Effect of Laparoscopic Sleeve Gastrectomy on Hypothyroidism in Patients with Morbid Obesity: A one-year follow-up Prospective Cohort Study.

Q3 Medicine

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI:10.30699/ijp.2024.2026732.3290

Nasser Malekpour Alamdari, Iman Ansari, Mohammad Ali Azizi Nadian, Mahdiyeh Sadat Seyyedi, Maryam Abbasi

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Abstract

Background & objective: Obesity is a growing public health problem worldwide. Bariatric surgery is considered the safest and most effective therapeutic option, although it is associated with various metabolic and neurohormonal consequences. This study aims to evaluate the effect of sleeve gastrectomy (SG) on hypothyroidism within one year following surgery.

Methods: In this single-center prospective cross-sectional study, patients with morbid obesity who were candidates for SG were included. Body mass index (BMI), levothyroxine dosage, and thyroid function tests were compared at baseline and 12 months after surgery.

Results & conclusion: Patients' BMI, levothyroxine dosage, TSH, and T4 levels decreased significantly after surgery (P<0.0001). The effect of SG on T3 levels was not statistically significant. The results of this study demonstrate that SG can significantly improve thyroid function tests in patients with morbid obesity and reduce their need for levothyroxine within one year following surgery.

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腹腔镜袖胃切除术对病态肥胖患者甲状腺功能减退的影响：一项为期一年的随访前瞻性队列研究。

背景与目的：肥胖是一个日益严重的全球公共卫生问题。减肥手术被认为是最安全、最有效的治疗选择，尽管它与各种代谢和神经激素的后果有关。本研究旨在评估袖胃切除术（SG）对术后一年内甲状腺功能减退的影响。方法：在这项单中心前瞻性横断面研究中，纳入了SG候选的病态肥胖患者。在基线和术后12个月比较体重指数（BMI）、左旋甲状腺素剂量和甲状腺功能测试。结果与结论：术后患者BMI、左甲状腺素用量、TSH、T4水平均显著降低(P

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