Iranian Journal of Pathology最新文献

Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors. 桥本甲状腺炎患者血清CTRP-4、CTRP-12水平与对照组的比较分析及其与生化因素的相关性

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2025001.3276

Doaa Jawad Al-Husseini, Mohsen Saravani, Shahin Nosratzehi, Hamideh Akbari, Afsaneh Shafiei, Seyyed Mehdi Jafari

{"title":"Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors.","authors":"Doaa Jawad Al-Husseini, Mohsen Saravani, Shahin Nosratzehi, Hamideh Akbari, Afsaneh Shafiei, Seyyed Mehdi Jafari","doi":"10.30699/ijp.2024.2025001.3276","DOIUrl":"10.30699/ijp.2024.2025001.3276","url":null,"abstract":"Background & objective: Hashimoto's thyroiditis (HT) is one of the most common thyroid disorders and is characterized by manifestations attributed to thyroid gland damage and inflammatory conditions. Disturbances in thyroid hormones have physiological effects on lipoprotein metabolism and liver enzymes. CTRP family: C1q/TNF-related protein (CTRP) is an adipokine superfamily of proteins. Its essential role is anti-inflammatory activation, insulin sensitization, and regulation of blood lipids. In this study, we investigated the levels of CTRP-4 and CTRP-12 in the serum of HT patients and determined their association with biochemical factors.Methods: The study included 60 participants, divided into HT patients and control groups. Diagnostic criteria for HT patients included anti-thyroid peroxidase antibodies (anti-TPO)>50 IU/mL. Serum levels of CTRP-4, CTRP-12, and anti-TPO were measured using an Enzyme-Linked Immunosorbent Assay.Results: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than in the control groups (P=0.012 and P=0.003, respectively). HT patients also exhibited higher fasting blood glucose (FBG), cholesterol, TG, HDL, and LDL serum levels. Spearman's correlation analysis revealed a positive association between serum levels of CTRP-4 and CTRP-12 and anti-TPO (respectively, r= 0.295, P=0.022 and r = 0.346, P=0.007).Conclusion: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than those in the control groups. These factors probably play a role in the pathogenesis of Hashimoto's thyroiditis. The clinical significance of these factors should be evaluated in future studies.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"42-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma. TIPE2和CD36免疫组化表达对尿路上皮癌预后影响的研究

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2029525.3301

Amira M Abd El Maged, Nahla M Badr, Hanan Lotfy Mohammed

{"title":"An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma.","authors":"Amira M Abd El Maged, Nahla M Badr, Hanan Lotfy Mohammed","doi":"10.30699/ijp.2024.2029525.3301","DOIUrl":"10.30699/ijp.2024.2029525.3301","url":null,"abstract":"Background & objective: While there are fast advances in the detection and management of bladder carcinoma, the number of deaths remains high. Therefore, the identification of an effective biomarker predicting tumor progression in cancer bladder patients is a crucial issue. This study aimed to identify TIPE2 and CD36 expressions in cancer bladder and examine their relationship with clinicopathological data and prognosis.Methods: Using immunohistochemistry, 60 specimens of bladder urothelial cancer (UC) for the expression of TIPE2 and CD36 were studied and compared with the clinicopathologic parameters and survival data. Furthermore, the association between TIPE2 and CD36 expression and Vimentin expression to elucidate the influence of TIPE2 and CD36 on the epithelial-mesenchymal transition (EMT) were investigated in UC.Results: TIPE2 expression was associated with lower stages and prolonged disease-free survival (DFS) and overall survival (OS). Therefore, TIPE2 may be considered a good indicator of UC prognosis. CD36 immuno-positivity was associated with high tumor grade, stages, shorter OS, and DFS. Therefore, the immune positivity of CD36 may be a poor prognostic marker for UC patients. Furthermore, Vimentin expression was directly correlated with CD36 expression and inversely correlated with TIPE2 expression.Conclusion: TIPE2 and CD36 may be novel biomarkers for predicting tumor metastasis and prognosis in patients with bladder UC and hold promise as therapeutic targets.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"48-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Thrombomodulin Expression with Bladder Cancer Grade, Stage, and Recurrence: A Single-Center Prospective Pilot Study. 血栓调节蛋白表达与膀胱癌分级、分期和复发的关系：一项单中心前瞻性先导研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-07-01 DOI: 10.30699/ijp.2025.2047132.3387

Mohammad Reza Nikoobakht, Shima Esmaeilpanah, Iman Menbari Oskouie, Mahdi Khoshchehreh, Farshid Alaeidini, Seyed Mohammad Kazem Aghamir

{"title":"Association of Thrombomodulin Expression with Bladder Cancer Grade, Stage, and Recurrence: A Single-Center Prospective Pilot Study.","authors":"Mohammad Reza Nikoobakht, Shima Esmaeilpanah, Iman Menbari Oskouie, Mahdi Khoshchehreh, Farshid Alaeidini, Seyed Mohammad Kazem Aghamir","doi":"10.30699/ijp.2025.2047132.3387","DOIUrl":"https://doi.org/10.30699/ijp.2025.2047132.3387","url":null,"abstract":"Background & objective: Bladder cancer is the fourth most prevalent malignancy and lacks reliable biomarkers for predicting tumor stage, grade, and clinical outcomes. This study aimed to evaluate the association between thrombomodulin (TM)-positive cell rate (PR) and tumor grade, stage, and recurrence in patients with bladder cancer.Methods: This prospective observational pilot study was conducted at the Urology Clinic of Sina Hospital, Tehran, between March and December 2022. A total of 51 patients diagnosed with bladder cancer following cystoscopy and transurethral resection of bladder tumor (TURBT) were enrolled. Of these, 11 patients with stage T2 disease underwent radical cystectomy. TM expression was assessed by immunohistochemical staining, and the PR score was calculated. The remaining 40 patients underwent follow-up cystoscopy 3 months post-TURBT to assess for recurrence or progression. Statistical analyses were performed using SPSS version 26, with comparisons of quantitative variables conducted using ANOVA and t tests.Results: The mean age of participants was 66.73 ± 11.00 years, and 46 were male. The mean TM PR value was 25.51 ± 6.24. No significant differences in TM PR values were observed among different tumor grades (p = 0.144) or stages (p = 0.815). Additionally, there were no significant differences in TM PR values or PR scores between patients with and without recurrence at 3-month follow-up cystoscopy (p = 0.144 and p = 0.085, respectively).Conclusion: TM PR values did not correlate with tumor grade, stage, or recurrence in this cohort of bladder cancer patients. Further studies with larger sample sizes and longer follow-up periods are warranted.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 3","pages":"266-272"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Cytokeratin 19 Expression in Oral Carcinogenesis. 细胞角蛋白19在口腔癌变中的表达评价。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-07-01 DOI: 10.30699/ijp.2025.2044451.3375

Narges Ghazi, Nasrollah Saghravanian, Soheila Shamshiri, Yasamin Ayatollahi

{"title":"Evaluation of Cytokeratin 19 Expression in Oral Carcinogenesis.","authors":"Narges Ghazi, Nasrollah Saghravanian, Soheila Shamshiri, Yasamin Ayatollahi","doi":"10.30699/ijp.2025.2044451.3375","DOIUrl":"https://doi.org/10.30699/ijp.2025.2044451.3375","url":null,"abstract":"Background & objective: Oral squamous cell carcinoma (OSCC) accounts for over 90% of oral cancers. Cytokeratin 19 (CK19), produced by suprabasal epithelial cells, reflects alterations in cellular behavior and has been associated with premalignant changes in the oral epithelium. This study aimed to evaluate the expression of CK19 in OSCC and oral epithelial dysplasia (OED) and its potential role in oral carcinogenesis.Methods: A total of 50 samples were analyzed, including 30 OSCC cases and 10 OED cases obtained from the archives of the Department of Pathology, as well as 10 normal oral mucosa samples collected from clinically healthy areas adjacent to mucocele lesions. CK19 expression was assessed using immunohistochemistry.Results: Positive immunoreactivity for CK19 was observed in 90% (27/30) of OSCC samples. CK19 expression in the OSCC group was significantly higher compared to the OED and normal mucosa groups. Among OSCC cases, grade III tumors exhibited stronger CK19 expression than grades I and II. Additionally, CK19 expression in grade II OSCC was higher than in the OED group.Conclusion: The progressive increase in CK19 expression from normal mucosa to OED and OSCC supports its involvement in oral mucosal carcinogenesis. Moreover, higher CK19 expression correlated with increasing tumor grade and decreasing cellular differentiation, suggesting its potential value as a diagnostic and prognostic biomarker in OSCC.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 3","pages":"280-287"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent Microscopy: A Useful and Adjunct Tool in Leprosy Diagnosis: A Cross Sectional Study. 荧光显微镜：一个有用的辅助工具在麻风病诊断：横断面研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2023590.3263

Swati Soni, Vaishali Walke, Dinesh Asati, Anand Maurya, Sramana Mukhopadhyay

{"title":"Fluorescent Microscopy: A Useful and Adjunct Tool in Leprosy Diagnosis: A Cross Sectional Study.","authors":"Swati Soni, Vaishali Walke, Dinesh Asati, Anand Maurya, Sramana Mukhopadhyay","doi":"10.30699/ijp.2024.2023590.3263","DOIUrl":"10.30699/ijp.2024.2023590.3263","url":null,"abstract":"Background & objective: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Fite-Faraco (FF) is the routine staining method used to demonstrate the presence of Mycobacterium leprae in tissue sections. Fluorescent microscopy (FM) can help visualize lepra bacilli better. The present study compares two methodologies, fluorescent microscopy, and Fite-Faraco, in detecting Mycobacterium leprae in tissue sections.Methods: Histopathology of skin biopsies in 60 cases of Hansen's were evaluated with FF stain. The performance of Auramine- Rhodamine Fluroscencent stain was compared with conventional FF staining in identifying Lepra bacilli.Results: A total of 60 clinically and histopathologically confirmed cases of Hansen's disease were included in this ambispective study. The cases were sub-classified into various histological categories. Auramine-rhodamine fluorescent staining was performed and examined under a fluorescent microscope with an LED light illuminator. The bacteriological index (BI) was calculated under an oil immersion field for both Fite-Faraco (FF) staining and fluorescent microscopy (FM), graded from zero to six plus according to Ridley's logarithmic scale. Lepra bacilli were identified in 70% of patients on FF staining, while fluorescent microscopy showed positivity in 80%. The mean BI calculated by FM (2.48) was significantly higher than that by the FF method (2.18), and more multibacillary disease was identified by fluorescent staining compared to FF staining.Conclusion: It is advantageous to use fluorescent microscopy as an adjunct to conventional Fite-Faraco stain especially in cases where the latter fails to detect lepra bacilli and in a clinically suspected multibacillary disease.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Tubular Adenoma of the Breast in an Adolescent: Diagnostic Challenges and Literature Review. 青少年乳腺巨大管状腺瘤：诊断挑战和文献回顾。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-07-01 DOI: 10.30699/ijp.2025.2056026.3428

Monica Mishra, Seetu Palo

引用次数: 0

The Link Between High Sensitivity Troponin T Levels and Outcomes Among Patients with Congestive Heart Failure: A Systematic Review and Meta-Analysis Study. 高敏感性肌钙蛋白T水平与充血性心力衰竭患者预后之间的联系：一项系统回顾和荟萃分析研究

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-07-01 DOI: 10.30699/ijp.2025.2057561.3440

Alireza Abdollahi, Zohreh Nozarian, Samaneh Salarvand, Elham Pourebrahimi

{"title":"The Link Between High Sensitivity Troponin T Levels and Outcomes Among Patients with Congestive Heart Failure: A Systematic Review and Meta-Analysis Study.","authors":"Alireza Abdollahi, Zohreh Nozarian, Samaneh Salarvand, Elham Pourebrahimi","doi":"10.30699/ijp.2025.2057561.3440","DOIUrl":"https://doi.org/10.30699/ijp.2025.2057561.3440","url":null,"abstract":"Background & objective: High-sensitivity cardiac troponin T (hs-cTnT) has emerged as a critical biomarker in cardiovascular diseases, particularly in congestive heart failure (CHF). This systematic review and meta-analysis aimed to assess the association between hs-cTnT levels and clinical outcomes in patients with CHF.Methods: A comprehensive literature search was performed across multiple databases to identify studies evaluating the relationship between hs-cTnT levels and clinical outcomes in CHF. Eligible studies reported hazard ratios (HRs) or odds ratios (ORs) for all-cause mortality, cardiovascular mortality, or cardiovascular hospitalization.Results: Elevated hs-cTnT levels were significantly associated with adverse outcomes. The pooled HR and OR for all-cause mortality were 1.70 (95% CI, 1.49-1.94) and 6.19 (95% CI, 3.88-9.86), respectively. For cardiovascular mortality, the pooled HR was 1.59 (95% CI, 1.38-1.83) and the pooled OR was 6.87 (95% CI, 3.93-12.01). For cardiovascular hospitalization, the pooled HR was 1.56 (95% CI, 1.42-1.70) and the pooled OR was 4.32 (95% CI, 2.22-8.39).Conclusion: Elevated hs-cTnT levels are strongly associated with an increased risk of all-cause mortality, cardiovascular mortality, and cardiovascular hospitalization in patients with CHF. These findings highlight the prognostic value of hs-cTnT in the clinical management of heart failure.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 3","pages":"245-256"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study. 腹腔镜袖胃切除术对病态肥胖患者甲状腺功能减退的影响：一项为期一年的随访前瞻性队列研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2026732.3290

Nasser Malekpour Alamdari, Iman Ansari, Mohammad Ali Azizi Nadian, Mahdiyeh Sadat Seyyedi, Maryam Abbasi

{"title":"Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study.","authors":"Nasser Malekpour Alamdari, Iman Ansari, Mohammad Ali Azizi Nadian, Mahdiyeh Sadat Seyyedi, Maryam Abbasi","doi":"10.30699/ijp.2024.2026732.3290","DOIUrl":"10.30699/ijp.2024.2026732.3290","url":null,"abstract":"Background & objective: Obesity is a growing public health problem worldwide. Bariatric surgery is considered the safest and most effective therapeutic option, although it is associated with various metabolic and neurohormonal consequences. This study aims to evaluate the effect of sleeve gastrectomy (SG) on hypothyroidism within one year following surgery.Methods: In this single-center prospective cross-sectional study, patients with morbid obesity who were candidates for SG were included. Body mass index (BMI), levothyroxine dosage, and thyroid function tests were compared at baseline and 12 months after surgery.Results & conclusion: Patients' BMI, levothyroxine dosage, TSH, and T4 levels decreased significantly after surgery (P<0.0001). The effect of SG on T3 levels was not statistically significant. The results of this study demonstrate that SG can significantly improve thyroid function tests in patients with morbid obesity and reduce their need for levothyroxine within one year following surgery.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"133-137"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sclerosing Angiomatoid Nodular Transformation of Spleen (SANTS); Case Report of a 12-Year-Old Patient. 脾脏硬化性血管瘤样结节转化；1例12岁患者报告。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2034980.3332

Farzaneh Ramezani, Sare Kamali, Ramin Mashoufi, Seyed Ali Ebrahimi, Maryam Soltan

{"title":"Sclerosing Angiomatoid Nodular Transformation of Spleen (SANTS); Case Report of a 12-Year-Old Patient.","authors":"Farzaneh Ramezani, Sare Kamali, Ramin Mashoufi, Seyed Ali Ebrahimi, Maryam Soltan","doi":"10.30699/ijp.2025.2034980.3332","DOIUrl":"10.30699/ijp.2025.2034980.3332","url":null,"abstract":"Background: Sclerosing angiomatoid nodular transformation of the spleen (SANT) is a rare, benign vascular lesion predominantly described in adults. Pediatric cases are exceptionally uncommon and present a diagnostic challenge due to nonspecific clinical presentations and imaging findings.Case presentation: We report the case of a 12-year-old boy presenting with recurrent abdominal pain localized around the umbilicus, accompanied by intermittent nausea over a three-month period. Physical examination revealed mild tenderness without guarding. Laboratory findings were unremarkable. Abdominal ultrasound demonstrated a hypoechoic splenic lesion, further evaluated by multidetector computed tomography (MDCT), which revealed a heterogeneous hypodense mass in the spleen. The patient underwent partial laparoscopic splenectomy. Histopathological examination showed a nodular architecture with fibrous bands, capillary-like vascular channels lined by endothelial cells, and a lymphoplasmacytic infiltrate. Immunohistochemical staining was positive for CD31, CD34, and CD8, supporting the diagnosis of SANT.Conclusion: Although benign, SANT can mimic more aggressive splenic pathologies. This case underscores the importance of considering SANT in the differential diagnosis of splenic masses in pediatric patients and highlights the role of histopathology and immunohistochemistry in achieving a definitive diagnosis.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"239-243"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value of Biomarkers in the Diagnosis of Cholangiocarcinoma and Its Benign Mimickers. 生物标志物在胆管癌及其良性类似物诊断中的价值。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2029980.3307

Elmira Zolfeghari Khiavy, Nasser Rakhshani, Hamid Rezvani, Behnaz Bouzari, Hossein Ajdarkosh, Mahshid Panahi, Hemin Ashayeri, Seyed Mir Yaghub Musaviani, Soheil Khalili, Ali Basi, Mohammad Hadi Karbalaie Niya

{"title":"Diagnostic Value of Biomarkers in the Diagnosis of Cholangiocarcinoma and Its Benign Mimickers.","authors":"Elmira Zolfeghari Khiavy, Nasser Rakhshani, Hamid Rezvani, Behnaz Bouzari, Hossein Ajdarkosh, Mahshid Panahi, Hemin Ashayeri, Seyed Mir Yaghub Musaviani, Soheil Khalili, Ali Basi, Mohammad Hadi Karbalaie Niya","doi":"10.30699/ijp.2025.2029980.3307","DOIUrl":"10.30699/ijp.2025.2029980.3307","url":null,"abstract":"Background & objective: Cholangiocarcinoma (CCA) is a malignancy that accounts for approximately 3% gastrointestinal cancer. The aim of this study was to evaluate and compare the diagnostic value of CD56, SMAD4, CEA, and p53 biomarkers in diagnosing cholangiocarcinoma and its benign mimickers.Methods: This retrospective cross-sectional study was conducted on 54 CCA specimens and 27 non-cancerous pancreatobiliary tissue samples diagnosed between 2018 and 2022. All specimens were evaluated using immunohistochemistry (IHC) staining for CD56, SMAD4, CEA, and p53 expression. The cut-off value of each marker was obtained from the respective kit instructions and previous studies. The results were analyzed using SPSS version 26. A significance level of less than 0.05 was considered statistically significant.Results: Of the 81 specimens, the mean age in the case and control groups was 57.33 ± 11.99 and 44.7 ± 16.69 years, respectively, and 51 (63%) samples were obtained from male patients. We found that 39.5% had grade III p53 expression, 13.5% had grade II p53 expression, 41.9% had grade III CEA expression, and 9.8% had grade II CEA expression. Additionally, 17.3% were positive for CD56 expression, and 7.4% showed SMAD4 loss. There were significant associations between the expression of CEA (79.6%) and p53 (74%) in the CCA group (p-value < 0.05). However, SMAD4 loss and CD56 expression were not statistically significant.Conclusion: Expression of CEA and p53 based on IHC staining is associated with the occurrence of CCA. However, SMAD4 and CD56 were not significantly associated with CCA. Further survival analysis and sensitivity and specificity assessments are needed to obtain more comprehensive results.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"159-166"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0