunohistochemically, were included in the study.Results: In 70.6% of the cases a high grade of in situ and invasive carcinoma was observed. In 45.1% of the studied cases, a solid structure was observed in in-situ carcinoma, and no otherwise specified structure was observed in invasive carcinoma. In 74.5% of both in situ and invasive carcinoma types, ER.PR had a positive value. In 45.5% of the cases, both in situ and invasive carcinoma components show low Ki67. In 42.2%, both in situ and invasive carcinomas were Her2 negative. There was no significant difference between the grade (P=0.687), Her2 type (P=0.532), and structure (P=0.532). ER.PR (P=1.00) and Ki67 (P=0.180) of in situ and invasive carcinoma in this study.Conclusion: Our study showed differences between in situ and invasive biomarker expression. According to our findings, owing to heterogeneity, in situ components can't be representative of invasive components for treatment choices.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 3","pages":"318-325"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Malignancy of the Eyelid: Report A Case of Primary Periocular Histiocytoid Carcinoma. 罕见的眼睑恶性肿瘤：报告一例原发性眼周组织细胞样癌。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-07-24 DOI: 10.30699/IJP.2024.2016655.3219

Arezu Rahnavard, Elham Mirzaian, Reyhaneh Safaei, Ida Mehrabi

引用次数: 0

CD10 Expression in Colorectal Adenoma and Carcinoma and Its Association with the Pathological Prognostic Factors. CD10在结直肠腺瘤和癌中的表达及其与病理预后因素的关系。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-10-02 DOI: 10.30699/ijp.2024.2013354.3185

Bhavana G R, Clement Wilfred D

{"title":"CD10 Expression in Colorectal Adenoma and Carcinoma and Its Association with the Pathological Prognostic Factors.","authors":"Bhavana G R, Clement Wilfred D","doi":"10.30699/ijp.2024.2013354.3185","DOIUrl":"10.30699/ijp.2024.2013354.3185","url":null,"abstract":"Background & objective: Since early detection increases survival rates, colorectal carcinoma (CRC) is a major concern for researchers. CD10 is a cell membrane-bound metalloproteinase involved in carcinogenesis. Studies have associated it with the progression of CRC to advanced stages, metastasis, and venous invasions. We aimed to evaluate the immunohistochemical expression of CD10 in the tumor and stromal cells of colorectal adenoma and CRC and its correlation with the pathological prognostic factors.Methods: This cross-sectional study was conducted on radical resection specimens of CRC and polypectomy specimens of the colorectal adenomas received for routine histopathological evaluation in the Department of Pathology, Ramaiah Medical College and Hospitals, Bengaluru, from March 2021 to October 2022. Tumor morphology was examined by light microscopy, and CD10 expression was evaluated by immunohistochemistry. Descriptive statistics in terms of percentage and Chi-square test/ Fisher exact tests were used for the statistical analysis.Results: The study includes 46 cases of adenomas and CRCs each. Stromal CD10 expression was significantly higher in the carcinomas (63.4%) than in the adenomas (41.3%). Proliferative CRCs showed a significantly higher tumoral CD10 expression. The increase in the stromal CD10 expression in CRCs with increasing grades was found to be statistically significant. No significant association was seen between CD10 expression and other factors.Conclusion: The results indicate a potential role of CD10 in the adenoma-carcinoma sequence. The significant increase in proliferating and high-grade CRCs suggests that CD10 could prove to be a potential biomarker for aggressiveness and also a therapeutic target in CRCs.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 4","pages":"441-446"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Cyclin D1 and Claudin-1 in Invasive Breast Carcinoma and Their Correlation with Clinicopathological Parameters. 浸润性乳腺癌中Cyclin D1和Claudin-1的表达及其与临床病理参数的关系

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-10-02 DOI: 10.30699/ijp.2024.2028643.3299

Roopali Sehrawat, Vishesh Dhawan, Maitrayee Roy, Ayushi Kediya, Vijay Shrawan Nijhawan

{"title":"Expression of Cyclin D1 and Claudin-1 in Invasive Breast Carcinoma and Their Correlation with Clinicopathological Parameters.","authors":"Roopali Sehrawat, Vishesh Dhawan, Maitrayee Roy, Ayushi Kediya, Vijay Shrawan Nijhawan","doi":"10.30699/ijp.2024.2028643.3299","DOIUrl":"10.30699/ijp.2024.2028643.3299","url":null,"abstract":"Background & objective: Evidence-based medicine has shown that patients with similar risk factors, stages, and therapy often have different clinical outcomes, highlighting the heterogeneity of breast cancer. In a quest for a better, cost-effective approach, researchers proposed the selection of surrogate IHC markers such as cyclin D1 and claudin-1 for the prognosis of breast cancer patients, supplementing the traditional ER, PR, and HER2/neu receptor.Methods: This retrospective study was conducted in a tertiary care hospital in northern India and included 50 cases of invasive breast carcinoma obtained from mastectomies, wide local excisions, and biopsies diagnosed over 4 years. In addition to ER, PR, and Her2/neu, claudin-1 and cyclin D1 IHC expression was assessed.Results: Cyclin D1 expression exhibited a statistically significant correlation with nodal status involvement (P=0.011) and with luminal-type breast carcinoma (P=0.023). Though there was no significant statistical correlation between claudin-1 and various clinic pathological features, it was seen to be positive in both luminal and HER2/neu-positive tumors.Conclusion: Our findings advocated the expression of IHC namely, cyclin D1 and claudin-1, in cases of breast cancer. Cyclin D1 positivity may show a significant association with better prognostic determinants while claudin-1 negative tumors may tend to be more often triple negative. Thus, IHC can be used in resource-constraint settings to substitute expensive molecular techniques.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 4","pages":"408-414"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Carcinoma Coexistent with Ipsilateral Axillary Non-Hodgkin Lymphoma: Cytological Diagnosis Aided with Cellblock Immunohistochemistry. 乳腺癌与同侧腋窝非霍奇金淋巴瘤并存：细胞学诊断辅以细胞块免疫组化。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.30699/IJP.2024.2014737.3203

Krishnendu Mondal, Rupali Mandal

引用次数: 0

Comparing Length and Telomere Expression at Oral Precancerous and Cancerous Stages. 比较口腔癌前病变和癌变阶段的长度和端粒表达。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.30699/IJP.2024.1996330.3081

Fahad Mansoor Samadi, Shaista Suhail, Manjari Sonam, Mohd Kaleem Ahmad, Vijay Kumar, Shaleen Chandra, Shadab Mohammad

{"title":"Comparing Length and Telomere Expression at Oral Precancerous and Cancerous Stages.","authors":"Fahad Mansoor Samadi, Shaista Suhail, Manjari Sonam, Mohd Kaleem Ahmad, Vijay Kumar, Shaleen Chandra, Shadab Mohammad","doi":"10.30699/IJP.2024.1996330.3081","DOIUrl":"10.30699/IJP.2024.1996330.3081","url":null,"abstract":"Background & objective: Telomeres consist of repetitive G-rich nucleotides located at the end of each chromosome, acting as protein binding sites. The aim of this study was to examine the differences in telomere length in blood, saliva, and tissue samples at various stages of oral precancerous and cancerous lesions.Methods: Samples of blood, tissue, and saliva were collected from patients with oral precancerous and cancerous lesions. DNA extraction was performed. Then, a TRAP assay was conducted to assess and compare the telomere length and telomerase expression.Results: The levels of telomerase activity (TA) in the DNA samples ranged from 0.19 to 6.91 (2.05+1.37) among oral squamous cell carcinoma (OSCC) patients and from 0.17 to 4.5 (0.28+4.25) among precancerous patients. A significant difference was observed in TA levels between OSCC and precancerous samples (t=3.9691, P= 0.0000).Conclusion: Assessing the telomerase activity is crucial for studying the behavior of carcinoma in the clinical setting. The augmented telomerase expression and the length of telomere contribute to OSCC progression. Hence, this study adds a diagnostic tool that can serve as a biomarker for the early detection and prognosis of OSCC.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 2","pages":"146-151"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer. 乳腺癌预后标志物和 LDLR 相关蛋白家族成员免疫渗透的综合分析

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-03-29 DOI: 10.30699/IJP.2024.1995769.3077

Shabnam Shahidi, Parvin Ansari Shayesteh, Mahsa Alami, Negin Parsamanesh

{"title":"Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer.","authors":"Shabnam Shahidi, Parvin Ansari Shayesteh, Mahsa Alami, Negin Parsamanesh","doi":"10.30699/IJP.2024.1995769.3077","DOIUrl":"10.30699/IJP.2024.1995769.3077","url":null,"abstract":"Background & objective: Breast cancer (BC) is one of the most frequent tumors worldwide, accounting for 15% of all cancer-related deaths. A timely diagnosis of BC is essential for optimal treatment and increasing patients' survival rates. LRP family proteins are important components of cell-surface receptors involved in numerous biological activities. Expression of LRP is related to breast malignancy. In this study, we initially studied the expression of LRPs in BC tissues compared to normal tissues-the relation of LRP expression with relapse-free survival (RFS) and overall survival (OS). Then, we investigated the association of LRPs relation and immune infiltrating abundance.Methods: We analyzed the LDLR family expression and prognostic value in BC by mining UALCAN, TIMER, and Kaplan-Meier plotter databases. Subsequently, we explored the association of LDLR expression and immune infiltrating abundance via the TIMER database.Results: Expression levels of LRP1/2/4/9/10 were found to be higher in the cases with positive estrogen receptors. There was a positive association between LRP1/6 expression and the infiltration of CD8+ T cells, CD4+ T Cell, Macrophage, Dendritic Cell, and Neutrophil.Conclusion: Our study recommends LDLR as a potential prognostic biomarker that can be promising to improve the survival of BC patients' survival. However, further investigations are needed to evaluate the studied LDLR members in more detail.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 1","pages":"31-49"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0