Medeniyet medical journal最新文献

{"title":"Wound Healing Activity of <i>Arum Maculatum</i>.","authors":"Ayse Arzu Sakul,&nbsp;Mehmet Evren Okur,&nbsp;Sule Ayla,&nbsp;Benay Daylan,&nbsp;Ayse Esra Karadag,&nbsp;Sebnem Batur,&nbsp;Ekrem Musa Ozdemir,&nbsp;Ebrar Altinalan,&nbsp;Mehmet Yalcin Gunal","doi":"10.4274/MMJ.galenos.2022.73368","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.73368","url":null,"abstract":"<p><strong>Objective: </strong>In this study, the antioxidant properties of <i>Arum maculatum</i> plant were evaluated. This study reported for the first time the wound healing activity of the methanol extract of <i>A. maculatum</i> fruits. This study aimed to assess and determine the possible pharmacological activities of <i>A. maculatum</i> and evaluate its potential to act as a wound care plant.</p><p><strong>Methods: </strong>The antioxidant and antimicrobial activities of <i>A. maculatum</i> were investigated using excisional <i>in vivo</i> and <i>in vitro</i> wound healing mouse models. A total of 32 Balb-c mice were used, which were equally, divided into four groups: saline control group, control group, <i>A. maculatum</i> group, and <i>Centella asiatica</i> extract group. Treatment applications were performed topically once per day. Wound area narrowing, wound healing percentage, and epithelialization time were analyzed.</p><p><strong>Results: </strong><i>A. maculatum</i> application supported the healing process in <i>in vivo</i> and <i>in vitro</i> wound models. <i>A. maculatum</i> contributed to the healing process by promoting granulation tissue formation, epidermal regeneration, and angiogenesis.</p><p><strong>Conclusions: </strong>Wound healing is a complex and well-organized process that requires communication between cells. The antioxidant and antimicrobial activities of <i>A. maculatum</i> extract have been determined by current studies. <i>A. maculatum</i> extract may provide significant benefits in promoting the wound healing process.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/69/medj-38-8.PMC10064101.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9227880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Classification of Benign Epithelial Tumors: Colorectal Polyps and Synchronous Neoplasms: An Update and Critical Assessment: An Analysis of 678 Consecutive Cases and 1137 Polyps.","authors":"Ali Koyuncuer,&nbsp;Tulay Zen","doi":"10.4274/MMJ.galenos.2023.22755","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.22755","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate of colorectal high-risk polyps and synchronized neoplasms and carcinomas with anatomical localization and demographic characteristics.</p><p><strong>Methods: </strong>Between July 1, 2018 and July 1, 2022, 1137 polypectomy materials of 678 consecutive patients who were diagnosed in the pathology department and underwent total colonoscopy were included in the study. All epithelial polyps were re-classified according to the World Health Organization classification of digestive system tumors-2019, 5^th edition.</p><p><strong>Results: </strong>The cases of 60.5% were male and 39.5% were female. The mean age of patients with polyps was 61.1 (±11.1) years. There was a statistically significant difference between the presence of gender and all epithelial polyps (p=0.044). Epithelial polyps were more common in men than in women (ratio; male/female 1.58:1). While the average size of the polyps was 5.2 (±5.08) millimeters (mm), 86.6% of all polyps were smaller than 10 mm. Solitary polyps were observed in 62.5% of all polyps, and multiple polyps were observed in 37.5%. Epithelial polyps constituted 96% of all polyps, and conventional tubular adenoma (69%) was the most common type of polyp. Advanced adenomas (intramucosal adenocarcinomas, polyp cancer) and synchronous adenocarcinomas were found to be 1.4% (16 polyps) and 0.9% (6 patients) respectively. Polyps were most frequently observed in the sigmoid colon, with a rate of 22.8%, followed by the descending colon and rectum most frequently. There was a significant association between epithelial polyps and anatomical locations (p<0.001).</p><p><strong>Conclusions: </strong>In conventional colorectal adenomas, the frequency of co-occurrence of synchronous neoplasms is higher than in other polyp types.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/57/medj-38-39.PMC10064098.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Osteo Refurbishment Method and Choice of Colouring Materials for Anatomy Specimens.","authors":"Dibakar Borthakur,&nbsp;Rajesh Kumar,&nbsp;Neerja Rani,&nbsp;Rima Dada","doi":"10.4274/MMJ.galenos.2023.38275","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.38275","url":null,"abstract":"<p><strong>Objective: </strong>The introduction of competency-based medical education curriculum and a shifted focus towards self-directed learning (SDL) in medical schools across the world has necessitated a reduction of didactic teaching hours. Museum specimens are an indispensable tool in anatomy teaching and can play a pivotal role in fostering and reinforcing SDL. Coloring of specimens makes it attractive and facilitates understanding anatomy. The aims of this study were: (1) weigh up the two commonly used coloring materials in anatomy viz. acrylic paint and nail polish; and (2) to assess the perception of anatomy students towards a Novel Osteo Refurbishment Method (NORM) for restoration of partially damaged osteology specimens.</p><p><strong>Methods: </strong>Undergraduate and postgraduate students of anatomy were recruited in the study. Participants responded to a 5-point Likert scale questionnaire. Obtained data were analyzed using Microsoft Excel version 2019. For a comparison of the two coloring agents Mann-Whitney U test was applied to the responses toward the Likert scale-based questionnaire. P-value <0.05 was considered significant.</p><p><strong>Results: </strong>Out of 318 study participants, 63.7% and 36.3% of the respondents were male and female, respectively. 90.5 % were new entrants to university and the remainder 9.5% had a prior university degree. Students found the acrylic paint to be a better coloring agent and they also opined that NORM generated refurbished osteology specimens could serve as a useful self-learning tool. Acrylic paint was found to be more suitable as compared to nail polish with significant p-value in most of the parameters tested.</p><p><strong>Conclusions: </strong>Acrylic colour holds a good place in coloring both specimens and models in anatomy. Nail polish can be an alternative but with some noted disadvantages. The initial experience with NORM yielded encouraging results with potential practical utility.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/9d/medj-38-54.PMC10064105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Medical Treatments According to the Characteristics of Idiopathic Premature Ventricular Contractions: Beta-blockers or Calcium Channel Blockers?","authors":"Omer Faruk Baycan,&nbsp;Serdar Fidan,&nbsp;Fatma Betul Celik,&nbsp;Mustafa Adem Tatlisu,&nbsp;Serhan Ozyildirim,&nbsp;Mustafa Caliskan","doi":"10.4274/MMJ.galenos.2023.00532","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2023.00532","url":null,"abstract":"<p><strong>Objective: </strong>Premature ventricular contractions (PVCs) are a common arrhythmic condition. The first approach in patients with symptomatic and frequent PVC is medical treatment, primarily beta-blockers (BB) or calcium channel blockers (CCB), but it is still unclear which of the two should be chosen. This study investigated which drug treatment would be beneficial according to patient and electrocardiography (ECG) characteristics in patients with idiopathic PVC.</p><p><strong>Methods: </strong>We retrospectively analyzed 156 patients with PVC who came to the cardiology outpatient clinic. Seventy-one patients were responsive to BB, and 85 were responsive to CCB. Their demographic and ECG characteristics were compared.</p><p><strong>Results: </strong>The male ratio was higher (p<0.001), and the left ventricular ejection fraction was lower in BB responders than in CCB responders (p<0.001). Although the mean heart rate was higher in BB responders (p<0.001), the initial PVC burden was lower in BB responders than in CCB responders (p<0.001). The PVC QRS duration was longer in BB responders than in CCB responders (p<0.001). Similarly, the coupling interval variability was higher in BB responders (p=0.006).</p><p><strong>Conclusions: </strong>The evaluation of clinical and ECG parameters in patients with frequent idiopathic PVCs may determine whether BBs or CCBs should be chosen as initial treatment. Further prospective studies are needed to verify our findings and establish their clinical applicability.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a0/ef/medj-38-32.PMC10064106.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal System Involvement in Pediatric Patients with Acute SARS-CoV-2 Infection.","authors":"Ozlem Kalaycik Sengul,&nbsp;Burcin Beken,&nbsp;Zehra Ozturk,&nbsp;Seyma Ozpinar,&nbsp;Gizem Ozkan,&nbsp;Gizem Gungor","doi":"10.4274/MMJ.galenos.2022.79674","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.79674","url":null,"abstract":"<p><strong>Objective: </strong>The prevalence of gastrointestinal symptoms in coronavirus disease-2019 (COVID-19) has been reported widely. In this study, the prevalence of gastrointestinal system (GIS) involvement in pediatric COVID-19 and its effect on prognosis were investigated.</p><p><strong>Methods: </strong>Children (aged 0-18 years) with acute COVID-19 were included in the study. The patients were grouped according to system involvement: isolated respiratory system (RS), isolated GIS, and combination of both (RS+GIS). These groups were compared in terms of demographic data, clinical characteristics, laboratory and imaging findings, and hospitalization.</p><p><strong>Results: </strong>A total of 223 pediatric patients were included in the study. Of these patients, 19 were asymptomatic, 12 were diagnosed with a multisystem inflammatory syndrome in children, 21 had chronic disorders that may affect disease severity, and 27 had symptoms not related to RS or GIS. The remaining 144 patients were classified according to system involvement: 79 (35.4%), 14 (6.3%), and 51 (22.9%) had isolated RS, isolated GIS, and RS+GIS involvement, respectively. The GIS group was much younger than the RS group (median, 30 and 150 months, respectively, p=0.006). Three patients from the RS group were followed in the intensive care unit (ICU). Moreover, 17 (21.5%) and 4 (7.8%) patients from the RS group had severe-critical respiratory symptoms, in the RS+GIS group had severe-critical respiratory symptoms (p=0.039).</p><p><strong>Conclusions: </strong>Our study showed that GIS involvement in children with COVID-19 is more prevalent than RS involvement in the younger age group. Respiratory symptom severity and ICU admission also decreased with accompanying GIS involvement. GIS involvement was still associated with a milder disease course after adjustment for age.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/96/medj-37-332.PMC9808857.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10505222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microcystic Elongated and Fragmented Pattern Invasion in Endometrial Cancer: Possible Prognostic Value to Precise and Individualized Therapeutic Strategies.","authors":"Christos Iavazzo,&nbsp;Alexandros Fotiou,&nbsp;Ioannis D Gkegkes,&nbsp;Nikolaos Vrachnis","doi":"10.4274/MMJ.galenos.2022.39024","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.39024","url":null,"abstract":"the invasive front of the MELF pattern and concluded that programed cell death protein 1/PD-L1 immunotherapy demonstrated significant therapeutic effect on the management of patients with endometrial cancer and grade 1 MELF. Furthermore, Rabe et al. 4 claimed that cytokeratin IHC staining could detect malignant cells in the sentinel lymph nodes of patients with endometrial cancer and MELF. Finally, in a large cohort study, He et al. 5 revealed that participants with POLE-mutated tumors and MELF pattern invasion had a 15.1-fold increase in tumor recurrence or progression risk than POLE-wild type tumors. Once again, we thank the authors for their excellent study.","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/b7/medj-37-352.PMC9808849.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9077886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Importance of Optic Nerve Sheath Diameter in Patients with Traumatic Brain Injury: Preliminary Report.","authors":"Burcu Avci Ozbalik,&nbsp;Tugba Bingol Tanriverdi,&nbsp;Hafize Gulsah Ozcan,&nbsp;Melek Gura Celik","doi":"10.4274/MMJ.galenos.2022.42966","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.42966","url":null,"abstract":"<p><strong>Objective: </strong>Traumatic brain injury (TBI) is a serious health problem that is related to an increased mortality. In cases of severe TBI, the prediction of prognosis is essential. The enlargement of the optic nerve sheath diameter (ONSD) shows an increased intracranial pressure and is associated with poor outcomes. In this study, we aimed to evaluate the prognostic value of ONSD in patients with severe TBI.</p><p><strong>Methods: </strong>Forty-four patients with severe TBI were retrospectively enrolled in the study. The patients were divided into two groups: survivors (n=17) and non-survivors (n=27). Baseline characteristics, clinical data, Glasgow coma scale (GCS) on hospital admission, brain computed tomography (CT) results, injury severity score (ISS), and Marshall score were recorded for all patients. ONSD was calculated at 3 mm distance from the globe, immediately below the sclera.</p><p><strong>Results: </strong>The ONSD on the initial CT was significantly higher in non-survivors compared with survivors (6.83±1.40 vs. 6.40±1.36, p<0.05). In addition, ISS and Marshall score were significantly higher, whereas GCS was significantly lower in non-survivors. ONSD was positively correlated with Marshall score (r=0.332, p<0.05). Receiver operating characteristics analysis demonstrated that ONSD ≥6.61 had a sensitivity of 70.4% and specificity of 64.7% for predicting mortality. It was shown that ONSD ≥6.61 had a 4.3-fold increased risk for in-hospital mortality (odds ratio: 4.35; 95% confidence interval: 1.195-15.865; p<0.05).</p><p><strong>Conclusions: </strong>The enlargement of ONSD on initial CT was detected to be associated with increased in-hospital mortality in patients with severe TBI.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/2a/medj-37-320.PMC9808856.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10515246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in Superficial Palmar Arch: Case Series with Clinico-anatomical Perspective.","authors":"Dibakar Borthakur,&nbsp;Rajesh Kumar,&nbsp;Seema Singh","doi":"10.4274/MMJ.galenos.2022.82598","DOIUrl":"10.4274/MMJ.galenos.2022.82598","url":null,"abstract":"<p><p>The superficial palmar arch (SPA) is an important anastomotic network primarily formed by the superficial branch of the ulnar artery with one of the superficial branches of the radial artery. SPA variations were observed in three out of 20 cadaveric hand specimens. Two cases of unilateral incomplete SPA and the third case of a unilateral ulnar-to-median complete SPA were recorded. The incomplete SPA was located superficial to the flexor digitorum tendons and deep to the palmar aponeurosis. SPA in the remaining 17 hands was anatomically normal, with major contributions from the superficial palmar branch of the ulnar artery and minor contributions from the superficial palmar branch of the radial artery. These variations are clinically important, especially during procedures like arterial blood sampling, cardiac catheterization, and hemodialysis. Thus, anatomical variabilities in this region may cause complications with vascular occlusion if not ascertained before the procedure.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/8b/medj-37-346.PMC9808850.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10515247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Searching for Biomarkers in Proliferative Diabetic Retinopathy: Amphiregulin and Progranulin.","authors":"Burak Bilgin,&nbsp;Mete Guler,&nbsp;Hulya Cicek,&nbsp;Selma Urfalioglu,&nbsp;Gokhan Kokusari,&nbsp;Bedia Marangozoglu Sahin","doi":"10.4274/MMJ.galenos.2022.10270","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.10270","url":null,"abstract":"<p><strong>Objective: </strong>Diabetic retinopathy is a common diabetic microvascular problem. Its diagnosis and classification are based on visible changes in clinical fundus examination. However, the discovery of possible vitreous biomarkers in patients with proliferative and nonproliferative diabetic retinopathy may guide both the differentiation and degree of retinopathy. Biomarkers that will be accepted can be also a treatment target. Amphiregulin (AREG) promotes proliferative and regenerative activity and repairs most cell types by binding and activating epidermal growth factor receptors. Progranulin (PGRN) has complex functions in many physiological and pathological processes. Thus, this study aimed to report vitreous AREG and PGRN levels in patients with diabetes and proliferative retinopathy and compare the results with those without diabetes.</p><p><strong>Methods: </strong>Thirty-three eyes of 33 patients with proliferative diabetic retinopathy and 31 eyes of 31 patients without diabetes were included in this study. Vitreous humor samples were collected from all patients at the time of pars plana vitrectomy surgery immediately before the surgical procedure. Vitreous AREG and PGRN values were determined by the ELISA method.</p><p><strong>Results: </strong>The mean AREG and PGRN values were similar in the groups (p=0.427, p=0.459, respectively).</p><p><strong>Conclusions: </strong>The results demonstrated that vitreous AREG and PGRN levels have no significant relationship with proliferative diabetic retinopathy.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/95/medj-37-327.PMC9808851.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10515243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking Induces the Circulating Levels of Matrix Metalloproteinase-9 and Its Association with Cardiovascular Risk in Young Smokers.","authors":"Dinesh Nath,&nbsp;Meera Shivasekar,&nbsp;V M Vinodhini","doi":"10.4274/MMJ.galenos.2022.45057","DOIUrl":"https://doi.org/10.4274/MMJ.galenos.2022.45057","url":null,"abstract":"<p><strong>Objective: </strong>Smoking causes cardiovascular risk, which may alter the stability between the production and degradation of the extracellular matrix. Matrix metalloproteinase-9 (MMP-9) is a zinc-containing endopeptidase that degrades the extracellular matrix and is involved in tissue remodelling and several physiological processes. As a result, smoking-induced elevated serum MMP-9 levels, particularly at a younger age, raise the risk of coronary heart disease (CHD). Thus, this study aimed to determine the possible relationship between smoking-induced circulating MMP-9 and the risk of cardiovascular disease in young smokers.</p><p><strong>Methods: </strong>In this cross-sectional study, the patients were divided into three groups. Each group contains 120 study participants. Group one consisted of 120 healthy individuals with no physical and mental illness, group two consisted of 120 active smokers with a heart disease, and group three consisted of 120 active smokers with a heart disease and diabetes, who attended Sri Ramaswamy Memorial Hospital for cardiology checkup at the age of 20-55 years. The serum MMP-9, high-sensitivity C-reactive protein (hs-CRP), and apolipoprotein-E (APO-E) levels were analyzed using the ELISA method, and the lipid levels were measured enzymatically using AU480 automatic analyzer (Beckman Coulter).</p><p><strong>Results: </strong>Compared with non-smokers, the study shows that the mean serum MMP-9, hs-CRP, and APO-E levels were significantly higher in smokers (p<0.001). A strong relationship was also found between MMP-9 and hs-CRP, APO-E, smoking load, and smoking intensity.</p><p><strong>Conclusions: </strong>A significant association was found between cigarette smoking with MMP-9, and relative exposure to circulating inflammation markers plays a potential role in the pathogenesis of CHD.</p>","PeriodicalId":37427,"journal":{"name":"Medeniyet medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/22/medj-37-306.PMC9808855.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10515244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}