Iranian Journal of Pathology最新文献

{"title":"An Intriguing Case of Rapidly Growing Vulval Fibroepithelial Polyp: Awareness of Histologic Mimickers is Crucial.","authors":"Aparna Jarathi, Seetu Palo, Poojitha Kanikaram","doi":"10.30699/ijp.2025.2044987.3372","DOIUrl":"10.30699/ijp.2025.2044987.3372","url":null,"abstract":"","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 3","pages":"344-347"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Amelanotic Plasmacytoid Melanoma with Strong CD138 Expression, Mimicking Multiple Myeloma - A Case Report.","authors":"Ery Kus Dwianingsih, Yuni Artha Prabowo, Sofia Pranacipta, Shinta Andi Sarasati, Amri Wicaksono, Sekar Safitri, Eviana Norahmawati, Rahadyan Magetsari","doi":"10.30699/ijp.2025.2040460.3354","DOIUrl":"10.30699/ijp.2025.2040460.3354","url":null,"abstract":"<p><strong>Background & objective: </strong>Melanomas have diverse pathological features that mimic other tumors, such as lymphoma, sarcoma, and even poorly differentiated carcinoma. The most recently identified variant, the plasmacytoid variant, is an uncommon variant that can appear as a solitary tumor or a metastatic disease. Due to its rarity, the epidemiologic profile of this variant is not well characterized. This case report illustrates a diagnostic challenge of plasmacytoid cell mimicker, which is rarely found in daily practice.</p><p><strong>Case presentation: </strong>A 49-year-old man presented with multiple subcutaneous soft tissue nodules in the thoracic area and multiple pathological fractures in the left distal humerus and distal ulna. Clinical and radiological findings were suggestive of metastatic bone disease with differential diagnosis of multiple myeloma. Fine needle aspiration biopsy and histopathological findings were suggestive of multiple myeloma with differential diagnoses of metastatic carcinoma, rhabdomyosarcoma, and amelanotic melanoma. Thus, immunostaining for CD138, CK, desmin, vimentin, S-100, and HMB45 were requested and the results were compatible with the final diagnosis of amelanotic plasma melanoma.</p><p><strong>Conclusion: </strong>It is crucial to consider melanoma as one of the differential diagnoses of a tumor with plasmacytoid feature and CD138 positive staining as it can mimic multiple myeloma as demonstrated in this case report.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"225-230"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Characterization of Aminoglycoside-modifying Enzymes (AMEs)in Aminoglycoside-Resistant <i>Staphylococcus aureus</i>: A Cross-sectional Study in Northeastern Iran.","authors":"Malihe Naderi, Neda Yousefi Nojookambari, Somayeh Talebi, Mohammad Reza Mohammadi, Sajjad Yazdansetad","doi":"10.30699/ijp.2024.2038509.3342","DOIUrl":"10.30699/ijp.2024.2038509.3342","url":null,"abstract":"<p><strong>Background & objective: </strong>The resistance genes encoding aminoglycoside-modifying enzymes (AMEs) are now widely prevalent in different populations of <i>Staphylococcus aureus</i>. The study aimed to determine the frequency of AMEs-encoding genes in clinical isolates of <i>S. aureus</i>.</p><p><strong>Methods: </strong>A total of 105 <i>S. aureus</i> isolates were obtained from the different clinical samples; and then were identified by conventional biochemical tests. The antibiotic resistance patterns of the isolates were characterized by the agar disk diffusion method. The distribution of the AMEs and <i>femA</i> genes was determined by conventional and multiplex PCR.</p><p><strong>Results: </strong>The aminoglycoside resistance rates of kanamycin, tobramycin, gentamicin, amikacin, and netilmicin were 47.6%, 46.6%, 45.7%, 45.7%, and 26.6%, respectively. 16.1% and 1.9% of isolates were MDR and XDR phenotypes, respectively. 21.9% of <i>S. aureus</i> isolates harbored the <i>femA</i> gene and were determined as methicillin-resistant <i>S. aureus</i> (MRSA) clones. The <i>aac(6')/aph(2'')</i> was the most prevalent (47.8%) AME-encoding gene in aminoglycoside-resistant <i>S.</i> <i>aureus</i>, followed by <i>ant(4')-Ia</i> (30.4%) and <i>aph(3')-IIIa</i> (21.7%).</p><p><strong>Conclusion: </strong>Our study demonstrated that the coexistence of several AMEs and the spread of the resistance determinants like <i>femA</i> in <i>S. aureus</i> clinical isolates are alarming and may contribute to the broadening of aminoglycoside resistance spectra and limit treatment options for staphylococcal infections.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyllodes Tumor, A Cytomorphologic Study of 17 Cases with Histologic Correlation.","authors":"Savita Agarwal, Pinki Pandey, Megha Sawhney, Alka Yadav, Sunita Kumari Meena","doi":"10.30699/ijp.2024.2033852.3322","DOIUrl":"10.30699/ijp.2024.2033852.3322","url":null,"abstract":"<p><strong>Background & objective: </strong>Phyllodes tumor (PT) is a rare fibroepithelial tumor of the breast exhibiting varied clinicopathologic behavior, ranging from benign to borderline to frankly malignant, based on the presence of infiltrative margins, stromal overgrowth, stromal atypia, cellularity, and mitotic activity. In this study, a detailed cytomorphological study of cases of PT with the clinical and histological correlation was performed.</p><p><strong>Methods: </strong>A cytomorphological study of 17 cases of histologically proven PT diagnosed between Jan 2014 and July 2021 was done retrospectively. Relevant data including age at the time of diagnosis, the duration of illness, presenting symptoms, personal and family history, tumor size, tumor localization, and surgical procedure were obtained. A detailed cytomorphological assessment of stromal and epithelial components was performed, and further histological correlation was obtained for each case.</p><p><strong>Results: </strong>Age of the patients ranged from 25 to 65 years old. The chief complaint was a palpable breast mass in all patients. The mean size of the lump was 11.86 cm. A complete cytohistological concordance was achieved among malignant cases. Stromal metaplasia was observed in only one case of benign phyllodes tumor, which was chondroid differentiation, and malignant heterologous component as fibrosarcomatous differentiation in one of the malignant PTs. Each of the benign and malignant phyllode tumors ductal carcinoma in situ (DCIS) of its epithelial component was seen in one case.</p><p><strong>Conclusion: </strong>Phyllodes should be considered in differential diagnosing of any rapidly growing breast lump. Breast imaging has limited role in diagnosis of phyllode tumors. FNAC or trucut biopsy is mandatory in preoperative diagnosis. An extended follow-up is needed in all cases.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"90-97"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Maxillary Swelling in a 21-Year-Old Male - A Case Report.","authors":"Pushpak U Shah, Punnya V Angadi, Sanjay S Rao","doi":"10.30699/ijp.2025.2024697.3271","DOIUrl":"10.30699/ijp.2025.2024697.3271","url":null,"abstract":"<p><p>Ewing sarcoma (ES) of the head and Neck is a rare entity. The most common location for ES is long bones accounting for 58%, with head and neck accounting only for 3% of all the sites. Here we highlight a unique presentation of ES involving the maxillary region in a 21-year-old male. Patient presented with right maxillary swelling for the last 2 months. Imaging studies reveal osteolytic lesion involving the right maxilla. Ewing's sarcoma rarely affects the head and neck region, posing diagnostic challenges as it mimics many common lesions. Accurate diagnosis requires a multidisciplinary approach involving clinical, radiological, histopathological, and molecular evaluations.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"126-132"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterotopic Pancreatic Tissue in Gallbladder: A Report of an Unusual Entity at an Extremely Rare Location.","authors":"Mukta Pujani, Aparna Khandelwal, Kanika Singh, Meenu Pujani, Cherry Bansal","doi":"10.30699/ijp.2025.2019770.3244","DOIUrl":"10.30699/ijp.2025.2019770.3244","url":null,"abstract":"<p><strong>Background & objective: </strong>Heterotopic pancreas (HP) or ectopic pancreas is the occurrence of pancreatic tissue in an atypical location with absence of any neurovascular or anatomic connection with the normal pancreas. In an autopsy series, the incidence of this embryologic anomaly is 0.55% to 13.7% of patients. Gallbladder is an extremely rare site for ectopic pancreatic tissue with approximately 40 documented cases.</p><p><strong>Case presentation: </strong>We hereby report a case of incidental discovery of ectopic pancreatic tissue in the excised gallbladder from a 27-year-old female who presented with nausea, vomiting, and abdominal pain intermittently. The gallbladder lumen was filled with biliary sludge containing a single gallstone. Histopathology revealed chronic cholecystitis along with a tiny focus of ectopic pancreatic tissue comprising only pancreatic acini.</p><p><strong>Conclusion: </strong>This case highlights that histopathology should be mandatory for all excised gallbladder specimens and that this entity should be considered among the differentials for nodular/polypoidal gallbladder lesions. Although the cases where the ectopic pancreas is discovered incidentally do not have much clinical significance, this may prevent the patient from undergoing more aggressive treatment reserved for conditions like pancreatitis or malignancy in cases where the ectopic pancreas mimics a malignancy.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"231-234"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Histologic Growth Patterns and Some Histopathologic Features in Clear Cell Renal Cell Carcinoma with Patient's Survival after Nephrectomy: A Cross-Sectional Study.","authors":"Mehdi Farzadnia, Naser Tayyebi Meibodi, Ahmad Jafari Joshaghan, Mahnaz Baradaran, Motahare Ebrahimnejad, Saeid Dehghan Nezhad, Farideh Ranjbar","doi":"10.30699/ijp.2025.2033228.3319","DOIUrl":"10.30699/ijp.2025.2033228.3319","url":null,"abstract":"<p><strong>Background & objective: </strong>Clear cell renal cell carcinoma (CCRCC) is the most common type of renal cancer. Limited studies have been conducted about factors affecting the survival of patients with CCRCC. In this study, we aimed to evaluate the association between histologic growth patterns (HGPs) and some pathologic features and survival in CCRCC.</p><p><strong>Methods: </strong>This cross-sectional study evaluated the association between HGPs and other pathologic features and the survival of 145 patients with CCRCC after nephrectomy in Emam-Reza Hospital (Mashhad, Iran) from 2012 to 2022. Two expert pathologists assessed HGPs and other pathologic features, like cytopathologic changes. All analyses were performed using IBM SPSS version 26 software. A <i>P</i> value less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>In the current study, we assessed the association of the 6 most prevalent growth patterns with the patient's survival. Some clinicopathologic features like tumor stage and grade, tumor size, and necrosis are negatively linked with survival. Two important cytologic features, including sarcomatoid and rhabdoid, were also associated with survival time in patients with CCRCC (P values < 0.05). Regardless of the nuclear grade of the tumor, some patterns like solid sheet, papillary, and thick trabecular were associated with lower survival.</p><p><strong>Conclusion: </strong>Some HGPs are significantly associated with the patient's survival in CCRCC. A greater variety of patterns within each specimen has been associated with a reduced survival rate. The impact of HGPs on patient survival may be as significant as the nuclear grade.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 2","pages":"198-206"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12142019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144250111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Missense Mutation of c.965C>T (p.Ala322Val) in the Human <i>GALNS</i> Gene Results in Severe Mucopolysaccharidosis Type IVA.","authors":"Moeinadin Safavi, Aria Setoodeh, Mahdiieh Ghoddoosi","doi":"10.30699/ijp.2024.2025376.3278","DOIUrl":"10.30699/ijp.2024.2025376.3278","url":null,"abstract":"","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"138-139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Notch1 and CD10 Expressions in Colorectal Carcinoma and Their Relationship with Prognosis.","authors":"Noha Elkady, Reham Ahmed Abdelaziz, Rania Abdallah","doi":"10.30699/ijp.2024.2029781.3304","DOIUrl":"10.30699/ijp.2024.2029781.3304","url":null,"abstract":"<p><strong>Background & objective: </strong>Even with improvements of colorectal cancer (CRC) treatment strategies, this cancer still has an unfavorable outcome. The primary cause of CRC development and recurrence is chemoresistance. CD10 and Notch1 are among cancer stem cell regulators, and they have roles in cancer progression and chemoresistance. This research aims to evaluate the expression of Notch1 and CD10 in CRC and their relationship with different clinicopathological parameters using immunohistochemistry.</p><p><strong>Methods: </strong>This retrospective study included 100 cases of colorectal carcinoma that were immunohistochemically stained using Notch1 and CD10 antibodies. Expression of Notch1 and CD10 was evaluated and compared with different clinicopathological parameters.</p><p><strong>Results: </strong>Notch1 expression was detected in the tumor and stromal cells in 92% of the cases, while CD10 expression was seen in 31% of tumor cells 79% of stromal cells of the included cases. Their expressions in tumor cells were significantly associated with higher grade (<i>P</i>=0.029 and 0.001), deeper invasion (<i>P</i>=0.01 and 0.002), advanced stage (<i>P</i>=0.012 and 0.001), and distant metastasis (<i>P</i>=0.001 and 0.02). Notch1 expression was positively correlated with CD10 expression (<i>P</i>=0.018). Both Notch1 expression and high CD10 expression in the stromal cells were associated with short overall survival (<i>P</i>=0.003 and 0.01).</p><p><strong>Conclusion: </strong>CD10 and Notch1 may have roles in colorectal carcinoma progression via induction of tumor invasion, metastasis and impairment of tumor response to therapy. CD10 and Notch1 could be used as biomarkers for aggressive CRC and may be considered for future target therapy.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 1","pages":"68-75"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Challenges and Predictive Risk Factors for Outcomes in COVID-19-Associated Mucormycosis.","authors":"Fardin Ahmadkhani, Seyed Jamal Hashemi, Roshanak Daei Ghazvini, Mohammadreza Salehi, Azin Tabari, Laura Alcazar-Fuoli, Farzad Pakdel, Alireza Abdollahi, Mohammadreza Firouzifar, Masoud Moradi, Sadegh Khodavaisy","doi":"10.30699/ijp.2025.2044252.3371","DOIUrl":"10.30699/ijp.2025.2044252.3371","url":null,"abstract":"<p><strong>Background & objective: </strong>Mucormycosis has emerged as a severe complication in COVID-19 patients, particularly among those with uncontrolled diabetes and those receiving corticosteroid therapy. The infection's tendency to spread from the sinuses to the orbit and central nervous system (CNS) significantly increases morbidity and mortality. This study aimed to identify clinical risk factors and outcomes associated with disease severity and mortality in COVID-19-associated mucormycosis (CAM), with a focus on disease progression to orbital and CNS involvement.</p><p><strong>Methods: </strong>A total of 180 confirmed CAM patients were enrolled and classified into three groups based on disease extent: sinus-only, sinus with orbital involvement, and sinus with both orbital and CNS involvement. Data were collected on demographics, clinical history, laboratory findings, imaging results, treatment modalities, and outcomes.</p><p><strong>Results: </strong>Of the 180 patients, 63.3% had sinus-only involvement, 23.9% had sinus and orbital involvement, and 12.8% had sinus, orbital, and CNS involvement. Uncontrolled diabetes was observed in 38% of patients and was more prevalent in those with extensive disease. Corticosteroid use was significantly associated with disease severity (<i>p</i> = 0.002). Invasive procedures, such as orbital exenteration, were significantly linked to CNS progression (<i>p</i> < 0.05). The overall mortality rate was 31% (55 of 180 patients).</p><p><strong>Conclusion: </strong>Uncontrolled diabetes and corticosteroid therapy are major risk factors for severe CAM. Extension of mucormycosis beyond the sinuses, particularly to the orbit and CNS, is associated with poor clinical outcomes and often requires aggressive surgical management. Early diagnosis and prompt intervention are essential to improve survival in these patients.</p>","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"20 3","pages":"288-296"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}