Iranian Journal of Pathology最新文献

{"title":"Delving into the Role of α-Smooth Muscle Actin as a Predictive Biomarker of Early Recurrence in Invasive Ductal Adenocarcinoma of Breast.","authors":"Seetu Palo","doi":"10.30699/IJP.2024.2022442.3255","DOIUrl":"10.30699/IJP.2024.2022442.3255","url":null,"abstract":"","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 3","pages":"363-364"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Most Common Multi-Drug Resistant Bacteria Associated with Hospital Infections, in Urmia, Iran.","authors":"Seyyed Jalil Mousavi, Rahim Nezhadrahim, Farima Abdulzadeh","doi":"10.30699/IJP.2024.2014294.3195","DOIUrl":"10.30699/IJP.2024.2014294.3195","url":null,"abstract":"<p><strong>Background & objective: </strong>Hospital-acquired infections (HAIs) are a major healthcare problem in hospitalized patients, especially in developing countries, where they affect millions of patients and cause high mortality rates. This study aimed to investigate multidrug-resistant bacterial strains in NIs at Imam Khomeini University Hospital in Urmia, Iran.</p><p><strong>Methods: </strong>This cross-sectional study was conducted using a convenience sampling method. The study population comprised all positive clinical samples from HAIs registered in the laboratory of Imam Khomeini Hospital, Urmia, Iran, in 2019. Bacteria were identified by culturing the samples on blood agar and MacConkey agar, followed by performing standard biochemical tests. Antibiotic susceptibility testing was carried out using the disk diffusion method, in accordance with CLSI guidelines.</p><p><strong>Results: </strong>Of the 607 positive samples, the most common microorganisms isolated were <i>Escherichia coli</i> (27.5%), <i>Acinetobacter baumannii</i> (18.5%), and <i>Klebsiella pneumoniae</i> (15.2%). The distribution of resistance to the number of antibiotics in bacterial isolates from the samples showed that 19.8% of them were resistant to one antibiotic and 13.2% were resistant to three antibiotics. 40.5% of the samples showed no resistance to antibiotics.</p><p><strong>Conclusion: </strong>This study highlights the critical issue of HAIs and the prevalence of multidrug-resistant bacteria in Urmia, Iran. Urgent measures, including improved hygiene, accurate diagnostics, appropriate antibiotic use, and stakeholder education, are essential. Establishing a robust HAI surveillance system is also recommended. Future efforts should aim at understanding and mitigating the spread of these pathogens.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 3","pages":"283-291"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Hepatic Mast Cell Concentration (MCC) in NAFLD and NASH Severity and Fibrosis Grade.","authors":"Mahshid Panahi, Nasser Rakhshani, Alireza Sarhaddi, Monavvar Afzalaghaee, Hamid Rezvani, Nikoo Emtiazi, Farkhonde Sarhaddi","doi":"10.30699/IJP.2024.2016320.3216","DOIUrl":"10.30699/IJP.2024.2016320.3216","url":null,"abstract":"<p><strong>Background & objective: </strong>Mast cells play a role in the immune responses to fatty liver disease. The present study aimed to investigate the diagnostic value of hepatic mast cell concentration (MCC) in NAFLD and NASH severity and fibrosis grade.</p><p><strong>Methods: </strong>The present cross-sectional unremarkable hepatic histology, NAFLD, or NASH cases were enrolled. Demographic variables, BMI, hepatic stiffness assessed using fibroscan, portal inflammation, hepatic disease grade assessed using the NAFLD Activity Score (NAS), and hepatic fibrosis severity assessed using the NASH fibrosis stage, hepatic necrosis severity, and hepatic steatosis severity of the patients were collected. The hepatic specimens underwent immunohistochemical (IHC) staining.</p><p><strong>Results: </strong>Of a total of 92 patients with a mean age of 38.7±13.3 years, 56 (60.9%) were males. There were significant relationships between the NAS score of the patients and hepatic steatosis. Moreover, the NASH fibrosis stage had significant relationships with the variables of hepatic necrosis, steatosis, and stiffness. There were significant positive correlations between the mast cell concentration (MCC) in all zones of the hepatic tissue (zone 1, zone 2, zone 3, portal area, and total) and the variables of age, BMI, and hepatic necrosis, steatosis, and stiffness. The patients with a higher NASH fibrosis stage showed a significantly higher MCC in all zones of the hepatic tissue.</p><p><strong>Conclusion: </strong>Hepatic mast cell number may have a significant impact on the grade and fibrosis in NAFLD. However, it is recommended to perform further studies with larger sample sizes on patients with various etiologies for hepatic injury to confirm the present study results.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 3","pages":"291-299"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemolytic Uremic Syndrome Secondary to Scorpion Envenomation in a 7-Year-Old Boy from Southwestern Iran.","authors":"Nafiseh Mortazavi, Nakysa Hooman, Mitra Mehrazma, Yasaman Moradi, Parvin Aghavali","doi":"10.30699/ijp.2024.2024403.3272","DOIUrl":"10.30699/ijp.2024.2024403.3272","url":null,"abstract":"<p><p><i>Hemiscorpius lepturus</i> is a deadly scorpion species found in the tropical regions of the Middle East. Its venom consists of a complex mixture of peptides and enzymes, including the protease toxin hemiscorpius crolysin, the analgesic peptide, and the cytotoxic agent which attacks vascular low-body weight patients, and especially young patients, are prone to systemic complications such as nephrotoxicity, hemolysis, hepatotoxicity, and even death. In this case report, we present a 7-year-old boy from city of Ahwaz in southwestern Iran, who was bitten by Gadeem (<i>H. lepturus</i>) and developed hemolytic uremic syndrome. After being stung, the patient developed hemolytic anemia, thrombocytopenia, and uremia in the subsequent days. The patient received supportive treatment, hemodialysis, and plasma exchange, and was discharged after 30 days of hospitalization.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 4","pages":"467-471"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Non-Coding RNA-Related Autophagy Alterations in Drug-Resistant Multiple Myeloma Plasma Cells.","authors":"Leila Sarafraznia, Zari Tahan Nejad Asadi, Dian Dayer, Mohammad Ali Jalalifar, Nariman Ghanatir","doi":"10.30699/ijp.2024.2022061.3256","DOIUrl":"10.30699/ijp.2024.2022061.3256","url":null,"abstract":"<p><strong>Background & objective: </strong>Multiple myeloma (MM) drug resistance is thought to be caused by the development of protective autophagy. This work aimed to assess the non-coding RNA (ncRNA) autophagy-related alterations in drug-resistant (DR) myeloma cells.</p><p><strong>Methods: </strong>DR Plasma cells were extracted from the bone marrow of DR patients referred to Baghai 2 Hospital in Ahvaz, Iran. The cells were grown in RPMI-1640 media containing 10% FBS and 1% Pen/Strep and incubated at 37˚C and 5% CO₂. After six passages, the plasma cells were precisely isolated and utilized as DR cells. The U266B1 cell line (IBRC C10148) was grown in the RPMI-1640 media containing 10% FBS and 1% Pen/Strep and utilized as drug-sensitive (DS) cells. The relative expression of the genes was determined using the Real-time PCR method. Statistical analysis of the data was performed using GraphPad Prism 8 software.</p><p><strong>Results: </strong>When the DR cells were compared to the DS cells, there was a notable increase in the expression of <i>ULK1</i> and <i>LC3B</i>. However, expression of <i>P62</i> in the DR plasma cells showed a significant decrease compared to the DS plasma cells. The <i>miR-1297</i> level was considerably higher in the DR cells than in the DS cells. Although, there was no statistically significant difference in the expression of <i>miR-26a-5p</i> between the DS and DR cells. The DR cells exhibited a statistically significant increase in the expression of <i>MALAT1</i> and <i>SNHG6</i>.</p><p><strong>Conclusion: </strong>Drug resistance in MM cells may result from overexpression of non-coding RNAs involved in autophagy.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 4","pages":"422-430"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Pattern of GATA3 Immunohistochemical Expression in Female Genital Tract Adenocarcinomas.","authors":"Elham Mirzaian, Tahereh Doustmohammadi, Mahshid Panahi, Soheila Sarmadi, Fereshteh Ameli, Fatemeh Nili","doi":"10.30699/IJP.2024.2016228.3217","DOIUrl":"10.30699/IJP.2024.2016228.3217","url":null,"abstract":"<p><strong>Background & objective: </strong>GATA3 immunohistochemistry has been described as a highly sensitive marker in determining carcinomas of breast and urothelial origin. In the gynecologic system, it can be used as a marker to diagnose mesonephric or mesonephric-like carcinomas and trophoblastic tumors. The present study was performed to determine the diagnostic value of GATA3 in gynecological adenocarcinomas.</p><p><strong>Methods: </strong>A total of 187 samples from different types of endometrial, endocervical, and ovarian carcinomas were analyzed for intensity and percentage of GATA3 expression in tumor cells. The relationship between GATA3 expression and clinicopathological parameters was investigated.</p><p><strong>Results: </strong>A total of 187 patients including 101 ovarian, 77 endometrial, and 9 endocervical adenocarcinomas were investigated. Weak and focal expression of this marker was observed in 5. 1% (4/77) endometrial, 12.9% (13/101) ovarian, and 11.1% (1/9) endocervical adenocarcinomas. The mean H score in all subtypes was less than 10.6 (2-35). There was no statistically significant correlation between GATA3 expression in tumor cells with clinical stage, and tumor recurrence or metastasis.</p><p><strong>Conclusion: </strong>GATA3 is infrequently, weak, or focally expressed in most of the common gynecological adenocarcinomas.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 2","pages":"218-224"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatic-based Study to Investigate the Structure and Function of Pro-inflammatory Cytokines TNFα and IL-6 Involved in the Pathogenesis of COVID-19.","authors":"Seyedeh Elham Norollahi, Kosar Babaei, Vida Balooei, Seyed Masoud Hashemi Karouei, Mohammad Taghi Ashoobi, Elahe Asghari Gharakhyli, Ali Akbar Samadani","doi":"10.30699/IJP.2024.2015557.3211","DOIUrl":"10.30699/IJP.2024.2015557.3211","url":null,"abstract":"<p><strong>Background & objective: </strong>Besides the clinical and laboratory research on the COVID-19 virus, the bioinformatics study in the field of genetics of immunity to COVID-19 is of particular importance. In this account, studies show that in patients with COVID-19, the level of tumor necrosis alpha (TNFα) and interleukin-6 (IL-6) is high and in severe cases of COVID-19, the production of IL-6, TNF-α, and other cytokines increases profoundly. On the other hand, investigating the molecular structure and receptors of IL-6 and TNFα and the structural analysis of the receptor proteins may potentially help to develop new therapeutic plans for COVID-19 infection.</p><p><strong>Methods: </strong>To identify genes with significant and different expressions in patients with COVID-19 in a microarray data set containing transcriptional profiles from GEO as a functional genomic database the GEO query package version 2.64.2 in a programming language R version 4.2.1 was downloaded. In this way, functional enrichment analysis for DEGs, WikiPathways, REGO, gene ontology, and STRING database was also investigated and employed.</p><p><strong>Results: </strong>The structure and function of pro-inflammatory cytokines TNFα and IL-6 involved in the pathogenesis of COVID-19 were investigated, and in general, after performing various analyses in this study and extracting A series of genes with different expressions from the KEGG database, the final 5 DEGs include CXCL14, CXCL6, CCL8, CXCR1, TNFRSF10, and the relationship and expression effects of them were observed in different pathways.</p><p><strong>Conclusion: </strong>IL-6 and TNFα were involved in immunological processes that had a direct and indirect relationship with the activation of cytokines, including IL6 and TNF-a, and cytokine storm, and this indicates their role in the formation of problems and complications, including ARDS, in COVID-19 patients. Of course, determining the effectiveness of each of these genes requires more specialized and clinical studies.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 2","pages":"205-217"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Therapy with a Novel Superantigen-based Fusion Protein Against Interleukin-13 Receptor α2-overexpressing Tumor Cells: An In-silico Study.","authors":"Zahra Gholipour, Abbas Ali Imani Fooladi, Kazem Parivar","doi":"10.30699/IJP.2024.2014231.3200","DOIUrl":"10.30699/IJP.2024.2014231.3200","url":null,"abstract":"<p><strong>Background & objective: </strong>Superantigens are bacterial toxins that induce a massive immune response in the host. Superantigen staphylococcal enterotoxin B (SEB) can form a ternary complex with its receptors, MHC class II (MHCII) and TCR, and can be used in tumor-targeting therapy, particularly when cooperating with a specific vector. In this study, SEB was fused to interleukin-13 (IL13), which forms a complex with IL13 receptor α2 (IL13Rα2) overexpressed in glioblastoma multiforme (GBM) cells for therapeutic goals.</p><p><strong>Methods: </strong>We designed four fusion proteins based on the arrangement of SEB (N- or C-terminal domain) and provided a flexible inter-domain linker (no or yes), resulting in the formation of SEB-IL13, SEB-L-IL13, IL13-SEB, and IL13-L-SEB, respectively. These fusion proteins were then evaluated for their various physicochemical properties and structural characteristics. Bioinformatics tools were employed to predict, refine, and validate the three-dimensional structure of the fusion proteins. In addition, the fusion proteins were docked with IL13Rα2, MHCII, and TCR receptors through the HADDOCK 2.4 server. The candidate fusion protein was subjected to molecular dynamics simulation.</p><p><strong>Results: </strong>There were differences among the designed fusion proteins. The model with the N-terminal domain of IL13 and containing an inter-domain linker (IL13-L-SEB) was stable and had a long half-life. The docking analysis revealed that the IL13-L-SEB fusion protein had a higher binding affinity to the IL13Rα2, MHCII, and TCR receptors. Finally, using molecular dynamics simulation through iMODS, acceptable results were obtained for the IL13-L-SEB docked complexes.</p><p><strong>Conclusion: </strong>The results suggest IL13-L-SEB is a promising novel fusion protein for cancer therapeutic application.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 2","pages":"193-204"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of P4HB and SOX4 in Prostatic Carcinoma and Their Clinical Significance.","authors":"Marwa Mohammed Dawoud, Noha Elkady, Rasha Adel Abdelmoneum, Ahmed S Ghonaimy, Dina Mohamed Allam","doi":"10.30699/IJP.2024.2017851.3227","DOIUrl":"10.30699/IJP.2024.2017851.3227","url":null,"abstract":"<p><strong>Background & objective: </strong>Prostatic adenocarcinoma (PAC) is the second most prevalent cancer and the fifth leading cause of cancer death in men worldwide. Additionally, pathologists may face problems diagnosing it reliably and may need more than one marker. Thus, the search for new immunohistochemical biomarkers becomes mandatory. This study aims to investigate P4HB and SOX4 expression in prostatic carcinoma, their possible roles, and clinical significance.</p><p><strong>Methods: </strong>This retrospective study included fifty-six cases of PAC and an equal number of nodular prostatic hyperplasia (NPH) that were immunohistochemically stained by P4HB and SOX4. The results of expression were compared between PAC and NPH cases, followed by correlations with available clinicopathological parameters.</p><p><strong>Results: </strong>There was a highly significant difference between PAC and NPH regarding P4HB and SOX4 expressions in favor of PAC (both <i>P</i><0.001). ROC curve analysis of the diagnostic power of P4HB showed 79% sensitivity, 76% specificity, and an area under the ROC curve of 0.845, while SOX4 showed (89%, 100%, and 0.946, respectively). P4HB and SOX4 expression showed a direct correlation (<i>P</i><0.001). Moreover, the H-score of SOX4 expression showed a significant inverse relation with ERG expression (<i>P</i>=0.047). There was a significant correlation between P4HB and SOX4 and Gleason score (<i>P</i><0.001). Moreover, P4HB expression was significantly associated with lymphovascular invasion (<i>P</i>=0.013), while SOX4 expression showed a significant association with perineural invasion (<i>P</i>=0.05).</p><p><strong>Conclusion: </strong>SOX4 and P4HB seem to have diagnostic and prognostic value in PAC. While there was a direct correlation between SOX4 and P4HB, an inverse relationship between SOX4 and ERG was detected.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 2","pages":"225-235"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of ER, p53, CEA and Napsin A in Histological Subtyping of Endometrial Carcinoma and Their Correlation with Clinicopathological Prognostic Parameters: Experience from a Referral Institute.","authors":"Saumya Shivakumar, Kausalya K Sahu, Ranjitha Rao, Chaithra Gv, Cheryl Sarah Philipose, Sharada Rai","doi":"10.30699/IJP.2024.2008693.3154","DOIUrl":"10.30699/IJP.2024.2008693.3154","url":null,"abstract":"<p><strong>Background & objective: </strong>Endometrial Carcinoma (EC) is the most common gynecological cancer with a global incidence of 23.2 per 1 lakh population. Histological subclassification of EC is extremely crucial for the diagnosis, proper management strategies, and prognosis. This study was conducted in a tertiary care institute to analyze the expression pattern of a minimum panel of 4 markers (ER, p53, CEA, Napsin A) with emphasis on their utility in the routine histological subtyping, aberrant expression, and correlation with various clinicopathological parameters.</p><p><strong>Methods: </strong>A time-bound cross-sectional observational and analytical study was conducted, which includes cases diagnosed in our laboratory from January 2016 to April 2021.</p><p><strong>Results: </strong>Sixty cases diagnosed as EC during the study period formed the sample cases. The ER was expressed in 85% (53/60) of cases in the current study. Among them, 94% (50/53) were endometrioid endometrial carcinomas (EECs). A negative correlation was found between ER intensity and age (r= -1.48). Of 60 EC cases, 10 (16%) cases expressed p53. The tumors positive for p53 with higher intensity were negative for ER and vice versa. The expression pattern of ER and p53 was statistically significant (<i>P</i>=-0.021). On IHC, 84.6% (11/13) of CEA-positive cases expressed both ER and CEA, suggesting mucinous differentiation. Napsin A was expressed in two cases of EEC, FIGO grade I, and one case of serous carcinoma.</p><p><strong>Conclusion: </strong>An inverse association was found between ER and p53 expression. The CEA is valuable in identifying EEC with mucinous differentiation.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 2","pages":"236-243"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}