Iranian Journal of Pathology最新文献_第6页

Current Understanding of PCSK9 and Its Relevance to Cancer Prognosis and Immune Therapy: A Review. 目前对 PCSK9 及其与癌症预后和免疫疗法相关性的了解：综述。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2023-12-29 DOI: 10.30699/IJP.2023.1999459.3093

Morteza Hassandokht Mashhadi, Fahime Taheri, Sadaf Irani, Arshiya Mesbah Mousavi, Ali Mehri, Hossein Javid

{"title":"Current Understanding of PCSK9 and Its Relevance to Cancer Prognosis and Immune Therapy: A Review.","authors":"Morteza Hassandokht Mashhadi, Fahime Taheri, Sadaf Irani, Arshiya Mesbah Mousavi, Ali Mehri, Hossein Javid","doi":"10.30699/IJP.2023.1999459.3093","DOIUrl":"10.30699/IJP.2023.1999459.3093","url":null,"abstract":"The effectiveness of immunotherapy for most cancer patients remains low, with approximately 10-30% of those treated surviving. Thus, much effort is being put into finding new ways to improve immune checkpoint therapy. Our review concludes that inhibition of proprotein convertase subtilisin/Kexin type 9 (PCSK9), which plays a critical role in regulating cholesterol metabolism, can cause movement of T cells toward tumors, with increased sensitivity to immune checkpoint therapies. We searched PubMed, NCBI, Scopus, and Google Scholar for the published articles without limitations on publication dates. We used the following terms: \"PCSK9\", \"Cancer\", \"Immune Checkpoint\", and \"Cancer Prognosis\" in the title and/or abstract. Our search initially revealed 600 records on the subject and stored them in the used databases under EndNote X8 management software. A total of 161 articles were selected and through a careful review, 76 were included in our research. We concluded that PCSK9 reduces the number of LDL receptors (LDL-R) on the cell surface, which is linked to its ability to regulate cholesterol levels in the body. Also, we discuss how suppressing PCSK9 leads to the MHC-1 accumulation on the surface of cancer cells, which results in T lymphocyte invasion. Finally, we believe that inhibiting PCSK9 may be an effective strategy for improving cancer immunotherapy.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Malignancy of the Eyelid: Report A Case of Primary Periocular Histiocytoid Carcinoma. 罕见的眼睑恶性肿瘤：报告一例原发性眼周组织细胞样癌。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-07-24 DOI: 10.30699/IJP.2024.2016655.3219

Arezu Rahnavard, Elham Mirzaian, Reyhaneh Safaei, Ida Mehrabi

引用次数: 0

Comparison of the Structural, Cytological and Biomarker Expression in Carcinoma in situ and Invasive Components in Breast Carcinoma. 乳腺癌原位癌和浸润性成分结构、细胞学和生物标志物表达的比较。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-04-07 DOI: 10.30699/IJP.2024.2025907.3285

Azar Naimi, Niloufar Mohaghegh

{"title":"Comparison of the Structural, Cytological and Biomarker Expression in Carcinoma in situ and Invasive Components in Breast Carcinoma.","authors":"Azar Naimi, Niloufar Mohaghegh","doi":"10.30699/IJP.2024.2025907.3285","DOIUrl":"10.30699/IJP.2024.2025907.3285","url":null,"abstract":"Background & objective: Breast cancer is thought to arise from non-invasive breast lesions, such as atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS). DCIS is considered a direct precursor of invasive carcinoma. The morphological features alone do not reflect the biological truth of this disease. Therefore, we investigated features of carcinoma in situ and the invasive components in women diagnosed with breast cancer.Methods: This study was a cross-sectional study. The corresponding IHC slides were selected from the pathology archive and examined by the pathologist. Fifty-one samples which showed both in situ and invasive components confirmed immunohistochemically, were included in the study.Results: In 70.6% of the cases a high grade of in situ and invasive carcinoma was observed. In 45.1% of the studied cases, a solid structure was observed in in-situ carcinoma, and no otherwise specified structure was observed in invasive carcinoma. In 74.5% of both in situ and invasive carcinoma types, ER.PR had a positive value. In 45.5% of the cases, both in situ and invasive carcinoma components show low Ki67. In 42.2%, both in situ and invasive carcinomas were Her2 negative. There was no significant difference between the grade (P=0.687), Her2 type (P=0.532), and structure (P=0.532). ER.PR (P=1.00) and Ki67 (P=0.180) of in situ and invasive carcinoma in this study.Conclusion: Our study showed differences between in situ and invasive biomarker expression. According to our findings, owing to heterogeneity, in situ components can't be representative of invasive components for treatment choices.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 3","pages":"318-325"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Carcinoma Coexistent with Ipsilateral Axillary Non-Hodgkin Lymphoma: Cytological Diagnosis Aided with Cellblock Immunohistochemistry. 乳腺癌与同侧腋窝非霍奇金淋巴瘤并存：细胞学诊断辅以细胞块免疫组化。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.30699/IJP.2024.2014737.3203

Krishnendu Mondal, Rupali Mandal

引用次数: 0

Comparing Length and Telomere Expression at Oral Precancerous and Cancerous Stages. 比较口腔癌前病变和癌变阶段的长度和端粒表达。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-02-15 DOI: 10.30699/IJP.2024.1996330.3081

Fahad Mansoor Samadi, Shaista Suhail, Manjari Sonam, Mohd Kaleem Ahmad, Vijay Kumar, Shaleen Chandra, Shadab Mohammad

{"title":"Comparing Length and Telomere Expression at Oral Precancerous and Cancerous Stages.","authors":"Fahad Mansoor Samadi, Shaista Suhail, Manjari Sonam, Mohd Kaleem Ahmad, Vijay Kumar, Shaleen Chandra, Shadab Mohammad","doi":"10.30699/IJP.2024.1996330.3081","DOIUrl":"10.30699/IJP.2024.1996330.3081","url":null,"abstract":"Background & objective: Telomeres consist of repetitive G-rich nucleotides located at the end of each chromosome, acting as protein binding sites. The aim of this study was to examine the differences in telomere length in blood, saliva, and tissue samples at various stages of oral precancerous and cancerous lesions.Methods: Samples of blood, tissue, and saliva were collected from patients with oral precancerous and cancerous lesions. DNA extraction was performed. Then, a TRAP assay was conducted to assess and compare the telomere length and telomerase expression.Results: The levels of telomerase activity (TA) in the DNA samples ranged from 0.19 to 6.91 (2.05+1.37) among oral squamous cell carcinoma (OSCC) patients and from 0.17 to 4.5 (0.28+4.25) among precancerous patients. A significant difference was observed in TA levels between OSCC and precancerous samples (t=3.9691, P= 0.0000).Conclusion: Assessing the telomerase activity is crucial for studying the behavior of carcinoma in the clinical setting. The augmented telomerase expression and the length of telomere contribute to OSCC progression. Hence, this study adds a diagnostic tool that can serve as a biomarker for the early detection and prognosis of OSCC.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 2","pages":"146-151"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11304464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer. 乳腺癌预后标志物和 LDLR 相关蛋白家族成员免疫渗透的综合分析

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-03-29 DOI: 10.30699/IJP.2024.1995769.3077

Shabnam Shahidi, Parvin Ansari Shayesteh, Mahsa Alami, Negin Parsamanesh

{"title":"Comprehensive Analysis of the Prognostic Marker and Immune Infiltrates of LDLR-Related Proteins Family Members in Breast Cancer.","authors":"Shabnam Shahidi, Parvin Ansari Shayesteh, Mahsa Alami, Negin Parsamanesh","doi":"10.30699/IJP.2024.1995769.3077","DOIUrl":"10.30699/IJP.2024.1995769.3077","url":null,"abstract":"Background & objective: Breast cancer (BC) is one of the most frequent tumors worldwide, accounting for 15% of all cancer-related deaths. A timely diagnosis of BC is essential for optimal treatment and increasing patients' survival rates. LRP family proteins are important components of cell-surface receptors involved in numerous biological activities. Expression of LRP is related to breast malignancy. In this study, we initially studied the expression of LRPs in BC tissues compared to normal tissues-the relation of LRP expression with relapse-free survival (RFS) and overall survival (OS). Then, we investigated the association of LRPs relation and immune infiltrating abundance.Methods: We analyzed the LDLR family expression and prognostic value in BC by mining UALCAN, TIMER, and Kaplan-Meier plotter databases. Subsequently, we explored the association of LDLR expression and immune infiltrating abundance via the TIMER database.Results: Expression levels of LRP1/2/4/9/10 were found to be higher in the cases with positive estrogen receptors. There was a positive association between LRP1/6 expression and the infiltration of CD8+ T cells, CD4+ T Cell, Macrophage, Dendritic Cell, and Neutrophil.Conclusion: Our study recommends LDLR as a potential prognostic biomarker that can be promising to improve the survival of BC patients' survival. However, further investigations are needed to evaluate the studied LDLR members in more detail.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 1","pages":"31-49"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11164315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141306996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delving into the Role of α-Smooth Muscle Actin as a Predictive Biomarker of Early Recurrence in Invasive Ductal Adenocarcinoma of Breast. α-平滑肌肌动蛋白在乳腺浸润性导管腺癌早期复发预测中的作用

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-07-15 DOI: 10.30699/IJP.2024.2022442.3255

Seetu Palo

引用次数: 0

The Most Common Multi-Drug Resistant Bacteria Associated with Hospital Infections, in Urmia, Iran. 在伊朗乌尔米亚与医院感染相关的最常见多重耐药细菌

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-07-24 DOI: 10.30699/IJP.2024.2014294.3195

Seyyed Jalil Mousavi, Rahim Nezhadrahim, Farima Abdulzadeh

{"title":"The Most Common Multi-Drug Resistant Bacteria Associated with Hospital Infections, in Urmia, Iran.","authors":"Seyyed Jalil Mousavi, Rahim Nezhadrahim, Farima Abdulzadeh","doi":"10.30699/IJP.2024.2014294.3195","DOIUrl":"10.30699/IJP.2024.2014294.3195","url":null,"abstract":"Background & objective: Hospital-acquired infections (HAIs) are a major healthcare problem in hospitalized patients, especially in developing countries, where they affect millions of patients and cause high mortality rates. This study aimed to investigate multidrug-resistant bacterial strains in NIs at Imam Khomeini University Hospital in Urmia, Iran.Methods: This cross-sectional study was conducted using a convenience sampling method. The study population comprised all positive clinical samples from HAIs registered in the laboratory of Imam Khomeini Hospital, Urmia, Iran, in 2019. Bacteria were identified by culturing the samples on blood agar and MacConkey agar, followed by performing standard biochemical tests. Antibiotic susceptibility testing was carried out using the disk diffusion method, in accordance with CLSI guidelines.Results: Of the 607 positive samples, the most common microorganisms isolated were Escherichia coli (27.5%), Acinetobacter baumannii (18.5%), and Klebsiella pneumoniae (15.2%). The distribution of resistance to the number of antibiotics in bacterial isolates from the samples showed that 19.8% of them were resistant to one antibiotic and 13.2% were resistant to three antibiotics. 40.5% of the samples showed no resistance to antibiotics.Conclusion: This study highlights the critical issue of HAIs and the prevalence of multidrug-resistant bacteria in Urmia, Iran. Urgent measures, including improved hygiene, accurate diagnostics, appropriate antibiotic use, and stakeholder education, are essential. Establishing a robust HAI surveillance system is also recommended. Future efforts should aim at understanding and mitigating the spread of these pathogens.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 3","pages":"283-291"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Value of Hepatic Mast Cell Concentration (MCC) in NAFLD and NASH Severity and Fibrosis Grade. 肝肥大细胞浓度（MCC）在NAFLD和NASH严重程度及纤维化分级中的诊断价值。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-04-29 DOI: 10.30699/IJP.2024.2016320.3216

Mahshid Panahi, Nasser Rakhshani, Alireza Sarhaddi, Monavvar Afzalaghaee, Hamid Rezvani, Nikoo Emtiazi, Farkhonde Sarhaddi

{"title":"Diagnostic Value of Hepatic Mast Cell Concentration (MCC) in NAFLD and NASH Severity and Fibrosis Grade.","authors":"Mahshid Panahi, Nasser Rakhshani, Alireza Sarhaddi, Monavvar Afzalaghaee, Hamid Rezvani, Nikoo Emtiazi, Farkhonde Sarhaddi","doi":"10.30699/IJP.2024.2016320.3216","DOIUrl":"10.30699/IJP.2024.2016320.3216","url":null,"abstract":"Background & objective: Mast cells play a role in the immune responses to fatty liver disease. The present study aimed to investigate the diagnostic value of hepatic mast cell concentration (MCC) in NAFLD and NASH severity and fibrosis grade.Methods: The present cross-sectional unremarkable hepatic histology, NAFLD, or NASH cases were enrolled. Demographic variables, BMI, hepatic stiffness assessed using fibroscan, portal inflammation, hepatic disease grade assessed using the NAFLD Activity Score (NAS), and hepatic fibrosis severity assessed using the NASH fibrosis stage, hepatic necrosis severity, and hepatic steatosis severity of the patients were collected. The hepatic specimens underwent immunohistochemical (IHC) staining.Results: Of a total of 92 patients with a mean age of 38.7±13.3 years, 56 (60.9%) were males. There were significant relationships between the NAS score of the patients and hepatic steatosis. Moreover, the NASH fibrosis stage had significant relationships with the variables of hepatic necrosis, steatosis, and stiffness. There were significant positive correlations between the mast cell concentration (MCC) in all zones of the hepatic tissue (zone 1, zone 2, zone 3, portal area, and total) and the variables of age, BMI, and hepatic necrosis, steatosis, and stiffness. The patients with a higher NASH fibrosis stage showed a significantly higher MCC in all zones of the hepatic tissue.Conclusion: Hepatic mast cell number may have a significant impact on the grade and fibrosis in NAFLD. However, it is recommended to perform further studies with larger sample sizes on patients with various etiologies for hepatic injury to confirm the present study results.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"19 3","pages":"291-299"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemolytic Uremic Syndrome Secondary to Scorpion Envenomation in a 7-Year-Old Boy from Southwestern Iran. 伊朗西南部一名7岁男孩蝎子中毒继发溶血性尿毒症综合征。

Iranian Journal of Pathology Pub Date : 2024-01-01 Epub Date: 2024-10-02 DOI: 10.30699/ijp.2024.2024403.3272

Nafiseh Mortazavi, Nakysa Hooman, Mitra Mehrazma, Yasaman Moradi, Parvin Aghavali

引用次数: 0