Iranian Journal of Pathology最新文献

{"title":"From the Microscope to the Multidisciplinary Team: The Expanding Influence of Pathology on Clinical Decision-Making.","authors":"Alireza Abdollahi, Mohammad Reza Jalali Nadoushan, Haniyeh Rafiepoor","doi":"10.22034/ijp.2026.2602.3631","DOIUrl":"10.22034/ijp.2026.2602.3631","url":null,"abstract":"","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 3","pages":"341-343"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13348208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between IL-4 (rs2243250) and IL-13 (rs20541) Gene Polymorphisms and Total IgE Levels in Bronchial Asthma: A Study from Aswan Governorate, Egypt.","authors":"Amgad A Ezzat, A Sadek, Shazly B Ali, Mostafa M Abdelnaser, Mohamed M Amin, Ayman S Yassin Alsayed","doi":"10.22034/ijp.2026.2076607.3573","DOIUrl":"10.22034/ijp.2026.2076607.3573","url":null,"abstract":"<p><strong>Background & objective: </strong>Bronchial asthma is a persistent inflammatory disorder of the respiratory system, characterised by the involvement of numerous immune cells and mediators. Interleukin-4 (IL-4) and interleukin-13 (IL-13) are Th2 cytokines involved in asthma pathophysiology. This study aimed to assess the impact of IL-4 rs2243250 and IL-13 rs20541 genetic variants, in combination with total blood IgE levels, on asthma patients from Aswan governorate, Egypt.</p><p><strong>Methods: </strong>This case-control study included 50 patients with asthma and 30 healthy controls matched for age and environment. Serum levels of IL-4, IL-13, and IgE were quantified using ELISA. IL-4 and IL-13 polymorphisms were identified using PCR-RFLP genotyping.</p><p><strong>Results: </strong>Serum IgE levels showed strong correlations with IL-4 and IL-13 levels (Spearman r = 0.742 and 0.937, respectively; p = 0.001). Genotype distributions of IL-4 rs2243250 and IL-13 rs20541 differed significantly between asthma cases and controls (p < 0.05), with enrichment of the IL-13 rs20541 A allele among cases. IL-13 rs20541 genotype distribution did not differ significantly across asthma severity categories; however, severity-stratified analyses were underpowered. After Benjamini-Hochberg FDR adjustment for the prespecified genetic family (m = 4), IL-4 genotype distribution (p = 0.0027, q = 0.0107) and T-allele enrichment (p = 0.0185, q = 0.037) remained significant. For IL-13 rs20541, genotype distribution (p = 0.009, q = 0.0105) and A-allele enrichment (p = 0.0005, q = 0.0035) were also significant.</p><p><strong>Conclusion: </strong>This study supports Th2-skewed immune activation in bronchial asthma, with higher serum IgE, IL-4, and IL-13 levels in cases. Genetic analyses suggest associations between IL-4 rs2243250 and IL-13 rs20541 polymorphisms and asthma susceptibility. Given the modest control sample and absence of A/A cells among controls, the rs20541 finding should be interpreted as suggestive and hypothesis-generating. Larger, ancestry-matched cohorts with objective phenotyping and standardized treatment sampling are warranted.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 3","pages":"372-381"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13348205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Atrium Large Masses Due to Endocarditis Following Permcath Insertion After Covid-19-Induced Renal Failure.","authors":"Seyed Mohsen Mirhosseini, Hossein Yarmohammadi, Arash Anisian, Fatemeh Ravand, Mahdi Rezaei, Masood Soltanipu","doi":"10.30699/ijp.2025.2068882.3506","DOIUrl":"10.30699/ijp.2025.2068882.3506","url":null,"abstract":"<p><strong>Background & objective: </strong>COVID-19 infection is known to affect the kidneys, potentially resulting in Acute Kidney Injury (AKI). In some patients, however, renal failure may necessitate hemodialysis following a COVID-19 infection. Pneumothorax, hemothorax, cardiac arrhythmias, and endocarditis are some complications associated with Permcath insertion, a type of vascular access used in hemodialysis.</p><p><strong>Case presentation: </strong>In this report, we present a 29-year-old man who suffered from endocarditis following hemodialysis treatments through a Permcath because of acute renal failure following COVID-19. Removing the large masses (3×3 cm) inside the right atrium (RA) and taking out the Permcath was completed surgically.</p><p><strong>Conclusion: </strong>A suitable Permcath and its accurate insertion are recommended to provide prompt AKI treatment and prevent further complications, such as endocarditis and thrombosis.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 1","pages":"136-142"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating HBcrAg, miRNA-122, and M2BPGi as Predictive Biomarkers for Hepatocellular Carcinoma in Chronic Hepatitis B Patients: A Case-Control Study.","authors":"Amgad Ahmed Ezzat Othman, Mohamed S Hemeda, Khaled Mohamed Hassanein Mohamed, Mohammed Saad Ahmed, Ayman S Yassin, Mohamed Nabil Mohamed, Abd Elmoaty Arafat Abd Elmoaty, Mahmoud M Khafagi, Mohammed Mostafa Mohammed Abdo, Mohamed Abdel Basit Ibrahim Mohamed","doi":"10.22034/ijp.2026.2075531.3567","DOIUrl":"10.22034/ijp.2026.2075531.3567","url":null,"abstract":"<p><p>miRNA-122, HBcrAg, M2BPGi, Hepatocellular carcinoma, Chronic hepatitis B, Forensic biomarkers, Toxicological relevance.</p><p><strong>Background & objective: </strong>Hepatitis B Virus (HBV) infection has highly negative consequences for the global population, with chronic hepatitis B (CHB) infection and the resulting hepatocellular carcinoma (HCC) representing one of the most concerning long-term outcomes. This study focuses on the use of several biomarkers (miRNA-122, HBcrAg, and M2BPGi) in liquid biopsies to evaluate their efficacy in detecting early-stage HCC and assessing risk in patients with CHB.</p><p><strong>Methods: </strong>This study included 90 participants. Of these participants, 30 had chronic hepatitis B (CHB), 30 had hepatocellular carcinoma with HBV (HCC), and 30 were healthy controls. Serum miRNA-122 was quantified with real-time PCR, and HBcrAg and M2BPGi were measured using ELISA.</p><p><strong>Results: </strong>MiRNA-122 had an AUC of 0.801 and a sensitivity of 85.2%, indicating the highest diagnostic performance among the studies evaluated. M2BPGi demonstrated strong performance, with an AUC of 0.84. By contrast, HBcrAg had a very weak discriminative value. These previously stated biomarkers can improve the peripheral non-invasive screening.</p><p><strong>Conclusion: </strong>In this initial cohort study, circulating miRNA-122 and M2BPGi demonstrate an unsuspected capacity to predict HCC differentiation in CHB patients. However, these are preliminary and have yet to be tested for robustness across multicenter studies with appropriately estimated sample sizes.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"175-185"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of the L858R Mutation in Exon 21 of the Epidermal Growth Factor Receptor in Patients with Non-Small Cell Lung Cancer.","authors":"Hossein Ayatollahi, Amir Hossein Jafarian, Zohreh Emamdadi, Farideh Ranjbar, Hassan Mehrad-Majd, Batul Oudi","doi":"10.30699/ijp.2025.2057190.3438","DOIUrl":"10.30699/ijp.2025.2057190.3438","url":null,"abstract":"<p><strong>Background & objective: </strong>Epidermal growth factor receptor (EGFR) mutations are among the most common oncogenic drivers in non-small cell lung cancer (NSCLC). The L858R mutation in exon 21 of the EGFR gene is associated with responsiveness to targeted therapies in NSCLC patients. This study aimed to evaluate the frequency of L858R mutation and its correlation with clinicopathological characteristics in NSCLC patients.</p><p><strong>Methods: </strong>In this cross-sectional study, Allele-specific Polymerase Chain Reaction (ASPCR) was used to detect L858R mutation in genomic DNA obtained from 336 patients diagnosed with NSCLC. Patients were categorized into mutation-positive groups and mutation-negative subgroups. Associations between the L858R mutation, clinicopathological features, and overall survival were analyzed using appropriate statistical methods.</p><p><strong>Results: </strong>The L858R mutation was identified in 6% of patients (20 out of 336) and showed no significant association with clinicopathological features such as age, gender, tumor grade, histology subtypes, or metastasis (all P > 0.05). Survival analysis indicated an overall mortality rate of 81.8%, with no statistically significant difference in median survival between mutation-negative (11 months) and mutation-positive groups (8 months, P=0.246). Cox regression analysis identified Tumor Grade I as a b significant prognostic factor in both Univariate (HR=0.46, P=0.031) and multivariate (HR=0.46, P=0.040) models.</p><p><strong>Conclusion: </strong>The frequency of the L858R mutation in this Iranian cohort with NSCLC was lower than that reported in global studies. However, its association with metastasis and mortality indicates the potential clinical relevance of this mutation in treatment planning.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 1","pages":"3-10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12911665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146221339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Intraoperative Squash Cytology of Intracranial and Spinal Cord Lesions with Histopathological Correlation.","authors":"Birundha Baskaran, Preethi Sri, Prema Devi","doi":"10.22034/ijp.2026.2070253.3525","DOIUrl":"10.22034/ijp.2026.2070253.3525","url":null,"abstract":"<p><strong>Background & objective: </strong>Central nervous system (CNS) tumors display significant diversity in clinical behavior and morphology. Timely intraoperative diagnosis is critical for surgical decision-making. Squash cytology is a rapid, cost-effective tool for evaluating CNS lesions intraoperatively, especially where frozen section has limitations. This study aimed to assess the utility and diagnostic accuracy of squash cytology in the intraoperative diagnosis of intracranial and spinal cord space-occupying lesions, with correlation to histopathology.</p><p><strong>Methods: </strong>This prospective study included 57 patients undergoing surgery for CNS lesions at Government Medical College from January 2019 to June 2020. Intraoperative squash smears were prepared and stained with rapid hematoxylin and eosin. The cytological diagnosis was compared with paraffin-embedded histopathology. Statistical analysis was performed to evaluate sensitivity, specificity, diagnostic accuracy, and concordance in tumor grading.</p><p><strong>Results: </strong>Among the 57 cases, 91% were neoplastic and 9% were non-neoplastic. Meningioma (33.3%) and diffuse astrocytic/oligodendroglial tumors (28.1%) were the most common neoplasms. The diagnostic accuracy of squash cytology was 94.73%, with high sensitivity and specificity. Cytological grading matched histopathological grading in the majority of cases. Diagnostic errors were mainly observed in tumors with poor smearability, high cohesiveness, or crush artifacts.</p><p><strong>Conclusion: </strong>Intraoperative squash cytology is a valuable diagnostic adjunct in CNS surgeries. It offers high accuracy and rapid turnaround and is particularly useful in resource-limited settings. While histopathology remains the gold standard, squash cytology significantly aids intraoperative decision-making.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"264-270"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148035807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EZH2 and MMP1 Overexpression in Colorectal Cancer: Correlation with Tumor Aggressiveness and Clinicopathologic Features.","authors":"Mayada S Farrag, Mohamed S Hemeda, Ziad Emarah, Khaled El Naghy, Khaled Abdelwahab, Nesrine S Farrag, Afaf T Ibrahiem","doi":"10.22034/ijp.2025.2067098.3494","DOIUrl":"10.22034/ijp.2025.2067098.3494","url":null,"abstract":"<p><strong>Background & objective: </strong>One of the most lethal as well as prevalent malignancies across the globe is colorectal cancer (CRC). MMP1, a certain type of matrix metalloproteinase, as well as EZH2, a histone methyltransferase, are gaining attention for their part in metastasis and tumor progression. This research analyses the expression of immunohistochemistry EZH2 and MMP1 in relation to colorectal carcinoma, and how these two proteins correlate with other clinicopathological features.</p><p><strong>Methods: </strong>An analysis was done retrospectively on 38 cases of colorectal cancer, which were formalin-fixed and paraffin-embedded. MMP1 and EZH2 staining were assessed immunohistochemically and correlated with the tumor's stage, lymph nodes, clinical stage, and prognosis. Statistical analysis was conducted with SPSS version16.0 and a level of significance of p <0.05.</p><p><strong>Results: </strong>Markedly increased expression of EZH2 and MMP1 had notable correlation with advanced T stage (p =0.01 and0.03) along with metastasis to the regional lymph nodes (p =0.027) and clinical stages III or IV (p =0.04 for EZH2 and p =0.023 for MMP1). Although both markers demonstrated a trend for decreased disease-free survival (DFS), neither achieved statistical significance for DFS or overall survival (OS).</p><p><strong>Conclusion: </strong>EZH2 and MMP1 overexpression were associated with aggressive clinicopathologic features (higher T stage, nodal involvement, and advanced clinical stage). However, neither marker showed a statistically significant association with overall survival (OS) or disease-free survival (DFS) in this cohort. Larger, adequately powered studies are required to clarify any potential prognostic value.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"252-263"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of CD8+ and CD4+ Tumor-Infiltrating Lymphocytes and Perineural/Vascular Invasion in Laryngeal Squamous Cell Carcinoma.","authors":"Maryam Lotfi, Mina Majdi, Parin Tanzifi, Tahereh Yousefi, Elham Nazar, Aysan Nozheh","doi":"10.22034/ijp.2026.2066899.3493","DOIUrl":"10.22034/ijp.2026.2066899.3493","url":null,"abstract":"<p><strong>Background & objective: </strong>Squamous cell carcinoma (SCC) is characterized by infiltration of CD4+ and CD8+ T lymphocytes, which represent an early host immune response against malignant cells. This immune response may inhibit tumor progression and suppress malignancy. This study aimed to evaluate the density of CD4+ and CD8+ lymphocytes and their ratio within tumor nests and surrounding stroma in conventional laryngeal SCC. It also examined associations with prognostic factors such as regional lymph node metastasis, tumor histologic differentiation, vascular invasion, and perineural invasion.</p><p><strong>Methods: </strong>This retrospective study analyzed 54 laryngeal SCC samples from patients who underwent total laryngectomy and cervical lymph node dissection without prior neoadjuvant chemoradiation therapy. Immunohistochemistry was used to assess CD4+ and CD8+ T lymphocytes in tumor nests and surrounding stroma. Statistical analyses evaluated correlations between lymphocyte infiltration and prognostic factors, including lymph node metastasis, histologic differentiation, vascular invasion, and perineural invasion.</p><p><strong>Results: </strong>A significant association was found between high intratumoral CD8+ T lymphocyte density and a lower incidence of vascular and perineural invasion (mean, 10.9 cells/HPF vs 4.5 cells/HPF; p = 0.03). No significant correlations were observed between lymphocyte density and lymph node metastasis or tumor histologic differentiation.</p><p><strong>Conclusion: </strong>High intratumoral CD8+ T-cell infiltration correlates with reduced vascular and perineural invasion in laryngeal SCC, suggesting a protective role in limiting tumor invasiveness. These findings highlight the prognostic significance of CD8+ T lymphocytes and warrant further research into immune mechanisms affecting SCC progression and patient outcomes.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"240-251"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148035752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmacytoma of the Cervix Possibly Caused by Neglected Pessary: A Case Report and Literature Review.","authors":"Noviana Nugrohowati, Bening Rahimi Titisari, Hanggoro Tri Rinonce, Rita Cempaka, Irianiwati Widodo Widodo, Tania Kusuma","doi":"10.30699/ijp.2025.2061514.3465","DOIUrl":"10.30699/ijp.2025.2061514.3465","url":null,"abstract":"<p><strong>Background & objective: </strong>Plasmacytoma is a rare plasma cell dyscrasia marked by localized monoclonal plasma cell proliferation, distinct from multiple myeloma by its lack of systemic symptoms. Extramedullary plasmacytoma (EMP), the rarest form, typically occurs in the upper respiratory tract. Cervical involvement is rare. Chronic inflammation may play a role in the development of cervical plasmacytoma, though this remains unproven for cervical cases.</p><p><strong>Case presentation: </strong>We present a unique case of a 74-year-old woman who presented with vaginal bleeding linked to a neglected pessary inserted 15 years earlier. Upon examination, we discovered overgrown tissue with active bleeding. The biopsy revealed a monomorphic plasma cell infiltration, and immunohistochemistry confirmed CD138-positive, BCL2-negative cervical plasmacytoma, a rare occurrence in the cervix.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering cervical EMP in atypical cytology and suggests a possible link to chronic pessary-induced inflammation. Early diagnosis through histopathology and immunohistochemistry is essential.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 1","pages":"121-127"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of the HOXA10-AS1 LncRNA in Gastric Cancer: An Expression and Bioinformatics Analysis.","authors":"Farideh Ghanbari Mardasi, Sharareh Eskandarieh, Reza Taslimi, Mohsen Eghtedari, Zeinab Jamali, Masoomeh Safaei, Majid Kabuli, Reza Shirkoohi","doi":"10.30699/ijp.2025.2046969.3385","DOIUrl":"10.30699/ijp.2025.2046969.3385","url":null,"abstract":"<p><strong>Background & objective: </strong>Gastric cancer (GC) is a lethal disease with poor prognosis. Long non-coding RNAs (lncRNAs) involved in the development of cancer through changes in their expression levels. In present study, we aimed to evaluate HOXA10-AS gene expression and its potential as a biomarker in GC.</p><p><strong>Methods: </strong>In this study 60 subjects (30 gastric carcinoma tissues and 30 adjacent non-carcinoma tissues) were examined. The expression level of the HOXA10-AS gene was evaluated using quantitative PCR. Furthermore, clinicopathological characteristicswere taken into consideration. Diagnostic value of the HOXA10-AS was examined by ROC curve analysis. Bioinformatics analysis was performed using different databases.</p><p><strong>Results: </strong>Expression of HOXA10-AS was significantly upregulated in GC tumoral tissues. Roc curve analysis revealed that the diagnostic power of HOXA10-AS was high (AUC = 0.64) in the tumor compared to the normal GC tissues.</p><p><strong>Conclusion: </strong>Our findings show that HOXA10-AS expression level is higher in the GC tumor compared to the adjacent non-carcinoma tissues and can act as a strong diagnostic biomarker in GC patients.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 1","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}