Iranian Journal of Pathology最新文献_第3页

Molecular Characterization of Aminoglycoside-modifying Enzymes (AMEs)in Aminoglycoside-Resistant Staphylococcus aureus: A Cross-sectional Study in Northeastern Iran. 耐氨基糖苷金黄色葡萄球菌氨基糖苷修饰酶（AMEs）的分子特征：伊朗东北部的一项横断面研究

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2038509.3342

Malihe Naderi, Neda Yousefi Nojookambari, Somayeh Talebi, Mohammad Reza Mohammadi, Sajjad Yazdansetad

{"title":"Molecular Characterization of Aminoglycoside-modifying Enzymes (AMEs)in Aminoglycoside-Resistant Staphylococcus aureus: A Cross-sectional Study in Northeastern Iran.","authors":"Malihe Naderi, Neda Yousefi Nojookambari, Somayeh Talebi, Mohammad Reza Mohammadi, Sajjad Yazdansetad","doi":"10.30699/ijp.2024.2038509.3342","DOIUrl":"10.30699/ijp.2024.2038509.3342","url":null,"abstract":"Background & objective: The resistance genes encoding aminoglycoside-modifying enzymes (AMEs) are now widely prevalent in different populations of Staphylococcus aureus. The study aimed to determine the frequency of AMEs-encoding genes in clinical isolates of S. aureus.Methods: A total of 105 S. aureus isolates were obtained from the different clinical samples; and then were identified by conventional biochemical tests. The antibiotic resistance patterns of the isolates were characterized by the agar disk diffusion method. The distribution of the AMEs and femA genes was determined by conventional and multiplex PCR.Results: The aminoglycoside resistance rates of kanamycin, tobramycin, gentamicin, amikacin, and netilmicin were 47.6%, 46.6%, 45.7%, 45.7%, and 26.6%, respectively. 16.1% and 1.9% of isolates were MDR and XDR phenotypes, respectively. 21.9% of S. aureus isolates harbored the femA gene and were determined as methicillin-resistant S. aureus (MRSA) clones. The aac(6')/aph(2'') was the most prevalent (47.8%) AME-encoding gene in aminoglycoside-resistant S. aureus, followed by ant(4')-Ia (30.4%) and aph(3')-IIIa (21.7%).Conclusion: Our study demonstrated that the coexistence of several AMEs and the spread of the resistance determinants like femA in S. aureus clinical isolates are alarming and may contribute to the broadening of aminoglycoside resistance spectra and limit treatment options for staphylococcal infections.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phyllodes Tumor, A Cytomorphologic Study of 17 Cases with Histologic Correlation. 叶状瘤17例组织学相关性的细胞形态学研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2033852.3322

Savita Agarwal, Pinki Pandey, Megha Sawhney, Alka Yadav, Sunita Kumari Meena

{"title":"Phyllodes Tumor, A Cytomorphologic Study of 17 Cases with Histologic Correlation.","authors":"Savita Agarwal, Pinki Pandey, Megha Sawhney, Alka Yadav, Sunita Kumari Meena","doi":"10.30699/ijp.2024.2033852.3322","DOIUrl":"10.30699/ijp.2024.2033852.3322","url":null,"abstract":"Background & objective: Phyllodes tumor (PT) is a rare fibroepithelial tumor of the breast exhibiting varied clinicopathologic behavior, ranging from benign to borderline to frankly malignant, based on the presence of infiltrative margins, stromal overgrowth, stromal atypia, cellularity, and mitotic activity. In this study, a detailed cytomorphological study of cases of PT with the clinical and histological correlation was performed.Methods: A cytomorphological study of 17 cases of histologically proven PT diagnosed between Jan 2014 and July 2021 was done retrospectively. Relevant data including age at the time of diagnosis, the duration of illness, presenting symptoms, personal and family history, tumor size, tumor localization, and surgical procedure were obtained. A detailed cytomorphological assessment of stromal and epithelial components was performed, and further histological correlation was obtained for each case.Results: Age of the patients ranged from 25 to 65 years old. The chief complaint was a palpable breast mass in all patients. The mean size of the lump was 11.86 cm. A complete cytohistological concordance was achieved among malignant cases. Stromal metaplasia was observed in only one case of benign phyllodes tumor, which was chondroid differentiation, and malignant heterologous component as fibrosarcomatous differentiation in one of the malignant PTs. Each of the benign and malignant phyllode tumors ductal carcinoma in situ (DCIS) of its epithelial component was seen in one case.Conclusion: Phyllodes should be considered in differential diagnosing of any rapidly growing breast lump. Breast imaging has limited role in diagnosis of phyllode tumors. FNAC or trucut biopsy is mandatory in preoperative diagnosis. An extended follow-up is needed in all cases.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"90-97"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Maxillary Swelling in a 21-Year-Old Male - A Case Report. 21岁男性上颌异常肿胀1例。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2025.2024697.3271

Pushpak U Shah, Punnya V Angadi, Sanjay S Rao

引用次数: 0

A Case of Amelanotic Plasmacytoid Melanoma with Strong CD138 Expression, Mimicking Multiple Myeloma - A Case Report. 具有强烈CD138表达的无色性浆细胞样黑色素瘤1例，模拟多发性骨髓瘤。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2040460.3354

Ery Kus Dwianingsih, Yuni Artha Prabowo, Sofia Pranacipta, Shinta Andi Sarasati, Amri Wicaksono, Sekar Safitri, Eviana Norahmawati, Rahadyan Magetsari

{"title":"A Case of Amelanotic Plasmacytoid Melanoma with Strong CD138 Expression, Mimicking Multiple Myeloma - A Case Report.","authors":"Ery Kus Dwianingsih, Yuni Artha Prabowo, Sofia Pranacipta, Shinta Andi Sarasati, Amri Wicaksono, Sekar Safitri, Eviana Norahmawati, Rahadyan Magetsari","doi":"10.30699/ijp.2025.2040460.3354","DOIUrl":"10.30699/ijp.2025.2040460.3354","url":null,"abstract":"Background & objective: Melanomas have diverse pathological features that mimic other tumors, such as lymphoma, sarcoma, and even poorly differentiated carcinoma. The most recently identified variant, the plasmacytoid variant, is an uncommon variant that can appear as a solitary tumor or a metastatic disease. Due to its rarity, the epidemiologic profile of this variant is not well characterized. This case report illustrates a diagnostic challenge of plasmacytoid cell mimicker, which is rarely found in daily practice.Case presentation: A 49-year-old man presented with multiple subcutaneous soft tissue nodules in the thoracic area and multiple pathological fractures in the left distal humerus and distal ulna. Clinical and radiological findings were suggestive of metastatic bone disease with differential diagnosis of multiple myeloma. Fine needle aspiration biopsy and histopathological findings were suggestive of multiple myeloma with differential diagnoses of metastatic carcinoma, rhabdomyosarcoma, and amelanotic melanoma. Thus, immunostaining for CD138, CK, desmin, vimentin, S-100, and HMB45 were requested and the results were compatible with the final diagnosis of amelanotic plasma melanoma.Conclusion: It is crucial to consider melanoma as one of the differential diagnoses of a tumor with plasmacytoid feature and CD138 positive staining as it can mimic multiple myeloma as demonstrated in this case report.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"225-230"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Histologic Growth Patterns and Some Histopathologic Features in Clear Cell Renal Cell Carcinoma with Patient's Survival after Nephrectomy: A Cross-Sectional Study. 透明细胞肾细胞癌的组织学生长模式和一些组织病理学特征与肾切除术后患者生存的关系：一项横断面研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2033228.3319

Mehdi Farzadnia, Naser Tayyebi Meibodi, Ahmad Jafari Joshaghan, Mahnaz Baradaran, Motahare Ebrahimnejad, Saeid Dehghan Nezhad, Farideh Ranjbar

{"title":"Association of Histologic Growth Patterns and Some Histopathologic Features in Clear Cell Renal Cell Carcinoma with Patient's Survival after Nephrectomy: A Cross-Sectional Study.","authors":"Mehdi Farzadnia, Naser Tayyebi Meibodi, Ahmad Jafari Joshaghan, Mahnaz Baradaran, Motahare Ebrahimnejad, Saeid Dehghan Nezhad, Farideh Ranjbar","doi":"10.30699/ijp.2025.2033228.3319","DOIUrl":"10.30699/ijp.2025.2033228.3319","url":null,"abstract":"Background & objective: Clear cell renal cell carcinoma (CCRCC) is the most common type of renal cancer. Limited studies have been conducted about factors affecting the survival of patients with CCRCC. In this study, we aimed to evaluate the association between histologic growth patterns (HGPs) and some pathologic features and survival in CCRCC.Methods: This cross-sectional study evaluated the association between HGPs and other pathologic features and the survival of 145 patients with CCRCC after nephrectomy in Emam-Reza Hospital (Mashhad, Iran) from 2012 to 2022. Two expert pathologists assessed HGPs and other pathologic features, like cytopathologic changes. All analyses were performed using IBM SPSS version 26 software. A P value less than 0.05 was considered statistically significant.Results: In the current study, we assessed the association of the 6 most prevalent growth patterns with the patient's survival. Some clinicopathologic features like tumor stage and grade, tumor size, and necrosis are negatively linked with survival. Two important cytologic features, including sarcomatoid and rhabdoid, were also associated with survival time in patients with CCRCC (P values < 0.05). Regardless of the nuclear grade of the tumor, some patterns like solid sheet, papillary, and thick trabecular were associated with lower survival.Conclusion: Some HGPs are significantly associated with the patient's survival in CCRCC. A greater variety of patterns within each specimen has been associated with a reduced survival rate. The impact of HGPs on patient survival may be as significant as the nuclear grade.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"198-206"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterotopic Pancreatic Tissue in Gallbladder: A Report of an Unusual Entity at an Extremely Rare Location. 胆囊内异位胰腺组织：一个罕见位置的不寻常实体报告。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2019770.3244

Mukta Pujani, Aparna Khandelwal, Kanika Singh, Meenu Pujani, Cherry Bansal

{"title":"Heterotopic Pancreatic Tissue in Gallbladder: A Report of an Unusual Entity at an Extremely Rare Location.","authors":"Mukta Pujani, Aparna Khandelwal, Kanika Singh, Meenu Pujani, Cherry Bansal","doi":"10.30699/ijp.2025.2019770.3244","DOIUrl":"10.30699/ijp.2025.2019770.3244","url":null,"abstract":"Background & objective: Heterotopic pancreas (HP) or ectopic pancreas is the occurrence of pancreatic tissue in an atypical location with absence of any neurovascular or anatomic connection with the normal pancreas. In an autopsy series, the incidence of this embryologic anomaly is 0.55% to 13.7% of patients. Gallbladder is an extremely rare site for ectopic pancreatic tissue with approximately 40 documented cases.Case presentation: We hereby report a case of incidental discovery of ectopic pancreatic tissue in the excised gallbladder from a 27-year-old female who presented with nausea, vomiting, and abdominal pain intermittently. The gallbladder lumen was filled with biliary sludge containing a single gallstone. Histopathology revealed chronic cholecystitis along with a tiny focus of ectopic pancreatic tissue comprising only pancreatic acini.Conclusion: This case highlights that histopathology should be mandatory for all excised gallbladder specimens and that this entity should be considered among the differentials for nodular/polypoidal gallbladder lesions. Although the cases where the ectopic pancreas is discovered incidentally do not have much clinical significance, this may prevent the patient from undergoing more aggressive treatment reserved for conditions like pancreatitis or malignancy in cases where the ectopic pancreas mimics a malignancy.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"231-234"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Missense Mutation of c.965C>T (p.Ala322Val) in the Human GALNS Gene Results in Severe Mucopolysaccharidosis Type IVA. 人类GALNS基因c.965C . >T （p.a ala322val）新错义突变导致IVA型严重粘多糖病。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2025376.3278

Moeinadin Safavi, Aria Setoodeh, Mahdiieh Ghoddoosi

引用次数: 0

Evaluation of Notch1 and CD10 Expressions in Colorectal Carcinoma and Their Relationship with Prognosis. Notch1和CD10在结直肠癌中的表达及其与预后的关系

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-01-10 DOI: 10.30699/ijp.2024.2029781.3304

Noha Elkady, Reham Ahmed Abdelaziz, Rania Abdallah

{"title":"Evaluation of Notch1 and CD10 Expressions in Colorectal Carcinoma and Their Relationship with Prognosis.","authors":"Noha Elkady, Reham Ahmed Abdelaziz, Rania Abdallah","doi":"10.30699/ijp.2024.2029781.3304","DOIUrl":"10.30699/ijp.2024.2029781.3304","url":null,"abstract":"Background & objective: Even with improvements of colorectal cancer (CRC) treatment strategies, this cancer still has an unfavorable outcome. The primary cause of CRC development and recurrence is chemoresistance. CD10 and Notch1 are among cancer stem cell regulators, and they have roles in cancer progression and chemoresistance. This research aims to evaluate the expression of Notch1 and CD10 in CRC and their relationship with different clinicopathological parameters using immunohistochemistry.Methods: This retrospective study included 100 cases of colorectal carcinoma that were immunohistochemically stained using Notch1 and CD10 antibodies. Expression of Notch1 and CD10 was evaluated and compared with different clinicopathological parameters.Results: Notch1 expression was detected in the tumor and stromal cells in 92% of the cases, while CD10 expression was seen in 31% of tumor cells 79% of stromal cells of the included cases. Their expressions in tumor cells were significantly associated with higher grade (P=0.029 and 0.001), deeper invasion (P=0.01 and 0.002), advanced stage (P=0.012 and 0.001), and distant metastasis (P=0.001 and 0.02). Notch1 expression was positively correlated with CD10 expression (P=0.018). Both Notch1 expression and high CD10 expression in the stromal cells were associated with short overall survival (P=0.003 and 0.01).Conclusion: CD10 and Notch1 may have roles in colorectal carcinoma progression via induction of tumor invasion, metastasis and impairment of tumor response to therapy. CD10 and Notch1 could be used as biomarkers for aggressive CRC and may be considered for future target therapy.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"68-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Epidemiology and MLST-Based Typing of Pandrug-Resistant Acinetobacter baumannii Clinical Isolates in Iraq: A Cross-Sectional Study. 伊拉克全耐药鲍曼不动杆菌临床分离株的分子流行病学和基于mlst的分型：一项横断面研究。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/ijp.2025.2052426.3412

Hani Hasan Jubair, Marwa Jabbar Mezher, Noor Ayyed Mayea

{"title":"Molecular Epidemiology and MLST-Based Typing of Pandrug-Resistant Acinetobacter baumannii Clinical Isolates in Iraq: A Cross-Sectional Study.","authors":"Hani Hasan Jubair, Marwa Jabbar Mezher, Noor Ayyed Mayea","doi":"10.30699/ijp.2025.2052426.3412","DOIUrl":"10.30699/ijp.2025.2052426.3412","url":null,"abstract":"Background & objective: Acinetobacter baumannii is a globally recognized nosocomial pathogen capable of developing multidrug resistance. This study investigates antibiotic resistance patterns, evaluates common resistance genotypes, and explores the genetic relatedness of PDR A. baumannii clinical isolates from hospitals in the Middle Euphrates region of Iraq.Methods: Fourteen PDR A. baumannii isolates were obtained and subjected to antimicrobial susceptibility testing using the Vitek-2 compact system. Resistance genes were identified via conventional PCR, and clonal relationships were analyzed using multilocus sequence typing (MLST).Results: Among 175 A. baumannii isolates, 8% (14/175) were classified as PDR strains, exhibiting resistance to all tested antibiotics. TEM was the most prevalent resistance gene (50%), followed by CTX-M (43%). SHV, IMP, KPC, OXA-48, and Mcr-1 genes were absent in all PDR isolates. MLST analysis identified five sequence types (STs): ST2, ST218, ST138, ST123, and ST460, with ST2 being the most common (50%).Conclusion: The high prevalence of PDR A. baumannii strains in Iraq highlights the need for enhanced antibiotic surveillance. A comprehensive molecular investigation is necessary to mitigate the spread of these resistant pathogens.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"173-180"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous miliary Lymphocytoma: A Case Report with Immunohistochemical Findings. 皮肤军事性淋巴细胞瘤：1例免疫组化结果报告。

Iranian Journal of Pathology Pub Date : 2025-01-01 Epub Date: 2025-03-10 DOI: 10.30699/iijp.2024.2025080.3287

Shatila Torabi, Sima Davoodi, Mostafa Izanlu, Pouria Etesamizade, Naser Tayebi Meibodi

引用次数: 0