Iranian Journal of Pathology最新文献_第8页

CD155 Expression in Invasive Breast Carcinoma: Association with Immune Tumor Microenvironment. CD155在浸润性乳腺癌中的表达：与肿瘤免疫微环境的关系

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-02-25 DOI: 10.22034/ijp.2026.2070624.3530

Asmaa Abdelkerim, Fatma Mohamed Khairy Ibrahim, Radwa Oreby, Aliaa Atef, Karima El-Desouky

{"title":"CD155 Expression in Invasive Breast Carcinoma: Association with Immune Tumor Microenvironment.","authors":"Asmaa Abdelkerim, Fatma Mohamed Khairy Ibrahim, Radwa Oreby, Aliaa Atef, Karima El-Desouky","doi":"10.22034/ijp.2026.2070624.3530","DOIUrl":"10.22034/ijp.2026.2070624.3530","url":null,"abstract":"Background & objective: CD155 is as an immune checkpoint molecule that interacts with various activating and inhibitory receptors on T- lymphocytes and natural killer (NK) cells in tumor microenvironment (TME). NK cells and tumor associated macrophages (TAMs) are major components of the immune TME.Methods: 85 cases of invasive breast carcinoma (IBC) were evaluated for immunohistochemical expression of CD155, CD56, and CD163.Results: CD155 was positive in 52.9% of cases, and was significantly associated with larger sized, higher grade, advanced stage tumors, positive lymphovascular invasion (LVI), and aggressive molecular subtypes of IBC. High density of CD56 stained tumor infiltrating NK cells was detected in 30.6% of cases, which was significantly related to larger sized, higher-grade tumors, and aggressive molecular subtypes. High density of stromal TAMs was detected in 55.3% of cases, and was significantly associated with large tumor sizes, higher grade, advanced stage, positive LVI, and aggressive molecular subtypes. CD155 expression was significantly correlated with the densities of NK cells and TAMs in TME.Conclusion: CD155 expression, high density of tumor infiltrating NK cells, and high density of stromal TAMs contribute to progression of IBC. CD155 can play an important immunoregulatory role in the TME.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"281-294"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Urinary Ferritin as a Non-Invasive Diagnostic Test for Iron Deficiency Anemia in Pediatric Populations: A Case-Control Study. 评估尿铁蛋白作为儿童人群缺铁性贫血的无创诊断试验：一项病例对照研究。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2025-11-12 DOI: 10.30699/ijp.2025.2049356.3395

Hossein Esfahani, Arya Derakhshesh, Ali Reza Soltanian, Hassan Bazmamoun, Alireza Rastgoo Haghi

{"title":"Assessment of Urinary Ferritin as a Non-Invasive Diagnostic Test for Iron Deficiency Anemia in Pediatric Populations: A Case-Control Study.","authors":"Hossein Esfahani, Arya Derakhshesh, Ali Reza Soltanian, Hassan Bazmamoun, Alireza Rastgoo Haghi","doi":"10.30699/ijp.2025.2049356.3395","DOIUrl":"10.30699/ijp.2025.2049356.3395","url":null,"abstract":"Background & objective: Iron deficiency anemia is the most prevalent form of anemia worldwide and can cause complications in children and adolescents. This study investigates the correlation between serum and urinary ferritin and evaluates the feasibility of using urinary ferritin to diagnose iron deficiency.Methods: In this case-control study, 45 patients with iron deficiency anemia were included in the case group and 45 healthy children in the control group. From each participant, 1.5 mL blood and 5 mL of urine were collected, and serum and urinary ferritin levels were measured using the chemiluminescent immunoassay (CLIA) method with Mindray kits. The results were analyzed and compared using SPSS software, version 16 (IBM Corp).Results: The mean age of patients was 7.95 years, and that of controls was 7.26 years. Female patients constituted 62.2% of the case group, and female controls represented 46.7% of the control group. In patients, the mean serum ferritin level was 13.39 ng/mL (SD = 6.37), and the mean urinary ferritin level was 3.50 ng/mL (SD = 2.65). In controls, the mean serum ferritin level was 63.7 ng/mL (SD = 41.8), and the mean urinary ferritin level was 3.98 ng/mL (SD = 2.89). Urinary ferritin demonstrated lower diagnostic accuracy for iron deficiency anemia compared with serum ferritin. The Spearman correlation coefficient between serum and urinary ferritin was 0.155, indicating a weak positive correlation.Conclusion: The findings of this study demonstrate an insignificant relationship between urine and serum ferritin levels. These findings indicate that urinary ferritin is not a reliable non-invasive alternative for diagnosing iron deficiency.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 1","pages":"41-46"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12863426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146114545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Compound Heterozygous NAGLU Gene Mutation in Two Siblings with Mucopolysaccharidosis type Iiib. 一个罕见的复合杂合NAGLU基因突变在两个兄弟姐妹粘多糖病Iiib型。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.30699/ijp.2025.2055938.3426

Laleh Vahedi-Larijani, Maryam Sotoudeh Anvari, Alireza Biglari, Maryam Nabati, Hosna Banihashemi, Marzie Mohammadi Kharkeshi

{"title":"A Rare Compound Heterozygous NAGLU Gene Mutation in Two Siblings with Mucopolysaccharidosis type Iiib.","authors":"Laleh Vahedi-Larijani, Maryam Sotoudeh Anvari, Alireza Biglari, Maryam Nabati, Hosna Banihashemi, Marzie Mohammadi Kharkeshi","doi":"10.30699/ijp.2025.2055938.3426","DOIUrl":"10.30699/ijp.2025.2055938.3426","url":null,"abstract":"Background & objective: Mucopolysaccharidosis (MPS) type III, or Sanfilippo syndrome, is an autosomal recessive lysosomal storage disorder caused by mutations in genes encoding enzymes responsible for glycosaminoglycan (GAG) degradation. This case report describes two siblings with MPS type IIIB who exhibit a rare compound heterozygous mutation in the NAGLU gene.Case presentation: A 7-year-old girl and her 4-year-old brother were referred for evaluation due to learning disabilities, aggressiveness, and coarse facial features. Enzyme assay using tandem mass spectrometry on dried blood spots in both siblings revealed absent N-acetyl-α-glucosaminidase activity.Conclusion: Targeted sequencing confirmed the diagnosis, identifying two heterozygous mutations-an in-frame insertion and a missense mutation-in exon 3 of the NAGLU gene: c.214_237dup (p.Ala72_Gly79dup) and c.625A>C (p.Thr209Pro). This rare genetic finding in two siblings with Sanfilippo syndrome type B underscores the importance of precise mutation identification. Accurate characterization of defective gene variants may provide insights into potential targets for gene therapy in monogenic disorders.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 1","pages":"128-135"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging Cytology and Histology: Concordance Analysis of Lymph Node Lesions within the Sydney Framework. 桥接细胞学和组织学：悉尼框架内淋巴结病变的一致性分析。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-05-10 DOI: 10.22034/ijp.2026.2072878.3548

Pinky Pandey, Alka Yadav, Alok Dixit, Roopak Aggarwal, Asttha Kapoor, Neelshi Pandey, Parul Verma

{"title":"Bridging Cytology and Histology: Concordance Analysis of Lymph Node Lesions within the Sydney Framework.","authors":"Pinky Pandey, Alka Yadav, Alok Dixit, Roopak Aggarwal, Asttha Kapoor, Neelshi Pandey, Parul Verma","doi":"10.22034/ijp.2026.2072878.3548","DOIUrl":"10.22034/ijp.2026.2072878.3548","url":null,"abstract":"Background & objective: Benign and malignant lymphadenopathy is a common presenting feature in a wide spectrum of diseases. Previously, there was no standard reporting system or common terminology available for lymph node cytology. A diagnostic \"gray zone\" exists in lymph node cytology, where accuracy declines, making it difficult to categorize certain lesions and leading to diagnostic discrepancies. The aim of the study was to assess the accuracy of fine needle aspiration of the lymph nodes and critically evaluate the cytohistological discordant cases. In the 20th International Congress of Cytology held in Sydney in 2019, a standardized category-based lymph node cytology reporting system was proposed.Methods: This is a retrospective study conducted at the Department of Cytopathology from January 2021 to December 2025. A total of 1500 cases were re-evaluated and reviewed and were classified according to the Sydney System and compared with clinical and histopathological diagnoses. The present study aimed to analyze and classify lymph node samples as per the newly proposed Sydney System and to calculate risk of malignancy, sensitivity, specificity, positive predictive value, and negative predictive value (NPV) for all categories, considering histopathology as the reference standard. The statistical analysis was performed using SPSS version 20.Results: Of the 1500 cases, distribution was as follows: L1, 150; L2, 1000; L3, 180; L4, 115; and L5, 55. Risk of malignancy (ROM) was 1.3% for L1, 0.7% for L2, 99.4% for L3, 99.1% for L4, and 96.36% for L5.Conclusion: The Sydney System study helped in achieving uniformity and reproducibility of cytological diagnosis. It enhanced understanding and communication between clinicians and pathologists, thereby improving patient care.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 3","pages":"359-371"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical Expression of Metastasis-Associated Gene 3 (MTA3) and Epithelial-Mesenchymal Transition (EMT) Markers in Colorectal Carcinoma: A Cross-sectional Study. 转移相关基因3 （MTA3）和上皮-间质转化（EMT）标志物在结直肠癌中的免疫组织化学表达：一项横断面研究

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-05-10 DOI: 10.22034/ijp.2026.2079960.3600

Aya Salah Ali Saad Rezk, Mohamed Alaa Mokhtar, Mohamed Ali Alrashidy, Assia Mahfouz Abd El-Raoof, Nehal Abd El-Ghaffar Heabah

{"title":"Immunohistochemical Expression of Metastasis-Associated Gene 3 (MTA3) and Epithelial-Mesenchymal Transition (EMT) Markers in Colorectal Carcinoma: A Cross-sectional Study.","authors":"Aya Salah Ali Saad Rezk, Mohamed Alaa Mokhtar, Mohamed Ali Alrashidy, Assia Mahfouz Abd El-Raoof, Nehal Abd El-Ghaffar Heabah","doi":"10.22034/ijp.2026.2079960.3600","DOIUrl":"10.22034/ijp.2026.2079960.3600","url":null,"abstract":"Background & objective: Colorectal carcinoma (CRC) is a main cause of cancer-related deaths worldwide. Studying genes involved in CRC progression helps predict prognosis and develop new therapeutic modalities. Metastasis-Associated Gene 3 (MTA3) is one of these studied genes. MTA3 could regulate tumor carcinogenesis and modulate the epithelial-mesenchymal transition (EMT) pathway due to its ability to promote or suppress target gene expression. This study evaluated the immunohistochemical expression of MTA3 and EMT markers (E-cadherin and Slug) in CRC specimens.Methods: This retrospective cross-sectional study included 81 cases of primary CRC. All cases were stained with MTA3, E-cadherin, and Slug antibodies. The relations between their expression and clinicopathological parameters, as well as the relation between MTA3 and EMT markers, were assessed.Results: High MTA3 expression and preserved membranous E-cadherin were significantly related to low tumor grade, absence of lymphovascular and perineural invasion, low depth of invasion, absence of lymph node and distant metastasis, as well as early tumor stage. High Slug expression was related to higher tumor grade, high depth of invasion, presence of lymph node and distant metastasis, as well as advanced tumor stage. There was a significant correlation between high MTA3 expression and both preserved E-cadherin (rs = 0.520, P < 0.001) and low Slug expression (rs = -0.290, P = 0.009) in the studied cases.Conclusion: MTA3 is related to favorable clinicopathological parameters in CRC and could regulate EMT marker expression, suggesting that MTA3 may play a possible role in controlling tumor cell invasion and metastasis and could exhibit a potential tumor-suppressive role.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 3","pages":"437-449"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13351380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Impact of Tumor Regression and Downstaging After Neoadjuvant Therapy in Rectal Cancer. 直肠癌新辅助治疗后肿瘤消退和降分期对预后的影响。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-05-10 DOI: 10.22034/ijp.2026.2077156.3579

Mohammad Hossein Sanei, Zohre Hemati, Behnam Sanei, Alireza Izadi, Alireza Modares, Maryam Sanei

{"title":"Prognostic Impact of Tumor Regression and Downstaging After Neoadjuvant Therapy in Rectal Cancer.","authors":"Mohammad Hossein Sanei, Zohre Hemati, Behnam Sanei, Alireza Izadi, Alireza Modares, Maryam Sanei","doi":"10.22034/ijp.2026.2077156.3579","DOIUrl":"10.22034/ijp.2026.2077156.3579","url":null,"abstract":"Background & objective: Rectal cancer is a common malignancy associated with substantial morbidity. Neoadjuvant chemoradiotherapy (CRT) is the standard treatment for locally advanced disease, often resulting in tumor regression and downstaging. This study aimed to evaluate the relationship between these response patterns and patient prognosis.Methods: A retrospective cohort study was conducted on 200 rectal cancer patients treated with neoadjuvant therapy between 2022 and 2024 at a private pathology laboratory in Isfahan, Iran. Tumor regression was graded using the Dworak system, and downstaging was assessed according to AJCC/UICC-TNM criteria. Patients were followed to evaluate associations with mortality and three-year disease-free survival (DFS).Results: Neither downstaging nor tumor regression significantly predicted disease-free survival in linear models, with downstaging showing F = 0.828 (p = 0.364) and regression yielding R² = 0.001 (p = 0.658). However, logistic regression analysis demonstrated that tumor regression significantly predicted mortality (B = 0.568, p = 0.046, Exp(B) = 1.765), whereas downstaging was not significant (B = -0.290, p = 0.600). The model explained 2.2%-4.5% of the variance in mortality and showed acceptable fit (Hosmer-Lemeshow χ² = 3.418, p = 0.491).Conclusion: Tumor biology and lymph node involvement appear to be stronger predictors of prognosis than regression or downstaging alone. Neither parameter significantly predicted disease-free survival. However, tumor regression was significantly associated with mortality, whereas downstaging was not.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 3","pages":"450-456"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors. 桥本甲状腺炎患者血清CTRP-4、CTRP-12水平与对照组的比较分析及其与生化因素的相关性

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2025001.3276

Doaa Jawad Al-Husseini, Mohsen Saravani, Shahin Nosratzehi, Hamideh Akbari, Afsaneh Shafiei, Seyyed Mehdi Jafari

{"title":"Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors.","authors":"Doaa Jawad Al-Husseini, Mohsen Saravani, Shahin Nosratzehi, Hamideh Akbari, Afsaneh Shafiei, Seyyed Mehdi Jafari","doi":"10.30699/ijp.2024.2025001.3276","DOIUrl":"10.30699/ijp.2024.2025001.3276","url":null,"abstract":"Background & objective: Hashimoto's thyroiditis (HT) is one of the most common thyroid disorders and is characterized by manifestations attributed to thyroid gland damage and inflammatory conditions. Disturbances in thyroid hormones have physiological effects on lipoprotein metabolism and liver enzymes. CTRP family: C1q/TNF-related protein (CTRP) is an adipokine superfamily of proteins. Its essential role is anti-inflammatory activation, insulin sensitization, and regulation of blood lipids. In this study, we investigated the levels of CTRP-4 and CTRP-12 in the serum of HT patients and determined their association with biochemical factors.Methods: The study included 60 participants, divided into HT patients and control groups. Diagnostic criteria for HT patients included anti-thyroid peroxidase antibodies (anti-TPO)>50 IU/mL. Serum levels of CTRP-4, CTRP-12, and anti-TPO were measured using an Enzyme-Linked Immunosorbent Assay.Results: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than in the control groups (P=0.012 and P=0.003, respectively). HT patients also exhibited higher fasting blood glucose (FBG), cholesterol, TG, HDL, and LDL serum levels. Spearman's correlation analysis revealed a positive association between serum levels of CTRP-4 and CTRP-12 and anti-TPO (respectively, r= 0.295, P=0.022 and r = 0.346, P=0.007).Conclusion: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than those in the control groups. These factors probably play a role in the pathogenesis of Hashimoto's thyroiditis. The clinical significance of these factors should be evaluated in future studies.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"42-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma. TIPE2和CD36免疫组化表达对尿路上皮癌预后影响的研究

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2029525.3301

Amira M Abd El Maged, Nahla M Badr, Hanan Lotfy Mohammed

{"title":"An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma.","authors":"Amira M Abd El Maged, Nahla M Badr, Hanan Lotfy Mohammed","doi":"10.30699/ijp.2024.2029525.3301","DOIUrl":"10.30699/ijp.2024.2029525.3301","url":null,"abstract":"Background & objective: While there are fast advances in the detection and management of bladder carcinoma, the number of deaths remains high. Therefore, the identification of an effective biomarker predicting tumor progression in cancer bladder patients is a crucial issue. This study aimed to identify TIPE2 and CD36 expressions in cancer bladder and examine their relationship with clinicopathological data and prognosis.Methods: Using immunohistochemistry, 60 specimens of bladder urothelial cancer (UC) for the expression of TIPE2 and CD36 were studied and compared with the clinicopathologic parameters and survival data. Furthermore, the association between TIPE2 and CD36 expression and Vimentin expression to elucidate the influence of TIPE2 and CD36 on the epithelial-mesenchymal transition (EMT) were investigated in UC.Results: TIPE2 expression was associated with lower stages and prolonged disease-free survival (DFS) and overall survival (OS). Therefore, TIPE2 may be considered a good indicator of UC prognosis. CD36 immuno-positivity was associated with high tumor grade, stages, shorter OS, and DFS. Therefore, the immune positivity of CD36 may be a poor prognostic marker for UC patients. Furthermore, Vimentin expression was directly correlated with CD36 expression and inversely correlated with TIPE2 expression.Conclusion: TIPE2 and CD36 may be novel biomarkers for predicting tumor metastasis and prognosis in patients with bladder UC and hold promise as therapeutic targets.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"48-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichosporon Urinary Tract Infections: A Hidden Menace Revealed. 尿路感染：一个隐藏的威胁揭示。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-08-15 DOI: 10.30699/ijp.2025.2039595.3348

Ahmad Elmimoghaddam, Mahmoud Vahidi, Reza Heidari, Mahdi Ghorbani, Peyman Aslani

{"title":"Trichosporon Urinary Tract Infections: A Hidden Menace Revealed.","authors":"Ahmad Elmimoghaddam, Mahmoud Vahidi, Reza Heidari, Mahdi Ghorbani, Peyman Aslani","doi":"10.30699/ijp.2025.2039595.3348","DOIUrl":"10.30699/ijp.2025.2039595.3348","url":null,"abstract":"Urinary tract infections (UTIs) caused by Trichosporon are a significant concern for hospitalized patients and those with weakened immune systems. This narrative review study aims to provide a comprehensive overview of UTIs caused by Trichosporon, including its frequency, risk factors, laboratory diagnostic aspects, drug resistance, and the importance of accurate identification in clinical settings. A search of international databases was conducted to identify relevant studies, and it was found that Trichosporon asahii, specifically the G1 type, is the predominant causative agent of UTIs among various Trichosporon species. Prolonged hospitalization and immunosuppressive drug use were identified as significant risk factors for this fungal infection. Conventional methods for laboratory identification are commonly used. Still, rapid and accurate tools such as Matrix-Assisted Laser Desorption-Ionisation-Time of Flight Mass Spectrometry (MALDI-TOF MS) and DNA sequencing can improve the diagnostic process. Against all T. asahii isolates for which this triazole, polyene, and echinocandin were tested, voriconazole demonstrated the most potent in vitro activity, while amphotericin B had high MIC values and echinocandins had inherent resistance. This review provides valuable insights into the clinical significance and management of UTIs caused by Trichosporon.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"367-379"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between FOXP3 Expression and Disease-Free Survival in Triple Negative Breast Cancer. 三阴性乳腺癌中FOXP3表达与无病生存的关系

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-08-15 DOI: 10.30699/ijp.2025.2052684.3418

Himawan Adhitama, Suwardjo Suwardjo, Ery Kus Dwianingsih, Teguh Aryandono

{"title":"Association between FOXP3 Expression and Disease-Free Survival in Triple Negative Breast Cancer.","authors":"Himawan Adhitama, Suwardjo Suwardjo, Ery Kus Dwianingsih, Teguh Aryandono","doi":"10.30699/ijp.2025.2052684.3418","DOIUrl":"10.30699/ijp.2025.2052684.3418","url":null,"abstract":"Background & objective: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen, progesterone, and HER2 receptors, often leading to poor prognosis due to high recurrence and metastasis. FOXP3 expression, associated with suppressed anti-tumor immunity, is a potential prognostic marker in TNBC. However, the association between FOXP3 expression and disease-free survival (DFS) in TNBC remains controversial. This study aims to explore the relationship between FOXP3 expression and DFS in TNBC patients, contributing to the understanding of its prognostic significance.Methods: This retrospective study included 47 TNBC patients. Immunohistochemistry examination assessed FOXP3 expression, which was then categorized into low and high expression based on an optimal cut-off point. Univariate and multivariate analyses were conducted using Cox regression test to determine association between variables and DFS. Survival analysis was assessed using the Kaplan-Meier method and the log-rank test.Results: All patients were female mostly over 50 years old (66%). The majority had tumors >2 cm (87.2%) and LVI (66%). High-grade tumors (grade 3) were predominant (93.6%). Most patients showed moderate TIL levels (91.5%). No significant associations were found between FOXP3 expression and age (p=0.253), tumor size (p=0.308), lymph node status (p=0.466), tumor grade (p=0.476), LVI (p=0.422), patient's stage (p=0.644), and TILs (p=0.783). However, high FOXP3 expression was significantly associated with worse DFS (p=0.019). Additionally, a higher stage was associated with worse DFS (p=0.002).Conclusion: High FOXP3 expression is associated with lower DFS in TNBC patients. FOXP3 expression was not associated with age, tumor size, lymph node status, tumor grade, LVI, TILs, or cancer stage.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"386-393"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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