Iranian Journal of Pathology最新文献_第4页

EGFR Gene Mutations in Tongue Squamous Cell Carcinoma: Frequency and Association with Clinicopathological Features. 舌鳞癌中表皮生长因子受体基因突变：频率及其与临床病理特征的关系。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-05-10 DOI: 10.22034/ijp.2026.2069751.3517

Yasamin Ayatollahi, Hossein Aatollahi, Nasrollah Saghravanian, Narges Ghazi

{"title":"EGFR Gene Mutations in Tongue Squamous Cell Carcinoma: Frequency and Association with Clinicopathological Features.","authors":"Yasamin Ayatollahi, Hossein Aatollahi, Nasrollah Saghravanian, Narges Ghazi","doi":"10.22034/ijp.2026.2069751.3517","DOIUrl":"10.22034/ijp.2026.2069751.3517","url":null,"abstract":"Background & objective: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. Epidermal growth factor receptor (EGFR) mutations are well recognized in lung cancer and several other epithelial tumors, but their role in tongue squamous cell carcinoma (TSCC) remains unclear. Understanding their frequency and clinical relevance may provide insight into their potential therapeutic significance.Methods: In this study, 30 paraffin-embedded tissue samples from patients with TSCC were examined. Demographic and clinicopathological data, including age, sex, tumor stage, histological grade, and recurrence, were collected. DNA was extracted, and mutations in exons 18 to 21 of the EGFR gene were analyzed using real-time polymerase chain reaction. Statistical analyses were performed to assess possible associations between EGFR mutation status and clinical or pathological features, as well as patient survival.Results: The mean age of the patients was 58.77 years, with an equal male-to-female distribution. EGFR mutation was identified in only one patient (3.3%), consisting of a deletion in exon 19. No significant associations were observed between EGFR mutation status and age, sex, tumor stage, histological grade, or recurrence. Survival analysis also showed no prognostic impact of EGFR mutation in this cohort.Conclusion: EGFR mutation appears to be rare in TSCC and was not significantly associated with clinicopathological features or patient survival in this study. Larger studies are needed to confirm these findings and to clarify any potential therapeutic implications.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 3","pages":"457-462"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148431308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synchronous Diffuse Large BCell Lymphoma Identified During Retroperitoneal Lymph Node Dissection for Stage III Clear Cell Renal Cell Carcinoma: A Case Report. III期透明细胞肾细胞癌腹膜后淋巴结清扫时发现同步弥漫性大b细胞淋巴瘤1例。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-02-25 DOI: 10.22034/ijp.2026.2072118.3540

Reihane Chegini, Mandana Rahimi, Mohammad Eslami

{"title":"Synchronous Diffuse Large BCell Lymphoma Identified During Retroperitoneal Lymph Node Dissection for Stage III Clear Cell Renal Cell Carcinoma: A Case Report.","authors":"Reihane Chegini, Mandana Rahimi, Mohammad Eslami","doi":"10.22034/ijp.2026.2072118.3540","DOIUrl":"10.22034/ijp.2026.2072118.3540","url":null,"abstract":"Background & objective: NonHodgkin lymphoma (NHL) and renal cell carcinoma (RCC) are common malignancies, and survivors of either are at increased risk of second primary cancers. Synchronous presentation of diffuse large Bcell lymphoma (DLBCL) with clear cell RCC (ccRCC) is rare.Case report: An 82yearold man presented with right flank pain and gross hematuria. Imaging showed an 11.3 × 8.0 cm enhancing right renal mass with extension into the renal vein and inferior vena cava and multiple paraaortic lymphadenopathies. He underwent radical right nephrectomy with perirenal and retroperitoneal lymphnode dissection. Kidney histology showed ccRCC, ISUP grade 4, with extension to the renal sinus and renal pelvis. Retroperitoneal nodes were infiltrated by large atypical Bcells positive for CD20 and PAX5 and negative for CD3, CD15, and CD30, with Ki67 ~50%, consistent with DLBCL. A postoperative wholebody PET/CT showed no residual malignancy. Treatment and outcome: He received six cycles of RCHOP for DLBCL and adjuvant pembrolizumab for highrisk ccRCC. He remains in complete remission four years after diagnosis.Conclusion: This case illustrates the possibility of synchronous primary DLBCL in patients undergoing surgery for RCC. Routine pathological evaluation of dissected nodes can change staging and management.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"320-325"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic perivascular epithelioid cell tumor (PEComa): Clinicopathological Findings and Prognosis-A Systematic Review and Meta-Analysis. 肝血管周围上皮样细胞瘤（PEComa）：临床病理表现和预后——系统回顾和荟萃分析。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-05-10 DOI: 10.22034/ijp.2026.2062240.3468

Alireza Abdollahi, Masoomeh Safaei

{"title":"Hepatic perivascular epithelioid cell tumor (PEComa): Clinicopathological Findings and Prognosis-A Systematic Review and Meta-Analysis.","authors":"Alireza Abdollahi, Masoomeh Safaei","doi":"10.22034/ijp.2026.2062240.3468","DOIUrl":"10.22034/ijp.2026.2062240.3468","url":null,"abstract":"Background & objective: Hepatic Perivascular epithelioid cell tumors (PEComas) are rare and can complicate diagnosis due to their low incidence, possible malignant potential and misdiagnosis as melanoma and hepatocellular carcinoma (HCC). The purpose of this systematic review and meta-analysis was to investigate the clinicopathological traits, diagnostic indicators, and prognostic implications associated with hepatic PEComas.Methods: We conducted a systematic literature search in PubMed, Web of Science, and Scopus using relevant keywords. Studies were included if they assessed clinicopathological findings or prognostic outcomes of hepatic PEComas. Data extraction was performed using a standardized sheet and data were pooled using RStudio.Results: The initial search retrieved 1,172 articles, from which 286 duplicates were removed. Ultimately, 15 studies met our eligibility criteria for inclusion in the meta-analysis. The mean patient age was 45.42 years. Misdiagnosis as HCC occurred in 18% of cases. The pooled malignancy rate was 8.6% with 6% of cases demonstrating tumor progression. Immunohistochemistry analysis revealed HMB-45 positivity in 98.8% (95% CI: 97% - 100%) and Smooth Muscle Actin positivity in 95.2% (95% CI: 81% - 98%) of cases. The mean tumor size was 67.1 mm (95% CI: 52.86 - 81.34), with 4.7% (95% CI: 3% - 8%) showing invasive features.Conclusion: Hepatic PEComas are predominantly benign but can pose diagnostic challenges due to their resemblance to HCC and melanoma. Despite generally favorable outcomes, long-term follow-up is crucial due to the risk of recurrence. Further prospective studies utilizing standardized diagnostic criteria are warranted to refine management strategies and identify prognostic indicators.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 3","pages":"344-358"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13348207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytopathological Findings of Axillary Lymph Nodes in Patients with Breast Cancer in Correlation with Ultrasound Findings. 乳腺癌患者腋窝淋巴结的细胞病理学表现与超声表现的相关性。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-05-10 DOI: 10.22034/ijp.2026.2071233.3534

Zainab Kh Almukhtar, Noora M Kareem, Sura Tami Abduljabbar, Osama A Mohsein

{"title":"Cytopathological Findings of Axillary Lymph Nodes in Patients with Breast Cancer in Correlation with Ultrasound Findings.","authors":"Zainab Kh Almukhtar, Noora M Kareem, Sura Tami Abduljabbar, Osama A Mohsein","doi":"10.22034/ijp.2026.2071233.3534","DOIUrl":"10.22034/ijp.2026.2071233.3534","url":null,"abstract":"Background & objective: Another important factor in the staging and management of breast cancer is axillary lymph node metastasis. This research paper was intended to evaluate the diagnostic effectiveness of axillary ultrasound (US) and its relationship with fine-needle aspiration cytology (FNAC) as a preoperative staging method in patients with breast cancer.Methods: We recruited 130 patients with newly diagnosed breast cancer. All patients underwent axillary US, and FNAC was performed on any suspicious lymph nodes.Results: A correlation between axillary lymph node ultrasound characteristics and cytology was also significant in the study of 130 patients with breast cancer. Positive biopsy results were related to irregular shape, increased size, thickened cortex, hypoechoic echogenicity, and absence of an intact hilum. It was found that ultrasound had a sensitivity of 98.9%, a PPV of 72%, an NPV of 80%, and an accuracy of 72.3%, which proved its usefulness in predicting nodal malignancy.Conclusion: Axillary US is highly sensitive in the identification of axillary lymph node involvement, and it has a close correlation with FNAC. These two techniques together can be used successfully to direct preoperative tumor staging, which may result in fewer patients undergoing unnecessary surgical procedures, such as sentinel lymph node biopsy or axillary lymph node dissection, thereby reducing morbidity.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 3","pages":"390-398"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13348206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraosseous Angiolipoma of the Mandible: A Rare Case Report. 下颌骨骨内血管脂肪瘤1例报告。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-02-25 DOI: 10.22034/ijp.2026.2073701.3563

Hamid Mojtahedi, Mohamadreza Yegane, Katayoun Amirzadegan, Pouyan Aminishakib

{"title":"Intraosseous Angiolipoma of the Mandible: A Rare Case Report.","authors":"Hamid Mojtahedi, Mohamadreza Yegane, Katayoun Amirzadegan, Pouyan Aminishakib","doi":"10.22034/ijp.2026.2073701.3563","DOIUrl":"10.22034/ijp.2026.2073701.3563","url":null,"abstract":"Background & objective: We report the case of an extremely rare intraosseous adipocytic tumor of the mandible. Angiolipoma is a unique variant of lipoma composed of mature fat cells with proliferating capillaries.Case report: An asymptomatic 63-year-old patient attended a dental check-up, and a bordered radiolucency was incidentally found on the lower left side of the mandibular body. Conservative enucleation was performed with significant intraoperative bleeding. The preliminary diagnosis was central giant cell granuloma (CGCG). Histological analysis revealed that the lesion consisted of lobules of mature adipocytes interspersed with numerous vascular spaces. These findings were consistent with the diagnosis of intraosseous angiolipoma of the mandible. To the best of our knowledge, this represents the eighth case to be reported in the literature, showcasing the rarity of this lesion.Conclusion: The diagnosis of intraosseous angiolipoma in the jaws poses numerous difficulties and requires detailed histopathological examination. It is essential for oral pathologists to be familiar with such rare lesions to guarantee an accurate diagnosis. Conservative surgical enucleation of the lesion is usually the preferred treatment approach. Recognizing these atypical variants will assist pathologists in optimizing patient care through a precise and timely diagnosis and intervention.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"326-331"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Serum Ferritin level and Liver Fibrosis Severity in Non-Alcoholic Fatty Liver Disease Patients. 非酒精性脂肪肝患者血清铁蛋白水平与肝纤维化严重程度的关系

Iranian Journal of Pathology Pub Date : 2026-01-01 DOI: 10.22034/ijp.2025.2065639.3487

Bahram Memar, Alireza Khodadadi, Pegah Bahrami, Ali Beheshti Namdar, Hassan Mehrad-Majd, Mitra Ahadi

{"title":"Association between Serum Ferritin level and Liver Fibrosis Severity in Non-Alcoholic Fatty Liver Disease Patients.","authors":"Bahram Memar, Alireza Khodadadi, Pegah Bahrami, Ali Beheshti Namdar, Hassan Mehrad-Majd, Mitra Ahadi","doi":"10.22034/ijp.2025.2065639.3487","DOIUrl":"10.22034/ijp.2025.2065639.3487","url":null,"abstract":"Background & objective: Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition characterized by hepatic fat accumulation, which can progress fibrosis and cirrhosis. Serum ferritin has been proposed as a biomarker for liver disease, but its relationship with fibrosis severity in NAFLD remains unclear. This study explored the relationship between serum ferritin levels and liver fibrosis severity in NAFLD patients.Methods: In this cross-sectional study, 204 NAFLD patients were enrolled, including 139 with mild fibrosis and 65 with severe fibrosis. Baseline and demographic characteristics were compared between groups. Serum ferritin and other biochemical parameters were measured. Logistic regression analyses assessed the predictive value of serum ferritin levels for liver fibrosis severity, and a receiver operating characteristic (ROC) curve determined the optimal ferritin cutoff for identifying sever fibrosis.Results: Patients with severe fibrosis had significantly higher serum ferritin levels than those with mild fibrosis (197.70 ± 79.40 vs 95.70 ± 73.20, P<0.001). Logistic regression analysis confirmed a significant association between ferritin levels and fibrosis severity (OR = 1.015, 95% CI = 1.009-1.02, P<0.001). ROC analysis showed that ferritin distinguished severe from mild fibrosis with 80% sensitivity and 80% specificity at a cutoff of 129 ng/ml (AUC = 0.86).Conclusion: Elevated serum ferritin levels are associated with more severe liver fibrosis in NAFLD patients, supporting ferritin's potential as a non-invasive biomarker for fibrosis severity. Further studies are needed to validate these findings and explore ferritin's diagnostic and prognostic utility in diverse populations.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"167-174"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Association of Delayed Villous Maturation in Gestational Diabetes Mellitus Pregnancy: A Prospective Study. 妊娠期糖尿病妊娠期绒毛成熟延迟的临床关联：一项前瞻性研究。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-02-25 DOI: 10.22034/ijp.2026.2074182.3559

Supriya NovelTony, Shilpa M Bhimalli, Ganga S Pilli, Hemalatha K R, Prajna K Shetty

{"title":"Clinical Association of Delayed Villous Maturation in Gestational Diabetes Mellitus Pregnancy: A Prospective Study.","authors":"Supriya NovelTony, Shilpa M Bhimalli, Ganga S Pilli, Hemalatha K R, Prajna K Shetty","doi":"10.22034/ijp.2026.2074182.3559","DOIUrl":"10.22034/ijp.2026.2074182.3559","url":null,"abstract":"Background & objective: Delayed Villous Maturation (DVM) is a histological hallmark in Gestational Diabetes Mellitus (GDM) pregnancies commonly observed after 36 weeks of gestation. It is associated with perinatal morbidity and mortality. Our study aims to assess DVM in the term placentas of GDM pregnancies and its association with its perinatal outcomes compared to normal pregnancies.Methods: A total of 120 term placentae from GDM and normal pregnancies were collected from the Obstetrics and Gynaecology Department for one year and subjected to histopathological examination to evaluate DVM and its association with placental morphology and perinatal outcomes.Results: The current study found statistically significant increased presence of DVM in GDM placentas and its association with placental weight, diameter, maternal weight, glycated haemoglobin and foetal weight. The present study also observed presence of DVM with chorangiosis in a GDM placenta.Conclusion: \u0000 The present study has found a statistically significant association of DVM in GDM pregnancies with its perinatal outcomes compared to normal pregnancies. There is no antenatal ultrasound marker to detect placental DVM and adverse foetal outcomes caused due to it. Since there is risk of reoccurrence of DVM and type 2 diabetes in future pregnancies, identification of DVM in GDM pregnancies and its clinical association with foetal outcomes should be considered clinically important. This may explain the cause of intrauterine foetal deaths and adverse neonatal outcomes in the current pregnancy and indicating a need for comprehensive maternal care in future pregnancies to prevent perinatal outcomes by implementing Rescue by birth.\u0000 ","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"295-302"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Salivary and Serum Total Carbohydrate Levels in Oral Precancerous Disorders and Oral Cancer: A Novel Approach. 评估口腔癌前病变和口腔癌患者唾液和血清总碳水化合物水平：一种新方法。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-02-20 DOI: 10.22034/ijp.2025.2039390.3345

Imran Mohtesham, Vishnudas Prabhu, Vinitha Ramanath Pai, Maji Jose, Jyothi Dsouza, Sindhu Harish

{"title":"Evaluation of Salivary and Serum Total Carbohydrate Levels in Oral Precancerous Disorders and Oral Cancer: A Novel Approach.","authors":"Imran Mohtesham, Vishnudas Prabhu, Vinitha Ramanath Pai, Maji Jose, Jyothi Dsouza, Sindhu Harish","doi":"10.22034/ijp.2025.2039390.3345","DOIUrl":"10.22034/ijp.2025.2039390.3345","url":null,"abstract":"Background & objective: Enhanced glucose uptake creates a hyperglycaemic environment that contributes to the oral carcinogenetic cascade but has received less attention and has not been fully elucidated. This study aimed to assess the levels of free and bound carbohydrates in saliva and serum among healthy individuals, subjects with potentially malignant disorders, and oral cancer/oral squamous cell carcinoma (OSCC) patients.Methods: A cross-sectional comparative study was conducted among 90 subjects randomly selected based on clinical and histological criteria and allocated into three groups: Group 1, healthy individuals (n = 30); Group 2, potentially malignant disorders (n = 30); and Group 3, OSCC cases (n = 30). Saliva and serum samples were collected and subjected to biochemical analysis for carbohydrate level estimation. Descriptive statistics and the Mann-Whitney test were applied to assess differences between independent groups.Results: Mean salivary-bound total carbohydrate levels were 12.06 mg/dL, 37.67 mg/dL, and 65.45 mg/dL for Groups 1, 2, and 3, respectively. Mean serum-bound total carbohydrate levels were 30.39 mg/dL, 68.28 mg/dL, and 88.33 mg/dL for Groups 1, 2, and 3, respectively. Mean salivary-free total carbohydrate levels were 25.58 mg/dL (Group 1), 24.28 mg/dL (Group 2), and 53.13 mg/dL (Group 3), while mean serum-free total carbohydrate levels were 62.39 mg/dL, 74.01 mg/dL, and 193.68 mg/dL for Groups 1, 2, and 3, respectively. A highly significant increase was observed (P < 0.001).Conclusion: A substantial increase in serum and salivary total carbohydrate levels, particularly in bound forms, was observed across the three groups, highlighting the potential utility of carbohydrate levels as biomarkers for disease progression in oral cancer.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"193-199"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult-Onset Still's Disease and Secondary Hemophagocytic Lymphohistiocytosis: Diagnostic Pitfalls in Lymph Node Histology. 成人发病的斯蒂尔氏病和继发性噬血细胞性淋巴组织细胞增多症：淋巴结组织学的诊断缺陷。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-02-25 DOI: 10.22034/ijp.2026.2067545.3498

Saikat Mitra, Keshao Nagpure

{"title":"Adult-Onset Still's Disease and Secondary Hemophagocytic Lymphohistiocytosis: Diagnostic Pitfalls in Lymph Node Histology.","authors":"Saikat Mitra, Keshao Nagpure","doi":"10.22034/ijp.2026.2067545.3498","DOIUrl":"10.22034/ijp.2026.2067545.3498","url":null,"abstract":"Background & objective: Adult-onset Still's disease (AOSD) is a rare systemic autoinflammatory disorder characterized by high spiking fevers, evanescent rash, arthritis, and systemic inflammation. Its diagnosis is challenging due to the lack of specific biomarkers and clinical overlap with infections, malignancies, and autoimmune diseases.Case report: We present the case of a 20-year-old female with a two-year history of recurrent fever, polyarthritis, and erythematous rash, accompanied by generalized lymphadenopathy and splenomegaly. Initial workup revealed severe anemia, leukocytosis, markedly elevated serum ferritin, and abnormal liver function tests. Infectious and malignant etiologies were excluded. Lymph node biopsies initially suggested dermatopathic lymphadenitis, but subsequent histology showed paracortical hyperplasia with features mimicking peripheral T-cell lymphoma. Immunohistochemistry revealed a polyclonal T-cell population and hemophagocytosis, leading to a revised diagnosis of reactive lymphadenopathy associated with AOSD. The patient fulfilled criteria for secondary hemophagocytic lymphohistiocytosis (HLH), a life-threatening hyperinflammatory syndrome. High-dose corticosteroid therapy resulted in significant clinical and biochemical improvement.Conclusion: This case highlights the diagnostic complexities of AOSD with secondary HLH, particularly when lymph node histology mimics malignancy. Awareness of the varied lymph node patterns in AOSD and integration of clinical, laboratory, and immunohistochemical data are crucial for accurate diagnosis and timely management, preventing unnecessary interventions and improving outcomes.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"310-314"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148036097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Donor and Recipient Duffy and Kidd Genotypes with GVHD in Leukemia Patients Undergoing Bone Marrow Transplantation. 供体和受体Duffy和Kidd基因型与骨髓移植白血病患者GVHD的关系。

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.30699/ijp.2025.2061229.3461

Hawar Nasr Mohammad, Arman Ahmadi, Mehrdad Payandeh, Mahsa Dabir, Mahdi Taqadosi, Fakhredin Saba

{"title":"Association of Donor and Recipient Duffy and Kidd Genotypes with GVHD in Leukemia Patients Undergoing Bone Marrow Transplantation.","authors":"Hawar Nasr Mohammad, Arman Ahmadi, Mehrdad Payandeh, Mahsa Dabir, Mahdi Taqadosi, Fakhredin Saba","doi":"10.30699/ijp.2025.2061229.3461","DOIUrl":"10.30699/ijp.2025.2061229.3461","url":null,"abstract":"Background & objective: Graft-versus-host disease (GVHD) is a major complication following allogeneic bone marrow transplant (BMT), often limiting therapeutic success in leukemia patients. Chemokine receptors, such as those encoded by Duffy (FY) and Kidd (JK) blood group genes, may influence GVHD development by modulating immune cell trafficking. To evaluate the association between donor and recipient Duffy and Kidd genotypes and GVHD incidence in leukemia patients undergoing HLA-identical sibling BMT.Methods: This retrospective cross-sectional study analyzed 100 DNA samples from 50 donor-recipient pairs (20 with GVHD, 30 without). Genotyping for FY and JK antigens was conducted using PCR-RFLP. Statistical analysis was performed using chi-square and logistic regression tests in SPSS v19, with significance set at P < 0.05.Results: Kidd and Duffy genotype distributions differed between BMT recipients who developed GVHD and those who did not. However, when gender was included as an additional variable, these associations in recipients were no longer statistically significant for either genotype. In donors, neither the Kidd nor the Duffy genotypes showed a significant association with GVHD status overall. Interestingly, when stratified by gender, a significant difference was observed only for the Kidd genotype in donors of GVHD-positive recipients, but not in donors of GVHD-negative recipients. However, multivariate logistic regression did not confirm any independent association between Kidd or Duffy genotypes and GVHD in recipients (OR = 2.94, 95% CI: 0.494-17.49, P = 0.236) or donors (OR = 2.273, P = 0.323).Conclusion: Kidd and Duffy blood group phenotypes may influence susceptibility to GVHD. Understanding this relationship can support better donor-recipient matching in BMT.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 1","pages":"80-92"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146107961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0