Iranian Journal of Pathology最新文献

Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors. 桥本甲状腺炎患者血清CTRP-4、CTRP-12水平与对照组的比较分析及其与生化因素的相关性

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2025001.3276

Doaa Jawad Al-Husseini, Mohsen Saravani, Shahin Nosratzehi, Hamideh Akbari, Afsaneh Shafiei, Seyyed Mehdi Jafari

{"title":"Evaluation of Serum CTRP-4 and CTRP-12 Levels in Hashimoto's Thyroiditis Patients: A Comparative Analysis with a Control Group and Their Correlation with Biochemical Factors.","authors":"Doaa Jawad Al-Husseini, Mohsen Saravani, Shahin Nosratzehi, Hamideh Akbari, Afsaneh Shafiei, Seyyed Mehdi Jafari","doi":"10.30699/ijp.2024.2025001.3276","DOIUrl":"10.30699/ijp.2024.2025001.3276","url":null,"abstract":"Background & objective: Hashimoto's thyroiditis (HT) is one of the most common thyroid disorders and is characterized by manifestations attributed to thyroid gland damage and inflammatory conditions. Disturbances in thyroid hormones have physiological effects on lipoprotein metabolism and liver enzymes. CTRP family: C1q/TNF-related protein (CTRP) is an adipokine superfamily of proteins. Its essential role is anti-inflammatory activation, insulin sensitization, and regulation of blood lipids. In this study, we investigated the levels of CTRP-4 and CTRP-12 in the serum of HT patients and determined their association with biochemical factors.Methods: The study included 60 participants, divided into HT patients and control groups. Diagnostic criteria for HT patients included anti-thyroid peroxidase antibodies (anti-TPO)>50 IU/mL. Serum levels of CTRP-4, CTRP-12, and anti-TPO were measured using an Enzyme-Linked Immunosorbent Assay.Results: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than in the control groups (P=0.012 and P=0.003, respectively). HT patients also exhibited higher fasting blood glucose (FBG), cholesterol, TG, HDL, and LDL serum levels. Spearman's correlation analysis revealed a positive association between serum levels of CTRP-4 and CTRP-12 and anti-TPO (respectively, r= 0.295, P=0.022 and r = 0.346, P=0.007).Conclusion: Our findings showed that the CTRP-4 and CTRP-12 levels in HT patients were higher than those in the control groups. These factors probably play a role in the pathogenesis of Hashimoto's thyroiditis. The clinical significance of these factors should be evaluated in future studies.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"42-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma. TIPE2和CD36免疫组化表达对尿路上皮癌预后影响的研究

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2029525.3301

Amira M Abd El Maged, Nahla M Badr, Hanan Lotfy Mohammed

{"title":"An Insight into Prognostic Impact of TIPE2 & CD36 Immunohistochemical Expression in Urothelial Carcinoma.","authors":"Amira M Abd El Maged, Nahla M Badr, Hanan Lotfy Mohammed","doi":"10.30699/ijp.2024.2029525.3301","DOIUrl":"10.30699/ijp.2024.2029525.3301","url":null,"abstract":"Background & objective: While there are fast advances in the detection and management of bladder carcinoma, the number of deaths remains high. Therefore, the identification of an effective biomarker predicting tumor progression in cancer bladder patients is a crucial issue. This study aimed to identify TIPE2 and CD36 expressions in cancer bladder and examine their relationship with clinicopathological data and prognosis.Methods: Using immunohistochemistry, 60 specimens of bladder urothelial cancer (UC) for the expression of TIPE2 and CD36 were studied and compared with the clinicopathologic parameters and survival data. Furthermore, the association between TIPE2 and CD36 expression and Vimentin expression to elucidate the influence of TIPE2 and CD36 on the epithelial-mesenchymal transition (EMT) were investigated in UC.Results: TIPE2 expression was associated with lower stages and prolonged disease-free survival (DFS) and overall survival (OS). Therefore, TIPE2 may be considered a good indicator of UC prognosis. CD36 immuno-positivity was associated with high tumor grade, stages, shorter OS, and DFS. Therefore, the immune positivity of CD36 may be a poor prognostic marker for UC patients. Furthermore, Vimentin expression was directly correlated with CD36 expression and inversely correlated with TIPE2 expression.Conclusion: TIPE2 and CD36 may be novel biomarkers for predicting tumor metastasis and prognosis in patients with bladder UC and hold promise as therapeutic targets.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"48-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescent Microscopy: A Useful and Adjunct Tool in Leprosy Diagnosis: A Cross Sectional Study. 荧光显微镜：一个有用的辅助工具在麻风病诊断：横断面研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2023590.3263

Swati Soni, Vaishali Walke, Dinesh Asati, Anand Maurya, Sramana Mukhopadhyay

{"title":"Fluorescent Microscopy: A Useful and Adjunct Tool in Leprosy Diagnosis: A Cross Sectional Study.","authors":"Swati Soni, Vaishali Walke, Dinesh Asati, Anand Maurya, Sramana Mukhopadhyay","doi":"10.30699/ijp.2024.2023590.3263","DOIUrl":"10.30699/ijp.2024.2023590.3263","url":null,"abstract":"Background & objective: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Fite-Faraco (FF) is the routine staining method used to demonstrate the presence of Mycobacterium leprae in tissue sections. Fluorescent microscopy (FM) can help visualize lepra bacilli better. The present study compares two methodologies, fluorescent microscopy, and Fite-Faraco, in detecting Mycobacterium leprae in tissue sections.Methods: Histopathology of skin biopsies in 60 cases of Hansen's were evaluated with FF stain. The performance of Auramine- Rhodamine Fluroscencent stain was compared with conventional FF staining in identifying Lepra bacilli.Results: A total of 60 clinically and histopathologically confirmed cases of Hansen's disease were included in this ambispective study. The cases were sub-classified into various histological categories. Auramine-rhodamine fluorescent staining was performed and examined under a fluorescent microscope with an LED light illuminator. The bacteriological index (BI) was calculated under an oil immersion field for both Fite-Faraco (FF) staining and fluorescent microscopy (FM), graded from zero to six plus according to Ridley's logarithmic scale. Lepra bacilli were identified in 70% of patients on FF staining, while fluorescent microscopy showed positivity in 80%. The mean BI calculated by FM (2.48) was significantly higher than that by the FF method (2.18), and more multibacillary disease was identified by fluorescent staining compared to FF staining.Conclusion: It is advantageous to use fluorescent microscopy as an adjunct to conventional Fite-Faraco stain especially in cases where the latter fails to detect lepra bacilli and in a clinically suspected multibacillary disease.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study. 腹腔镜袖胃切除术对病态肥胖患者甲状腺功能减退的影响：一项为期一年的随访前瞻性队列研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2026732.3290

Nasser Malekpour Alamdari, Iman Ansari, Mohammad Ali Azizi Nadian, Mahdiyeh Sadat Seyyedi, Maryam Abbasi

{"title":"Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study.","authors":"Nasser Malekpour Alamdari, Iman Ansari, Mohammad Ali Azizi Nadian, Mahdiyeh Sadat Seyyedi, Maryam Abbasi","doi":"10.30699/ijp.2024.2026732.3290","DOIUrl":"10.30699/ijp.2024.2026732.3290","url":null,"abstract":"Background & objective: Obesity is a growing public health problem worldwide. Bariatric surgery is considered the safest and most effective therapeutic option, although it is associated with various metabolic and neurohormonal consequences. This study aims to evaluate the effect of sleeve gastrectomy (SG) on hypothyroidism within one year following surgery.Methods: In this single-center prospective cross-sectional study, patients with morbid obesity who were candidates for SG were included. Body mass index (BMI), levothyroxine dosage, and thyroid function tests were compared at baseline and 12 months after surgery.Results & conclusion: Patients' BMI, levothyroxine dosage, TSH, and T4 levels decreased significantly after surgery (P<0.0001). The effect of SG on T3 levels was not statistically significant. The results of this study demonstrate that SG can significantly improve thyroid function tests in patients with morbid obesity and reduce their need for levothyroxine within one year following surgery.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"133-137"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sclerosing Angiomatoid Nodular Transformation of Spleen (SANTS); Case Report of a 12-Year-Old Patient. 脾脏硬化性血管瘤样结节转化；1例12岁患者报告。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2034980.3332

Farzaneh Ramezani, Sare Kamali, Ramin Mashoufi, Seyed Ali Ebrahimi, Maryam Soltan

{"title":"Sclerosing Angiomatoid Nodular Transformation of Spleen (SANTS); Case Report of a 12-Year-Old Patient.","authors":"Farzaneh Ramezani, Sare Kamali, Ramin Mashoufi, Seyed Ali Ebrahimi, Maryam Soltan","doi":"10.30699/ijp.2025.2034980.3332","DOIUrl":"10.30699/ijp.2025.2034980.3332","url":null,"abstract":"Background: Sclerosing angiomatoid nodular transformation of the spleen (SANT) is a rare, benign vascular lesion predominantly described in adults. Pediatric cases are exceptionally uncommon and present a diagnostic challenge due to nonspecific clinical presentations and imaging findings.Case presentation: We report the case of a 12-year-old boy presenting with recurrent abdominal pain localized around the umbilicus, accompanied by intermittent nausea over a three-month period. Physical examination revealed mild tenderness without guarding. Laboratory findings were unremarkable. Abdominal ultrasound demonstrated a hypoechoic splenic lesion, further evaluated by multidetector computed tomography (MDCT), which revealed a heterogeneous hypodense mass in the spleen. The patient underwent partial laparoscopic splenectomy. Histopathological examination showed a nodular architecture with fibrous bands, capillary-like vascular channels lined by endothelial cells, and a lymphoplasmacytic infiltrate. Immunohistochemical staining was positive for CD31, CD34, and CD8, supporting the diagnosis of SANT.Conclusion: Although benign, SANT can mimic more aggressive splenic pathologies. This case underscores the importance of considering SANT in the differential diagnosis of splenic masses in pediatric patients and highlights the role of histopathology and immunohistochemistry in achieving a definitive diagnosis.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"239-243"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value of Biomarkers in the Diagnosis of Cholangiocarcinoma and Its Benign Mimickers. 生物标志物在胆管癌及其良性类似物诊断中的价值。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2029980.3307

Elmira Zolfeghari Khiavy, Nasser Rakhshani, Hamid Rezvani, Behnaz Bouzari, Hossein Ajdarkosh, Mahshid Panahi, Hemin Ashayeri, Seyed Mir Yaghub Musaviani, Soheil Khalili, Ali Basi, Mohammad Hadi Karbalaie Niya

{"title":"Diagnostic Value of Biomarkers in the Diagnosis of Cholangiocarcinoma and Its Benign Mimickers.","authors":"Elmira Zolfeghari Khiavy, Nasser Rakhshani, Hamid Rezvani, Behnaz Bouzari, Hossein Ajdarkosh, Mahshid Panahi, Hemin Ashayeri, Seyed Mir Yaghub Musaviani, Soheil Khalili, Ali Basi, Mohammad Hadi Karbalaie Niya","doi":"10.30699/ijp.2025.2029980.3307","DOIUrl":"10.30699/ijp.2025.2029980.3307","url":null,"abstract":"Background & objective: Cholangiocarcinoma (CCA) is a malignancy that accounts for approximately 3% gastrointestinal cancer. The aim of this study was to evaluate and compare the diagnostic value of CD56, SMAD4, CEA, and p53 biomarkers in diagnosing cholangiocarcinoma and its benign mimickers.Methods: This retrospective cross-sectional study was conducted on 54 CCA specimens and 27 non-cancerous pancreatobiliary tissue samples diagnosed between 2018 and 2022. All specimens were evaluated using immunohistochemistry (IHC) staining for CD56, SMAD4, CEA, and p53 expression. The cut-off value of each marker was obtained from the respective kit instructions and previous studies. The results were analyzed using SPSS version 26. A significance level of less than 0.05 was considered statistically significant.Results: Of the 81 specimens, the mean age in the case and control groups was 57.33 ± 11.99 and 44.7 ± 16.69 years, respectively, and 51 (63%) samples were obtained from male patients. We found that 39.5% had grade III p53 expression, 13.5% had grade II p53 expression, 41.9% had grade III CEA expression, and 9.8% had grade II CEA expression. Additionally, 17.3% were positive for CD56 expression, and 7.4% showed SMAD4 loss. There were significant associations between the expression of CEA (79.6%) and p53 (74%) in the CCA group (p-value < 0.05). However, SMAD4 loss and CD56 expression were not statistically significant.Conclusion: Expression of CEA and p53 based on IHC staining is associated with the occurrence of CCA. However, SMAD4 and CD56 were not significantly associated with CCA. Further survival analysis and sensitivity and specificity assessments are needed to obtain more comprehensive results.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"159-166"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Role of Claudin-4 Antigen Overexpression in Triple-Negative Breast Cancer Patients: A 5-Year Survival Analysis. 评价Claudin-4抗原过表达在三阴性乳腺癌患者中的作用：一项5年生存分析。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2040168.3350

Maryam Soltan, Azar Naimi, Razieh Hafez Forghan, Marjan Mansourian

{"title":"Evaluation of the Role of Claudin-4 Antigen Overexpression in Triple-Negative Breast Cancer Patients: A 5-Year Survival Analysis.","authors":"Maryam Soltan, Azar Naimi, Razieh Hafez Forghan, Marjan Mansourian","doi":"10.30699/ijp.2025.2040168.3350","DOIUrl":"10.30699/ijp.2025.2040168.3350","url":null,"abstract":"Background & objective: Breast cancer (BC) can be categorized into 4 groups based on molecular and pathological evidence: Luminal A, Luminal B, HER2+ tumors, and triple-negative breast cancer (TNBC). TNBC has a poorer survival rate and a higher chance of recurrence and metastasis compared to other BC types, primarily due to its challenging treatment course. Claudin 4 (CLDN4), a transmembrane protein in tight junctions between cells, has been linked to poor prognosis and faster disease progression in these malignancies.Methods: Patients previously diagnosed with TNBC and tested for CLDN4 overexpression were contacted for follow-up and to determine disease outcomes. The current health status, cause, and time of death (if applicable) were recorded. Patient files were accessed to obtain information on age, tumor size and grading, lymph node involvement, metastasis, Ki67, and CLDN4 expression.Results: Patients with high CLDN expression showed a significantly lower mortality rate. However, after controlling for other covariates, the hazard ratio (HR) was 0.48 (95%CI= [0.13 - 1.27]) in the crude model for survival, 0.54 (95%CI = [0.2 - 1.43]) when adjusted for age at diagnosis, and 0.58 (95%CI = [0.18-1.82]) when adjusted for other covariates. CLDN4 was also not correlated with tumor metastasis (HR=0.64, p=0.203, in the crude model; HR=0.52, p=0.409, when adjusted for other covariates). Patients in the CLDN4 high group had a significantly higher number of tumors >2cm.Conclusion: Although previous studies have shown that CLDN4 overexpression worsens TNBC prognosis and increases metastasis or recurrence, the current study found no such association.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"167-172"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The In vitro Effect of Nanoliposomal Amphotericin B Against Rhizopus arrhizus Isolated From COVID-19-Associated Mucormycosis Patients. 纳米脂质体两性霉素B对新型冠状病毒相关毛霉病患者分离的阿根霉的体外抑制作用

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2033626.3320

Ali Ahmadi, Sayed Jamal Hashemi, Seyed Mahdi Rezayat, Roshanak Daie-Ghazvini, Mahmoud Reza Jaafari, Jamileh Esmaeili, Fatemeh Saiedmohammadi, Farzaneh Afshari, Laura Alcazar-Fuoli, Alireza Abdollahi, Sadegh Khodavaisy

{"title":"The In vitro Effect of Nanoliposomal Amphotericin B Against Rhizopus arrhizus Isolated From COVID-19-Associated Mucormycosis Patients.","authors":"Ali Ahmadi, Sayed Jamal Hashemi, Seyed Mahdi Rezayat, Roshanak Daie-Ghazvini, Mahmoud Reza Jaafari, Jamileh Esmaeili, Fatemeh Saiedmohammadi, Farzaneh Afshari, Laura Alcazar-Fuoli, Alireza Abdollahi, Sadegh Khodavaisy","doi":"10.30699/ijp.2024.2033626.3320","DOIUrl":"10.30699/ijp.2024.2033626.3320","url":null,"abstract":"Background & objective: Rhizopus arrhizus, a major contributor to COVID-19-associated mucormycosis (CAM) globally. Nanoliposomal amphotericin B (NLAmB) presents a promising approach due to its enhanced drug delivery and reduced side effects. This study aimed to assess the in vitro antifungal susceptibility of NLAmB against R. arrhizus isolated from CAM patients.Methods: Thirty-nine R. arrhizus isolated from CAM patients were identified through phenotypic characterization, MALDI-TOF, and the internal transcribed spacer rDNA region (ITS) sequencing approaches. Antifungal susceptibility testing (AFST) for NLAmB, amphotericin B (AmB), posaconazole (PSC), and isavuconazole (ISC) was conducted through broth microdilution methods according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) standard E.DEF 9.4. Results were analyzed for MIC ranges, MIC50, MIC90, and distributions.Results: NLAmB demonstrated superior in vitro efficacy against R. arrhizus (MIC50/90, 0.063/0.25 μg/ml) compared to AmB, PSC, and ISC. PSC exhibited notable activity (MIC range: ≤0.031 - ≥16 μg/ml).Conclusion: The study emphasized NLAmB's sustained activity, making it a potential alternative to LAmB. Further exploration and clinical correlation are warranted to validate NLAmB in CAM treatment.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"84-89"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Significance of Eosinophil Infiltration in Diagnosis of Psoriasis: A Cross-sectional Analysis. 探讨嗜酸性粒细胞浸润在银屑病诊断中的意义：横断面分析。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2013501.3191

Maryam Khalili, Afsaneh Kooshesh, Simin Shamsi-Meymandi, Niloofar Mehrolhasani, Rezvan Amiri, Mohammad Rezaei Zadeh Rukerd, Mahin Aflatoonian

{"title":"Exploring the Significance of Eosinophil Infiltration in Diagnosis of Psoriasis: A Cross-sectional Analysis.","authors":"Maryam Khalili, Afsaneh Kooshesh, Simin Shamsi-Meymandi, Niloofar Mehrolhasani, Rezvan Amiri, Mohammad Rezaei Zadeh Rukerd, Mahin Aflatoonian","doi":"10.30699/ijp.2024.2013501.3191","DOIUrl":"10.30699/ijp.2024.2013501.3191","url":null,"abstract":"Background & objective: There is controversy whether eosinophils are involved in the pathogenesis of psoriasis. This study aims to assess the quantity of eosinophils in pathological specimens obtained from individuals diagnosed with psoriasis.Methods: cross-sectional and retrospective study 91 skin samples were obtained from patients with diagnosis of psoriasis. Two experienced dermatologists thoroughly reviewed the specimens' demographic characteristics, clinical features, and pathological attributes. Subsequently, eosinophils were counted within all microscopic fields, utilizing a magnification of 200.Results: Eosinophils were present in approximately 70.3% of the examined samples, with a mean eosinophil count of 2.42±0.63. Although no significant correlation was observed between the clinical subtype and the average eosinophil count, eosinophils were most commonly detected in the cases presenting generalized pustular psoriasis (100%) and vulgaris types (71.11%). Notably, patients exhibiting Munro's microabscess and dilated papillary dermal blood vessels exhibited a significantly higher number of eosinophils (P=0.007 and P=0.039, respectively). Additionally, a notable association was identified between presence of spongiosis, and eosinophil counts in the pathological samples (P=0.04).Conclusion: Presence of eosinophils may not contradict a diagnosis of psoriasis. Furthermore, a notable association may be observed between the number of eosinophils and presence of spongiosis, dilated dermal papillary vessels, and Munro's microabscess.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Value of the Galactomannan Test in Diagnosing COVID-19-Associated Pulmonary Aspergillosis: A Review. 半乳甘露聚糖试验在新冠肺炎相关肺曲霉病诊断中的价值

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2044324.3369

Mohammadreza Salehi, Jon Salmanton-García, Alireza Abdollahi, Maryam Albaji, Effat Davoudi-Monfared, Zeinab Siami, Saeed Mohammadi, Sadegh Khodavaisy, Pershang Nazemi

{"title":"The Value of the Galactomannan Test in Diagnosing COVID-19-Associated Pulmonary Aspergillosis: A Review.","authors":"Mohammadreza Salehi, Jon Salmanton-García, Alireza Abdollahi, Maryam Albaji, Effat Davoudi-Monfared, Zeinab Siami, Saeed Mohammadi, Sadegh Khodavaisy, Pershang Nazemi","doi":"10.30699/ijp.2025.2044324.3369","DOIUrl":"10.30699/ijp.2025.2044324.3369","url":null,"abstract":"COVID-19-associated pulmonary aspergillosis (CAPA) is a complication of COVID-19. Galactomannan (GM) is a non-invasive test used to diagnose invasive aspergillosis. We collected the existing studies on the diagnostic value of GM to determine a GM level for predicting CAPA. All articles on the value of GM in CAPA diagnosis published until November 2023 were reviewed. The main databases were searched using the following keywords: \"aspergillus\", \"aspergillosis\", \"SARS-CoV-2\", \"COVID\", \"2019 ncovnCOV\", \"novel coronavirus\", \"COVID-19\", \"galactomannan\", and \"CAPA\". Studies with reported levels of serum or BAL GM were included. Patients were classified into two groups: non-confirmed and proven aspergillosis. Finally, the receiver operating characteristic (ROC) curve analysis was used to determine a GM level to predict the likelihood of CAPA. A total of 26 articles were selected, of which 239 patients were included. A count of 123 patients (50%) were in the non-confirmed group and 124 (50%) patients were proven. The median serum GM was 0.51 in the non-confirmed group and 0.47 in the proven group (p= 0.73). The level of GM in BAL fluid was 0.10 in the non-confirmed and 2.80 in the proven group, which was statistically different (p<0.001). With 81.3 % sensitivity and 79.5% specificity, the BAL GM cut-off was 1.01 ODI. The results showed that BAL GM ≥1.01 can be used to predict CAPA. Serum GM did not show any predictive value in diagnosing CAPA. However, BAL GM level can be a reliable diagnostic test in patients with CAPA.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"142-151"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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