Iranian Journal of Pathology最新文献

{"title":"Prevalence of <i>algD</i>, <i>pslD</i>, and <i>pelF</i> Genes Involved in Biofilm <i>Formation in Clinical MDR Pseudomonas aeruginosa</i> Strains.","authors":"Zahra Haghighatian, Negar Shirani, Gholamreza Goudarzi, Pegah Shakib, Fatemeh Jahani, Sodabeh Zare","doi":"10.30699/ijp.2025.2057524.3439","DOIUrl":"10.30699/ijp.2025.2057524.3439","url":null,"abstract":"<p><strong>Background & objective: </strong>The purpose of this research was to determine the frequency of <i>algD, pslD,</i> and <i>pelF genes</i> in biofilm formation among MDR and non-MDR clinical strains of <i>Pseudomonas aeruginosa</i> in Khorramabad, Iran (2024).</p><p><strong>Methods: </strong>This cross-sectional study included all <i>Pseudomonas aeruginosa</i> isolates collected from various clinical samples in Khorramabad teaching hospitals in 2024. After confirming the isolates and determining their antibiotic resistance patterns using the disc diffusion method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines, <i>algD, pelF,</i> and <i>pslD</i> genes were detected by PCR.</p><p><strong>Results: </strong>The highest sensitivity was observed to imipenem (75%) and meropenem (71.3%), while the greatest resistance was recorded against ciprofloxacin, ceftazidime, and tobramycin 45 (56.25%). The frequencies of the <i>algD, pelF</i>, and <i>pslD</i> genes were 88.8, 76.3, and 96.3%, respectively. A significant association was found between the <i>PelF</i> and <i>algD</i> genes with multidrug resistance (MDR) (P<0.05).</p><p><strong>Conclusion: </strong>The presence of multi-drug resistance (MDR) in this study indicates the need for serious measures to control infections caused by this bacterium. Further research is recommended to explore the contribution of biofilm-associated genes to the development of multi-drug resistance (MDR).</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"380-385"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiosarcoma Revisited: Diagnostic Challenges and a 16-Year Retrospective Analysis from a Single Institution.","authors":"Swathi Prabhu, Nischitha Suvarna, Kanthilatha Pai, Ranjini Kudva, Deepak Nayak, Harshavardhan Shetty, Vidya Monappa","doi":"10.30699/ijp.2025.2056760.3434","DOIUrl":"10.30699/ijp.2025.2056760.3434","url":null,"abstract":"<p><strong>Background & objective: </strong>Angiosarcomas (AS) are rare, aggressive malignant tumors characterized by marked histopathologic heterogeneity, often mimicking other neoplasms and complicating diagnosis. This 16-year retrospective study aimed to evaluate the clinicopathological spectrum of AS, with particular emphasis on diagnostic challenges and strategies for accurate identification.</p><p><strong>Methods: </strong>We retrospectively reviewed 11 histologically confirmed cases of AS diagnosed at our institution between January 2008 and December 2023. The data collected included patient demographics, clinical presentation, tumor location, histopathologic features, immunohistochemical (IHC) profiles, treatment modalities, and clinical outcomes.</p><p><strong>Results: </strong>Patient ages ranged from 25 to 62 years, with a slight female predominance (male-to-female ratio, 0.8:1). Tumor locations were variable, and histologic patterns ranged from well-differentiated, low-grade vascular proliferations resembling hemangiomas to poorly differentiated neoplasms mimicking pleomorphic undifferentiated sarcomas. IHC findings demonstrated overlapping marker expression, including cytokeratin (CK) positivity, which may lead to misdiagnosis as carcinoma, and loss of H3K27me3 expression, which can raise suspicion for malignant peripheral nerve sheath tumors (MPNST). Several cases also exhibited morphologic features closely resembling epithelioid hemangioendothelioma.</p><p><strong>Conclusion: </strong>Angiosarcoma poses considerable diagnostic difficulty due to its morphologic variability and overlapping immunophenotypic profiles. Accurate diagnosis necessitates a multidisciplinary approach, integrating clinical, radiologic, and pathologic data. This study highlights the importance of diagnostic vigilance and comprehensive evaluation when assessing vascular neoplasms.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"411-420"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EGFR Status by Immunohistochemistry in Triple-Negative Breast Cancer: An Evaluation of Prevalence and Association with Clinical and Pathological Parameters.","authors":"Elham Jafari, Mina Bagheri, Shahriar Dabiri, Aliasghar Tirgar, Vahid Moazed","doi":"10.30699/ijp.2025.2042447.3363","DOIUrl":"10.30699/ijp.2025.2042447.3363","url":null,"abstract":"<p><strong>Background & objective: </strong>This study aimed to evaluate the expression patterns of epidermal growth factor receptor (EGFR) in patients with triple-negative breast cancer (TNBC) in Kerman, Iran, and investigate its association with various clinicopathological factors.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted on 54 TNBC patients diagnosed between 2013 and 2022. Immunohistochemistry (IHC) was performed to assess EGFR expression levels in tumor tissue samples. Patients were classified as EGFR-positive or EGFR-negative based on IHC staining results. Clinicopathological data, including age, tumor grade, vascular invasion, lymph node involvement, Ki-67 proliferation index, presence of necrosis, ductal carcinoma in situ (DCIS), and microcalcifications, were collected. Statistical analyses were performed to examine the association between EGFR expression and clinicopathological variables.</p><p><strong>Results: </strong>EGFR expression was positive in 61.1% of the patients. A significant association was found between EGFR positivity and higher tumor histologic grade (P = 0.045), with 69.7% of EGFR-positive patients exhibiting grade III tumors compared to 38.1% in the EGFR-negative group. Although not statistically significant, EGFR-positive patients tended to be younger (median age 44 years) than EGFR-negative patients (median age 52 years) (P = 0.157). The Ki-67 proliferation index was higher in EGFR-positive patients (median 60.0%) compared to EGFR-negative patients (median 47.5%).</p><p><strong>Conclusion: </strong>EGFR expression is significantly associated with higher tumor grade, suggesting a correlation with more aggressive tumor behavior. EGFR may serve as a potential prognostic marker and therapeutic target in TNBC. Further research with larger cohorts is recommended to validate these findings and explore the implications of EGFR-targeted therapies in TNBC management.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"463-470"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Thrombomodulin Expression with Bladder Cancer Grade, Stage, and Recurrence: A Single-Center Prospective Pilot Study.","authors":"Mohammad Reza Nikoobakht, Shima Esmaeilpanah, Iman Menbari Oskouie, Mahdi Khoshchehreh, Farshid Alaeidini, Seyed Mohammad Kazem Aghamir","doi":"10.30699/ijp.2025.2047132.3387","DOIUrl":"10.30699/ijp.2025.2047132.3387","url":null,"abstract":"<p><strong>Background & objective: </strong>Bladder cancer is the fourth most prevalent malignancy and lacks reliable biomarkers for predicting tumor stage, grade, and clinical outcomes. This study aimed to evaluate the association between thrombomodulin (TM)-positive cell rate (PR) and tumor grade, stage, and recurrence in patients with bladder cancer.</p><p><strong>Methods: </strong>This prospective observational pilot study was conducted at the Urology Clinic of Sina Hospital, Tehran, between March and December 2022. A total of 51 patients diagnosed with bladder cancer following cystoscopy and transurethral resection of bladder tumor (TURBT) were enrolled. Of these, 11 patients with stage T2 disease underwent radical cystectomy. TM expression was assessed by immunohistochemical staining, and the PR score was calculated. The remaining 40 patients underwent follow-up cystoscopy 3 months post-TURBT to assess for recurrence or progression. Statistical analyses were performed using SPSS version 26, with comparisons of quantitative variables conducted using ANOVA and t tests.</p><p><strong>Results: </strong>The mean age of participants was 66.73 ± 11.00 years, and 46 were male. The mean TM PR value was 25.51 ± 6.24. No significant differences in TM PR values were observed among different tumor grades (p = 0.144) or stages (p = 0.815). Additionally, there were no significant differences in TM PR values or PR scores between patients with and without recurrence at 3-month follow-up cystoscopy (p = 0.144 and p = 0.085, respectively).</p><p><strong>Conclusion: </strong>TM PR values did not correlate with tumor grade, stage, or recurrence in this cohort of bladder cancer patients. Further studies with larger sample sizes and longer follow-up periods are warranted.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 3","pages":"266-272"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Cytokeratin 19 Expression in Oral Carcinogenesis.","authors":"Narges Ghazi, Nasrollah Saghravanian, Soheila Shamshiri, Yasamin Ayatollahi","doi":"10.30699/ijp.2025.2044451.3375","DOIUrl":"10.30699/ijp.2025.2044451.3375","url":null,"abstract":"<p><strong>Background & objective: </strong>Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral cancers. Cytokeratin 19 (CK19), produced by suprabasal epithelial cells, reflects alterations in cellular behavior and has been associated with premalignant changes in the oral epithelium. This study aimed to evaluate the expression of CK19 in OSCC and oral epithelial dysplasia (OED) and its potential role in oral carcinogenesis.</p><p><strong>Methods: </strong>A total of 50 samples were analyzed, including 30 OSCC cases and 10 OED cases obtained from the archives of the Department of Pathology, as well as 10 normal oral mucosa samples collected from clinically healthy areas adjacent to mucocele lesions. CK19 expression was assessed using immunohistochemistry.</p><p><strong>Results: </strong>Positive immunoreactivity for CK19 was observed in 90% (27/30) of OSCC samples. CK19 expression in the OSCC group was significantly higher compared to the OED and normal mucosa groups. Among OSCC cases, grade III tumors exhibited stronger CK19 expression than grades I and II. Additionally, CK19 expression in grade II OSCC was higher than in the OED group.</p><p><strong>Conclusion: </strong>The progressive increase in CK19 expression from normal mucosa to OED and OSCC supports its involvement in oral mucosal carcinogenesis. Moreover, higher CK19 expression correlated with increasing tumor grade and decreasing cellular differentiation, suggesting its potential value as a diagnostic and prognostic biomarker in OSCC.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 3","pages":"280-287"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interobserver Variability in Ki-67 Index Assessment of Gastroenteropancreatic Neuroendocrine Neoplasms: A Comparative Evaluation of Three Counting Methods.","authors":"Emerine Selma Edwin, Pooja K Suresh, Hema Kini, Saraswathy Sreeram, Jyoti Kini, Sridevi Hb, Sneha Ar Rao","doi":"10.30699/ijp.2025.2055662.3423","DOIUrl":"10.30699/ijp.2025.2055662.3423","url":null,"abstract":"<p><strong>Background & objective: </strong>Accurate evaluation of the Ki-67 proliferation index is critical in the grading and prognostication of neuroendocrine neoplasms (NENs). This study aimed to compare three different methods of Ki-67 index assessment in primary gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs).</p><p><strong>Methods: </strong>The Ki-67 proliferation index was assessed by immunohistochemical (IHC) staining in 41 cases of primary GEP-NENs. Two pathologists independently evaluated the Ki-67 index using two visual estimation methods: eyeballing and eye-counting under a light microscope. A third method involved manual counting of Ki-67-positive and -negative nuclei on a captured image using ImageJ software. Interobserver and intermethod reproducibility were analyzed using Pearson's correlation coefficient (R) and the intraclass correlation coefficient (ICC) to assess agreement among the four observers and between each observer and the manual method.</p><p><strong>Results: </strong>The ICC among the four observers was 0.993, indicating excellent interobserver agreement. The ICC between each observer's score and the manual counting method was 0.994, also demonstrating high concordance.</p><p><strong>Conclusion: </strong>All three methods, eyeballing, eye-counting, and manual counting using ImageJ, proved to be comparably effective in assessing the Ki-67 proliferation index in GEP-NENs. Notably, the simpler microscopic techniques of eyeballing and eye-counting showed excellent agreement with the manual image-based method, supporting their reliability in routine practice.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"404-410"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance, a Global Challenge.","authors":"Alireza Abdollahi, Mohammad Reza Jalali Nadoushan","doi":"10.30699/ijp.2025.2056060.3444","DOIUrl":"10.30699/ijp.2025.2056060.3444","url":null,"abstract":"","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"352-354"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Serum IL-35 and TGF-β Levels with the Incidence, Severity, and Treatment Response in Iraqi Patients with Graves' Disease.","authors":"Zahraa L Hussein, Karrar S Zayed","doi":"10.30699/ijp.2025.2066164.3489","DOIUrl":"10.30699/ijp.2025.2066164.3489","url":null,"abstract":"<p><strong>Background & objective: </strong>Graves' disease (GD) is a common autoimmune thyroid disorder characterized by thyroid hormone hypersecretion and autoantibody formation against the thyrotropin receptor (TRAb). Interleukin-35 (IL-35), a novel immunosuppressive cytokine of the IL-12 family secreted primarily by regulatory T and B cells, has been implicated in the modulation of autoimmune responses. Transforming growth factor β (TGF-β) is a cytokine with immunoregulatory properties that plays a central role in T-regulatory cell differentiation. This study aimed to investigate serum IL-35 and TGF-β levels in Iraqi patients with GD and assess their association with disease severity, clinical manifestations, and response to carbimazole therapy.</p><p><strong>Methods: </strong>A total of 103 participants were enrolled, including 66 patients with GD (mean age, 41.6 [SD, 13.95] years) and 37 healthy controls (mean age, 37.43 [SD, 10.25] years). Serum IL-35 and TGF-β concentrations were measured using enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>IL-35 levels were significantly reduced in untreated GD patients compared with healthy controls and partially increased after carbimazole therapy (<i>P < .001</i>). TGF-β levels were highest in untreated patients and declined after treatment (<i>P < .001</i>). IL-35 showed no correlation with FT3, FT4, or TRAb but was elevated in patients with disease duration longer than 5 years (<i>P = .046</i>) and in those with severe exophthalmos (<i>P = .03</i>). TGF-β levels were inversely correlated with FT3, FT4, and TRAb (<i>P < .05</i>) and were higher in carbimazole nonresponders and in patients with severe exophthalmos (<i>P < .05</i>).</p><p><strong>Conclusion: </strong>IL-35 may serve as a promising biomarker for monitoring disease activity, prognosis, and therapeutic response in patients with GD.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"446-453"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>STAT4</i> (rs7574865) Polymorphism and Serum STAT4 Levels in Rheumatoid Arthritis Susceptibility, Severity, and Treatment Response: A Case-Control Study in Iraqi Patients.","authors":"Amna R Abdalhussein, Karrar S Zayed","doi":"10.30699/ijp.2025.2064449.3485","DOIUrl":"10.30699/ijp.2025.2064449.3485","url":null,"abstract":"<p><strong>Background & objective: </strong>Signal Transducer and Activator of Transcription 4 (STAT4) is a key transcription factor involved in immune signaling pathways and has been implicated in susceptibility to rheumatoid arthritis (RA) across various populations. However, its role in Iraqi Arab cohorts remains largely unexplored.</p><p><strong>Methods: </strong>A case-control study was conducted including 68 RA patients and 39 age- and sex-matched apparently healthy individuals. The association between the STAT4 (rs7574865) polymorphism, serum STAT4 levels, RA susceptibility, and therapeutic response to methotrexate (MTX), MTX + infliximab, and tofacitinib was investigated using PCR-RFLP and ELISA techniques.</p><p><strong>Results: </strong>The frequencies of the GT and (GT+TT) genotypes were significantly higher among RA patients than in controls under codominant and dominant models (<i>P</i> = .003 and <i>P</i> < .001, respectively). The T allele was also significantly more frequent in RA patients than in healthy individuals (<i>P</i> = .001). GT and TT genotypes were significantly associated with severe disease (<i>P</i> = .042) and poor response to tofacitinib compared with the GG genotype (<i>P</i> = .042). Serum STAT4 levels were markedly elevated in RA patients compared with controls (<i>P</i> = .01), particularly in those with severe RA (<i>P</i> = .042).</p><p><strong>Conclusion: </strong>\u0000 <b>The STAT4 rs7574865 T allele may contribute to increased susceptibility to RA, greater disease severity, and reduced responsiveness to tofacitinib therapy in Iraqi patients.</b>\u0000 </p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 4","pages":"421-430"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145303931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Tubular Adenoma of the Breast in an Adolescent: Diagnostic Challenges and Literature Review.","authors":"Monica Mishra, Seetu Palo","doi":"10.30699/ijp.2025.2056026.3428","DOIUrl":"10.30699/ijp.2025.2056026.3428","url":null,"abstract":"","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 3","pages":"348-351"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}