Iranian Journal of Pathology最新文献

Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors. 桥本甲状腺炎患者血清CTRP-4、CTRP-12水平与对照组的比较分析及其与生化因素的相关性

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2025001.3276

Doaa Jawad Al-Husseini, Mohsen Saravani, Shahin Nosratzehi, Hamideh Akbari, Afsaneh Shafiei, Seyyed Mehdi Jafari

{"title":"Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors.","authors":"Doaa Jawad Al-Husseini, Mohsen Saravani, Shahin Nosratzehi, Hamideh Akbari, Afsaneh Shafiei, Seyyed Mehdi Jafari","doi":"10.30699/ijp.2024.2025001.3276","DOIUrl":"10.30699/ijp.2024.2025001.3276","url":null,"abstract":"Background & objective: Hashimoto's thyroiditis (HT) is one of the most common thyroid disorders and is characterized by manifestations attributed to thyroid gland damage and inflammatory conditions. Disturbances in thyroid hormones have physiological effects on lipoprotein metabolism and liver enzymes. CTRP family: C1q/TNF-related protein (CTRP) is an adipokine superfamily of proteins. Its essential role is anti-inflammatory activation, insulin sensitization, and regulation of blood lipids. In this study, we investigated the levels of CTRP-4 and CTRP-12 in the serum of HT patients and determined their association with biochemical factors.Methods: The study included 60 participants, divided into HT patients and control groups. Diagnostic criteria for HT patients included anti-thyroid peroxidase antibodies (anti-TPO)>50 IU/mL. Serum levels of CTRP-4, CTRP-12, and anti-TPO were measured using an Enzyme-Linked Immunosorbent Assay.Results: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than in the control groups (P=0.012 and P=0.003, respectively). HT patients also exhibited higher fasting blood glucose (FBG), cholesterol, TG, HDL, and LDL serum levels. Spearman's correlation analysis revealed a positive association between serum levels of CTRP-4 and CTRP-12 and anti-TPO (respectively, r= 0.295, P=0.022 and r = 0.346, P=0.007).Conclusion: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than those in the control groups. These factors probably play a role in the pathogenesis of Hashimoto's thyroiditis. The clinical significance of these factors should be evaluated in future studies.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"42-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma. TIPE2和CD36免疫组化表达对尿路上皮癌预后影响的研究

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2029525.3301

Amira M Abd El Maged, Nahla M Badr, Hanan Lotfy Mohammed

{"title":"An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma.","authors":"Amira M Abd El Maged, Nahla M Badr, Hanan Lotfy Mohammed","doi":"10.30699/ijp.2024.2029525.3301","DOIUrl":"10.30699/ijp.2024.2029525.3301","url":null,"abstract":"Background & objective: While there are fast advances in the detection and management of bladder carcinoma, the number of deaths remains high. Therefore, the identification of an effective biomarker predicting tumor progression in cancer bladder patients is a crucial issue. This study aimed to identify TIPE2 and CD36 expressions in cancer bladder and examine their relationship with clinicopathological data and prognosis.Methods: Using immunohistochemistry, 60 specimens of bladder urothelial cancer (UC) for the expression of TIPE2 and CD36 were studied and compared with the clinicopathologic parameters and survival data. Furthermore, the association between TIPE2 and CD36 expression and Vimentin expression to elucidate the influence of TIPE2 and CD36 on the epithelial-mesenchymal transition (EMT) were investigated in UC.Results: TIPE2 expression was associated with lower stages and prolonged disease-free survival (DFS) and overall survival (OS). Therefore, TIPE2 may be considered a good indicator of UC prognosis. CD36 immuno-positivity was associated with high tumor grade, stages, shorter OS, and DFS. Therefore, the immune positivity of CD36 may be a poor prognostic marker for UC patients. Furthermore, Vimentin expression was directly correlated with CD36 expression and inversely correlated with TIPE2 expression.Conclusion: TIPE2 and CD36 may be novel biomarkers for predicting tumor metastasis and prognosis in patients with bladder UC and hold promise as therapeutic targets.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"48-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent Microscopy: A Useful and Adjunct Tool in Leprosy Diagnosis: A Cross Sectional Study. 荧光显微镜：一个有用的辅助工具在麻风病诊断：横断面研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2023590.3263

Swati Soni, Vaishali Walke, Dinesh Asati, Anand Maurya, Sramana Mukhopadhyay

{"title":"Fluorescent Microscopy: A Useful and Adjunct Tool in Leprosy Diagnosis: A Cross Sectional Study.","authors":"Swati Soni, Vaishali Walke, Dinesh Asati, Anand Maurya, Sramana Mukhopadhyay","doi":"10.30699/ijp.2024.2023590.3263","DOIUrl":"10.30699/ijp.2024.2023590.3263","url":null,"abstract":"Background & objective: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Fite-Faraco (FF) is the routine staining method used to demonstrate the presence of Mycobacterium leprae in tissue sections. Fluorescent microscopy (FM) can help visualize lepra bacilli better. The present study compares two methodologies, fluorescent microscopy, and Fite-Faraco, in detecting Mycobacterium leprae in tissue sections.Methods: Histopathology of skin biopsies in 60 cases of Hansen's were evaluated with FF stain. The performance of Auramine- Rhodamine Fluroscencent stain was compared with conventional FF staining in identifying Lepra bacilli.Results: A total of 60 clinically and histopathologically confirmed cases of Hansen's disease were included in this ambispective study. The cases were sub-classified into various histological categories. Auramine-rhodamine fluorescent staining was performed and examined under a fluorescent microscope with an LED light illuminator. The bacteriological index (BI) was calculated under an oil immersion field for both Fite-Faraco (FF) staining and fluorescent microscopy (FM), graded from zero to six plus according to Ridley's logarithmic scale. Lepra bacilli were identified in 70% of patients on FF staining, while fluorescent microscopy showed positivity in 80%. The mean BI calculated by FM (2.48) was significantly higher than that by the FF method (2.18), and more multibacillary disease was identified by fluorescent staining compared to FF staining.Conclusion: It is advantageous to use fluorescent microscopy as an adjunct to conventional Fite-Faraco stain especially in cases where the latter fails to detect lepra bacilli and in a clinically suspected multibacillary disease.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study. 腹腔镜袖胃切除术对病态肥胖患者甲状腺功能减退的影响：一项为期一年的随访前瞻性队列研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2026732.3290

Nasser Malekpour Alamdari, Iman Ansari, Mohammad Ali Azizi Nadian, Mahdiyeh Sadat Seyyedi, Maryam Abbasi

{"title":"Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study.","authors":"Nasser Malekpour Alamdari, Iman Ansari, Mohammad Ali Azizi Nadian, Mahdiyeh Sadat Seyyedi, Maryam Abbasi","doi":"10.30699/ijp.2024.2026732.3290","DOIUrl":"10.30699/ijp.2024.2026732.3290","url":null,"abstract":"Background & objective: Obesity is a growing public health problem worldwide. Bariatric surgery is considered the safest and most effective therapeutic option, although it is associated with various metabolic and neurohormonal consequences. This study aims to evaluate the effect of sleeve gastrectomy (SG) on hypothyroidism within one year following surgery.Methods: In this single-center prospective cross-sectional study, patients with morbid obesity who were candidates for SG were included. Body mass index (BMI), levothyroxine dosage, and thyroid function tests were compared at baseline and 12 months after surgery.Results & conclusion: Patients' BMI, levothyroxine dosage, TSH, and T4 levels decreased significantly after surgery (P<0.0001). The effect of SG on T3 levels was not statistically significant. The results of this study demonstrate that SG can significantly improve thyroid function tests in patients with morbid obesity and reduce their need for levothyroxine within one year following surgery.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"133-137"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The In vitro Effect of Nanoliposomal Amphotericin B Against Rhizopus arrhizus Isolated From COVID-19-Associated Mucormycosis Patients. 纳米脂质体两性霉素B对新型冠状病毒相关毛霉病患者分离的阿根霉的体外抑制作用

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2033626.3320

Ali Ahmadi, Sayed Jamal Hashemi, Seyed Mahdi Rezayat, Roshanak Daie-Ghazvini, Mahmoud Reza Jaafari, Jamileh Esmaeili, Fatemeh Saiedmohammadi, Farzaneh Afshari, Laura Alcazar-Fuoli, Alireza Abdollahi, Sadegh Khodavaisy

{"title":"The In vitro Effect of Nanoliposomal Amphotericin B Against Rhizopus arrhizus Isolated From COVID-19-Associated Mucormycosis Patients.","authors":"Ali Ahmadi, Sayed Jamal Hashemi, Seyed Mahdi Rezayat, Roshanak Daie-Ghazvini, Mahmoud Reza Jaafari, Jamileh Esmaeili, Fatemeh Saiedmohammadi, Farzaneh Afshari, Laura Alcazar-Fuoli, Alireza Abdollahi, Sadegh Khodavaisy","doi":"10.30699/ijp.2024.2033626.3320","DOIUrl":"10.30699/ijp.2024.2033626.3320","url":null,"abstract":"Background & objective: Rhizopus arrhizus, a major contributor to COVID-19-associated mucormycosis (CAM) globally. Nanoliposomal amphotericin B (NLAmB) presents a promising approach due to its enhanced drug delivery and reduced side effects. This study aimed to assess the in vitro antifungal susceptibility of NLAmB against R. arrhizus isolated from CAM patients.Methods: Thirty-nine R. arrhizus isolated from CAM patients were identified through phenotypic characterization, MALDI-TOF, and the internal transcribed spacer rDNA region (ITS) sequencing approaches. Antifungal susceptibility testing (AFST) for NLAmB, amphotericin B (AmB), posaconazole (PSC), and isavuconazole (ISC) was conducted through broth microdilution methods according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standard E.DEF 9.4. Results were analyzed for MIC ranges, MIC50, MIC90, and distributions.Results: NLAmB demonstrated superior in vitro efficacy against R. arrhizus (MIC50/90, 0.063/0.25 μg/ml) compared to AmB, PSC, and ISC. PSC exhibited notable activity (MIC range: ≤0.031 - ≥16 μg/ml).Conclusion: The study emphasized NLAmB's sustained activity, making it a potential alternative to LAmB. Further exploration and clinical correlation are warranted to validate NLAmB in CAM treatment.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"84-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Significance of Eosinophil Infiltration in Diagnosis of Psoriasis: A Cross-sectional Analysis. 探讨嗜酸性粒细胞浸润在银屑病诊断中的意义：横断面分析。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2013501.3191

Maryam Khalili, Afsaneh Kooshesh, Simin Shamsi-Meymandi, Niloofar Mehrolhasani, Rezvan Amiri, Mohammad Rezaei Zadeh Rukerd, Mahin Aflatoonian

{"title":"Exploring the Significance of Eosinophil Infiltration in Diagnosis of Psoriasis: A Cross-sectional Analysis.","authors":"Maryam Khalili, Afsaneh Kooshesh, Simin Shamsi-Meymandi, Niloofar Mehrolhasani, Rezvan Amiri, Mohammad Rezaei Zadeh Rukerd, Mahin Aflatoonian","doi":"10.30699/ijp.2024.2013501.3191","DOIUrl":"10.30699/ijp.2024.2013501.3191","url":null,"abstract":"Background & objective: There is controversy whether eosinophils are involved in the pathogenesis of psoriasis. This study aims to assess the quantity of eosinophils in pathological specimens obtained from individuals diagnosed with psoriasis.Methods: cross-sectional and retrospective study 91 skin samples were obtained from patients with diagnosis of psoriasis. Two experienced dermatologists thoroughly reviewed the specimens' demographic characteristics, clinical features, and pathological attributes. Subsequently, eosinophils were counted within all microscopic fields, utilizing a magnification of 200.Results: Eosinophils were present in approximately 70.3% of the examined samples, with a mean eosinophil count of 2.42±0.63. Although no significant correlation was observed between the clinical subtype and the average eosinophil count, eosinophils were most commonly detected in the cases presenting generalized pustular psoriasis (100%) and vulgaris types (71.11%). Notably, patients exhibiting Munro's microabscess and dilated papillary dermal blood vessels exhibited a significantly higher number of eosinophils (P=0.007 and P=0.039, respectively). Additionally, a notable association was identified between presence of spongiosis, and eosinophil counts in the pathological samples (P=0.04).Conclusion: Presence of eosinophils may not contradict a diagnosis of psoriasis. Furthermore, a notable association may be observed between the number of eosinophils and presence of spongiosis, dilated dermal papillary vessels, and Munro's microabscess.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of The Milan System for Reporting Salivary Gland Cytology: A 5-Year Retrospective Review. 米兰系统报告唾液腺细胞学的有效性：5年回顾性回顾。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2021304.3249

Afrooz Arashloo, Hana Saffar, Maryam Lotfi, Fereshteh Ameli

{"title":"Effectiveness of The Milan System for Reporting Salivary Gland Cytology: A 5-Year Retrospective Review.","authors":"Afrooz Arashloo, Hana Saffar, Maryam Lotfi, Fereshteh Ameli","doi":"10.30699/ijp.2024.2021304.3249","DOIUrl":"10.30699/ijp.2024.2021304.3249","url":null,"abstract":"Background & objective: Use of fine needle aspiration cytology (FNAC) in the diagnosis of salivary gland neoplasms is controversial due to the diverse morphologic patterns and overlapping features between benign and malignant lesions. The Milan system has been introduced to report salivary gland cytopathology. The present study aimed to reclassify salivary gland lesions according to the Milan system for reporting salivary gland cytopathology (MSRSGC) to determine the risk of malignancy (ROM) and to estimate the diagnostic accuracy of the Milan system.Methods: In this retrospective cohort study, 136 salivary gland fine needle aspiration cytology samples taken from patients referred to Imam Khomeini and Amir-Aalam Hospital, Tehran, Iran, from 2016 to 2021, were retrieved along with the histopathological follow-up. Cytology smears were reviewed and reclassified based on MSRSGC. In addition, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy were calculated.Results: ROM for each category was 26.7% for non-diagnostic, 12.5% for non-neoplastic, 40% for atypia of undetermined significance (AUS), 0 for benign neoplasm, 0 for salivary gland neoplasm with uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 100% for malignant group. Sensitivity, specificity, PPV, and NPV in differentiating benign from malignant neoplasms based on MSRSGC were 75.9%, 100%, 100%, and 93.8%, respectively. Diagnostic accuracy was calculated as 94.8%.Conclusion: MSRSGC may be associated with a high accuracy in differentiation of benign from malignant salivary gland neoplasms, indicating its potential value as an effective classification system for reporting salivary gland cytology. The ROM for cytological categories except SUMP can be almost similar to that suggested by MSRSGC.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"76-83"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the Diagnostic Accuracy of Impression Cytology for Conjunctival Lesions: A Comparative Study with Histopathology. 评价印象细胞学对结膜病变的诊断准确性：与组织病理学的比较研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2025786.3284

Fatemeh Eslami, Hamidreza Ghasemibasir, Sara Alipour, Ramin Mansouri

{"title":"Evaluating the Diagnostic Accuracy of Impression Cytology for Conjunctival Lesions: A Comparative Study with Histopathology.","authors":"Fatemeh Eslami, Hamidreza Ghasemibasir, Sara Alipour, Ramin Mansouri","doi":"10.30699/ijp.2024.2025786.3284","DOIUrl":"10.30699/ijp.2024.2025786.3284","url":null,"abstract":"Background & objective: Conjunctival lesions have a wide range of histological manifestations that are difficult to distinguish clinically. The gold standard for diagnosis of these lesions is the pathological examination, a costly and invasive procedure that may also adversely affect patients. Therefore, clinical researchers seek less invasive, inexpensive, and easier methods to detect conjunctival lesions. This study aims to compare the accuracy of impression cytology with pathology in patients referred to Farshchian Hospital in Iran.Methods: In this descriptive/cross-sectional study, 64 patients with conjunctival lesions were selected from patients referred to Farshchian Hospital in Hamedan in 2021. A cytology specimen was obtained from the patients and sent to the laboratory. The diagnostic accuracy of this method was compared with pathological results (gold standard). Data were analyzed by SPSS 16 software.Results: The mean age of patients was 54.47 ±16.94 years; 70.3% were male, and 29.7% were female. In the cytologic and pathologic examination, 28.1% of the specimens showed dysplasia, and 71.9% were non-dysplastic. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the cytologic impression compared to the pathologic methods were 91.30%, 77.78%, 91.30%, 77.78%, and 87.5%, respectively. A positive and significant correlation was observed between pathological and cytological diagnosis scores (r=0.825, P-value<0.001).Conclusion: In conjunctival lesions, impression cytology may be a relatively accurate and sensitive procedure that can distinguish dysplastic from non-dysplastic conjunctival lesions.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "p53 IHC Result as a Prognostic Tool in MDS". 对“p53 IHC结果作为MDS预后工具”的评论。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2027620.3295

William Gesztes, Vahid Mehrtash, Victor E Nava

引用次数: 0

The Association Between RACK1 Gene Polymorphisms rs1279736 and rs3756585 in Uterine Cervical Cancer with the Risk Factor of HPV: A Focus on Squamous Cell Carcinoma (SCC). 子宫颈癌RACK1基因多态性rs1279736和rs3756585与HPV危险因素的关系：以鳞状细胞癌（SCC）为例

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2019194.3236

Maryam Fekri Soofi Abadi, Fatemeh Hashemi, Saeedeh Shojaeepour, Sahar Amirpour-Rostami, Mohammad Reza Zangouey, Sara Pourshaikhali, Fatemeh Pouya, Shahriar Dabiri

{"title":"The Association Between RACK1 Gene Polymorphisms rs1279736 and rs3756585 in Uterine Cervical Cancer with the Risk Factor of HPV: A Focus on Squamous Cell Carcinoma (SCC).","authors":"Maryam Fekri Soofi Abadi, Fatemeh Hashemi, Saeedeh Shojaeepour, Sahar Amirpour-Rostami, Mohammad Reza Zangouey, Sara Pourshaikhali, Fatemeh Pouya, Shahriar Dabiri","doi":"10.30699/ijp.2024.2019194.3236","DOIUrl":"10.30699/ijp.2024.2019194.3236","url":null,"abstract":"Background & objective: Cervical cancer is the second most common malignancy among women worldwide. The Receptor for Activated C Kinase 1 (RACK1) has a key role in regulating the pathways of cell signaling, angiogenesis, cell migration, invasion, and metastasis. This study investigated the association of polymorphisms rs1279736 and rs3756585 with cervical cancer.Methods: In this study, 100 LB pap-smear and paraffin block samples of cervical squamous carcinoma associated with Human papillomavirus (HPV) were selected along with 100 LB smear cytology samples from healthy women with normal pap smears, serving as the control group. Genomic DNA was extracted from the samples, and the polymorphisms rs1279736 and rs3756585 in the RACK1 genes were examined using the RFLP-PCR and ARMS-PCR methods, respectively.Results: The rs1279736 polymorphism shows that the chance of cervical cancer in individuals with CA and AA genotypes is 3.772 and 1.852 times that of CC genotypes, respectively. This suggests that the A allele is involved in developing cervical cancer (P=0.005; OR=2.113). The rs3756585 polymorphism indicates that the chance of cervical cancer in TG and GG genotypes is 0.373 and 4.235 times that of TT genotypes, respectively. This also points towards the involvement of the G allele in the development of cervical cancer (P=0.032; OR=1.800). Also, there was no significant relationship between the genotype of polymorphisms, age, and subtype of papillomavirus 16 and 18 in patients.Conclusion: The present study was conducted for the first time. Our results showed that two polymorphisms are significantly associated with cervical cancer.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"24-32"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0